KEGG   Homo sapiens (human): 4985
Entry
4985              CDS       T01001                                 

Gene name
OPRD1, DOP, DOR, DOR1, OPRD
Definition
(RefSeq) opioid receptor delta 1
  KO
K04213  delta-type opioid receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Disease
H01703  Eating Disorders
Drug target
Eluxadoline: D10403<US>
Etorphine: D07937
Ketobemidone (DG00815): D08100 D08101
Levallorphan tartrate: D02238<JP>
Loperamide (DG00092): D00729<JP/US> D08144
Loperamide oxide (DG00092): D07113
Metkephamid acetate: D05007
Nalbuphine (DG00822): D00843<US> D08246
Nalmefene (DG00998): D02104 D05111 D10812<JP>
Naloxone (DG01155): D01340<JP/US> D08249 D11620<US>
Naltrexone (DG00997): D02095<US> D05113<US>
Oxycodone (DG00813): D00847<US> D03783 D05312 D05462<JP>
Quadazocine mesylate: D05667
Tonazocine mesylate: D06189
Xorphanol mesylate: D06342
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    4985 (OPRD1)
   04022 cGMP-PKG signaling pathway
    4985 (OPRD1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4985 (OPRD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4985 (OPRD1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Opioid
    4985 (OPRD1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7TM_GPCR_Srv 7tm_4
Other DBs
NCBI-GeneID: 4985
NCBI-ProteinID: NP_000902
OMIM: 165195
HGNC: 8153
Ensembl: ENSG00000116329
Vega: OTTHUMG00000003646
Pharos: P41143(Tclin)
UniProt: P41143
LinkDB
Position
1p35.3
AA seq 372 aa
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
NT seq 1119 nt   +upstreamnt  +downstreamnt
atggaaccggccccctccgccggcgccgagctgcagcccccgctcttcgccaacgcctcg
gacgcctaccctagcgcctgccccagcgctggcgccaatgcgtcggggccgccaggcgcg
cggagcgcctcgtccctcgccctggcaatcgccatcaccgcgctctactcggccgtgtgc
gccgtggggctgctgggcaacgtgcttgtcatgttcggcatcgtccggtacactaagatg
aagacggccaccaacatctacatcttcaacctggccttagccgatgcgctggccaccagc
acgctgcctttccagagtgccaagtacctgatggagacgtggcccttcggcgagctgctc
tgcaaggctgtgctctccatcgactactacaatatgttcaccagcatcttcacgctcacc
atgatgagtgttgaccgctacatcgctgtctgccaccctgtcaaggccctggacttccgc
acgcctgccaaggccaagctgatcaacatctgtatctgggtcctggcctcaggcgttggc
gtgcccatcatggtcatggctgtgacccgtccccgggacggggcagtggtgtgcatgctc
cagttccccagccccagctggtactgggacacggtgaccaagatctgcgtgttcctcttc
gccttcgtggtgcccatcctcatcatcaccgtgtgctatggcctcatgctgctgcgcctg
cgcagtgtgcgcctgctgtcgggctccaaggagaaggaccgcagcctgcggcgcatcacg
cgcatggtgctggtggttgtgggcgccttcgtggtgtgttgggcgcccatccacatcttc
gtcatcgtctggacgctggtggacatcgaccggcgcgacccgctggtggtggctgcgctg
cacctgtgcatcgcgctgggctacgccaatagcagcctcaaccccgtgctctacgctttc
ctcgacgagaacttcaagcgctgcttccgccagctctgccgcaagccctgcggccgccca
gaccccagcagcttcagccgcgcccgcgaagccacggcccgcgagcgtgtcaccgcctgc
accccgtccgatggtcccggcggtggcgctgccgcctga

KEGG   Homo sapiens (human): 4986
Entry
4986              CDS       T01001                                 

Gene name
OPRK1, K-OR-1, KOP, KOR, KOR-1, KOR1, OPRK
Definition
(RefSeq) opioid receptor kappa 1
  KO
K04214  kappa-type opioid receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Aticaprant: D11831
Buprenorphine (DG00820): D00836<JP/US> D07132<JP/US>
Butorphanol (DG00821): D00837<US> D03197
Cyclazocine: D03618
Dezocine: D00838
Difelikefalin (DG02914): D10890 D11111
Diprenorphine (DG01273): D07863 D07864
Eluxadoline: D10403<US>
Enadoline hydrochloride: D06395
Eptazocine (DG01340): D01879<JP> D07904
Etorphine: D07937
Ketazocine: D04649
Ketobemidone (DG00815): D08100 D08101
Levallorphan tartrate: D02238<JP>
Loperamide (DG00092): D00729<JP/US> D08144
Loperamide oxide (DG00092): D07113
Nalbuphine (DG00822): D00843<US> D08246
Nalfurafine: D06405<JP>
Nalmefene (DG00998): D02104 D05111 D10812<JP>
Nalorphine (DG01151): D08247 D08248
Naloxone (DG01155): D01340<JP/US> D08249 D11620<US>
Naltrexone (DG00997): D02095<US> D05113<US>
Oxilorphan: D05299
Oxycodone (DG00813): D00847<US> D03783 D05312 D05462<JP>
Pentazocine (DG00819): D00498<JP> D02111 D02227<JP>
Proxorphan tartrate: D05646
Quadazocine mesylate: D05667
Spiradoline mesylate: D05907
Tonazocine mesylate: D06189
Trimebutine (DG00031): D01500<JP> D08639
Xorphanol mesylate: D06342
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4986 (OPRK1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4986 (OPRK1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Opioid
    4986 (OPRK1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srv 7TM_GPCR_Srx
Other DBs
NCBI-GeneID: 4986
NCBI-ProteinID: NP_000903
OMIM: 165196
HGNC: 8154
Ensembl: ENSG00000082556
Vega: OTTHUMG00000164276
Pharos: P41145(Tclin)
UniProt: P41145
LinkDB
Position
8q11.23
AA seq 380 aa
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
NT seq 1143 nt   +upstreamnt  +downstreamnt
atggactccccgatccagatcttccgcggggagccgggccctacctgcgccccgagcgcc
tgcctgccccccaacagcagcgcctggtttcccggctgggccgagcccgacagcaacggc
agcgccggctcggaggacgcgcagctggagcccgcgcacatctccccggccatcccggtc
atcatcacggcggtctactccgtagtgttcgtcgtgggcttggtgggcaactcgctggtc
atgttcgtgatcatccgatacacaaagatgaagacagcaaccaacatttacatatttaac
ctggctttggcagatgctttagttactacaaccatgccctttcagagtacggtctacttg
atgaattcctggccttttggggatgtgctgtgcaagatagtaatttccattgattactac
aacatgttcaccagcatcttcaccttgaccatgatgagcgtggaccgctacattgccgtg
tgccaccccgtgaaggctttggacttccgcacacccttgaaggcaaagatcatcaatatc
tgcatctggctgctgtcgtcatctgttggcatctctgcaatagtccttggaggcaccaaa
gtcagggaagacgtcgatgtcattgagtgctccttgcagttcccagatgatgactactcc
tggtgggacctcttcatgaagatctgcgtcttcatctttgccttcgtgatccctgtcctc
atcatcatcgtctgctacaccctgatgatcctgcgtctcaagagcgtccggctcctttct
ggctcccgagagaaagatcgcaacctgcgtaggatcaccagactggtcctggtggtggtg
gcagtcttcgtcgtctgctggactcccattcacatattcatcctggtggaggctctgggg
agcacctcccacagcacagctgctctctccagctattacttctgcatcgccttaggctat
accaacagtagcctgaatcccattctctacgcctttcttgatgaaaacttcaagcggtgt
ttccgggacttctgctttccactgaagatgaggatggagcggcagagcactagcagagtc
cgaaatacagttcaggatcctgcttacctgagggacatcgatgggatgaataaaccagta
tga

KEGG   Homo sapiens (human): 4987
Entry
4987              CDS       T01001                                 

Gene name
OPRL1, KOR-3, KOR3, NOCIR, NOP, NOPr, OOR, OPRL, ORL1
Definition
(RefSeq) opioid related nociceptin receptor 1
  KO
K04216  nociceptin receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Cebranopadol: D10436
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4987 (OPRL1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4987 (OPRL1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Opioid
    4987 (OPRL1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srv 7TM_GPCR_Srx 7tm_4 PqiA
Other DBs
NCBI-GeneID: 4987
NCBI-ProteinID: NP_000904
OMIM: 602548
HGNC: 8155
Ensembl: ENSG00000125510
Vega: OTTHUMG00000033027
Pharos: P41146(Tchem)
UniProt: P41146
LinkDB
Position
20q13.33
AA seq 370 aa
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
NT seq 1113 nt   +upstreamnt  +downstreamnt
atggagcccctcttccccgcgccgttctgggaggttatctacggcagccaccttcagggc
aacctgtccctcctgagccccaaccacagtctgctgcccccgcatctgctgctcaatgcc
agccacggcgccttcctgcccctcgggctcaaggtcaccatcgtggggctctacctggcc
gtgtgtgtcggagggctcctggggaactgccttgtcatgtacgtcatcctcaggcacacc
aaaatgaagacagccaccaatatttacatctttaacctggccctggccgacactctggtc
ctgctgacgctgcccttccagggcacggacatcctcctgggcttctggccgtttgggaat
gcgctgtgcaagacagtcattgccattgactactacaacatgttcaccagcaccttcacc
ctaactgccatgagtgtggatcgctatgtagccatctgccaccccatccgtgccctcgac
gtccgcacgtccagcaaagcccaggctgtcaatgtggccatctgggccctggcctctgtt
gtcggtgttcccgttgccatcatgggctcggcacaggtcgaggatgaagagatcgagtgc
ctggtggagatccctacccctcaggattactggggcccggtgtttgccatctgcatcttc
ctcttctccttcatcgtccccgtgctcgtcatctctgtctgctacagcctcatgatccgg
cggctccgtggagtccgcctgctctcgggctcccgagagaaggaccggaacctgcggcgc
atcactcggctggtgctggtggtagtggctgtgttcgtgggctgctggacgcctgtccag
gtcttcgtgctggcccaagggctgggggttcagccgagcagcgagactgccgtggccatt
ctgcgcttctgcacggccctgggctacgtcaacagctgcctcaaccccatcctctacgcc
ttcctggatgagaacttcaaggcctgcttccgcaagttctgctgtgcatctgccctgcgc
cgggacgtgcaggtgtctgaccgcgtgcgcagcattgccaaggacgtggccctggcctgc
aagacctctgagacggtaccgcggcccgcatga

KEGG   Homo sapiens (human): 4988
Entry
4988              CDS       T01001                                 

Gene name
OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM
Definition
(RefSeq) opioid receptor mu 1
  KO
K04215  mu-type opioid receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04915  Estrogen signaling pathway
hsa05032  Morphine addiction
Disease
H01611  Alcohol dependence
Drug target
Acetyldihydrocodeine: D07557
Alfentanil (DG00792): D00835<US> D07122
Alvimopan: D02878<US>
Anileridine (DG00794): D02941 D02942
Asalhydromorphone (DG02967): D11291 D11292
Axelopran (DG01857): D10690 D10740
Benzhydrocodone (DG01850): D10612 D10692
Bevenopran: D10349
Brifentanil hydrochloride: D03156
Buprenorphine (DG00820): D00836<JP/US> D07132<JP/US>
Butorphanol (DG00821): D00837<US> D03197
Carfentanil (DG01339): D03405 D07620
Cebranopadol: D10436
Codeine (DG01076): D00195 D02101<JP> D03579 D03580<US> D07740
Cyclazocine: D03618
Dextropropoxyphene (DG00818): D00482<US> D05632 D07809
Dezocine: D00838
Diamorphine (DG01003): D07286 D07810
Difenoxin (DG03054): D03809 D11583
Dihydrocodeine (DG00814): D01481<JP> D03825 D07831 D07832
Diphenoxylate (DG00090): D03860 D07861
Diprenorphine (DG01273): D07863 D07864
Eluxadoline: D10403<US>
Eptazocine (DG01340): D01879<JP> D07904
Ethoheptazine citrate: D01435
Ethylmorphine (DG01074): D02205 D07929
Etorphine: D07937
Fentanyl (DG00791): D00320<JP/US> D01399<JP/US> D10811
Hydrocodone (DG01075): D03725<US> D04461 D08045 D08046
Hydromorphone (DG00811): D00839<JP/US> D08047
Ketobemidone (DG00815): D08100 D08101
Levacetylmethadol (DG01000): D00840 D04716
Levallorphan tartrate: D02238<JP>
Levomethadone (DG01002): D08121 D08122
Levorphanol (DG01341): D00841<US> D08123
Lofentanil oxalate: D04764
Loperamide (DG00092): D00729<JP/US> D08144
Loperamide oxide (DG00092): D07113
Meptazinol (DG00825): D04924 D08182
Methadone (DG00999): D02102<JP/US> D08195
Methadyl acetate: D04973
Methylnaltrexone bromide: D06618<US>
Methylsamidorphan (DG01830): D10371 D10648
Mirfentanil hydrochloride: D05048
Morphine (DG00810): D00842<JP/US> D02271<JP> D08233 D08234
Nalbuphine (DG00822): D00843<US> D08246
Naldemedine (DG01342): D10188 D10478<JP/US>
Nalmefene (DG00998): D02104 D05111 D10812<JP>
Nalorphine (DG01151): D08247 D08248
Naloxegol (DG00078): D10375<US> D10479
Naloxone (DG01155): D01340<JP/US> D08249 D11620<US>
Naltrexone (DG00997): D02095<US> D05113<US>
Nicomorphine (DG00812): D07285 D08273
Ocfentanil hydrochloride: D05217
Oliceridine: D11214<US>
Oxycodegol (DG03013): D11424 D11425
Oxycodone (DG00813): D00847<US> D03783 D05312 D05462<JP>
Oxymorphone (DG01343): D00844<US> D08323
Pentazocine (DG00819): D00498<JP> D02111 D02227<JP>
Pethidine (DG00816): D01383<JP/US> D08343
Pholcodine: D07385
Propiram fumarate: D05631
Quadazocine mesylate: D05667
Remifentanil (DG00795): D01177<JP/US> D08473
Samidorphan (DG01538): D10162 D10163
Sufentanil (DG00793): D00845<US> D05938
Tapentadol (DG00826): D06007 D10199<JP/US>
Tilidine (DG00823): D06147 D08597
Tonazocine mesylate: D06189
Tramadol (DG00824): D01355<JP/US> D08623
Trefentanil hydrochloride: D06208
Trimebutine (DG00031): D01500<JP> D08639
Trimeperidine: D06268
Xorphanol mesylate: D06342
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4988 (OPRM1)
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    4988 (OPRM1)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    4988 (OPRM1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4988 (OPRM1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Opioid
    4988 (OPRM1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srx 7TM_GPCR_Srsx
Other DBs
NCBI-GeneID: 4988
NCBI-ProteinID: NP_000905
OMIM: 600018
HGNC: 8156
Ensembl: ENSG00000112038
Vega: OTTHUMG00000015870
Pharos: P35372(Tclin)
UniProt: P35372 G8XRH5
LinkDB
Position
6q25.2
AA seq 400 aa
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
NT seq 1203 nt   +upstreamnt  +downstreamnt
atggacagcagcgctgcccccacgaacgccagcaattgcactgatgccttggcgtactca
agttgctccccagcacccagccccggttcctgggtcaacttgtcccacttagatggcaac
ctgtccgacccatgcggtccgaaccgcaccgacctgggcgggagagacagcctgtgccct
ccgaccggcagtccctccatgatcacggccatcacgatcatggccctctactccatcgtg
tgcgtggtggggctcttcggaaacttcctggtcatgtatgtgattgtcagatacaccaag
atgaagactgccaccaacatctacattttcaaccttgctctggcagatgccttagccacc
agtaccctgcccttccagagtgtgaattacctaatgggaacatggccatttggaaccatc
ctttgcaagatagtgatctccatagattactataacatgttcaccagcatattcaccctc
tgcaccatgagtgttgatcgatacattgcagtctgccaccctgtcaaggccttagatttc
cgtactccccgaaatgccaaaattatcaatgtctgcaactggatcctctcttcagccatt
ggtcttcctgtaatgttcatggctacaacaaaatacaggcaaggttccatagattgtaca
ctaacattctctcatccaacctggtactgggaaaacctgctgaagatctgtgttttcatc
ttcgccttcattatgccagtgctcatcattaccgtgtgctatggactgatgatcttgcgc
ctcaagagtgtccgcatgctctctggctccaaagaaaaggacaggaatcttcgaaggatc
accaggatggtgctggtggtggtggctgtgttcatcgtctgctggactcccattcacatt
tacgtcatcattaaagccttggttacaatcccagaaactacgttccagactgtttcttgg
cacttctgcattgctctaggttacacaaacagctgcctcaacccagtcctttatgcattt
ctggatgaaaacttcaaacgatgcttcagagagttctgtatcccaacctcttccaacatt
gagcaacaaaactccactcgaattcgtcagaacactagagaccacccctccacggccaat
acagtggatagaactaatcatcagctagaaaatctggaagcagaaactgctccgttgccc
taa

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