KEGG   PATHWAY: arut04120
Entry
arut04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Acipenser ruthenus (sterlet)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
arut04120  Ubiquitin mediated proteolysis
arut04120

Other DBs
GO: 0016567
Organism
Acipenser ruthenus (sterlet) [GN:arut]
Gene
117430252  polyubiquitin-B isoform X1 [KO:K04551]
117962256  polyubiquitin-B [KO:K04551]
117428188  LOW QUALITY PROTEIN: polyubiquitin-B [KO:K08770]
117426929  polyubiquitin-C isoform X1 [KO:K08770]
117962933  polyubiquitin-C [KO:K08770]
117429187  polyubiquitin-C [KO:K08770]
117428916  ubiquitin-60S ribosomal protein L40 isoform X1 [KO:K02927]
117401241  ubiquitin-60S ribosomal protein L40 [KO:K02927]
117410763  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
117402620  ubiquitin-40S ribosomal protein S27a [KO:K02977]
117414101  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
117401766  ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
117404345  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
117412562  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
117394604  sae1; SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
117425463  LOW QUALITY PROTEIN: SUMO-activating enzyme subunit 2-like [KO:K10685] [EC:6.2.1.45]
117424754  SUMO-activating enzyme subunit 2-like [KO:K10685] [EC:6.2.1.45]
117411901  NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
117413772  NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
117409446  LOW QUALITY PROTEIN: ubiquitin-like modifier-activating enzyme 6 [KO:K10699] [EC:6.2.1.45]
117421264  ubiquitin-like modifier-activating enzyme 6 isoform X1 [KO:K10699] [EC:6.2.1.45]
117430622  ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
117412373  ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
117431606  ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
117413338  ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
117426756  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
117422568  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
117968946  ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
117397941  ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
117415741  ubiquitin-conjugating enzyme E2 D4-like isoform X1 [KO:K06689] [EC:2.3.2.23]
117409289  ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
117418259  ube2d1b; ubiquitin-conjugating enzyme E2 D1b [KO:K06689] [EC:2.3.2.23]
117421316  ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
117431499  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
117413250  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
117399530  ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:2.3.2.23]
117400440  ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
117427128  ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
117401422  ube2e3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
117394676  ubiquitin-conjugating enzyme E2 E1-like [KO:K20217] [EC:2.3.2.23]
117394987  ubiquitin-conjugating enzyme E2 E2-like isoform X1 [KO:K20217] [EC:2.3.2.23]
117426447  NEDD8-conjugating enzyme UBE2F-like [KO:K10687] [EC:2.3.2.34]
117400649  ube2f; NEDD8-conjugating enzyme UBE2F [KO:K10687] [EC:2.3.2.34]
117426974  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
117427763  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
117429508  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
117430880  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
117426890  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
117405339  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
117415606  ubiquitin-conjugating enzyme E2 H isoform X1 [KO:K10576] [EC:2.3.2.23]
117419468  ubiquitin-conjugating enzyme E2 H isoform X1 [KO:K10576] [EC:2.3.2.23]
117417585  SUMO-conjugating enzyme UBC9-like [KO:K10577]
117432569  SUMO-conjugating enzyme UBC9-like [KO:K10577]
117417969  SUMO-conjugating enzyme UBC9-B [KO:K10577]
117431379  SUMO-conjugating enzyme UBC9-B [KO:K10577]
117410937  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
117403096  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
117963801  ubiquitin-conjugating enzyme E2 J2-like isoform X1 [KO:K04554] [EC:2.3.2.23]
117425639  ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
117409282  ubiquitin-conjugating enzyme E2 K-like [KO:K04649] [EC:2.3.2.23]
117420780  ube2kb; ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast) isoform X1 [KO:K04649] [EC:2.3.2.23]
117426988  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
117428442  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
117407745  ube2m; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
117967268  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
117420146  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
117414753  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
117424342  LOW QUALITY PROTEIN: (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O-like [KO:K10581] [EC:2.3.2.24]
117423727  (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O-like [KO:K10581] [EC:2.3.2.24]
117435547  ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
117399658  ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
117428152  ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
117429537  ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
117973294  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
117973463  ubiquitin-conjugating enzyme E2 14-like [KO:K02207] [EC:2.3.2.23]
117962492  ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
117403979  ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
117401328  ubiquitin-conjugating enzyme E2 R1-like [KO:K02207] [EC:2.3.2.23]
117966179  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
117966197  ubiquitin-conjugating enzyme E2 R1-like [KO:K02207] [EC:2.3.2.23]
117969245  ubiquitin-conjugating enzyme E2 S-A-like [KO:K10583] [EC:2.3.2.23]
117410185  ube2s; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
117416461  ubiquitin-conjugating enzyme E2 U-like [KO:K10584] [EC:2.3.2.23]
117411320  ubiquitin-conjugating enzyme E2 U-like [KO:K10584] [EC:2.3.2.23]
117435414  flj11011l; probable ubiquitin-conjugating enzyme E2 W-B [KO:K10688] [EC:2.3.2.23 2.3.2.25]
117400400  ubiquitin-conjugating enzyme E2 W isoform X2 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
117433331  ubiquitin-conjugating enzyme E2 Z isoform X1 [KO:K10585] [EC:2.3.2.23]
117434695  ubiquitin-conjugating enzyme E2 Z-like [KO:K10585] [EC:2.3.2.23]
117411422  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 6-like [KO:K10586] [EC:2.3.2.23]
117402834  baculoviral IAP repeat-containing protein 6 [KO:K10586] [EC:2.3.2.23]
117407052  ube3a; LOW QUALITY PROTEIN: ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
117426320  ubiquitin-protein ligase E3B-like [KO:K10588] [EC:2.3.2.26]
117963192  ubiquitin-protein ligase E3B-like [KO:K10588] [EC:2.3.2.26]
117400677  ubiquitin-protein ligase E3C-like [KO:K10589] [EC:2.3.2.26]
117435231  ubiquitin-protein ligase E3C-like [KO:K10589] [EC:2.3.2.26]
117424634  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
117417617  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
117431517  E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
117423487  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
117421712  E3 ubiquitin-protein ligase Itchy-like isoform X1 [KO:K05632] [EC:2.3.2.26]
117431724  E3 ubiquitin-protein ligase Itchy-like isoform X1 [KO:K05632] [EC:2.3.2.26]
117400357  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
117394648  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
117424526  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
117425613  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
117416870  E3 ubiquitin-protein ligase TRIP12-like [KO:K10590] [EC:2.3.2.26]
117423339  trip12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
117429609  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
117408684  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
117404270  E3 ubiquitin-protein ligase HUWE1-like [KO:K10592] [EC:2.3.2.26]
117435794  E3 ubiquitin-protein ligase UBR5 [KO:K10593] [EC:2.3.2.26]
117399524  ubr5; E3 ubiquitin-protein ligase UBR5 isoform X1 [KO:K10593] [EC:2.3.2.26]
117428233  herc1; LOW QUALITY PROTEIN: probable E3 ubiquitin-protein ligase HERC1 [KO:K10594] [EC:2.3.2.26]
117409423  probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
117973139  probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
117405886  E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
117407414  E3 ubiquitin-protein ligase HERC2-like isoform X1 [KO:K10595] [EC:2.3.2.26]
117421388  herc3; probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
117418271  probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
117415804  LOW QUALITY PROTEIN: probable E3 ubiquitin-protein ligase HERC4 [KO:K10615] [EC:2.3.2.26]
117966539  ubiquitin conjugation factor E4 A-like [KO:K10596] [EC:2.3.2.27]
117397220  ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
117432258  ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
117425615  ubiquitin conjugation factor E4 B-like isoform X1 [KO:K10597] [EC:2.3.2.27]
117418528  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
117431112  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
117963140  RING-type E3 ubiquitin-protein ligase PPIL2-like isoform X1 [KO:K10598] [EC:5.2.1.8]
117428332  RING-type E3 ubiquitin-protein ligase PPIL2-like isoform X1 [KO:K10598] [EC:5.2.1.8]
117403501  RING finger protein 37-like isoform X1 [KO:K10600]
117404094  RING finger protein 37-like [KO:K10600]
117415877  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
117419350  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
117416320  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
117433827  cblc; E3 ubiquitin-protein ligase CBL-C [KO:K04707] [EC:2.3.2.27]
117964825  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
117962485  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
117397057  E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
117405466  E3 ubiquitin-protein ligase CBL-B-like isoform X1 [KO:K22517] [EC:2.3.2.27]
117407470  E3 ubiquitin-protein ligase CBL-B-like isoform X1 [KO:K22517] [EC:2.3.2.27]
117403298  prkn; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
117424847  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
117425774  E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
117427732  protein PML-like [KO:K10054] [EC:2.3.2.-]
117427810  uncharacterized protein LOC117427810 [KO:K10054] [EC:2.3.2.-]
117429037  protein PML-like [KO:K10054] [EC:2.3.2.-]
117429166  protein PML-like [KO:K10054] [EC:2.3.2.-]
117963211  protein PML-like [KO:K10054] [EC:2.3.2.-]
117963212  protein PML-like [KO:K10054] [EC:2.3.2.-]
117435117  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
117432247  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
117963658  mitogen-activated protein kinase kinase kinase 1-like isoform X1 [KO:K04416] [EC:2.7.11.25]
117425788  mitogen-activated protein kinase kinase kinase 1 isoform X3 [KO:K04416] [EC:2.7.11.25]
117416458  E3 ubiquitin-protein ligase COP1-like isoform X1 [KO:K10143] [EC:2.3.2.27]
117412397  E3 ubiquitin-protein ligase COP1-like isoform X1 [KO:K10143] [EC:2.3.2.27]
117408376  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
117421426  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
117972988  inhibitor of apoptosis protein-like [KO:K16060]
117405623  inhibitor of apoptosis protein isoform X1 [KO:K16060]
117430831  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
117421419  baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
117430398  baculoviral IAP repeat-containing protein 7-like isoform X1 [KO:K16061]
117428382  E3 SUMO-protein ligase PIAS1-like isoform X1 [KO:K04706] [EC:2.3.2.-]
117429462  E3 SUMO-protein ligase PIAS1-like isoform X1 [KO:K04706] [EC:2.3.2.-]
117404106  E3 SUMO-protein ligase PIAS2-like isoform X1 [KO:K16063] [EC:2.3.2.-]
117403556  E3 SUMO-protein ligase PIAS2-like isoform X1 [KO:K16063] [EC:2.3.2.-]
117962927  LOW QUALITY PROTEIN: E3 SUMO-protein ligase PIAS4-A-like [KO:K16065] [EC:2.3.2.27]
117401208  LOW QUALITY PROTEIN: E3 SUMO-protein ligase PIAS4-A [KO:K16065] [EC:2.3.2.27]
117962703  E3 ubiquitin-protein ligase synoviolin-like [KO:K10601] [EC:2.3.2.27]
117398652  E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
117400151  E3 ubiquitin-protein ligase NHLRC1-like [KO:K10602] [EC:2.3.2.27]
117416759  aire; autoimmune regulator [KO:K10603]
117418305  E3 ubiquitin-protein ligase MGRN1-like isoform X1 [KO:K10604] [EC:2.3.2.27]
117431590  probable E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
117433289  breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
117403005  fancl; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
117407287  E3 ubiquitin-protein ligase Midline-1 isoform X1 [KO:K08285] [EC:2.3.2.27]
117405155  E3 ubiquitin-protein ligase Midline-1-like [KO:K08285] [EC:2.3.2.27]
117422290  E3 ubiquitin-protein ligase TRIM32-like [KO:K10607] [EC:2.3.2.27]
117396813  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIM32-like [KO:K10607] [EC:2.3.2.27]
117429172  E3 ubiquitin-protein ligase TRIM37-like isoform X1 [KO:K10608] [EC:2.3.2.27]
117430275  E3 ubiquitin-protein ligase TRIM37-like isoform X1 [KO:K10608] [EC:2.3.2.27]
117400297  cullin-1-like isoform X1 [KO:K03347]
117394620  cullin-1 isoform X1 [KO:K03347]
117431303  S-phase kinase-associated protein 1 [KO:K03094]
117413036  S-phase kinase-associated protein 1 [KO:K03094]
117413404  F-box/WD repeat-containing protein 11 [KO:K03362]
117415480  beta-TrCP isoform X1 [KO:K03362]
117418534  beta-TrCP-like isoform X3 [KO:K03362]
117431581  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
117409303  S-phase kinase-associated protein 2 [KO:K03875]
117421557  skp2; S-phase kinase-associated protein 2 [KO:K03875]
117409316  F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
117421392  LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 7 [KO:K10260]
117968644  F-box only protein 2-like [KO:K10099]
117972145  F-box only protein 2-like [KO:K10099]
117425435  F-box only protein 2-like [KO:K10099]
117426070  F-box only protein 2 [KO:K10099]
117973257  F-box only protein 4-like [KO:K10291]
117403938  F-box only protein 4 [KO:K10291]
117395040  cullin-2 [KO:K03870]
117400445  cul2; cullin-2 isoform X1 [KO:K03870]
117400375  elongin-C isoform X1 [KO:K03872]
117395052  elongin-C [KO:K03872]
117969551  elongin-B [KO:K03873]
117398322  elongin-B [KO:K03873]
117420124  vhll; von Hippel-Lindau-like protein [KO:K03871]
117411739  von Hippel-Lindau disease tumor suppressor-like [KO:K03871]
117412333  von Hippel-Lindau disease tumor suppressor-like [KO:K03871]
117417317  cullin-3 [KO:K03869]
117423534  cullin-3-like [KO:K03869]
117966873  kelch-like ECH-associated protein 1B [KO:K10456]
117962286  kelch-like ECH-associated protein 1A [KO:K10456]
117402049  kelch-like ECH-associated protein 1B [KO:K10456]
117401476  kelch-like ECH-associated protein 1A isoform X1 [KO:K10456]
117407109  kelch-like protein 13 [KO:K10447]
117430585  klhl13; kelch-like protein 13 isoform X1 [KO:K10447]
117412174  kelch-like protein 13 isoform X1 [KO:K10447]
117405217  kelch-like protein 9 [KO:K10447]
117405274  kelch-like protein 13 [KO:K10447]
117397024  kelch-like protein 9 [KO:K10447]
117403717  rho-related BTB domain-containing protein 2-like isoform X1 [KO:K07868]
117962357  rho-related BTB domain-containing protein 2-like isoform X1 [KO:K07868]
117397851  rho-related BTB domain-containing protein 2-like isoform X3 [KO:K07868]
117418389  rho-related BTB domain-containing protein 1-like isoform X1 [KO:K07868]
117404038  rho-related BTB domain-containing protein 2-like isoform X2 [KO:K07868]
117415104  rho-related BTB domain-containing protein 1-like [KO:K07868]
117406335  cullin-4A-like [KO:K10609]
117407290  cullin-4A-like [KO:K10609]
117430870  cullin-4B-like [KO:K10609]
117412675  cullin-4B [KO:K10609]
117432318  DNA damage-binding protein 1-like [KO:K10610]
117434905  ddb1; DNA damage-binding protein 1 [KO:K10610]
117432036  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
117400155  DNA excision repair protein ERCC-8-like isoform X1 [KO:K10570]
117963681  DNA excision repair protein ERCC-8-like isoform X1 [KO:K10570]
117427773  DET1 homolog [KO:K10571]
117964206  DET1 homolog [KO:K10571]
117423175  rnf7; RING-box protein 2 [KO:K10611]
117973030  cullin-5 isoform X1 [KO:K10612]
117405897  cullin-5 isoform X2 [KO:K10612]
117973677  suppressor of cytokine signaling 1-like [KO:K04694]
117418045  suppressor of cytokine signaling 1 [KO:K04694]
117423091  suppressor of cytokine signaling 3-like [KO:K04696]
117424283  socs3b; suppressor of cytokine signaling 3b [KO:K04696]
117428421  F-box/WD repeat-containing protein 8-like isoform X1 [KO:K10264]
117426923  F-box/WD repeat-containing protein 8-like isoform X1 [KO:K10264]
117424590  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
117973952  anaphase-promoting complex subunit 2-like [KO:K03349]
117396688  anaphase-promoting complex subunit 2 [KO:K03349]
117405940  cdc20; cell division cycle protein 20 homolog [KO:K03363]
117416929  cell division cycle protein 20 homolog [KO:K03363]
117417255  fizzy-related protein homolog isoform X1 [KO:K03364]
117401195  fizzy-related protein homolog [KO:K03364]
117402491  fizzy-related protein homolog isoform X1 [KO:K03364]
117966173  fizzy-related protein homolog [KO:K03364]
117411528  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
117435073  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
117433273  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
117420937  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
117426611  anaphase-promoting complex subunit 5-like [KO:K03352]
117427876  anaphase-promoting complex subunit 5-like [KO:K03352]
117406108  LOW QUALITY PROTEIN: cell division cycle protein 16 homolog [KO:K03353]
117406958  cell division cycle protein 16 homolog [KO:K03353]
117426243  anaphase-promoting complex subunit 7 [KO:K03354]
117428461  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
117431124  cell division cycle protein 23 homolog [KO:K03355]
117412899  cell division cycle protein 23 homolog [KO:K03355]
117972383  anaphase-promoting complex subunit 10-like [KO:K03357]
117409616  anaphase-promoting complex subunit 10 [KO:K03357]
117964687  anaphase-promoting complex subunit CDC26-like [KO:K03359]
117396899  anaphase-promoting complex subunit CDC26 [KO:K03359]
117397474  anaphase-promoting complex subunit 13-like [KO:K12456]
117397099  anaphase-promoting complex subunit 13-like [KO:K12456]
117973037  anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
117405883  anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
117416101  anaphase-promoting complex subunit 16 [KO:K25229]
117417801  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
arut03050  Proteasome
KO pathway
ko04120   
LinkDB

DBGET integrated database retrieval system