KEGG   PATHWAY: arut04110
Entry
arut04110                   Pathway                                
Name
Cell cycle - Acipenser ruthenus (sterlet)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
arut04110  Cell cycle
arut04110

Other DBs
GO: 0000278
Organism
Acipenser ruthenus (sterlet) [GN:arut]
Gene
117435119  G1/S-specific cyclin-D1-like [KO:K04503]
117432035  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117398003  G1/S-specific cyclin-D2-like [KO:K10151]
117419684  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
117433893  G1/S-specific cyclin-D2-like [KO:K10151]
117415323  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
117962597  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
117401103  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
117394697  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
117400643  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
117412504  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
117407442  rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
117427793  retinoblastoma-like protein 1 [KO:K04681]
117434860  retinoblastoma-like protein 1 [KO:K04681]
117424503  rbl2; LOW QUALITY PROTEIN: retinoblastoma-like protein 2 [KO:K16332]
117425692  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
117422371  tyrosine-protein kinase ABL1-like isoform X1 [KO:K06619] [EC:2.7.10.2]
117396922  tyrosine-protein kinase ABL1-like isoform X2 [KO:K06619] [EC:2.7.10.2]
117413759  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
117411603  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
117403307  histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
117412982  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
117963853  transcription factor E2F1-like [KO:K17454]
117406596  transcription factor E2F1-like [KO:K17454]
117413953  e2f2; transcription factor E2F2 [KO:K09389]
117435318  transcription factor E2F3-like [KO:K06620]
117399900  transcription factor E2F3-like [KO:K06620]
117424822  e2f4; transcription factor E2F4 [KO:K04682]
117399799  transcription factor E2F5-like isoform X1 [KO:K04682]
117394950  transcription factor E2F5-like [KO:K04682]
117425373  transcription factor E2F4-like [KO:K04682]
117406482  transcription factor Dp-1-like isoform X1 [KO:K04683]
117405225  transcription factor Dp-1-like isoform X1 [KO:K04683]
117417278  transcription factor Dp-2-like isoform X1 [KO:K09392]
117423441  transcription factor Dp-2-like isoform X1 [KO:K09392]
117405839  LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
117407370  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117394578  transforming growth factor beta-1 proprotein-like [KO:K13375]
117962646  transforming growth factor beta-2 proprotein-like isoform X1 [KO:K13376]
117398621  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
117410435  transforming growth factor beta-2 proprotein-like [KO:K13376]
117402519  transforming growth factor beta-2 proprotein-like [KO:K13376]
117963928  transforming growth factor beta-3 proprotein-like [KO:K13377]
117422235  transforming growth factor beta-3 proprotein [KO:K13377]
117421319  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
117428208  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
117429671  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
117968709  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
117962470  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117409333  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117421209  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
117395592  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117394278  mycb; transcriptional regulator Myc-B [KO:K04377]
117409784  transcriptional regulator Myc-B-like [KO:K04377]
117428910  transcriptional regulator Myc-B-like [KO:K04377]
117963795  zinc finger and BTB domain-containing protein 17-like isoform X1 [KO:K10500]
117425784  zinc finger and BTB domain-containing protein 17-like isoform X1 [KO:K10500]
117970487  cyclin-dependent kinase inhibitor 2A-like [KO:K04685]
117409583  cyclin-dependent kinase inhibitor 2A-like [KO:K04685]
117421214  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
117417006  cyclin-dependent kinase 4 inhibitor C-like isoform X2 [KO:K06622]
117412162  cyclin-dependent kinase 4 inhibitor C-like [KO:K06622]
117401957  cyclin-dependent kinase 4 inhibitor D [KO:K06623]
117965549  cyclin-dependent kinase 4 inhibitor D-like [KO:K06623]
117419491  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb isoform X1 [KO:K06624]
117414998  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
117432174  cyclin-dependent kinase inhibitor 1C-like [KO:K09993]
117434788  cyclin-dependent kinase inhibitor 1C-like [KO:K09993]
117964374  cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
117419487  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
117425694  G1/S-specific cyclin-E1-like [KO:K06626]
117400604  G1/S-specific cyclin-E2-like [KO:K06626]
117394712  G1/S-specific cyclin-E2-like [KO:K06626]
117424350  G1/S-specific cyclin-E1-like [KO:K06626]
117400952  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
117966925  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
117967011  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
117967038  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
117431303  S-phase kinase-associated protein 1 [KO:K03094]
117413036  S-phase kinase-associated protein 1 [KO:K03094]
117400297  cullin-1-like isoform X1 [KO:K03347]
117394620  cullin-1 isoform X1 [KO:K03347]
117409303  S-phase kinase-associated protein 2 [KO:K03875]
117421557  skp2; S-phase kinase-associated protein 2 [KO:K03875]
117406242  ccna1; cyclin-A1 [KO:K06627]
117407197  cyclin-A1-like [KO:K06627]
117409547  cyclin-A2-like [KO:K06627]
117420984  cyclin-A2-like [KO:K06627]
117433100  uncharacterized protein LOC117433100 [KO:K02213]
117967993  uncharacterized protein LOC117967993 [KO:K02213]
117434627  cdc6; cell division control protein 6 homolog [KO:K02213]
117424212  cdt1; DNA replication factor Cdt1 [KO:K10727]
117405418  origin recognition complex subunit 1-like [KO:K02603]
117417184  origin recognition complex subunit 1-like [KO:K02603]
117426475  origin recognition complex subunit 2-like isoform X1 [KO:K02604]
117400765  origin recognition complex subunit 2-like [KO:K02604]
117410658  orc3; origin recognition complex subunit 3 [KO:K02605]
117427135  origin recognition complex subunit 4-like isoform X1 [KO:K02606]
117401472  origin recognition complex subunit 4-like [KO:K02606]
117415541  orc5; origin recognition complex subunit 5 isoform X1 [KO:K02607]
117425954  orc6; origin recognition complex subunit 6 [KO:K02608]
117412034  DNA replication licensing factor mcm2 [KO:K02540] [EC:5.6.2.3]
117413836  DNA replication licensing factor mcm2-like [KO:K02540] [EC:5.6.2.3]
117402887  zygotic DNA replication licensing factor mcm3 [KO:K02541] [EC:5.6.2.3]
117400773  maternal DNA replication licensing factor mcm3-like isoform X1 [KO:K02541] [EC:5.6.2.3]
117394215  LOW QUALITY PROTEIN: DNA replication licensing factor mcm4-A [KO:K02212] [EC:5.6.2.3]
117426538  zygotic DNA replication licensing factor mcm6-B-like [KO:K02542] [EC:5.6.2.3]
117394994  LOW QUALITY PROTEIN: maternal DNA replication licensing factor mcm6 [KO:K02542] [EC:5.6.2.3]
117404751  mcm6; LOW QUALITY PROTEIN: DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
117426106  cell division control protein 45 homolog [KO:K06628]
117427597  cell division control protein 45 homolog [KO:K06628]
117429821  LOW QUALITY PROTEIN: treslin-like [KO:K26117]
117428015  LOW QUALITY PROTEIN: treslin-like [KO:K26117]
117400243  mdm2-binding protein-like isoform X1 [KO:K26116]
117435602  mdm2-binding protein-like isoform X1 [KO:K26116]
117416816  cell division cycle 7-related protein kinase-like isoform X1 [KO:K02214] [EC:2.7.11.1]
117402226  LOW QUALITY PROTEIN: cell division cycle 7-related protein kinase-like [KO:K02214] [EC:2.7.11.1]
117399978  dbf4; protein DBF4 homolog A [KO:K06629]
117434647  uncharacterized protein LOC117434647 [KO:K06629]
117418033  cyclin-dependent kinase 1-B-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
117415121  cyclin-dependent kinase 1-B [KO:K02087] [EC:2.7.11.22 2.7.11.23]
117963921  G2/mitotic-specific cyclin-B1-like [KO:K05868]
117963946  G2/mitotic-specific cyclin-B1-like [KO:K05868]
117966120  G2/mitotic-specific cyclin-B1-like [KO:K05868]
117404009  G2/mitotic-specific cyclin-B1-like [KO:K05868]
117404010  G2/mitotic-specific cyclin-B1-like [KO:K05868]
117404013  G2/mitotic-specific cyclin-B1-like [KO:K05868]
117435703  cyclin N-terminal domain-containing protein 2-like [KO:K21770]
117428092  G2/mitotic-specific cyclin-B2 [KO:K21770]
117429551  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
117414910  cyclin N-terminal domain-containing protein 2-like [KO:K21770]
117408742  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
117420909  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
117431297  M-phase inducer phosphatase 1-B-like [KO:K05867] [EC:3.1.3.48]
117413446  M-phase inducer phosphatase 1-B-like [KO:K05867] [EC:3.1.3.48]
117400562  14-3-3 protein beta/alpha-1-like [KO:K16197]
117411435  ywhaqa; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a [KO:K16197]
117402928  14-3-3 protein theta [KO:K16197]
117431919  14-3-3 protein beta/alpha-1 isoform X1 [KO:K16197]
117394784  14-3-3 protein beta/alpha-1-like [KO:K16197]
117423019  14-3-3 protein beta/alpha isoform X1 [KO:K16197]
117429676  14-3-3 protein epsilon isoform X1 [KO:K06630]
117430706  14-3-3 protein epsilon isoform X1 [KO:K06630]
117428225  14-3-3 protein eta isoform X1 [KO:K16198]
117429847  14-3-3 protein gamma-B [KO:K16198]
117430789  14-3-3 protein gamma-B-like [KO:K16198]
117963206  14-3-3 protein eta isoform X1 [KO:K16198]
117418491  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
117431392  serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
117416099  wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
117419856  wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
117432117  wee1-like protein kinase 1-A isoform X2 [KO:K06632] [EC:2.7.11.1]
117434747  wee1-like protein kinase 1-A [KO:K06632] [EC:2.7.11.1]
117969548  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase-like [KO:K06633] [EC:2.7.11.1]
117398035  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
117974042  cyclin-H-like isoform X1 [KO:K06634]
117403975  cyclin-H-like isoform X2 [KO:K06634]
117973384  cyclin-dependent kinase 7-like [KO:K02202] [EC:2.7.11.22 2.7.11.23]
117403627  cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
117974168  cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
117403948  cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
117411528  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
117973952  anaphase-promoting complex subunit 2-like [KO:K03349]
117396688  anaphase-promoting complex subunit 2 [KO:K03349]
117435073  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
117433273  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
117420937  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
117426611  anaphase-promoting complex subunit 5-like [KO:K03352]
117427876  anaphase-promoting complex subunit 5-like [KO:K03352]
117406108  LOW QUALITY PROTEIN: cell division cycle protein 16 homolog [KO:K03353]
117406958  cell division cycle protein 16 homolog [KO:K03353]
117426243  anaphase-promoting complex subunit 7 [KO:K03354]
117428461  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
117431124  cell division cycle protein 23 homolog [KO:K03355]
117412899  cell division cycle protein 23 homolog [KO:K03355]
117972383  anaphase-promoting complex subunit 10-like [KO:K03357]
117409616  anaphase-promoting complex subunit 10 [KO:K03357]
117424590  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
117964687  anaphase-promoting complex subunit CDC26-like [KO:K03359]
117396899  anaphase-promoting complex subunit CDC26 [KO:K03359]
117397474  anaphase-promoting complex subunit 13-like [KO:K12456]
117397099  anaphase-promoting complex subunit 13-like [KO:K12456]
117973037  anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
117405883  anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
117416101  anaphase-promoting complex subunit 16 [KO:K25229]
117417801  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
117405940  cdc20; cell division cycle protein 20 homolog [KO:K03363]
117416929  cell division cycle protein 20 homolog [KO:K03363]
117413147  uncharacterized protein LOC117413147 [KO:K06635]
117431179  securin-like isoform X2 [KO:K06635]
117400942  separin [KO:K02365] [EC:3.4.22.49]
117967028  separin-like [KO:K02365] [EC:3.4.22.49]
117419883  smc1b; structural maintenance of chromosomes protein 1B isoform X1 [KO:K06636]
117401789  structural maintenance of chromosomes protein 1A [KO:K06636]
117416190  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
117418612  structural maintenance of chromosomes protein 3-like [KO:K06669]
117435406  double-strand-break repair protein rad21 homolog isoform X1 [KO:K06670]
117426506  double-strand-break repair protein rad21 homolog [KO:K06670]
117400675  double-strand-break repair protein rad21 homolog [KO:K06670]
117425078  double-strand-break repair protein rad21 homolog [KO:K06670]
117405996  si:ch211-269e2.1; cohesin subunit SA-2 isoform X1 [KO:K06671]
117417095  cohesin subunit SA-1-like [KO:K06671]
117412227  cohesin subunit SA-2 [KO:K06671]
117423481  cohesin subunit SA-1 [KO:K06671]
117430586  cohesin subunit SA-2 [KO:K06671]
117963337  transcriptional regulator ATRX-like [KO:K10779]
117430269  transcriptional regulator ATRX-like [KO:K10779]
117419679  ddx11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
117408895  nipped-B-like protein isoform X1 [KO:K06672]
117421088  LOW QUALITY PROTEIN: nipped-B-like protein [KO:K06672]
117428928  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
117966346  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
117411904  histone deacetylase 8-like [KO:K11405] [EC:3.5.1.98]
117430358  histone deacetylase 8-like [KO:K11405] [EC:3.5.1.98]
117400517  N-acetyltransferase ESCO1-like isoform X1 [KO:K11268] [EC:2.3.1.-]
117410988  N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
117403208  N-acetyltransferase ESCO2-like [KO:K11268] [EC:2.3.1.-]
117395032  esco1; N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
117421269  sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
117405970  sister chromatid cohesion protein PDS5 homolog B-like [KO:K11267]
117407208  sister chromatid cohesion protein PDS5 homolog B-like [KO:K11267]
117409394  sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
117415806  LOW QUALITY PROTEIN: wings apart-like protein homolog [KO:K25163]
117417702  waplb; wings apart-like protein homolog [KO:K25163]
117404566  aurora kinase B-like [KO:K11479] [EC:2.7.11.1]
117404565  aurora kinase B-like [KO:K11479] [EC:2.7.11.1]
117962985  aurora kinase B-like [KO:K11479] [EC:2.7.11.1]
117962975  aurora kinase B-like [KO:K11479] [EC:2.7.11.1]
117407894  aurora kinase B-like [KO:K11479] [EC:2.7.11.1]
117435248  shugoshin 1-like isoform X1 [KO:K11580]
117400410  shugoshin 1-like isoform X1 [KO:K11580]
117970742  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
117409015  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
117431670  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
117413387  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
117433644  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
117434266  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
117966538  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
117397413  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
117422429  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
117963845  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
117422740  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like [KO:K11584]
117398518  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
117967873  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
117416583  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
117410921  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform-like [KO:K11584]
117411139  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like isoform X1 [KO:K11584]
117402359  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
117402986  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
117426840  kinetochore protein NDC80 homolog [KO:K11547]
117962642  kinetochore protein NDC80 homolog isoform X1 [KO:K11547]
117421937  LOW QUALITY PROTEIN: kinetochore scaffold 1-like [KO:K11542]
117416944  kinetochore scaffold 1-like [KO:K11542]
117963873  kinetochore scaffold 1-like [KO:K11542]
117402769  ttk; dual specificity protein kinase Ttk isoform X1 [KO:K08866] [EC:2.7.12.1]
117431540  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
117421549  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
117425171  mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
117963594  mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728]
117418591  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
117422654  mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like [KO:K06637] [EC:2.7.11.1]
117417936  mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
117414700  mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
117410924  bub1; LOW QUALITY PROTEIN: mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
117400784  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
117410704  mad2l1bp; MAD2L1-binding protein [KO:K26093]
117417255  fizzy-related protein homolog isoform X1 [KO:K03364]
117401195  fizzy-related protein homolog [KO:K03364]
117402491  fizzy-related protein homolog isoform X1 [KO:K03364]
117966173  fizzy-related protein homolog [KO:K03364]
117410437  fbxo5; F-box only protein 5 [KO:K10292]
117401120  cdc14ab; dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
117409264  dual specificity protein phosphatase CDC14C-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
117411715  dual specificity protein phosphatase CDC14C-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
117432515  LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
117968047  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
117417994  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
117431768  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
117435350  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
117417029  serine/threonine-protein kinase ATR-like [KO:K06640] [EC:2.7.11.1]
117423407  serine/threonine-protein kinase ATR-like isoform X1 [KO:K06640] [EC:2.7.11.1]
117405719  serine-protein kinase ATM-like isoform X1 [KO:K04728] [EC:2.7.11.1]
117407051  serine-protein kinase ATM-like isoform X1 [KO:K04728] [EC:2.7.11.1]
117415877  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
117419350  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
117416320  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
117970978  cellular tumor antigen p53-like isoform X1 [KO:K04451]
117404615  cellular tumor antigen p53 [KO:K04451]
117400851  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117971933  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117971936  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117971940  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117416935  LOW QUALITY PROTEIN: growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
117408484  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117400855  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117400856  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117409183  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117409625  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117409629  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117428915  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117401312  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117404259  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
117397747  proliferating cell nuclear antigen [KO:K04802]
117966078  proliferating cell nuclear antigen [KO:K04802]
117397432  serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
117966660  serine/threonine-protein kinase Chk1-like isoform X1 [KO:K02216] [EC:2.7.11.1]
117427120  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
117428486  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
Reference
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CDC25 phosphatases in cancer cells: key players? Good targets?
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Nat Rev Cancer 7:495-507 (2007)
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J Cell Sci 121:3853-7 (2008)
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Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
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Proc Natl Acad Sci U S A 100:10231-6 (2003)
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Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
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Reference
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Harris SL, Levine AJ.
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The p53 pathway: positive and negative feedback loops.
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Reference
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Surfing the p53 network.
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Nature 408:307-10 (2000)
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PMID:7973727
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Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Reference
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Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
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Mol Cell 24:101-13 (2006)
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Reference
PMID:9029154
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Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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Reference
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CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
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The spindle-assembly checkpoint in space and time.
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Reference
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Chromosome cohesion and separation: from men and molecules.
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Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
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Annu Rev Genet 38:203-32 (2004)
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Reference
PMID:9618481
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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
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Proc Natl Acad Sci U S A 95:6733-8 (1998)
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Reference
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Controlling the response to DNA damage by the APC/C-Cdh1.
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Cell Mol Life Sci 73:949-60 (2016)
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Reference
PMID:20935501
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Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
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Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
arut03030  DNA replication
arut04010  MAPK signaling pathway
arut04120  Ubiquitin mediated proteolysis
arut04210  Apoptosis
KO pathway
ko04110   
LinkDB

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