PATHWAY: mmu04310 Help
Entry
Name
Wnt signaling pathway - Mus musculus (house mouse)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
22408 Wnt1; wingless-type MMTV integration site family, member 1 [KO:K03209 ]
22413 Wnt2; wingless-type MMTV integration site family, member 2 [KO:K00182 ]
22414 Wnt2b; wingless-type MMTV integration site family, member 2B [KO:K00182 ]
22415 Wnt3; wingless-type MMTV integration site family, member 3 [KO:K00312 ]
22416 Wnt3a; wingless-type MMTV integration site family, member 3A [KO:K00312 ]
22417 Wnt4; wingless-type MMTV integration site family, member 4 [KO:K00408 ]
22418 Wnt5a; wingless-type MMTV integration site family, member 5A [KO:K00444 ]
22419 Wnt5b; wingless-type MMTV integration site family, member 5B [KO:K00444 ]
22420 Wnt6; wingless-type MMTV integration site family, member 6 [KO:K00445 ]
22421 Wnt7a; wingless-type MMTV integration site family, member 7A [KO:K00572 ]
22422 Wnt7b; wingless-type MMTV integration site family, member 7B [KO:K00572 ]
20890 Wnt8a; wingless-type MMTV integration site family, member 8A [KO:K00714 ]
22423 Wnt8b; wingless-type MMTV integration site family, member 8B [KO:K00714 ]
216795 Wnt9a; wingless-type MMTV integration site family, member 9A [KO:K01064 ]
22412 Wnt9b; wingless-type MMTV integration site family, member 9B [KO:K01064 ]
22410 Wnt10b; wingless-type MMTV integration site family, member 10B [KO:K01357 ]
22409 Wnt10a; wingless-type MMTV integration site family, member 10A [KO:K01357 ]
22411 Wnt11; wingless-type MMTV integration site family, member 11 [KO:K01384 ]
93735 Wnt16; wingless-type MMTV integration site family, member 16 [KO:K01558 ]
12622 Cer1; cerberus 1, DAN family BMP antagonist [KO:K01645 ]
13380 Dkk1; dickkopf WNT signaling pathway inhibitor 1 [KO:K02165 ]
56811 Dkk2; dickkopf WNT signaling pathway inhibitor 2 [KO:K02165 ]
234130 Dkk4; dickkopf WNT signaling pathway inhibitor 4 [KO:K02165 ]
20317 Serpinf1; serine (or cysteine) peptidase inhibitor, clade F, member 1 [KO:K19614 ]
20377 Sfrp1; secreted frizzled-related protein 1 [KO:K02166 ]
20319 Sfrp2; secreted frizzled-related protein 2 [KO:K02176 ]
20379 Sfrp4; secreted frizzled-related protein 4 [KO:K02185 ]
54612 Sfrp5; secreted frizzled-related sequence protein 5 [KO:K02222 ]
107515 Lgr4; leucine-rich repeat-containing G protein-coupled receptor 4 [KO:K04309 ]
14160 Lgr5; leucine rich repeat containing G protein coupled receptor 5 [KO:K04308 ]
329252 Lgr6; leucine-rich repeat-containing G protein-coupled receptor 6 [KO:K08399 ]
16973 Lrp5; low density lipoprotein receptor-related protein 5 [KO:K03068 ]
16974 Lrp6; low density lipoprotein receptor-related protein 6 [KO:K03068 ]
68010 Bambi; BMP and activin membrane-bound inhibitor [KO:K10162 ]
494504 Apcdd1; adenomatosis polyposis coli down-regulated 1 [KO:K25812 ]
68339 Ccdc88c; coiled-coil domain containing 88C [KO:K25811 ]
13544 Dvl3; dishevelled segment polarity protein 3 [KO:K02353 ]
13542 Dvl1; dishevelled segment polarity protein 1 [KO:K02353 ]
13543 Dvl2; dishevelled segment polarity protein 2 [KO:K02353 ]
14296 Frat1; frequently rearranged in advanced T cell lymphomas [KO:K03069 ]
212398 Frat2; frequently rearranged in advanced T cell lymphomas 2 [KO:K03096 ]
13001 Csnk2b; casein kinase 2, beta polypeptide [KO:K03115 ]
11789 Apc; APC, WNT signaling pathway regulator [KO:K02085 ]
23805 Apc2; APC regulator of WNT signaling pathway 2 [KO:K02085 ]
21414 Tcf7; transcription factor 7, T cell specific [KO:K02620 ]
21415 Tcf7l1; transcription factor 7 like 1 (T cell specific, HMG box) [KO:K04490 ]
21416 Tcf7l2; transcription factor 7 like 2, T cell specific, HMG box [KO:K04491 ]
16842 Lef1; lymphoid enhancer binding factor 1 [KO:K04492 ]
226154 Lzts2; leucine zipper, putative tumor suppressor 2 [KO:K26471 ]
67087 Ctnnbip1; catenin beta interacting protein 1 [KO:K04493 ]
73739 Cby1; chibby family member 1, beta catenin antagonist [KO:K23402 ]
67772 Chd8; chromodomain helicase DNA binding protein 8 [KO:K04494 ] [EC:5.6.2.-]
219158 Ccar2; cell cycle activator and apoptosis regulator 2 [KO:K25816 ]
20671 Sox17; SRY (sex determining region Y)-box 17 [KO:K04495 ]
114606 Tle6; transducin-like enhancer of split 6 [KO:K04497 ]
21885 Tle1; transducin-like enhancer of split 1 [KO:K04497 ]
21886 Tle2; transducin-like enhancer of split 2 [KO:K04497 ]
21887 Tle3; transducin-like enhancer of split 3 [KO:K04497 ]
21888 Tle4; transducin-like enhancer of split 4 [KO:K04497 ]
22402 Ccn4; cellular communication network factor 4 [KO:K22471 ]
19015 Ppard; peroxisome proliferator activator receptor delta [KO:K04504 ]
22059 Trp53; transformation related protein 53 [KO:K04451 ]
21402 Skp1; S-phase kinase-associated protein 1 [KO:K03094 ]
21372 Tbl1x; transducin (beta)-like 1 X-linked [KO:K04508 ]
81004 Tbl1xr1; transducin (beta)-like 1X-linked receptor 1 [KO:K04508 ]
103583 Fbxw11; F-box and WD-40 domain protein 11 [KO:K03362 ]
12234 Btrc; beta-transducin repeat containing protein [KO:K03362 ]
243548 Prickle2; prickle planar cell polarity protein 2 [KO:K04511 ]
106042 Prickle1; prickle planar cell polarity protein 1 [KO:K04511 ]
381104 Prickle4; prickle planar cell polarity protein 4 [KO:K04511 ]
54630 Prickle3; prickle planar cell polarity protein 3 [KO:K04511 ]
208846 Daam1; dishevelled associated activator of morphogenesis 1 [KO:K04512 ]
76441 Daam2; dishevelled associated activator of morphogenesis 2 [KO:K04512 ]
67653 4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513 ]
19057 Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
19055 Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
19058 Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268 ]
19059 Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268 ]
18018 Nfatc1; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [KO:K04446 ]
18019 Nfatc2; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [KO:K17332 ]
18021 Nfatc3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [KO:K17333 ]
73181 Nfatc4; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 [KO:K17334 ]
Compound
Reference
Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title
Beta-catenin and Tcfs in mammary development and cancer.
Journal
Reference
Authors
Yang Y.
Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal
Reference
Authors
Kalderon D.
Title
Similarities between the Hedgehog and Wnt signaling pathways.
Journal
Reference
Authors
Nusse R.
Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal
Reference
Authors
Jope RS, Johnson GV.
Title
The glamour and gloom of glycogen synthase kinase-3.
Journal
Reference
Authors
Veeman MT, Axelrod JD, Moon RT.
Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal
Reference
Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal
Reference
Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title
The way Wnt works: Components and mechanism.
Journal
Reference
Authors
Carethers JM
Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal
Reference
Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal
Reference
Authors
Niehrs C
Title
The complex world of WNT receptor signalling.
Journal
Reference
Authors
Abou Ziki MD, Mani A
Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal
Reference
Authors
He Y, Ki H, Kim H, Kim K
Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal
Reference
Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal
Reference
Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal
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