KEGG   PATHWAY: oga05200
Entry
oga05200                    Pathway                                
Name
Pathways in cancer - Otolemur garnettii (small-eared galago)
Class
Human Diseases; Cancer: overview
Pathway map
oga05200  Pathways in cancer
oga05200

Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100965904  DCC; netrin receptor DCC [KO:K06765]
100961435  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100957904  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100960005  APPL1; DCC-interacting protein 13-alpha [KO:K08733]
100958318  cadherin-1 [KO:K05689]
100966689  CTNNB1; catenin beta-1 [KO:K02105]
100960331  CTNNA2; catenin alpha-2 isoform X3 [KO:K05691]
100960110  CTNNA1; catenin alpha-1 [KO:K05691]
100967150  CTNNA3; catenin alpha-3 [KO:K05691]
100964150  AXIN1; axin-1 isoform X2 [KO:K02157]
100964757  AXIN2; axin-2 [KO:K04385]
100950293  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100966348  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100952751  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
100947392  TCF7; transcription factor 7 isoform X1 [KO:K02620]
100940553  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100943434  TCF7L2; transcription factor 7-like 2 isoform X11 [KO:K04491]
100958411  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
100961291  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
100952981  MYC; myc proto-oncogene protein [KO:K04377]
100958947  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100943890  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100946400  WNT2; protein Wnt-2 [KO:K00182]
100960603  WNT2B; protein Wnt-2b [KO:K00182]
100964130  WNT3A; protein Wnt-3a [KO:K00312]
100954489  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100950370  WNT4; protein Wnt-4 [KO:K00408]
100962307  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100950006  WNT5B; protein Wnt-5b [KO:K00444]
100947622  WNT6; protein Wnt-6 [KO:K00445]
100959243  WNT7A; protein Wnt-7a [KO:K00572]
100943606  WNT7B; protein Wnt-7b [KO:K00572]
100947970  WNT8B; protein Wnt-8b [KO:K00714]
100963978  WNT8A; protein Wnt-8a [KO:K00714]
100957093  WNT9A; protein Wnt-9a [KO:K01064]
100954800  WNT9B; protein Wnt-9b [KO:K01064]
100943567  WNT10B; protein Wnt-10b [KO:K01357]
100947304  WNT10A; protein Wnt-10a [KO:K01357]
100954223  WNT11; protein Wnt-11 [KO:K01384]
100959119  WNT16; protein Wnt-16 [KO:K01558]
100963272  FZD7; frizzled-7 [KO:K02432]
100948251  FZD1; frizzled-1 [KO:K02432]
100963711  FZD2; frizzled-2 [KO:K02235]
100956711  FZD3; frizzled-3 [KO:K02329]
100964395  FZD4; frizzled-4 [KO:K02354]
100947964  FZD8; frizzled-8 [KO:K02375]
100963379  FZD5; frizzled-5 [KO:K02375]
100955382  FZD6; frizzled-6 isoform X2 [KO:K02376]
100943205  FZD10; frizzled-10 [KO:K02842]
100943348  FZD9; frizzled-9 [KO:K02842]
100961774  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100940907  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100947881  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100961331  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
100960572  FRAT1; proto-oncogene FRAT1 [KO:K03069]
100967077  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
100959798  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
100944302  AGT; angiotensinogen [KO:K09821]
100940909  F2R; proteinase-activated receptor 1 [KO:K03914]
100956724  F2RL3; proteinase-activated receptor 4 [KO:K04236]
100945428  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
100942103  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100963155  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100954954  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100951797  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
100954924  AGTR1; type-1 angiotensin II receptor [KO:K04166]
100956403  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100963709  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
100957349  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
100942946  ARHGEF11; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 11 [KO:K12331]
100951083  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
100949676  PLEKHG5; pleckstrin homology domain-containing family G member 5 isoform X1 [KO:K19464]
100954771  RHOA; transforming protein RhoA [KO:K04513]
100964845  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100953342  ROCK2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
100946548  CXCL12; stromal cell-derived factor 1 [KO:K10031]
100945275  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100962114  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100945007  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100962000  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X2 [KO:K04630]
100963130  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
100965094  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
100948374  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
100947256  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100966244  neuroendocrine secretory protein 55 [KO:K04632]
100966563  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
100955472  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100941250  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100942592  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100949638  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100942320  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100963748  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100956925  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100952034  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100943767  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100964083  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100966533  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100964694  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100940763  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100950950  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100961335  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100954252  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
111726116  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100947073  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100967014  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
111723289  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
111724938  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111728356  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111723667  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
100954553  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100950477  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111727847  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
111725594  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100954240  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
111724020  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100965274  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100945835  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
100945623  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
100945519  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
100950977  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
100958142  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
100964155  LAMA1; laminin subunit alpha-1 [KO:K05637]
100950964  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
100962025  LAMA3; laminin subunit alpha-3 [KO:K06240]
100954183  LAMA5; laminin subunit alpha-5 [KO:K06240]
100964189  LAMA4; laminin subunit alpha-4 [KO:K06241]
100944569  LAMB1; laminin subunit beta-1 [KO:K05636]
100952566  LAMB2; laminin subunit beta-2 [KO:K06243]
100965771  LAMB3; laminin subunit beta-3 [KO:K06244]
100947087  LAMB4; laminin subunit beta-4 [KO:K06245]
100953638  LAMC1; laminin subunit gamma-1 [KO:K05635]
100953119  LAMC2; laminin subunit gamma-2 [KO:K06246]
100960612  LAMC3; laminin subunit gamma-3 [KO:K06247]
100948167  FN1; fibronectin isoform X2 [KO:K05717]
100949511  ITGA2; integrin alpha-2 [KO:K06481]
100951652  ITGA2B; integrin alpha-IIb [KO:K06476]
100950802  ITGA3; integrin alpha-3 [KO:K06482]
100962528  ITGA6; integrin alpha-6 [KO:K06485]
100945899  ITGAV; integrin alpha-V [KO:K06487]
100955745  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100962373  PTK2; focal adhesion kinase 1 isoform X2 [KO:K05725] [EC:2.7.10.2]
100947138  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100953367  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100954109  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100956838  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100952580  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100949858  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100959283  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100964897  NKX3-1; homeobox protein Nkx-3.1 isoform X1 [KO:K09348]
100959825  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100955276  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100945977  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100949554  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100946157  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100958883  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100947991  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100951061  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100963289  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
100957990  RELA; transcription factor p65 isoform X3 [KO:K04735]
100944482  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100958618  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100955447  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100951387  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
100951719  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2-like [KO:K16060]
100950019  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
100951522  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100957318  BIRC7; baculoviral IAP repeat-containing protein 7 [KO:K16061]
100953032  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100959720  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
100966378  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100947925  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100948546  TRAF4; TNF receptor-associated factor 4 [KO:K09848]
100957799  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
100945817  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100957753  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100945805  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100940650  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X5 [KO:K04688] [EC:2.7.11.1]
100962306  BAD; bcl2-associated agonist of cell death [KO:K02158]
100960421  FOXO1; forkhead box protein O1 [KO:K07201]
100961605  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
100947328  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
100953808  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
111727809  E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100963622  TP53; cellular tumor antigen p53 [KO:K04451]
100964179  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100946725  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100960345  BCR; breakpoint cluster region protein [KO:K08878] [EC:2.7.11.1]
100961758  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100958636  CRK; adapter molecule crk isoform X1 [KO:K04438]
100951208  CRKL; crk-like protein [KO:K04438]
100958294  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
100958999  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
100955743  signal transducer and activator of transcription 5B [KO:K11224]
100947981  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
100949387  PIM2; serine/threonine-protein kinase pim-2 [KO:K08806] [EC:2.7.11.1]
100952099  KNG1; kininogen-1 isoform X5 [KO:K03898]
100961421  EDN1; endothelin-1 [KO:K16366]
100963177  BDKRB1; B1 bradykinin receptor [KO:K03915]
100962856  BDKRB2; B2 bradykinin receptor [KO:K03916]
100955327  EDNRA; endothelin-1 receptor [KO:K04197]
100964773  EDNRB; endothelin receptor type B [KO:K04198]
100946783  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100949562  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100966029  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100966182  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
100953462  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858] [EC:3.1.4.11]
100951857  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
100965377  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100943579  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100956877  PRKCG; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100942002  IL2; interleukin-2 [KO:K05429]
100946038  IL4; interleukin-4 isoform X1 [KO:K05430]
100955379  IL5; interleukin-5 isoform X1 [KO:K05428]
100949231  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
100943181  IL7; interleukin-7 isoform X1 [KO:K05431]
100959043  IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406]
100962204  IL12B; interleukin-12 subunit beta [KO:K05425]
100946348  IL13; interleukin-13 [KO:K05435]
100948308  IL15; interleukin-15 [KO:K05433]
100943872  IL23A; interleukin-23 subunit alpha [KO:K05426]
100961255  EPO; erythropoietin [KO:K05437]
100962353  interferon alpha-10-like [KO:K05414]
100955951  interferon alpha-10-like isoform X2 [KO:K05414]
100945944  interferon alpha-4-like [KO:K05414]
100945309  interferon alpha-5-like [KO:K05414]
100956963  interferon alpha-5-like [KO:K05414]
100957574  interferon alpha-5-like [KO:K05414]
100958440  interferon alpha-5-like [KO:K05414]
100958763  interferon alpha-10-like [KO:K05414]
100959074  interferon alpha-5-like [KO:K05414]
100946255  interferon alpha-10-like [KO:K05414]
100945607  IFNG; interferon gamma [KO:K04687]
100967179  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
100957798  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
100961176  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
100945479  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
100949360  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
100960327  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
100950177  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
100947685  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
100958958  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
100958917  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
100962079  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
100965357  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
100956002  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
100940599  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
100965684  IL23R; interleukin-23 receptor [KO:K05065]
100954028  EPOR; erythropoietin receptor [KO:K05079]
100958617  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100959248  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100960904  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
100957974  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
100961727  EML4; echinoderm microtubule-associated protein-like 4 isoform X2 [KO:K15420]
100962152  ALK; ALK tyrosine kinase receptor [KO:K05119] [EC:2.7.10.1]
100948727  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
100942339  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
100955151  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
100961453  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
100955095  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100948875  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100954742  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100958469  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100956762  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100944401  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
100957076  STAT4; LOW QUALITY PROTEIN: signal transducer and activator of transcription 4 [KO:K11222]
100949888  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
100960272  VEGFA; vascular endothelial growth factor A [KO:K05448]
100965129  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100967099  VEGFC; vascular endothelial growth factor C [KO:K05449]
100951253  VEGFD; vascular endothelial growth factor D [KO:K05449]
100959235  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
100959686  EGF; pro-epidermal growth factor [KO:K04357]
100950302  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100953964  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100944643  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100943395  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100961338  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100951606  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100951094  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100958631  IGF2; insulin-like growth factor II isoform X3 [KO:K13769]
100944394  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100949514  KITLG; kit ligand isoform X1 [KO:K05461]
100961872  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
100943945  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
100947062  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100963467  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
100948196  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100966077  FGF1; fibroblast growth factor 1 [KO:K18496]
100942631  FGF2; fibroblast growth factor 2 [KO:K18497]
100961245  FGF6; fibroblast growth factor 6 [KO:K04358]
100962391  FGF9; fibroblast growth factor 9 [KO:K04358]
100964809  FGF20; fibroblast growth factor 20 [KO:K04358]
100958629  FGF4; fibroblast growth factor 4 [KO:K04358]
100954515  FGF10; fibroblast growth factor 10 [KO:K04358]
100953298  FGF16; fibroblast growth factor 16 [KO:K04358]
100960938  FGF3; fibroblast growth factor 3 [KO:K04358]
100958585  FGF22; fibroblast growth factor 22 [KO:K04358]
100942388  FGF5; fibroblast growth factor 5 [KO:K04358]
100945380  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100948029  FGF18; fibroblast growth factor 18 [KO:K04358]
100947419  FGF7; fibroblast growth factor 7 [KO:K04358]
100940920  FGF8; fibroblast growth factor 8 isoform X4 [KO:K04358]
100961253  FGF19; fibroblast growth factor 19 [KO:K22603]
100947735  FGF21; fibroblast growth factor 21 [KO:K22429]
100958098  FGF23; fibroblast growth factor 23 [KO:K22428]
100960708  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100952813  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100962219  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100957667  FGFR4; fibroblast growth factor receptor 4 isoform X4 [KO:K05095] [EC:2.7.10.1]
100948701  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100958517  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100943020  SOS2; son of sevenless homolog 2 [KO:K03099]
100951644  HRAS; GTPase HRas isoform X1 [KO:K02833]
100953050  KRAS; GTPase KRas isoform X3 [KO:K07827]
100949583  NRAS; GTPase NRas isoform X1 [KO:K07828]
100947929  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100955336  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100941062  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100959926  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100956072  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100951533  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100957343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100965098  JUN; transcription factor AP-1 [KO:K04448]
100953435  FOS; proto-oncogene c-Fos [KO:K04379]
100944541  ETS1; protein C-ets-1 [KO:K02678]
100951906  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
100965003  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
100942813  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
111725388  CXCL8; interleukin-8 [KO:K10030]
100960589  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100964034  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
100942216  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100947101  CCDC6; coiled-coil domain-containing protein 6 [KO:K09288]
100947212  NCOA4; nuclear receptor coactivator 4 isoform X2 [KO:K09289]
100940422  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
100966951  TPM3; tropomyosin alpha-3 chain [KO:K09290]
100941107  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
100958039  TPR; nucleoprotein TPR [KO:K09291]
100941415  TFG; protein TFG isoform X1 [KO:K09292]
100964307  RASSF1; ras association domain-containing protein 1 isoform X3 [KO:K09850]
100951043  RASSF5; ras association domain-containing protein 5 [KO:K08015]
100959420  STK4; serine/threonine-protein kinase 4 [KO:K04411]
100944371  DAPK1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
100955132  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
100954257  DAPK2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
100948398  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
100948829  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100949181  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
100952803  calmodulin-like [KO:K02183]
100956147  calmodulin-like [KO:K02183]
105887316  CALML6; calmodulin-like protein 6 [KO:K02183]
100942721  calmodulin-like [KO:K02183]
100941613  CALM3; calmodulin-3 [KO:K02183]
100964319  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100946498  CALM2; calmodulin-2 [KO:K02183]
100966114  CALML5; calmodulin-like protein 5 [KO:K02183]
100948288  CALM1; calmodulin-1 [KO:K02183]
100941825  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
100955681  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
100956846  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
100950655  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100953476  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
100944758  RALA; ras-related protein Ral-A [KO:K07834]
100950310  RALB; ras-related protein Ral-B [KO:K07835]
100945636  RALBP1; ralA-binding protein 1 [KO:K08773]
100947706  cell division control protein 42 homolog [KO:K04393]
100950992  CDC42; cell division control protein 42 homolog [KO:K04393]
100951369  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100957182  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100948274  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
100959450  PLD1; phospholipase D1 isoform X4 [KO:K01115] [EC:3.1.4.4]
100957225  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
100957169  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100967053  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100960275  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100943070  PAX8; paired box protein Pax-8 [KO:K09293]
100943160  PPARG; peroxisome proliferator-activated receptor gamma isoform X2 [KO:K08530]
100962073  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
100962161  RXRB; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
100941535  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
100956106  RARB; retinoic acid receptor beta [KO:K08528]
100954847  ESR1; estrogen receptor isoform X2 [KO:K08550]
100946964  ESR2; estrogen receptor beta isoform X1 [KO:K08551]
100955534  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
100947872  NCOA3; nuclear receptor coactivator 3 isoform X6 [KO:K11256] [EC:2.3.1.48]
100953042  SP1; transcription factor Sp1 [KO:K04684]
100951033  PPARD; peroxisome proliferator-activated receptor delta isoform X2 [KO:K04504]
100965477  JUP; junction plakoglobin [KO:K10056]
100942092  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
100948279  RARA; retinoic acid receptor alpha isoform X2 [KO:K08527]
100942167  CCNA1; cyclin-A1 [KO:K06627]
100966485  CCNA2; cyclin-A2 [KO:K06627]
100964010  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
100940749  RUNX1; runt-related transcription factor 1 [KO:K08367]
100950251  RUNX1T1; LOW QUALITY PROTEIN: protein CBFA2T1 [KO:K10053]
100965330  SPI1; transcription factor PU.1 isoform X2 [KO:K09438]
100954648  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
100945167  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
100966247  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
100952454  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100943080  cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100957114  E2F1; transcription factor E2F1 [KO:K17454]
100956861  E2F2; transcription factor E2F2 [KO:K09389]
100942819  E2F3; transcription factor E2F3 [KO:K06620]
100943049  MAX; protein max isoform X1 [KO:K04453]
100943501  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X2 [KO:K10500]
100955700  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100952236  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100962188  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100945148  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
111722450  cyclin-dependent kinases regulatory subunit 1-like [KO:K02219]
100952432  CKS2; cyclin-dependent kinases regulatory subunit 2 [KO:K02219]
100966062  CKS1B; cyclin-dependent kinases regulatory subunit 1 [KO:K02219]
100947924  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
100962270  CUL1; cullin-1 [KO:K03347]
100963359  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
100942708  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
100964880  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100958215  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100959381  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100951476  RB1; retinoblastoma-associated protein [KO:K06618]
100946928  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100950782  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100950842  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X2 [KO:K04402]
100957285  BAX; apoptosis regulator BAX [KO:K02159]
100941755  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100962402  DDB2; DNA damage-binding protein 2 [KO:K10140]
100966233  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
100965364  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
100945117  MITF; microphthalmia-associated transcription factor isoform X2 [KO:K09455]
100949640  TGFB1; transforming growth factor beta-1 isoform X2 [KO:K13375]
100956747  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
100955213  TGFB3; transforming growth factor beta-3 [KO:K13377]
100953115  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100960821  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
100960336  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
100962223  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
100955502  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
100951161  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
100960121  CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
100949153  CTBP2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
100942963  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100965265  HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
100949586  LOW QUALITY PROTEIN: histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
100944025  MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
100957320  MSH2; DNA mismatch repair protein Msh2 [KO:K08735]
100950391  MSH3; DNA mismatch repair protein Msh3 [KO:K08736]
100948078  MSH6; DNA mismatch repair protein Msh6 [KO:K08737]
100952650  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
100962269  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
100951008  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100957582  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100960309  FADD; FAS-associated death domain protein [KO:K02373]
100965468  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100960302  BID; BH3-interacting domain death agonist [KO:K04726]
100957322  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
100945413  BBC3; bcl-2-binding component 3 isoform X1 [KO:K10132]
100947708  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
100952744  cytochrome c, somatic [KO:K08738]
100946237  cytochrome c [KO:K08738]
100961637  cytochrome c, testis-specific [KO:K08738]
100951508  cytochrome c-like [KO:K08738]
100959812  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
100942180  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
100960934  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
100962266  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
100965040  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
100945369  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
100956257  GSTT2B; glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
100957096  glutathione S-transferase theta-4 isoform X2 [KO:K00799] [EC:2.5.1.18]
100957715  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100958045  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
100943721  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
105886442  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
100960431  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
100956065  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
100944011  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100949338  glutathione S-transferase A3 isoform X7 [KO:K00799] [EC:2.5.1.18]
100949021  glutathione S-transferase A3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
105887236  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
111725262  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
100941135  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
100943404  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100940906  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100957213  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
100952495  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
100966292  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
100965976  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
100958968  TXNRD1; thioredoxin reductase 1, cytoplasmic isoform X1 [KO:K22182] [EC:1.8.1.9]
100959399  TXNRD2; thioredoxin reductase 2, mitochondrial [KO:K22182] [EC:1.8.1.9]
100950634  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
100952265  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
100945098  ELOC; elongin-C [KO:K03872]
100954615  ELOB; elongin-B [KO:K03873]
100966781  LOW QUALITY PROTEIN: cullin-2-like [KO:K03870]
100953859  CUL2; cullin-2 [KO:K03870]
100953629  EGLN2; egl nine homolog 2 isoform X1 [KO:K09592] [EC:1.14.11.29]
100961137  EGLN1; egl nine homolog 1 [KO:K09592] [EC:1.14.11.29]
100952096  EGLN3; egl nine homolog 3 [KO:K09592] [EC:1.14.11.29]
100943275  LOW QUALITY PROTEIN: fumarate hydratase, mitochondrial-like [KO:K01679] [EC:4.2.1.2]
100959591  FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
100941157  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
100955754  EPAS1; endothelial PAS domain-containing protein 1 [KO:K09095]
100941626  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
100951209  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 [KO:K15589]
100943144  CREBBP; CREB-binding protein isoform X3 [KO:K04498] [EC:2.3.1.48]
100963040  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
100959166  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
100950090  JAG1; protein jagged-1 [KO:K06052]
100950182  JAG2; protein jagged-2 [KO:K21635]
100948266  delta-like protein 3 [KO:K06051]
100958591  DLL4; delta-like protein 4 [KO:K06051]
100942514  DLL1; delta-like protein 1 [KO:K06051]
100948116  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
100963949  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
100965961  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
100952404  NOTCH4; neurogenic locus notch homolog protein 4 isoform X2 [KO:K20996]
100948316  HES1; transcription factor HES-1 [KO:K06054]
100966791  HES5; transcription factor HES-5 isoform X2 [KO:K06055]
100947077  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
100946129  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
100941302  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2 [KO:K09091]
100941807  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100946098  SHH; sonic hedgehog protein [KO:K11988]
100961156  PTCH1; protein patched homolog 1 isoform X2 [KO:K06225]
100954610  SMO; smoothened homolog [KO:K06226]
100956697  KIF7; kinesin-like protein KIF7 [KO:K18806]
100960983  SUFU; suppressor of fused homolog isoform X2 [KO:K06229]
100954193  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
100950930  GLI2; LOW QUALITY PROTEIN: zinc finger protein GLI2 [KO:K16798]
100947812  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
100952817  BMP2; bone morphogenetic protein 2 isoform X2 [KO:K21283]
100961860  BMP4; bone morphogenetic protein 4 [KO:K04662]
100950417  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
100941318  PTCH2; protein patched homolog 2 [KO:K11101]
100960541  AR; androgen receptor isoform X1 [KO:K08557]
100954869  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
100959852  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100949628  HSP90B1; endoplasmin [KO:K09487]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
  Authors
Mehlen P, Fearon ER.
  Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
  Journal
J Clin Oncol 22:3420-8 (2004)
DOI:10.1200/JCO.2004.02.019
Reference
  Authors
Peltomaki P.
  Title
DNA mismatch repair and cancer.
  Journal
Mutat Res 488:77-85 (2001)
DOI:10.1016/S1383-5742(00)00058-2
Reference
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Reference
  Authors
Watson AJ.
  Title
An overview of apoptosis and the prevention of colorectal cancer.
  Journal
Crit Rev Oncol Hematol 57:107-21 (2006)
DOI:10.1016/j.critrevonc.2005.06.005
Reference
  Authors
Watson AJ.
  Title
Apoptosis and colorectal cancer.
  Journal
Gut 53:1701-9 (2004)
DOI:10.1136/gut.2004.052704
Reference
  Authors
Houlston RS.
  Title
What we could do now: molecular pathology of colorectal cancer.
  Journal
Mol Pathol 54:206-14 (2001)
DOI:10.1136/mp.54.4.206
Reference
  Authors
Von Hoff D, Evans D, Hruban R (ed).
  Title
Pancreatic cancer
  Journal
Jones and Bartlett publishers (2005)
Reference
  Authors
Niitsu Y, Yokota J (ed).
  Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
  Journal
Nankodo (1999)
Reference
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
  Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
  Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
  Journal
Semin Cancer Biol 11:201-18 (2001)
DOI:10.1006/scbi.2000.0371
Reference
  Authors
Cowgill SM, Muscarella P.
  Title
The genetics of pancreatic cancer.
  Journal
Am J Surg 186:279-86 (2003)
DOI:10.1016/S0002-9610(03)00226-5
Reference
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
Reference
  Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
  Title
Understanding Ras: 'it ain't over 'til it's over'.
  Journal
Trends Cell Biol 10:147-54 (2000)
DOI:10.1016/S0962-8924(00)01740-2
Reference
  Authors
Holbro T, Civenni G, Hynes NE.
  Title
The ErbB receptors and their role in cancer progression.
  Journal
Exp Cell Res 284:99-110 (2003)
DOI:10.1016/S0014-4827(02)00099-X
Reference
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
Reference
  Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
  Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
  Journal
Cancer Lett 201:107-16 (2003)
DOI:10.1016/S0304-3835(03)00482-8
Reference
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
  Authors
Elliott RL, Blobe GC.
  Title
Role of transforming growth factor Beta in human cancer.
  Journal
J Clin Oncol 23:2078-93 (2005)
DOI:10.1200/JCO.2005.02.047
Reference
  Authors
Rudkin TM, Foulkes WD.
  Title
BRCA2: breaks, mistakes and failed separations.
  Journal
Trends Mol Med 11:145-8 (2005)
DOI:10.1016/j.molmed.2005.02.003
Reference
  Authors
Venkitaraman AR.
  Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
  Journal
J Cell Sci 114:3591-8 (2001)
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Tabuchi K (ed).
  Title
[Gliomas: Research and therapy] (In Japanese)
  Journal
Springer-Verlag Tokyo (2006)
Reference
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
  Authors
Hulleman E, Helin K.
  Title
Molecular mechanisms in gliomagenesis.
  Journal
Adv Cancer Res 94:1-27 (2005)
DOI:10.1016/S0065-230X(05)94001-3
Reference
  Authors
Schlessinger J.
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 103:211-25 (2000)
DOI:10.1016/S0092-8674(00)00114-8
Reference
PMID:9643506
  Authors
Ng HK, Lam PY.
  Title
The molecular genetics of central nervous system tumors.
  Journal
Pathology 30:196-202 (1998)
DOI:10.1080/00313029800169236
Reference
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Reference
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
  Authors
Tenen DG.
  Title
Disruption of differentiation in human cancer: AML shows the way.
  Journal
Nat Rev Cancer 3:89-101 (2003)
DOI:10.1038/nrc989
Reference
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
  Authors
Lorsbach RB, Downing JR.
  Title
The role of the AML1 transcription factor in leukemogenesis.
  Journal
Int J Hematol 74:258-65 (2001)
DOI:10.1007/BF02982058
Reference
  Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
  Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
  Journal
Blood 101:3164-73 (2003)
DOI:10.1182/blood-2002-06-1677
Reference
  Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
  Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
  Journal
Leukemia 21:1638-47 (2007)
DOI:10.1038/sj.leu.2404732
Reference
  Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
  Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
  Journal
Blood 107:3330-8 (2006)
DOI:10.1182/blood-2005-07-3068
Reference
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
  Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
  Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
  Journal
Haematologica 88:622-30 (2003)
Reference
  Authors
Baldwin AS.
  Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
  Journal
J Clin Invest 107:241-6 (2001)
DOI:10.1172/JCI11991
Reference
  Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
  Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Journal
Nat Med 8:1145-52 (2002)
DOI:10.1038/nm759
Reference
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
Reference
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
  Authors
Takata M, Saida T.
  Title
Genetic alterations in melanocytic tumors.
  Journal
J Dermatol Sci 43:1-10 (2006)
DOI:10.1016/j.jdermsci.2006.05.002
Reference
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
Reference
  Authors
Merlino G.
  Title
Cancer biology: the weakest link?
  Journal
Nature 436:33-5 (2005)
DOI:10.1038/436033a
Reference
  Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
  Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
  Journal
Nature 436:117-22 (2005)
DOI:10.1038/nature03664
Reference
  Authors
Levy C, Khaled M, Fisher DE.
  Title
MITF: master regulator of melanocyte development and melanoma oncogene.
  Journal
Trends Mol Med 12:406-14 (2006)
DOI:10.1016/j.molmed.2006.07.008
Reference
  Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
  Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
  Journal
J Invest Dermatol 122:337-41 (2004)
DOI:10.1046/j.0022-202X.2004.22243.x
Reference
  Authors
Gruss C, Herlyn M.
  Title
Role of cadherins and matrixins in melanoma.
  Journal
Curr Opin Oncol 13:117-23 (2001)
DOI:10.1097/00001622-200103000-00006
Reference
  Authors
Thompson JF, Scolyer RA, Kefford RF.
  Title
Cutaneous melanoma.
  Journal
Lancet 365:687-701 (2005)
DOI:10.1016/S0140-6736(05)17951-3
Reference
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
  Authors
Hussein MR.
  Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
  Journal
Tumour Biol 25:200-7 (2004)
DOI:10.1159/000081103
Reference
  Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
  Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
  Journal
Cytokine 12:547-54 (2000)
DOI:10.1006/cyto.1999.0614
Reference
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364
Reference
  Authors
Linehan WM, Walther MM, Zbar B.
  Title
The genetic basis of cancer of the kidney.
  Journal
J Urol 170:2163-72 (2003)
DOI:10.1097/01.ju.0000096060.92397.ed
Reference
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
  Authors
Kim WY, Kaelin WG.
  Title
Role of VHL gene mutation in human cancer.
  Journal
J Clin Oncol 22:4991-5004 (2004)
DOI:10.1200/JCO.2004.05.061
Reference
  Authors
Sudarshan S, Linehan WM, Neckers L.
  Title
HIF and fumarate hydratase in renal cancer.
  Journal
Br J Cancer 96:403-7 (2007)
DOI:10.1038/sj.bjc.6603547
Reference
  Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
  Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
  Journal
Nat Clin Pract Urol 4:104-10 (2007)
DOI:10.1038/ncpuro0711
Reference
  Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
  Title
Understanding familial and non-familial renal cell cancer.
  Journal
Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489
Reference
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
  Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
  Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
  Journal
Cancer Res 60:6298-302 (2000)
Reference
  Authors
Bellmunt J, Hussain M, Dinney CP.
  Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
  Journal
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003)
DOI:10.1016/S1040-8428(03)00067-2
Reference
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
  Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
  Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
  Journal
Biochem Cell Biol 83:1-14 (2005)
DOI:10.1139/o04-121
Reference
  Authors
Williams SG, Stein JP.
  Title
Molecular pathways in bladder cancer.
  Journal
Urol Res 32:373-85 (2004)
DOI:10.1007/s00240-003-0345-y
Reference
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
  Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
  Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
  Journal
Prostate Cancer Prostatic Dis 8:108-18 (2005)
DOI:10.1038/sj.pcan.4500776
Reference
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
  Authors
Heinlein CA, Chang C.
  Title
Androgen receptor in prostate cancer.
  Journal
Endocr Rev 25:276-308 (2004)
DOI:10.1210/er.2002-0032
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
Reference
  Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
  Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Journal
Nat Med 6:703-6 (2000)
DOI:10.1038/76287
Reference
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
  Authors
Steers WD.
  Title
5alpha-reductase activity in the prostate.
  Journal
Urology 58:17-24; discussion 24 (2001)
DOI:10.1016/S0090-4295(01)01299-7
Reference
PMID:8069858
  Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
  Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
  Journal
Cancer Res 54:4920-6 (1994)
Reference
  Authors
Grimes CA, Jope RS.
  Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
  Journal
Prog Neurobiol 65:391-426 (2001)
DOI:10.1016/S0301-0082(01)00011-9
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
  Authors
Sanchez-Cespedes M.
  Title
Dissecting the genetic alterations involved in lung carcinogenesis.
  Journal
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
Reference
  Authors
Kaye FJ.
  Title
Molecular biology of lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S35-41 (2001)
DOI:10.1016/S0169-5002(01)00342-7
Reference
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
  Authors
Sartorius UA, Krammer PH.
  Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
  Journal
Int J Cancer 97:584-92 (2002)
DOI:10.1002/ijc.10096
Reference
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
Reference
  Authors
Buttery RC, Rintoul RC, Sethi T.
  Title
Small cell lung cancer: the importance of the extracellular matrix.
  Journal
Int J Biochem Cell Biol 36:1154-60 (2004)
DOI:10.1016/S1357-2725(03)00261-9
Reference
  Authors
Yamada KM, Araki M.
  Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
  Journal
J Cell Sci 114:2375-82 (2001)
Reference
  Authors
Rintoul RC, Sethi T.
  Title
The role of extracellular matrix in small-cell lung cancer.
  Journal
Lancet Oncol 2:437-42 (2001)
DOI:10.1016/S1470-2045(00)00421-6
Reference
  Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
  Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
  Journal
Exp Cell Res 279:277-90 (2002)
DOI:10.1006/excr.2002.5608
Reference
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
  Authors
Yokota J, Nishioka M, Tani M, Kohno T.
  Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  Journal
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
Reference
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)
DOI:10.1007/s10541-005-0151-y
Reference
  Authors
Altucci L, Gronemeyer H.
  Title
The promise of retinoids to fight against cancer.
  Journal
Nat Rev Cancer 1:181-93 (2001)
DOI:10.1038/35106036
Reference
  Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
  Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
  Journal
J Natl Cancer Inst 92:1303-7 (2000)
DOI:10.1093/jnci/92.16.1303
Reference
  Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
  Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
  Journal
Lung Cancer 41 Suppl 1:S29-42 (2003)
DOI:10.1016/S0169-5002(03)00137-5
Reference
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
  Authors
Mitsuuchi Y, Testa JR.
  Title
Cytogenetics and molecular genetics of lung cancer.
  Journal
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
Reference
  Authors
Breuer RH, Postmus PE, Smit EF.
  Title
Molecular pathology of non-small-cell lung cancer.
  Journal
Respiration 72:313-30 (2005)
DOI:10.1159/000085376
Reference
  Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
  Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
  Journal
Clin Cancer Res 8:734-44 (2002)
Reference
  Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
  Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  Journal
J Clin Pathol 58:1076-80 (2005)
DOI:10.1136/jcp.2004.025585
Reference
  Authors
Lappano R, Maggiolini M
  Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
  Journal
Nat Rev Drug Discov 10:47-60 (2011)
DOI:10.1038/nrd3320
Reference
  Authors
O'Hayre M, Degese MS, Gutkind JS
  Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
  Journal
Curr Opin Cell Biol 27:126-35 (2014)
DOI:10.1016/j.ceb.2014.01.005
Reference
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
Related
pathway
oga03320  PPAR signaling pathway
oga04010  MAPK signaling pathway
oga04020  Calcium signaling pathway
oga04024  cAMP signaling pathway
oga04060  Cytokine-cytokine receptor interaction
oga04066  HIF-1 signaling pathway
oga04110  Cell cycle
oga04115  p53 signaling pathway
oga04150  mTOR signaling pathway
oga04151  PI3K-Akt signaling pathway
oga04210  Apoptosis
oga04310  Wnt signaling pathway
oga04330  Notch signaling pathway
oga04340  Hedgehog signaling pathway
oga04350  TGF-beta signaling pathway
oga04370  VEGF signaling pathway
oga04510  Focal adhesion
oga04512  ECM-receptor interaction
oga04520  Adherens junction
oga04630  JAK-STAT signaling pathway
oga04915  Estrogen signaling pathway
KO pathway
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