Entry Name Wnt signaling pathway - Rattus norvegicus (rat)
Description Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 293897 Dkk1; dickkopf-related protein 1 precursor [KO:K02165 ]
295445 Dkk2; dickkopf-related protein 2 precursor [KO:K02165 ]
502097 Dkk4; dickkopf-related protein 4 precursor [KO:K02165 ]
287526 Serpinf1; pigment epithelium-derived factor precursor [KO:K19614 ]
84402 Sfrp1; secreted frizzled-related protein 1 precursor [KO:K02166 ]
310552 Sfrp2; secreted frizzled-related protein 2 precursor [KO:K02176 ]
295691 Frzb; secreted frizzled-related protein 3 precursor [KO:K25481 ]
89803 Sfrp4; secreted frizzled-related protein 4 precursor [KO:K02185 ]
309377 Sfrp5; secreted frizzled-related protein 5 precursor [KO:K02222 ]
286994 Lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 precursor [KO:K04309 ]
299802 Lgr5; leucine-rich repeat-containing G-protein coupled receptor 5 precursor [KO:K04308 ]
498233 Lgr6; leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1 [KO:K08399 ]
293649 Lrp5; low-density lipoprotein receptor-related protein 5 precursor [KO:K03068 ]
312781 Lrp6; low-density lipoprotein receptor-related protein 6 isoform 2 precursor [KO:K03068 ]
83837 Bambi; BMP and activin membrane-bound inhibitor homolog precursor [KO:K10162 ]
83721 Dvl1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353 ]
303811 Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353 ]
303251 Dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
81650 Csnk2b; casein kinase II subunit beta [KO:K03115 ]
83824 Cxxc4; CXXC-type zinc finger protein 4 [KO:K03344 ]
24205 Apc; adenomatous polyposis coli protein [KO:K02085 ]
299611 Apc2; adenomatous polyposis coli protein 2 [KO:K02085 ]
365468 Lzts2; leucine zipper putative tumor suppressor 2 [KO:K26471 ]
503000 Ctnnbip1; beta-catenin-interacting protein 1 [KO:K04493 ]
65027 Chd8; chromodomain-helicase-DNA-binding protein 8 [KO:K04494 ] [EC:5.6.2.-]
306007 Ccar2; cell cycle and apoptosis regulator protein 2 [KO:K25816 ]
25565 Tle4; transducin-like enhancer protein 4 isoform 2 [KO:K04497 ]
299637 Tle6; transducin-like enhancer protein 6 isoform X1 [KO:K04497 ]
84424 Tle3; transducin-like enhancer protein 3 [KO:K04497 ]
50554 Smad4; mothers against decapentaplegic homolog 4 [KO:K04501 ]
25631 Smad3; mothers against decapentaplegic homolog 3 [KO:K23605 ]
25682 Ppard; peroxisome proliferator-activated receptor delta [KO:K04504 ]
287280 Skp1; S-phase kinase-associated protein 1 [KO:K03094 ]
302711 Tbl1x; F-box-like/WD repeat-containing protein TBL1X [KO:K04508 ]
365755 Tbl1xr1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508 ]
361765 Btrc; F-box/WD repeat-containing protein 1A [KO:K03362 ]
303024 Fbxw11; F-box/WD repeat-containing protein 11 isoform 1 [KO:K03362 ]
362550 Ror1; inactive tyrosine-protein kinase transmembrane receptor ROR1 precursor [KO:K05122 ] [EC:2.7.10.1 ]
306782 Ror2; tyrosine-protein kinase transmembrane receptor ROR2 precursor [KO:K05123 ] [EC:2.7.10.1 ]
317380 Prickle3; prickle planar cell polarity protein 3 [KO:K04511 ]
316201 Daam2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512 ]
314212 Daam1; disheveled-associated activator of morphogenesis 1 [KO:K04512 ]
297173 RSA-14-44; ras homolog gene family, member A [KO:K04513 ]
363875 Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
366957 Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
688319 Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861 ]
24654 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
29322 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
85240 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
25031 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
25400 Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515 ] [EC:2.7.11.17 ]
24246 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515 ] [EC:2.7.11.17 ]
24245 Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2 [KO:K04515 ] [EC:2.7.11.17 ]
171140 Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515 ] [EC:2.7.11.17 ]
24675 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348 ] [EC:3.1.3.16 ]
171378 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
100361818 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 [KO:K04446 ]
311658 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
361400 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
305897 Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
Compound Reference Authors Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title Beta-catenin and Tcfs in mammary development and cancer.
Journal Reference Authors Yang Y.
Title Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal Reference Authors Kalderon D.
Title Similarities between the Hedgehog and Wnt signaling pathways.
Journal Reference Authors Nusse R.
Title Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal Reference Authors Jope RS, Johnson GV.
Title The glamour and gloom of glycogen synthase kinase-3.
Journal Reference Authors Veeman MT, Axelrod JD, Moon RT.
Title A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal Reference Authors Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal Reference Authors Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title The way Wnt works: Components and mechanism.
Journal Reference Authors Carethers JM
Title Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal Reference Authors Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal Reference Authors Niehrs C
Title The complex world of WNT receptor signalling.
Journal Reference Authors Abou Ziki MD, Mani A
Title Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal Reference Authors He Y, Ki H, Kim H, Kim K
Title delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal Reference Authors Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal Reference Authors Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal Related KO pathway LinkDB All DBs
