KEGG   PATHWAY: mmu04115
Entry
mmu04115                    Pathway                                
Name
p53 signaling pathway - Mus musculus (house mouse)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
mmu04115  p53 signaling pathway
mmu04115

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
107831  Adgrb1; adhesion G protein-coupled receptor B1 [KO:K04596]
107986  Ddb2; damage specific DNA binding protein 2 [KO:K10140]
11783  Apaf1; apoptotic peptidase activating factor 1 [KO:K02084]
11920  Atm; ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
12028  Bax; BCL2-associated X protein [KO:K02159]
12043  Bcl2; B cell leukemia/lymphoma 2 [KO:K02161]
12048  Bcl2l1; BCL2-like 1 [KO:K04570]
12122  Bid; BH3 interacting domain death agonist [KO:K04726]
12367  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
12370  Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
12371  Casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
12442  Ccnb2; cyclin B2 [KO:K21770]
12443  Ccnd1; cyclin D1 [KO:K04503]
12444  Ccnd2; cyclin D2 [KO:K10151]
12445  Ccnd3; cyclin D3 [KO:K10152]
12447  Ccne1; cyclin E1 [KO:K06626]
12448  Ccne2; cyclin E2 [KO:K06626]
12450  Ccng1; cyclin G1 [KO:K10145]
12452  Ccng2; cyclin G2 [KO:K10146]
12521  Cd82; CD82 antigen [KO:K06509]
12534  Cdk1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
12566  Cdk2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
12567  Cdk4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
12571  Cdk6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
12575  Cdkn1a; cyclin dependent kinase inhibitor 1A [KO:K06625]
12578  Cdkn2a; cyclin dependent kinase inhibitor 2A [KO:K06621]
12649  Chek1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
13063  Cycs; cytochrome c, somatic [KO:K08738]
13067  Cyct; cytochrome c, testis [KO:K08738]
13197  Gadd45a; growth arrest and DNA-damage-inducible 45 alpha [KO:K04402]
13663  Ei24; etoposide induced 2.4 mRNA [KO:K10134]
140742  Sesn1; sestrin 1 [KO:K10141]
14102  Fas; Fas cell surface death receptor [KO:K04390]
16000  Igf1; insulin-like growth factor 1 [KO:K05459]
16009  Igfbp3; insulin-like growth factor binding protein 3 [KO:K10138]
170770  Bbc3; BCL2 binding component 3 [KO:K10132]
17246  Mdm2; transformed mouse 3T3 cell double minute 2 [KO:K06643] [EC:2.3.2.27]
17248  Mdm4; transformed mouse 3T3 cell double minute 4 [KO:K10127]
17873  Gadd45b; growth arrest and DNA-damage-inducible 45 beta [KO:K04402]
18787  Serpine1; serine (or cysteine) peptidase inhibitor, clade E, member 1 [KO:K03982]
19211  Pten; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
20135  Rrm2; ribonucleotide reductase M2 [KO:K10808] [EC:1.17.4.1]
20437  Siah1a; siah E3 ubiquitin protein ligase 1A [KO:K04506] [EC:2.3.2.27]
20438  Siah1b; siah E3 ubiquitin protein ligase 1B [KO:K04506] [EC:2.3.2.27]
20724  Serpinb5; serine (or cysteine) peptidase inhibitor, clade B, member 5 [KO:K10139]
21825  Thbs1; thrombospondin 1 [KO:K16857]
21933  Tnfrsf10b; tumor necrosis factor receptor superfamily, member 10b [KO:K04722]
22059  Trp53; transformation related protein 53 [KO:K04451]
22062  Trp73; transformation related protein 73 [KO:K10148]
22084  Tsc2; TSC complex subunit 2 [KO:K07207]
22401  Zmat3; zinc finger matrin type 3 [KO:K10137]
230784  Sesn2; sestrin 2 [KO:K20394]
23882  Gadd45g; growth arrest and DNA-damage-inducible 45 gamma [KO:K04402]
245000  Atr; ataxia telangiectasia and Rad3 related [KO:K06640] [EC:2.7.11.1]
26374  Cop1; COP1, E3 ubiquitin ligase [KO:K10143] [EC:2.3.2.27]
268697  Ccnb1; cyclin B1 [KO:K05868]
29813  Zfp385a; zinc finger protein 385A [KO:K26543]
29870  Gtse1; G two S phase expressed protein 1 [KO:K10129]
30954  Siva1; SIVA1, apoptosis-inducing factor [KO:K22744]
333654  Ppp1r13l; protein phosphatase 1, regulatory subunit 13 like [KO:K27356]
382985  Rrm2b; ribonucleotide reductase M2 B (TP53 inducible) [KO:K10808] [EC:1.17.4.1]
434175  Ccnb1-ps; cyclin B1, pseudogene [KO:K05868]
50883  Chek2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
53892  Ppm1d; protein phosphatase 1D magnesium-dependent, delta isoform [KO:K10147] [EC:3.1.3.16]
55948  Sfn; stratifin [KO:K06644]
57913  Pidd1; p53 induced death domain protein 1 [KO:K10130]
58801  Pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
64058  Perp; PERP, TP53 apoptosis effector [KO:K10136]
66940  Shisa5; shisa family member 5 [KO:K10135]
67874  Rprm; reprimo, TP53 dependent G2 arrest mediator candidate [KO:K10128]
68098  Rchy1; ring finger and CHY zinc finger domain containing 1 [KO:K10144] [EC:2.3.2.27]
68428  Steap3; STEAP family member 3 [KO:K10142] [EC:1.16.1.-]
71361  Aifm2; apoptosis-inducing factor, mitochondrion-associated 2 [KO:K22745]
75747  Sesn3; sestrin 3 [KO:K10141]
98376  Gorab; golgin, RAB6-interacting [KO:K19748]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
mmu04110  Cell cycle
mmu04210  Apoptosis
mmu04218  Cellular senescence
KO pathway
ko04115   

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