KEGG   PATHWAY: chx04622
chx04622                    Pathway                                

RIG-I-like receptor signaling pathway - Capra hircus (goat)
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Organismal Systems; Immune system
Pathway map
chx04622  RIG-I-like receptor signaling pathway

Capra hircus (goat) [GN:chx]
102183788  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:]
102183188  IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:]
102178286  MAVS; mitochondrial antiviral signaling protein [KO:K12648]
102183820  DHX58; DExH-box helicase 58 [KO:K12649] [EC:]
102171742  TRAF3; TNF receptor associated factor 3 [KO:K03174]
102185959  TANK; TRAF family member associated NFKB activator [KO:K12650]
102174516  AZI2; 5-azacytidine induced 2 [KO:K12651]
102172659  TBKBP1; TBK1 binding protein 1 [KO:K12652]
102171591  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102181474  TBK1; TANK binding kinase 1 [KO:K05410] [EC:]
102183809  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:]
102171811  IRF3; interferon regulatory factor 3 [KO:K05411]
106503773  IRF7; interferon regulatory factor 7 [KO:K09447]
108635529  interferon alpha-H-like [KO:K05414]
108633160  interferon alpha-1-like [KO:K05414]
100860850  IFNA; interferon-alpha [KO:K05414]
102174842  interferon alpha-1-like [KO:K05414]
102179943  interferon alpha-H-like [KO:K05414]
102180761  interferon alpha-H [KO:K05414]
102181299  interferon alpha-H-like [KO:K05414]
108636621  interferon alpha-H-like [KO:K05414]
108636627  interferon alpha-H-like [KO:K05414]
102178826  interferon omega-1-like [KO:K05414]
102181867  interferon beta-2 [KO:K05415]
102189208  IFNB; interferon beta-2 [KO:K05415]
102181595  interferon beta-2-like [KO:K05415]
108636544  interferon beta-2-like [KO:K05415]
108636629  IFNB; interferon beta-2-like [KO:K05415]
108636632  interferon beta-2-like [KO:K05415]
108636634  interferon beta-2 [KO:K05415]
108633243  interferon beta-2-like [KO:K05415]
108635454  interferon omega-1-like [KO:K05440]
108635455  interferon omega-1-like [KO:K05440]
108635503  IFN-tau; interferon omega-1-like [KO:K05440]
102180392  interferon omega-1-like [KO:K05440]
108635507  interferon omega-1-like [KO:K05440]
108635561  interferon omega-1-like [KO:K05440]
108634918  interferon omega-1-like [KO:K05440]
108634973  interferon omega-1-like [KO:K05440]
108634976  interferon omega-1-like [KO:K05440]
108635000  interferon omega-1-like [KO:K05440]
108635001  interferon omega-1-like [KO:K05440]
108635144  interferon tau-like [KO:K05440]
108634662  interferon omega-1-like [KO:K05440]
102178068  interferon omega-1-like [KO:K05440]
108634604  interferon omega-1 [KO:K05440]
102180492  interferon omega-1 [KO:K05440]
102178353  interferon omega-1-like [KO:K05440]
102179668  interferon omega-1-like [KO:K05440]
108636612  interferon omega-1-like [KO:K05440]
108636613  interferon omega-1-like [KO:K05440]
108636615  interferon omega-1-like [KO:K05440]
108636616  interferon omega-1-like [KO:K05440]
108636617  interferon omega-1-like [KO:K05440]
108636618  interferon omega-1-like [KO:K05440]
108633271  interferon omega-1-like [KO:K05440]
108636620  interferon omega-1-like [KO:K05440]
108636623  interferon omega-1-like [KO:K05440]
108636624  interferon omega-1-like [KO:K05440]
108636625  interferon omega-1-like [KO:K05440]
108636626  interferon omega-1-like [KO:K05440]
108636628  interferon omega-1-like [KO:K05440]
108636630  interferon omega-1-like [KO:K05440]
108636595  interferon tau-like [KO:K05440]
102177059  IFNE; interferon epsilon [KO:K05442]
102168537  IFNK; interferon kappa [KO:K05441]
102180248  TRADD; TNFRSF1A associated via death domain [KO:K03171]
102170760  FADD; Fas associated via death domain [KO:K02373]
102178407  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:]
102169919  CASP8; caspase 8 [KO:K04398] [EC:]
102181262  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:]
102177406  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:]
102181421  NFKBIB; NFKB inhibitor beta [KO:K02581]
102169137  NFKBIA; NFKB inhibitor alpha [KO:K04734]
102175660  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102174096  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102184255  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:]
102172719  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:]
102172830  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:]
102187530  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:]
102182774  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:]
102170408  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:]
100861087  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:]
102180926  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:]
100860996  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:]
102189174  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:]
102178438  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
100861232  TNF; tumor necrosis factor [KO:K03156]
100861293  IL12A; interleukin 12A [KO:K05406]
100860845  IL12B; interleukin 12B [KO:K05425]
100860873  CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
102181625  TRIM25; tripartite motif containing 25 [KO:K10652] [EC:]
102179035  CYLD; CYLD lysine 63 deubiquitinase [KO:K08601] [EC:]
102187179  RNF125; ring finger protein 125 [KO:K12170] [EC:]
102169982  ISG15; ISG15 ubiquitin-like modifier [KO:K12159]
102169291  ATG5; autophagy related 5 [KO:K08339]
102190519  ATG12; autophagy related 12 [KO:K08336]
102175496  NLRX1; NLR family member X1 [KO:K12653]
102171058  TMEM173; transmembrane protein 173 [KO:K12654]
102171046  OTUD5; OTU deubiquitinase 5 [KO:K12655] [EC:]
102186731  SIKE1; suppressor of IKBKE 1 [KO:K12656]
102171588  DDX3X; DEAD-box helicase 3, X-linked [KO:K11594] [EC:]
108634620  ATP-dependent RNA helicase DDX3X-like [KO:K11594] [EC:]
102185736  PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [KO:K09578] [EC:]
102173368  TKFC; triokinase and FMN cyclase [KO:K00863] [EC:]
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Nat Immunol 5:730-7 (2004)
Takeuchi O, Akira S
MDA5/RIG-I and virus recognition.
Curr Opin Immunol 20:17-22 (2008)
Yoneyama M, Fujita T
RNA recognition and signal transduction by RIG-I-like receptors.
Immunol Rev 227:54-65 (2009)
Nakhaei P, Genin P, Civas A, Hiscott J
RIG-I-like receptors: sensing and responding to RNA virus infection.
Semin Immunol 21:215-22 (2009)
Moore CB, Ting JP
Regulation of mitochondrial antiviral signaling pathways.
Immunity 28:735-9 (2008)
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
Pharmacol Ther 124:219-34 (2009)
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
Approaching the RNA ligand for RIG-I?
Immunol Rev 227:66-74 (2009)
Saito T, Gale M Jr
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
J Exp Med 205:1523-7 (2008)
Kawai T, Akira S
Toll-like receptor and RIG-I-like receptor signaling.
Ann N Y Acad Sci 1143:1-20 (2008)
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Immunity 28:651-61 (2008)
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
J Biol Chem 283:36211-20 (2008)
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
J Biol Chem 284:10774-82 (2009)
chx04010  MAPK signaling pathway
chx04120  Ubiquitin mediated proteolysis
chx04210  Apoptosis
chx04630  JAK-STAT signaling pathway
KO pathway

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