KEGG   PATHWAY: rno04120
Entry
rno04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Rattus norvegicus (rat)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
rno04120  Ubiquitin mediated proteolysis
rno04120

Other DBs
GO: 0016567
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100359803  Ube2d4l1; ubiquitin-conjugating enzyme E2D 4 like 1 [KO:K06689] [EC:2.3.2.23]
100360914  Fbxw7; F-box/WD repeat-containing protein 7 [KO:K10260]
100360936  Anapc16; anaphase-promoting complex subunit 16 isoform 1 [KO:K25229]
100362121  Ddb2; DNA damage-binding protein 2 [KO:K10140]
100366017  Ube2e1; ubiquitin-conjugating enzyme E2 E1 [KO:K20217] [EC:2.3.2.23]
100909445  Ube2w; ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
100910895  [KO:K10580] [EC:2.3.2.23]
100912032  Rps27a; ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
103690504  [KO:K10580] [EC:2.3.2.23]
103691088  Elocl1; elongin-C-like [KO:K03872]
103694557  Ube1y1; ubiquitin-like modifier-activating enzyme 1 Y [KO:K03178] [EC:6.2.1.45]
116667  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
116725  Ube2n; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
117060  Ubr5; E3 ubiquitin-protein ligase UBR5 [KO:K10593] [EC:2.3.2.26]
117519  Keap1; kelch-like ECH-associated protein 1 [KO:K10456]
117553  Uba3; NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
120097475  [KO:K03872]
120099165  Ube2wl1; ubiquitin-conjugating enzyme E2 W-like [KO:K10688] [EC:2.3.2.23 2.3.2.25]
120099227  [KO:K06689] [EC:2.3.2.23]
120099279  [KO:K03872]
120101893  Elob-ps3; elongin-B-like [KO:K03873]
120101894  Elob-ps13; elongin-B-like [KO:K03873]
120101895  Elob-ps5; elongin-B-like [KO:K03873]
120101896  Elob-ps7; elongin-B-like [KO:K03873]
120101899  Elob-ps15; elongin-B-like [KO:K03873]
134479414  [KO:K10598] [EC:5.2.1.8]
134479420  [KO:K10598] [EC:5.2.1.8]
134479421  [KO:K10598] [EC:5.2.1.8]
134482328  [KO:K03872]
134482331  [KO:K03872]
134482335  [KO:K03872]
134482343  [KO:K03872]
134482344  [KO:K03872]
134482347  [KO:K03872]
134482351  [KO:K03872]
134482354  [KO:K03872]
134482356  [KO:K03872]
134482358  [KO:K03872]
134482362  [KO:K03872]
134482363  [KO:K03872]
134482473  [KO:K03872]
134482479  [KO:K03872]
134482480  [KO:K03872]
134482481  [KO:K03872]
134482484  [KO:K03872]
134482485  [KO:K03872]
134482488  [KO:K03872]
134482489  [KO:K03872]
134482563  [KO:K03872]
134484397  [KO:K03178] [EC:6.2.1.45]
134486081  [KO:K03873]
134486082  [KO:K03873]
134486083  [KO:K03873]
134486084  [KO:K03873]
134486085  [KO:K03873]
140941  Siah1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
171136  Cblb; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
192255  Ubb; polyubiquitin-B precursor [KO:K04551]
246216  Prpf19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
24874  Vhl; von Hippel-Lindau disease tumor suppressor [KO:K03871]
25225  Uba1y; ubiquitin-activating enzyme, Chr Y [KO:K03178] [EC:6.2.1.45]
252971  Socs1; suppressor of cytokine signaling 1 [KO:K04694]
25489  Nedd4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
25573  Ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
287155  Stub1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
287280  Skp1; S-phase kinase-associated protein 1 [KO:K03094]
288671  Anapc5; anaphase-promoting complex subunit 5 isoform 1 [KO:K03352]
289508  Rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
289623  Ube2k; ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
290875  Cdc16; cell division cycle protein 16 homolog [KO:K03353]
291553  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
291689  Cdc23; cell division cycle protein 23 homolog [KO:K03355]
291999  Wwp2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [KO:K05630] [EC:2.3.2.26]
292588  Ube2s; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
292699  Cblc; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
293155  Anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
294328  Aire; autoimmune regulator [KO:K10603]
294331  Ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
294790  Skp2; S-phase kinase-associated protein 2 [KO:K03875]
295252  Ube2q1; ubiquitin-conjugating enzyme E2 Q1 [KO:K10582] [EC:2.3.2.23]
295686  Ube2e3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
295704  Ube2l6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
296161  Ubox5; RING finger protein 37 [KO:K10600]
296368  Ube2c; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
296468  Birc7; baculoviral IAP repeat-containing protein 7 [KO:K16061]
296558  Anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
296956  Ube2h; ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
297930  Wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
297961  Ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
298317  Ube2a; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
298652  Ube4b; ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
298689  Ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
299602  Cdc34; ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
300084  Rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
300772  Pias1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
300948  Rnf7; RING-box protein 2 [KO:K10611]
301000  Uba7; ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
301555  Cul3; cullin-3 [KO:K03869]
302502  Cul4b; cullin-4B [KO:K10609]
302938  Mgrn1; E3 ubiquitin-protein ligase MGRN1 [KO:K10604] [EC:2.3.2.27]
303024  Fbxw11; F-box/WD repeat-containing protein 11 isoform 1 [KO:K03362]
303478  Ube2z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
303614  Smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
303689  Ube2o; ubiquitin-conjugating enzyme E2 O [KO:K10581] [EC:2.3.2.24]
304490  Anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
304522  Fbxw8; F-box/WD repeat-containing protein 8 [KO:K10264]
305268  Uba6; ubiquitin-like modifier-activating enzyme 6 [KO:K10699] [EC:6.2.1.45]
305420  Anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
305600  Fancl; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
306004  Rhobtb2; rho-related BTB domain-containing protein 2 [KO:K07868]
308384  Sae1; SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
308508  Uba2; SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
308669  Herc2; E3 ubiquitin-protein ligase HERC2 [KO:K10595] [EC:2.3.2.26]
308775  Det1; DET1 homolog isoform 2 [KO:K10571]
309722  Rhobtb1; rho-related BTB domain-containing protein 1 [KO:K07868]
309758  Herc4; probable E3 ubiquitin-protein ligase HERC4 [KO:K10615] [EC:2.3.2.26]
310071  Ercc8; DNA excision repair protein ERCC-8 [KO:K10570]
310363  Fbxo4; F-box only protein 4 [KO:K10291]
311245  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
311412  Anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
311567  Itch; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
313264  Trim32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
313348  Klhl9; kelch-like protein 9 [KO:K10447]
313445  Klhl13; kelch-like protein 13 isoform c [KO:K10447]
313876  Birc6; baculoviral IAP repeat-containing protein 6 [KO:K10586] [EC:2.3.2.23]
314432  Uba1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
314642  Fzr1; fizzy-related protein homolog [KO:K03364]
314856  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
315608  Ube4a; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
315713  Pml; PML nuclear body scaffold [KO:K10054] [EC:2.3.2.-]
315771  Herc1; probable E3 ubiquitin-protein ligase HERC1 [KO:K10594] [EC:2.3.2.26]
316575  Trip12; E3 ubiquitin-protein ligase TRIP12 [KO:K10590] [EC:2.3.2.26]
317341  Ube2q2l; ubiquitin-conjugating enzyme E2Q family member 2-like [KO:K10582] [EC:2.3.2.23]
360592  Trim37; E3 ubiquitin-protein ligase TRIM37 [KO:K10608] [EC:2.3.2.27]
360643  Cdc27; cell division cycle protein 27 homolog isoform 2 [KO:K03350]
360746  Ppil2; RING-type E3 ubiquitin-protein ligase PPIL2 [KO:K10598] [EC:5.2.1.8]
360860  Cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
361013  Ube2e2; ubiquitin-conjugating enzyme E2 E2 isoform 1 [KO:K20217] [EC:2.3.2.23]
361181  Cul4a; cullin-4A [KO:K10609]
361258  Cul2; cullin-2 [KO:K03870]
361389  Anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
361509  Ube2m; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
361585  Ube3a; ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
361712  Syvn1; E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
361765  Btrc; F-box/WD repeat-containing protein 1A [KO:K03362]
361831  Ube2d1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
362294  Ube3c; ubiquitin protein ligase E3C [KO:K10589] [EC:2.3.2.26]
362356  Cul1; cullin-1 [KO:K03347]
362377  Herc3; probable E3 ubiquitin-protein ligase HERC3 [KO:K10614] [EC:2.3.2.26]
362827  Pias4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
363065  Ube2q2; ubiquitin-conjugating enzyme E2 Q2 [KO:K10582] [EC:2.3.2.23]
363284  Ube2f; NEDD8-conjugating enzyme UBE2F isoform 3 [KO:K10687] [EC:2.3.2.34]
363836  Ube2l3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
364068  Uba52-ps19; ubiquitin-ribosomal protein eL40 fusion protein-like [KO:K02927]
364682  Nhlrc1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
366381  Cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
497672  Brca1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
498030  Anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
500511  Ube2u; ubiquitin-conjugating enzyme E2 U isoform X1 [KO:K10584] [EC:2.3.2.23]
500985  Cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
501546  Huwe1; E3 ubiquitin-protein ligase HUWE1 [KO:K10592] [EC:2.3.2.26]
502620  Elob-ps8; elongin-B-like [KO:K03873]
50522  Ubc; polyubiquitin-C isoform 3 precursor [KO:K08770]
54252  Mid1; E3 ubiquitin-protein ligase Midline-1 [KO:K08285] [EC:2.3.2.27]
56816  Prkn; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
60371  Birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
63879  Xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
641452  Ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
64156  Uba52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
64470  Ddb1; DNA damage-binding protein 1 [KO:K10610]
64515  Cdc20; cell division cycle protein 20 homolog [KO:K03363]
64525  Eloc; elongin-C [KO:K03872]
64624  Cul5; cullin-5 [KO:K10612]
64631  Ube2g1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
679949  Ube2ql1; ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
680835  Cul7; cullin 7 [KO:K10613]
685029  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
687633  Ube3b; ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
689226  Ube2r2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
690241  Elob-ps14; elongin-B-like [KO:K03873]
690516  Smurf1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
78971  Birc3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
79435  Ube2d2b; ubiquitin-conjugating enzyme E2 D2B [KO:K06689] [EC:2.3.2.23]
81807  Elob; elongin-B [KO:K03873]
81816  Ube2b; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
81920  Ube2d3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
83422  Pias2; E3 SUMO-protein ligase PIAS2 isoform 2 [KO:K16063] [EC:2.3.2.-]
83614  Pias3; E3 SUMO-protein ligase PIAS3 [KO:K16064] [EC:2.3.2.-]
85273  Fbxo2; F-box only protein 2 [KO:K10099]
89829  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
rno03050  Proteasome
KO pathway
ko04120   

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