KEGG   REACTION: R06572
Entry
R06572                      Reaction                               
Definition
Coniferyl aldehyde + NADPH + H+ + Oxygen <=> 5-Hydroxyconiferaldehyde + NADP+ + H2O
Equation
C02666 + C00005 + C00080 + C00007 <=> C12204 + C00006 + C00001
Comment
ferulate 5-hydroxylase
Reaction class
RC00001  C00005_C00006
RC00046  C02666_C12204
Enzyme
1.14.13.-
Pathway
rn00940  Phenylpropanoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00039  Monolignol biosynthesis, phenylalanine/tyrosine => monolignol
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     R06572  Coniferyl aldehyde + NADPH + H+ + Oxygen <=> 5-Hydroxyconiferaldehyde + NADP+ + H2O
Orthology
K09755  ferulate-5-hydroxylase [EC:1.14.-.-]
LinkDB

KEGG   RCLASS: RC00046
Entry
RC00046                     RClass                                 
Definition
C8x-C8y:*-O1a:C8x+C8y-C8x+C8y
Reactant pair
C00082_C00355    C00090_C00146    C00108_C00632
C00156_C00230    C00180_C00805    C00223_C00323
C00223_C22070    C00230_C00587    C00230_C01424
C00328_C03227    C00389_C05903    C00389_C10107
C00398_C21762    C00406_C12203    C00406_C21459
C00423_C01772    C00463_C05658    C00468_C05298
C00483_C03758    C00509_C05631    C00530_C02814
C00544_C05593    C00587_C00628    C00590_C12205
C00642_C01161    C00799_C02921    C00811_C01197
C00814_C10520    C00814_C12135    C00852_C12208
C00858_C01562    C00858_C02920    C00870_C02235
C00951_C05301    C00974_C01617    C01161_C05593
C01198_C04044    C01198_C05629    C01378_C09751
C01455_C01542    C01468_C06730    C01477_C01514
C01494_C05619    C01514_C10192    C01542_C02923
C01598_C05643    C01617_C02906    C01717_C06325
C01751_C02814    C02124_C02375    C02495_C10208
C02499_C02526    C02625_C02933    C02646_C12206
C02666_C12204    C02947_C10434    C03056_C03458
C03582_C05901    C05176_C05202    C05191_C05247
C05193_C05194    C05200_C13425    C05608_C10945
C05631_C05911    C05800_C05801    C05807_C17551
C05810_C05811    C05848_C17554    C05852_C06207
C05852_C07086    C06330_C06343    C06338_C06342
C06563_C12134    C07073_C16560    C08543_C08565
C08576_C08577    C08578_C08650    C09614_C09762
C09762_C16232    C10522_C16226    C11422_C11432
C11449_C20810    C11714_C14785    C12396_C12402
C12404_C12407    C12463_C12467    C13624_C13626
C16561_C16572    C16601_C16603    C16602_C16603
C17744_C17745    C17747_C17748    C18023_C18024
C18358_C18360    C18631_C18632    C18683_C18778
C20430_C20431    C20800_C20801    C21183_C21184
C21375_C21376    C22015_C22016    C22930_C22931
 » show all
Related class
Reaction
R00031 R00731 R00815 R01296 R01298 R01628 R01637 R01815
R01960 R02078 R02254 R02339 R02354 R02355 R02383 R02442
R02515 R02517 R02589 R02698 R02950 R03006 R03023 R03088
R03090 R03124 R03299 R03369 R03560 R03568 R03608 R03629
R03639 R03687 R03964 R03997 R04130 R04257 R04342 R04693
R04702 R04708 R04899 R04902 R04980 R04987 R05001 R05154
R05158 R05249 R05441 R05487 R05655 R05732 R06537 R06538
R06560 R06561 R06572 R06573 R06579 R06580 R06582 R06584
R06606 R06607 R06656 R06661 R06764 R06851 R06865 R06881
R07018 R07212 R07371 R07436 R07440 R07711 R07746 R07776
R07826 R07994 R08002 R08011 R08032 R08294 R08298 R08315
R08320 R08768 R08770 R08801 R08802 R08826 R08838 R08922
R09313 R09330 R09357 R09517 R10043 R10193 R10258 R10260
R10721 R10731 R11211 R11347 R11348 R11424 R11549 R11653
R11912 R12232 R12306 R12541 R12611 R13031 R13340 R13439
 » show all
Enzyme
1.3.99.18       1.10.3.1        1.11.2.5        1.11.2.6        
1.14.11.61      1.14.11.62      1.14.13.2       1.14.13.4       
1.14.13.7       1.14.13.9       1.14.13.10      1.14.13.14      
1.14.13.20      1.14.13.23      1.14.13.24      1.14.13.29      
1.14.13.33      1.14.13.44      1.14.13.61      1.14.13.62      
1.14.13.63      1.14.13.219     1.14.13.220     1.14.13.223     
1.14.13.240     1.14.13.243     1.14.13.244     1.14.13.-       
1.14.14.1       1.14.14.8       1.14.14.9       1.14.14.15      
1.14.14.20      1.14.14.27      1.14.14.54      1.14.14.81      
1.14.14.82      1.14.14.88      1.14.14.89      1.14.14.90      
1.14.14.96      1.14.14.100     1.14.14.101     1.14.14.102     
1.14.14.131     1.14.14.142     1.14.14.165     1.14.14.190     
1.14.14.-       1.14.15.45      1.14.16.2       1.14.16.-       
1.14.18.1       1.14.18.-       1.14.99.47      1.14.99.59      
1.14.-.-        1.97.1.15
 » show all
Pathway
rn00130  Ubiquinone and other terpenoid-quinone biosynthesis
rn00140  Steroid hormone biosynthesis
rn00350  Tyrosine metabolism
rn00360  Phenylalanine metabolism
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn00362  Benzoate degradation
rn00363  Bisphenol degradation
rn00380  Tryptophan metabolism
rn00401  Novobiocin biosynthesis
rn00623  Toluene degradation
rn00624  Polycyclic aromatic hydrocarbon degradation
rn00627  Aminobenzoate degradation
rn00643  Styrene degradation
rn00760  Nicotinate and nicotinamide metabolism
rn00901  Indole alkaloid biosynthesis
rn00940  Phenylpropanoid biosynthesis
rn00941  Flavonoid biosynthesis
rn00943  Isoflavonoid biosynthesis
rn00944  Flavone and flavonol biosynthesis
rn00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
rn00950  Isoquinoline alkaloid biosynthesis
rn00965  Betalain biosynthesis
rn00980  Metabolism of xenobiotics by cytochrome P450
rn00982  Drug metabolism - cytochrome P450
rn00996  Biosynthesis of various alkaloids
rn00999  Biosynthesis of various plant secondary metabolites
rn01057  Biosynthesis of type II polyketide products
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
rn01240  Biosynthesis of cofactors
RModule
RM006  Dihydroxylation of aromatic ring, type 2 (two monooxygenase reactions)
RM007  Dihydroxylation of aromatic ring, type 3 (dealkylation and monooxygenase reactions)
RM012  Dihydroxylation and meta-cleavage of aromatic ring, type 3a
RM026  Hydoxylation and decarboxylation motif
RM027  Hydroxylation and methylation motif
RM029  Pterocarpan synthesis
Orthology
K00422  polyphenol oxidase [EC:1.10.3.1]
K00481  p-hydroxybenzoate 3-monooxygenase [EC:1.14.13.2]
K00483  4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
K00484  flavin reductase (NADH) [EC:1.5.1.36]
K00486  kynurenine 3-monooxygenase [EC:1.14.13.9]
K00501  tyrosine 3-monooxygenase [EC:1.14.16.2]
K00505  tyrosinase [EC:1.14.18.1]
K03380  phenol 2-monooxygenase (NADPH) [EC:1.14.13.7]
K05280  flavonoid 3'-monooxygenase [EC:1.14.14.82]
K06126  4-hydroxy-3-polyprenylbenzoate 5-hydroxylase / 2-methoxy-6-polyprenylphenol 4-hydroxylase [EC:1.14.15.45 1.14.15.46]
K06892  feruloyl-CoA 6-hydroxylase [EC:1.14.11.61]
K07408  cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K07410  cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]
K09754  5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase [EC:1.14.14.96]
K09755  ferulate-5-hydroxylase [EC:1.14.-.-]
K10437  phenylacetate 2-hydroxylase [EC:1.14.14.54]
K10438  3-hydroxyphenylacetate 6-hydroxylase [EC:1.14.13.63]
K10676  2,4-dichlorophenol 6-monooxygenase [EC:1.14.13.20]
K13083  flavonoid 3',5'-hydroxylase [EC:1.14.14.81]
K13260  isoflavone/4'-methoxyisoflavone 2'-hydroxylase [EC:1.14.14.90 1.14.14.89]
K13267  flavonoid 6-hydroxylase [EC:1.14.13.-]
K13385  N-methylcoclaurine 3'-monooxygenase [EC:1.14.14.102]
K14338  cytochrome P450 / NADPH-cytochrome P450 reductase [EC:1.14.14.1 1.6.2.4]
K14630  two-component flavin-dependent monooxygenase [EC:1.14.14.-]
K15930  bifunctional oxygenase/reductase
K15932  reductase LndZ4/LanZ4
K15933  oxygenase LndZ5/LanZ5
K15945  C-1 hydroxylase
K16242  phenol/toluene 2-monooxygenase (NADH) P3/A3 [EC:1.14.13.244 1.14.13.243]
K16243  phenol/toluene 2-monooxygenase (NADH) P1/A1 [EC:1.14.13.244 1.14.13.243]
K16244  phenol/toluene 2-monooxygenase (NADH) P2/A2 [EC:1.14.13.244 1.14.13.243]
K16245  phenol/toluene 2-monooxygenase (NADH) P4/A4 [EC:1.14.13.244 1.14.13.243]
K16246  phenol/toluene 2-monooxygenase (NADH) P5/A5 [EC:1.14.13.244 1.14.13.243]
K16249  phenol/toluene 2-monooxygenase (NADH) P0/A0
K16901  anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9]
K16902  FAD reductase [NAD(P)H] [EC:1.5.1.45]
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
K18800  2-polyprenylphenol 6-hydroxylase [EC:1.14.13.240]
K19065  3-hydroxybenzoate 4-monooxygenase [EC:1.14.13.23]
K19189  2,6-dihydroxypyridine 3-monooxygenase [EC:1.14.13.10]
K20208  3-methyl-L-tyrosine peroxygenase [EC:1.11.2.5]
K20942  resorcinol 4-hydroxylase (FADH2) [EC:1.14.14.27]
K20943  resorcinol 4-hydroxylase (NADPH) [EC:1.14.13.219]
K20944  resorcinol 4-hydroxylase (NADH) [EC:1.14.13.220]
K21184  two-component FAD-dependent monooxygenase [EC:1.14.14.15 1.14.14.-]
K21205  bursehernin 5'-monooxygenase [EC:1.14.14.131]
K21726  4-nitrophenol 2-monooxygenase / 4-nitrocatechol 4-monooxygenase, oxygenase component [EC:1.14.13.29 1.14.13.166]
K21727  4-nitrophenol 2-monooxygenase / 4-nitrocatechol 4-monooxygenase, reductase component
K22270  3-hydroxybenzoate 6-monooxygenase [EC:1.14.13.24]
K22434  tryptamine 4-monooxygenase [EC:1.14.99.59]
K22932  isoflavone 3'-hydroxylase [EC:1.14.14.88]
K23378  feruloyl-CoA 6-hydroxylase / trans-4-coumaroyl-CoA 2-hydroxylase [EC:1.14.11.61 1.14.11.62]
K23470  4-hydroxyphenylacetate 3-hydroxylase, reductase component [EC:1.5.1.36]
K23492  4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
K24287  L-tyrosine peroxygenase [EC:1.11.2.6]
K24844  2-(all-trans-polyprenyl)phenol 6-hydroxylase (prephenate) UbiU [EC:1.97.1.15]
K24845  2-(all-trans-polyprenyl)phenol 6-hydroxylase (prephenate) UbiV [EC:1.97.1.15]
K26037  tyrosine hydroxylase / L-DOPA oxygenase [EC:1.14.-.-]
K27788  beta-colubrine 11-hydroxylase [EC:1.14.14.190]

DBGET integrated database retrieval system