KEGG   PATHWAY: ecb05417
Entry
ecb05417                    Pathway                                
Name
Lipid and atherosclerosis - Equus caballus (horse)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
ecb05417  Lipid and atherosclerosis
ecb05417

Organism
Equus caballus (horse) [GN:ecb]
Gene
100071824  APOB; apolipoprotein B-100 [KO:K14462]
100062506  APOA4; apolipoprotein A-IV [KO:K08760]
100062583  APOA1; apolipoprotein A-I [KO:K08757]
100057389  LDLR; low-density lipoprotein receptor [KO:K12473]
100062370  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
102150569  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
100033896  MMP1; interstitial collagenase precursor [KO:K01388] [EC:3.4.24.7]
100053343  RHOA; transforming protein RhoA [KO:K04513]
100072339  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100063339  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100052122  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100054674  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100055447  BAD; bcl2-associated agonist of cell death [KO:K02158]
100053597  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100050934  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100052608  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100057961  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100051798  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100034223  SOD2; superoxide dismutase [Mn], mitochondrial precursor [KO:K04564] [EC:1.15.1.1]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100051363  POU2F1; POU domain, class 2, transcription factor 1 isoform X6 [KO:K09364]
100069713  POU2F2; POU domain, class 2, transcription factor 2 isoform X4 [KO:K09364]
100071489  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
100034049  CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
100054624  CD40LG; CD40 ligand isoform X1 [KO:K03161]
100062285  CYP1A1; cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
100067247  cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100051699  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
100146916  NOX1; NADPH oxidase 1 [KO:K08008]
100050132  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100146522  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100049843  CYBA; cytochrome b-245 light chain isoform X1 [KO:K08009]
100051787  NCF2; neutrophil cytosol factor 2 [KO:K08010]
100069566  NCF4; neutrophil cytosol factor 4 [KO:K08012]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100069870  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100051487  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100034011  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100058188  CDC42; cell division control protein 42 homolog [KO:K04393]
100073094  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
100147230  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100051632  FOS; proto-oncogene c-Fos [KO:K04379]
100067469  JUN; transcription factor AP-1 [KO:K04448]
100034136  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
100058207  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
100037400  CXCL8; interleukin-8 precursor [KO:K10030]
100053481  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100053056  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100056278  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100056239  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100063532  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106782258  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100051785  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
100059469  NRAS; GTPase NRas [KO:K07828]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100057483  RELA; transcription factor p65 [KO:K04735]
100067894  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580]
100033910  SELE; E-selectin precursor [KO:K06494]
100009695  SELP; P-selectin [KO:K06496]
100050252  VCAM1; vascular cell adhesion protein 1 precursor [KO:K06527]
100034195  MMP3; stromelysin-1 precursor [KO:K01394] [EC:3.4.24.17]
100056599  MMP9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
100071639  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100034237  IL1B; interleukin-1 beta [KO:K04519]
100052414  IL1B; interleukin-1 beta [KO:K04519]
111768185  interleukin-1 beta-like [KO:K04519]
100034196  IL6; interleukin-6 precursor [KO:K05405]
100033834  TNF; tumor necrosis factor [KO:K03156]
100055147  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
100050827  HSPA1A; heat shock 70kDa protein 1A [KO:K03283]
100051595  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
100050904  heat shock 70 kDa protein 1-like [KO:K03283]
100009679  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
111769297  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
100629616  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
100072809  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
100034150  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100033837  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100033933  HSP90B1; endoplasmin precursor [KO:K09487]
100009701  TLR2; toll-like receptor 2 precursor [KO:K10159]
100070103  LBP; lipopolysaccharide-binding protein [KO:K05399]
100070140  lipopolysaccharide-binding protein-like [KO:K05399]
100630219  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
111772122  monocyte differentiation antigen CD14-like [KO:K04391]
111767791  monocyte differentiation antigen CD14-like [KO:K04391]
100034040  LY96; lymphocyte antigen 96 precursor [KO:K05400]
100066890  TLR4; toll-like receptor 4 precursor [KO:K10160]
111771935  toll-like receptor 4 [KO:K10160]
100064503  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
100053940  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100054848  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100059262  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100052296  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100070300  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
100060433  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100065841  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
100070393  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100050167  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100058432  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100058000  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100529854  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
100062414  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100055110  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
100060229  MIB1; E3 ubiquitin-protein ligase MIB1 isoform X2 [KO:K10645] [EC:2.3.2.27]
100065291  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
100051339  TANK; TRAF family member-associated NF-kappa-B activator isoform X4 [KO:K12650]
100055384  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4 [KO:K07211] [EC:2.7.11.10]
100051650  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100055087  IRF7; interferon regulatory factor 7 isoform X6 [KO:K09447]
100055868  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100064468  interferon alpha-2-like [KO:K05414]
100064551  interferon alpha-2-like [KO:K05414]
100052921  interferon alpha-4 precursor [KO:K05414]
100052818  IFN-ALPHA2; interferon alpha-2 precursor [KO:K05414]
100629951  interferon alpha-1 [KO:K05414]
100053110  interferon alpha-4 [KO:K05414]
100053022  IFNA1; interferon alpha-1 precursor [KO:K05414]
100053210  interferon alpha-2-like [KO:K05414]
100064612  interferon alpha-2-like [KO:K05414]
100064731  IFND1; interferon delta 1 precursor [KO:K05414]
100064975  IFND2; interferon-delta 2 precursor [KO:K05414]
100629885  interferon alpha-2-like [KO:K05414]
100052545  IFNB1; interferon beta precursor [KO:K05415]
100052658  interferon beta-like [KO:K05415]
100147174  interferon beta [KO:K05415]
100049847  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
100051258  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
100069096  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
100061303  RXRB; retinoic acid receptor RXR-beta isoform X3 [KO:K08525]
100060371  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
100053129  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100058245  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
100057737  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
100069175  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100066010  VAV1; proto-oncogene vav [KO:K05730]
100064554  TLR6; toll-like receptor 6 [KO:K10169]
100049912  ras-related protein Rap-1A [KO:K04353]
100058930  RAP1A; ras-related protein Rap-1A [KO:K04353]
100052025  RAP1B; ras-related protein Rap-1b [KO:K07836]
100033925  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
100057909  CCL3; C-C motif chemokine 3 precursor [KO:K05408]
100034121  CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) precursor [KO:K05505]
100233237  CXCL2; C-X-C motif chemokine 2 precursor [KO:K05505]
100056258  MIP-2BETA; uncharacterized protein LOC100056258 precursor [KO:K05505]
100034215  IL12A; interleukin-12 subunit alpha [KO:K05406]
100034222  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
100073322  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
100034216  IL18; interleukin-18 precursor [KO:K05482]
100067235  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
111773414  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
100053417  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100054748  ERO1A; ERO1-like protein alpha isoform X1 [KO:K10950] [EC:1.8.4.-]
100052808  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100064138  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13 [KO:K04515] [EC:2.7.11.17]
100071654  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100072618  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6 [KO:K04515] [EC:2.7.11.17]
100146368  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100066488  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
100052709  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100070334  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100064339  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100068006  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
100073186  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100059209  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
100054241  ABCA1; ATP-binding cassette sub-family A member 1 isoform X2 [KO:K05641]
100058103  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
100066816  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
100063252  apoptosis-associated speck-like protein containing a CARD isoform X2 [KO:K12799]
100033888  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
100050907  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
100630736  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100061033  GSK3B; glycogen synthase kinase-3 beta isoform X6 [KO:K03083] [EC:2.7.11.26]
100065378  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100052657  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X4 [KO:K17332]
100053856  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100057315  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100051558  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100055407  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100051485  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100070545  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
100057133  CALML5; calmodulin-like protein 5 [KO:K02183]
100062752  CALM1; calmodulin-1 [KO:K02183]
100070422  calmodulin-like protein 3 [KO:K02183]
100071150  CALM3; calmodulin-3 [KO:K02183]
100629145  CALM2; calmodulin-2 [KO:K02183]
100064482  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100052798  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
100057357  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100067434  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100072862  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100061874  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102148270  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100064377  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
100057812  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
102149226  tumor necrosis factor receptor superfamily member 10A [KO:K04722]
102150834  tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K04722]
100059548  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100052326  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100066502  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100054988  BID; BH3-interacting domain death agonist [KO:K04726]
100053958  CYCS; cytochrome c [KO:K08738]
111768755  cytochrome c, testis-specific [KO:K08738]
100052552  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
100054331  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100072861  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
100034083  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100068258  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
100062044  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
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Related
pathway
ecb04020  Calcium signaling pathway
ecb04115  p53 signaling pathway
ecb04141  Protein processing in endoplasmic reticulum
ecb04151  PI3K-Akt signaling pathway
ecb04210  Apoptosis
ecb04620  Toll-like receptor signaling pathway
ecb04621  NOD-like receptor signaling pathway
ecb04668  TNF signaling pathway
ecb04670  Leukocyte transendothelial migration
ecb04975  Fat digestion and absorption
ecb04979  Cholesterol metabolism
ecb05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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