KEGG   PATHWAY: ecb04010
Entry
ecb04010                    Pathway                                
Name
MAPK signaling pathway - Equus caballus (horse)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ecb04010  MAPK signaling pathway
ecb04010

Other DBs
GO: 0000165
Organism
Equus caballus (horse) [GN:ecb]
Gene
100063873  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100058760  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100049924  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100051186  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100054582  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
100062861  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100070000  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
100067492  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
100070365  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
100034092  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100057533  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
100061645  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
100059197  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
100630648  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
100055054  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
100055971  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X3 [KO:K04863]
100051367  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X4 [KO:K04864]
100057916  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
100053535  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
100054570  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
100068407  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
106780860  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
100063388  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
100147407  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
100062937  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
100147684  CACNG8; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
100052828  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100064302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100069215  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100062549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100060005  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100063518  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100630574  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100057357  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100067434  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100072862  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100061874  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102148270  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100050202  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
100073254  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
100071578  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102150244  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
100070505  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100064247  RASGRP4; RAS guanyl-releasing protein 4 isoform X4 [KO:K12363]
100069003  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X14 [KO:K08018]
100071896  NF1; neurofibromin isoform X1 [KO:K08052]
100073242  RASA1; ras GTPase-activating protein 1 [KO:K04352]
100063323  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
100049912  ras-related protein Rap-1A [KO:K04353]
100058930  RAP1A; ras-related protein Rap-1A [KO:K04353]
100052025  RAP1B; ras-related protein Rap-1b [KO:K07836]
106782874  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100060423  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
100056605  EREG; proepiregulin [KO:K09784]
100050528  AREG; amphiregulin [KO:K09782]
100033960  FGF1; fibroblast growth factor 1 [KO:K18496]
100033955  FGF2; fibroblast growth factor 2 [KO:K18497]
100033961  FGF7; fibroblast growth factor 7 [KO:K04358]
100056444  FGF17; fibroblast growth factor 17 isoform X3 [KO:K04358]
100071790  FGF16; fibroblast growth factor 16 [KO:K04358]
100050353  FGF9; fibroblast growth factor 9 [KO:K04358]
100060219  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100052655  FGF10; fibroblast growth factor 10 [KO:K04358]
100050037  FGF20; fibroblast growth factor 20 [KO:K04358]
100060309  FGF8; fibroblast growth factor 8 [KO:K04358]
100051221  FGF6; fibroblast growth factor 6 [KO:K04358]
100629648  FGF18; fibroblast growth factor 18 [KO:K04358]
100072461  FGF22; fibroblast growth factor 22 [KO:K04358]
100146649  FGF3; fibroblast growth factor 3 [KO:K04358]
100060525  FGF4; fibroblast growth factor 4 [KO:K04358]
100060488  FGF19; fibroblast growth factor 19 [KO:K22603]
100054542  FGF21; fibroblast growth factor 21 [KO:K22429]
100058460  FGF23; fibroblast growth factor 23 [KO:K22428]
100065669  NGF; beta-nerve growth factor [KO:K02582]
100009689  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
100051839  NTF3; neurotrophin-3 isoform X2 [KO:K04356]
100054859  NTF4; neurotrophin-4 [KO:K12457]
111776000  INS; insulin [KO:K04526]
100034198  IGF1; insulin-like growth factor I precursor [KO:K05459]
100034182  IGF2; insulin-like growth factor II precursor [KO:K13769]
100055086  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100070283  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100062015  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100061488  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100146493  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100034127  KITLG; kit ligand precursor [KO:K05461]
100055522  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
100033839  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
100055238  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100051349  PGF; placenta growth factor isoform X1 [KO:K16859]
100050877  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
100060890  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
100049848  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100056482  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100051890  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100067818  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
100063240  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
100073202  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100063307  EFNA1; ephrin-A1 [KO:K05462]
100057186  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
111774429  EFNA2; ephrin-A2 [KO:K05462]
100067053  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
111774192  NRTN; neurturin [KO:K25414]
106782773  ARTN; artemin [KO:K25415]
100065517  PSPN; persephin [KO:K25416]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100054739  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100059216  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100050182  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X6 [KO:K05085] [EC:2.7.10.1]
100057614  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100033956  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
100034114  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100068679  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
100069694  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100064594  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100061700  NTRK2; BDNF/NT-3 growth factors receptor isoform X3 [KO:K04360] [EC:2.7.10.1]
100066248  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100055698  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100059815  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100071665  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100060422  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
100009704  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
100061780  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100033957  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
100066773  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100033959  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100056013  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100066963  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
100053644  EPHA2; ephrin type-A receptor 2 isoform X3 [KO:K05103] [EC:2.7.10.1]
100146791  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100051866  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100053889  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100066282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100051785  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
100059469  NRAS; GTPase NRas [KO:K07828]
100055781  RRAS; ras-related protein R-Ras [KO:K07829]
100071586  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
100064781  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
100061212  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
100065760  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100629409  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100064521  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
100146117  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
100058911  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
100057166  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
100050176  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
100072397  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
100070334  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100051388  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100050315  ELK4; ETS domain-containing protein Elk-4 isoform X2 [KO:K04376]
100068097  MYC; myc proto-oncogene protein [KO:K04377]
100055059  SRF; serum response factor [KO:K04378]
100051632  FOS; proto-oncogene c-Fos [KO:K04379]
100054638  MAPT; microtubule-associated protein tau isoform X8 [KO:K04380]
100057411  STMN1; stathmin [KO:K04381]
100071038  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100033889  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
100071062  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
100071016  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
100071025  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100033834  TNF; tumor necrosis factor [KO:K03156]
100064969  IL1A; interleukin-1 alpha precursor [KO:K04383]
100034237  IL1B; interleukin-1 beta [KO:K04519]
100052414  IL1B; interleukin-1 beta [KO:K04519]
111768185  interleukin-1 beta-like [KO:K04519]
100033900  TGFB1; transforming growth factor beta-1 precursor [KO:K13375]
100050377  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
111771316  transforming growth factor beta-2-like isoform X1 [KO:K13376]
100051765  TGFB3; transforming growth factor beta-3 [KO:K13377]
100059548  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100009699  IL1R1; interleukin-1 receptor type 1 precursor [KO:K04386]
100068726  IL1RAP; interleukin-1 receptor accessory protein isoform X3 [KO:K04723]
100034117  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100033860  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100052326  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100071639  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100630219  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
111772122  monocyte differentiation antigen CD14-like [KO:K04391]
111767791  monocyte differentiation antigen CD14-like [KO:K04391]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100054701  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
100054738  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100058188  CDC42; cell division control protein 42 homolog [KO:K04393]
100065824  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
100034083  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100068006  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
100146901  DAXX; death domain-associated protein 6 [KO:K02308]
100053940  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100059262  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100054848  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100052296  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100054996  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100059768  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100630299  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100070300  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
100060433  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100054814  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
100069835  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
100058919  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
100064279  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
100063217  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100060183  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100070861  STK4; serine/threonine-protein kinase 4 [KO:K04411]
100060508  STK3; serine/threonine-protein kinase 3 [KO:K04412]
100056001  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
100063602  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
100061688  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100057319  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
100050628  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
100064751  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
100054289  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
100059834  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
100064002  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
100059237  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
100053153  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X5 [KO:K04424] [EC:2.7.11.25]
100070933  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
100073186  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100065841  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
100058153  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
100050932  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
100059705  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
100066000  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
100073094  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
100147230  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100053481  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100053056  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100056764  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
100055523  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
100067809  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
100058256  FLNA; filamin-A isoform X1 [KO:K04437]
100072356  CRK; adapter molecule crk isoform X1 [KO:K04438]
100050855  CRKL; crk-like protein [KO:K04438]
100064657  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
100072892  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
100052608  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100057961  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100051798  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100056278  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100056239  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100063532  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106782258  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100057579  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
100055510  MAPKAPK2; LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102147500  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100061475  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X2 [KO:K04444] [EC:2.7.11.1]
100062953  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
100050279  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
100052425  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
100065378  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100053856  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100067469  JUN; transcription factor AP-1 [KO:K04448]
111769673  JUND; transcription factor jun-D [KO:K04449]
100053304  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100062044  TP53; cellular tumor antigen p53 [KO:K04451]
100053417  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100062536  MAX; protein max isoform X2 [KO:K04453]
100065153  MEF2C; myocyte-specific enhancer factor 2C isoform X7 [KO:K04454]
100059763  HSPB1; heat shock protein beta-1 [KO:K04455]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100051348  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
100063646  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X2 [KO:K04458] [EC:3.1.3.48]
100071930  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
100052261  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
100069834  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
100063475  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100058453  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100051611  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100060559  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100068966  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100146958  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100051565  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100057759  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
100050108  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
100064999  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
100071104  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
100053585  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
100050827  HSPA1A; heat shock 70kDa protein 1A [KO:K03283]
100051595  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
100050904  heat shock 70 kDa protein 1-like [KO:K03283]
100009679  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
111769297  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
100057450  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X2 [KO:K04462] [EC:2.1.1.367]
100052849  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X8 [KO:K04463] [EC:2.7.12.2]
100073174  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
100061353  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
100050140  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100070393  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100050167  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100058432  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100058876  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
100067894  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580]
100069984  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
100057483  RELA; transcription factor p65 [KO:K04735]
100070664  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Nat Rev Drug Discov 8:480-99 (2009)
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Related
pathway
ecb04070  Phosphatidylinositol signaling system
ecb04110  Cell cycle
ecb04115  p53 signaling pathway
ecb04210  Apoptosis
ecb04310  Wnt signaling pathway
ecb04668  TNF signaling pathway
KO pathway
ko04010   
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