KEGG   ORTHOLOGY: K04364Help
Entry
K04364                      KO                                     

Name
GRB2
Definition
growth factor receptor-binding protein 2
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04014  Ras signaling pathway
ko04062  Chemokine signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04320  Dorso-ventral axis formation
ko04380  Osteoclast differentiation
ko04510  Focal adhesion
ko04540  Gap junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04630  JAK-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04714  Thermogenesis
ko04722  Neurotrophin signaling pathway
ko04910  Insulin signaling pathway
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04917  Prolactin signaling pathway
ko04926  Relaxin signaling pathway
ko05034  Alcoholism
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04010 MAPK signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04013 MAPK signaling pathway - fly
    K04364  GRB2; growth factor receptor-binding protein 2
   04012 ErbB signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04630 Jak-STAT signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04068 FoxO signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04072 Phospholipase D signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04151 PI3K-Akt signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04150 mTOR signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04364  GRB2; growth factor receptor-binding protein 2
   04540 Gap junction
    K04364  GRB2; growth factor receptor-binding protein 2
   04550 Signaling pathways regulating pluripotency of stem cells
    K04364  GRB2; growth factor receptor-binding protein 2
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04364  GRB2; growth factor receptor-binding protein 2
   04660 T cell receptor signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04662 B cell receptor signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04664 Fc epsilon RI signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04062 Chemokine signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04912 GnRH signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04915 Estrogen signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04917 Prolactin signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
   04926 Relaxin signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04364  GRB2; growth factor receptor-binding protein 2
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    K04364  GRB2; growth factor receptor-binding protein 2
   04380 Osteoclast differentiation
    K04364  GRB2; growth factor receptor-binding protein 2
  09159 Environmental adaptation
   04714 Thermogenesis
    K04364  GRB2; growth factor receptor-binding protein 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05206 MicroRNAs in cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05205 Proteoglycans in cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05203 Viral carcinogenesis
    K04364  GRB2; growth factor receptor-binding protein 2
   05231 Choline metabolism in cancer
    K04364  GRB2; growth factor receptor-binding protein 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05225 Hepatocellular carcinoma
    K04364  GRB2; growth factor receptor-binding protein 2
   05226 Gastric cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05214 Glioma
    K04364  GRB2; growth factor receptor-binding protein 2
   05221 Acute myeloid leukemia
    K04364  GRB2; growth factor receptor-binding protein 2
   05220 Chronic myeloid leukemia
    K04364  GRB2; growth factor receptor-binding protein 2
   05211 Renal cell carcinoma
    K04364  GRB2; growth factor receptor-binding protein 2
   05215 Prostate cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05213 Endometrial cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05224 Breast cancer
    K04364  GRB2; growth factor receptor-binding protein 2
   05223 Non-small cell lung cancer
    K04364  GRB2; growth factor receptor-binding protein 2
  09165 Substance dependence
   05034 Alcoholism
    K04364  GRB2; growth factor receptor-binding protein 2
  09172 Infectious disease: viral
   05161 Hepatitis B
    K04364  GRB2; growth factor receptor-binding protein 2
   05160 Hepatitis C
    K04364  GRB2; growth factor receptor-binding protein 2
   05163 Human cytomegalovirus infection
    K04364  GRB2; growth factor receptor-binding protein 2
   05165 Human papillomavirus infection
    K04364  GRB2; growth factor receptor-binding protein 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04364  GRB2; growth factor receptor-binding protein 2
   01522 Endocrine resistance
    K04364  GRB2; growth factor receptor-binding protein 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04364  GRB2; growth factor receptor-binding protein 2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    K04364  GRB2; growth factor receptor-binding protein 2
BRITE hierarchy
Other DBs
GO: 0005070 0005154
Genes
HSA: 2885(GRB2)
PTR: 737245(GRB2)
PPS: 100993451(GRB2)
GGO: 101133976(GRB2)
PON: 100173972(GRB2)
NLE: 100588468(GRB2)
MCC: 702041(GRB2) 702473(GRAP)
MCF: 102118276(GRB2)
CSAB: 103243048(GRB2)
RRO: 104681311(GRB2)
RBB: 108537414(GRB2)
CJC: 100395682(GRB2)
SBQ: 101038666(GRB2)
MMU: 14784(Grb2)
MCAL: 110304772(Grb2)
MPAH: 110331195(Grb2)
RNO: 81504(Grb2)
MUN: 110547825(Grb2)
CGE: 100769627(Grb2)
NGI: 103732729(Grb2)
HGL: 101717035(Grb2)
CCAN: 109681589(Grb2)
OCU: 100342500(GRB2)
TUP: 102493080(GRB2)
CFA: 483312(GRB2)
VVP: 112920790(GRB2)
AML: 100468916(GRB2)
UMR: 103665736(GRB2)
UAH: 113244637(GRB2)
ORO: 101362094(GRB2)
FCA: 101099916(GRB2)
PTG: 102970459(GRB2)
AJU: 106987795(GRB2)
BTA: 535298(GRB2)
BOM: 102286241(GRB2)
BIU: 109574040(GRB2)
BBUB: 102394713(GRB2)
PHD: 102318888(GRB2)
CHX: 102170356(GRB2)
OAS: 101109893(GRB2) 114110058
SSC: 100192436(GRB2)
CFR: 102515306(GRB2)
CDK: 105104642(GRB2)
BACU: 103010512(GRB2)
LVE: 103079766(GRB2)
OOR: 101271441(GRB2)
DLE: 111182833(GRB2)
PCAD: 114483947(GRB2)
ECB: 100051866(GRB2)
EPZ: 103546580(GRB2)
EAI: 106830292(GRB2)
MYB: 102241832(GRB2)
MYD: 102754991(GRB2)
MNA: 107536618(GRB2)
HAI: 109383688(GRB2)
RSS: 109454705(GRB2)
DRO: 112298645(GRB2)
PALE: 102878822(GRB2)
RAY: 107503781(GRB2)
LAV: 100655474(GRB2)
TMU: 101359012
MDO: 100022894(GRB2)
SHR: 100928380(GRB2)
PCW: 110219266(GRB2)
OAA: 100075806(GRB2) 100079295(GRAP)
GGA: 386572(GRB2)
MGP: 100541322(GRB2)
CJO: 107322339(GRB2)
NMEL: 110406135(GRAP) 110407421(GRB2)
APLA: 101797458(GRB2)
ACYG: 106034739(GRB2)
TGU: 100190285(GRB2)
LSR: 110484064(GRB2)
SCAN: 103819847(GRB2)
GFR: 102038068(GRB2)
FAB: 101812321(GRB2)
PHI: 102101539(GRB2)
PMAJ: 107212507(GRB2)
CCAE: 111937316(GRB2)
CCW: 104684765 104694312(GRB2)
ETL: 114063378(GRB2)
FPG: 101913969(GRB2)
FCH: 102057209(GRB2)
CLV: 102098952(GRB2)
EGZ: 104125396(GRB2) 104135752(GRAP)
NNI: 104020665(GRB2)
ACUN: 113486738(GRB2)
PADL: 103916707(GRB2) 103921421(GRAP)
AAM: 106485676(GRB2)
ASN: 102376596(GRB2) 102386178(GRAP)
AMJ: 102564907(GRB2) 102577011(GRAP)
PSS: 102462646(GRAP) 102463609(GRB2)
CMY: 102941632(GRAP) 102945306(GRB2)
CPIC: 101937357(GRB2) 101946375(GRAP)
ACS: 100564375(grb2)
PVT: 110085805(GRB2)
PBI: 103062398(GRB2)
PMUR: 107292723(GRB2)
GJA: 107110018(GRB2)
XLA: 399458(grb2.L) 444095(grb2.S)
XTR: 493492(grb2)
NPR: 108791159(GRB2)
DRE: 406308(grb2b) 493609(grb2a)
PHYP: 113524560 113528201(grb2)
TRU: 101061204 101070656(grb2)
LCO: 104929435(grb2) 104929960
MZE: 101467818(grb2) 101477192
OLA: 101160816(grb2)
XMA: 102231736(grb2)
XCO: 114144852 114160045(grb2)
PRET: 103468398(grb2) 108165995
NFU: 107376249(grb2) 107376709(grap)
KMR: 108236256
AOCE: 111567912(grb2)
CSEM: 103383265 103393705(grb2)
LCF: 108898666(grb2)
SDU: 111238087(grb2)
HCQ: 109508473(grb2)
BPEC: 110155075(grb2)
MALB: 109973503(grb2)
SFM: 108937443(grb2) 108939904
PKI: 111833563 111834215(grb2)
LCM: 102353904(GRB2)
CMK: 103175438(grb2) 103187097(grap)
DME: Dmel_CG6033(drk)
DER: 6549549
DPE: 6592753
DSI: Dsimw501_GD25755(Dsim_drk)
DWI: 6637889
DAZ: 108615062
DNV: 108653840
DHE: 111599694
MDE: 101896778
LCQ: 111677404
AAG: 5564363
AME: 550857
BIM: 100748502
BTER: 100650501
SOC: 105194465
MPHA: 105836050
AEC: 105148473
ACEP: 105619053
PBAR: 105428079
VEM: 105570368
HST: 105181508
DQU: 106749264
CFO: 105251887
LHU: 105670624
PGC: 109851629
OBO: 105275755
PCF: 106790925
NVI: 100115944
MDL: 103569461
TCA: 658522
DPA: 109538190
NVL: 108561287
BMOR: 100862763(DRK)
PMAC: 106718231
PRAP: 110992781
HAW: 110371319
TNL: 113492015
PXY: 105385555
API: 100169346
DNX: 107166700
BTAB: 109031773
CLEC: 106663478
ZNE: 110836794
FCD: 110852988
TUT: 107362328
DPTE: 113790769
CEL: CELE_C14F5.5(sem-5)
CBR: CBG16856(Cbr-sem-5) CBG23363
BMY: Bm1_39900
TSP: Tsp_07994
CRG: 105329475
EGL: EGR_09709
HMG: 100199343
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7689150
  Authors
Suen KL, Bustelo XR, Pawson T, Barbacid M
  Title
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
  Journal
Mol Cell Biol 13:5500-12 (1993)
DOI:10.1128/MCB.13.9.5500
  Sequence
[mmu:14784]
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