KEGG   PATHWAY: arut04510
Entry
arut04510                   Pathway                                
Name
Focal adhesion - Acipenser ruthenus (sterlet)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
arut04510  Focal adhesion
arut04510

Other DBs
GO: 0005925
Organism
Acipenser ruthenus (sterlet) [GN:arut]
Gene
117971168  collagen alpha-1(I) chain-like [KO:K06236]
117434956  collagen alpha-1(I) chain-like isoform X1 [KO:K06236]
117400284  collagen alpha-2(I) chain-like [KO:K06236]
117394450  col1a2; collagen alpha-2(I) chain [KO:K06236]
117433526  collagen alpha-1(I) chain-like [KO:K06236]
117962559  collagen alpha-1(II) chain isoform X1 [KO:K19719]
117400958  collagen alpha-1(II) chain isoform X1 [KO:K19719]
117406566  collagen alpha-2(IV) chain-like [KO:K06237]
117406567  collagen alpha-1(IV) chain-like [KO:K06237]
117417044  collagen alpha-3(IV) chain-like [KO:K06237]
117417432  col4a4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
117412163  LOW QUALITY PROTEIN: collagen alpha-5(IV) chain-like [KO:K06237]
117430504  LOW QUALITY PROTEIN: collagen alpha-6(IV) chain-like [KO:K06237]
117405640  collagen alpha-2(IV) chain-like [KO:K06237]
117405641  collagen alpha-1(IV) chain-like isoform X1 [KO:K06237]
117400641  LOW QUALITY PROTEIN: collagen alpha-1(VI) chain-like [KO:K06238]
117973273  collagen alpha-3(VI) chain-like [KO:K06238]
117427179  LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
117400601  collagen alpha-2(VI) chain-like [KO:K06238]
117426794  collagen alpha-2(VI) chain-like [KO:K06238]
117427122  collagen alpha-1(VI) chain-like [KO:K06238]
117410099  collagen alpha-2(VI) chain-like [KO:K06238]
117410999  collagen alpha-1(VI) chain-like [KO:K06238]
117412744  collagen alpha-3(VI) chain-like isoform X1 [KO:K06238]
117400622  collagen alpha-3(IX) chain-like [KO:K08131]
117411272  col9a1b; collagen, type IX, alpha 1b [KO:K08131]
117435728  collagen alpha-3(IX) chain-like [KO:K08131]
117417103  collagen alpha-3(IX) chain-like [KO:K08131]
117428480  collagen alpha-3(IX) chain-like [KO:K08131]
117402753  collagen alpha-1(IX) chain-like [KO:K08131]
117413477  collagen alpha-2(IX) chain-like [KO:K08131]
117413651  collagen alpha-2(IX) chain-like [KO:K08131]
117435510  LOW QUALITY PROTEIN: laminin subunit alpha-1-like [KO:K05637]
117400698  laminin subunit alpha-1-like [KO:K05637]
117402862  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
117420258  laminin subunit alpha-5-like isoform X1 [KO:K06240]
117399383  laminin subunit alpha-3-like isoform X1 [KO:K06240]
117430696  LOW QUALITY PROTEIN: laminin subunit alpha-5-like [KO:K06240]
117411581  laminin subunit alpha-4-like [KO:K06241]
117403301  lama4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
117419632  LOW QUALITY PROTEIN: laminin subunit beta-1-like [KO:K05636]
117415858  laminin subunit beta-1-like [KO:K05636]
117412581  laminin subunit beta-2-like isoform X1 [KO:K06243]
117414029  laminin subunit beta-2-like isoform X1 [KO:K06243]
117414069  lamb2l; LOW QUALITY PROTEIN: laminin subunit beta-1 [KO:K06243]
117429693  laminin subunit beta-3 [KO:K06244]
117966023  laminin subunit beta-3-like [KO:K06244]
117414979  lamb4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
117417323  laminin subunit gamma-1-like [KO:K05635]
117412235  laminin subunit gamma-1-like [KO:K05635]
117416904  laminin subunit gamma-2-like [KO:K06246]
117412243  laminin subunit gamma-2-like [KO:K06246]
117396893  laminin subunit gamma-3-like [KO:K06247]
117422303  laminin subunit gamma-3-like [KO:K06247]
117423317  chad; chondroadherin [KO:K06248]
117414836  LOW QUALITY PROTEIN: reelin-like [KO:K06249] [EC:3.4.21.-]
117421302  thbs1b; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
117403561  thrombospondin-4-like isoform X1 [KO:K04659]
117970758  thrombospondin-3a-like isoform X1 [KO:K04659]
117403891  thrombospondin-4 [KO:K04659]
117410377  thrombospondin-2-like isoform X1 [KO:K04659]
117402241  thrombospondin-2-like isoform X1 [KO:K04659]
117962947  thrombospondin-4-like [KO:K04659]
117401522  thrombospondin-4-like [KO:K04659]
117395615  thrombospondin-3a isoform X1 [KO:K04659]
117426324  fibronectin-like isoform X1 [KO:K05717]
117409768  fibronectin-like isoform X1 [KO:K05717]
117429013  vitronectin-like [KO:K06251]
117430484  vitronectin-like [KO:K06251]
117973966  LOW QUALITY PROTEIN: tenascin-like [KO:K06252]
117406063  tnr; tenascin-R isoform X1 [KO:K06252]
117416598  tenascin-N-like [KO:K06252]
117416819  tenascin-R-like isoform X1 [KO:K06252]
117434005  LOW QUALITY PROTEIN: tenascin [KO:K06252]
117396966  LOW QUALITY PROTEIN: tenascin-like [KO:K06252]
117401662  tenascin-N-like isoform X1 [KO:K06252]
117419959  LOW QUALITY PROTEIN: von Willebrand factor-like [KO:K03900]
117415837  von Willebrand factor-like [KO:K03900]
117403712  integrin alpha-1-like [KO:K06480]
117403936  integrin alpha-1-like [KO:K06480]
117403811  integrin alpha-2-like [KO:K06481]
117403518  integrin alpha-2-like [KO:K06481]
117433237  itga2b; integrin alpha-IIb [KO:K06476]
117971170  integrin alpha-3-like isoform X1 [KO:K06482]
117435043  integrin alpha-3-like isoform X1 [KO:K06482]
117433488  integrin alpha-3-like isoform X1 [KO:K06482]
117408830  itga4; integrin alpha-4 isoform X1 [KO:K06483]
117426976  integrin alpha-4-like isoform X1 [KO:K06483]
117966984  integrin alpha-5-like isoform X1 [KO:K06484]
117401124  integrin alpha-5 isoform X1 [KO:K06484]
117426148  integrin alpha-6-like isoform X1 [KO:K06485]
117410272  integrin alpha-6-like isoform X1 [KO:K06485]
117401129  itga7; integrin alpha-7 isoform X1 [KO:K06583]
117972148  integrin alpha-7-like [KO:K06583]
117435244  integrin alpha-8-like [KO:K06584]
117400760  integrin alpha-8-like [KO:K06584]
117400459  integrin alpha-9-like isoform X1 [KO:K06585]
117394874  integrin alpha-9-like isoform X1 [KO:K06585]
117395217  integrin alpha-10-like [KO:K06586]
117428199  integrin alpha-11-like isoform X1 [KO:K06587]
117429657  integrin alpha-11-like isoform X1 [KO:K06587]
117426837  integrin alpha-V-like [KO:K06487]
117413994  integrin alpha-V-like [KO:K06487]
117394292  integrin beta-1-like [KO:K05719]
117399965  integrin beta-1-like isoform X1 [KO:K05719]
117433491  integrin beta-3-like [KO:K06493]
117434519  integrin beta-3-like [KO:K06493]
117424698  integrin beta-4-like [KO:K06525]
117423549  LOW QUALITY PROTEIN: integrin beta-4-like [KO:K06525]
117426884  integrin beta-5-like isoform X1 [KO:K06588]
117411711  integrin beta-5-like [KO:K06588]
117426276  integrin beta-6-like isoform X1 [KO:K06589]
117401462  itgb6; integrin beta-6 isoform X1 [KO:K06589]
117400915  integrin beta-7 [KO:K06590]
117967097  integrin beta-7-like [KO:K06590]
117399441  integrin beta-8-like [KO:K06591]
117394261  integrin beta-8-like isoform X1 [KO:K06591]
117973843  epithelial membrane protein 2-like [KO:K26256]
117418234  epithelial membrane protein 2 [KO:K26256]
117417838  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
117431157  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
117433133  platelet-derived growth factor subunit B-like isoform X1 [KO:K17386]
117965679  platelet-derived growth factor subunit B-like isoform X1 [KO:K17386]
117972789  platelet-derived growth factor D-like isoform X1 [KO:K05450]
117407401  platelet-derived growth factor D-like isoform X1 [KO:K05450]
117408382  platelet-derived growth factor C-like [KO:K05450]
117964366  uncharacterized protein LOC117964366 [KO:K05450]
117420633  platelet-derived growth factor C-like [KO:K05450]
117408408  pro-epidermal growth factor-like isoform X1 [KO:K04357]
117421414  pro-epidermal growth factor-like isoform X1 [KO:K04357]
117419510  insulin-like growth factor I isoform X1 [KO:K05459]
117414927  insulin-like growth factor I isoform X1 [KO:K05459]
117969907  vascular endothelial growth factor A-like [KO:K05448]
117398638  vascular endothelial growth factor A-like [KO:K05448]
117410588  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
117403077  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
117416693  placenta growth factor-like isoform X1 [KO:K16859]
117422031  placenta growth factor-like isoform X1 [KO:K16859]
117405792  vascular endothelial growth factor D-like [KO:K05449]
117406792  vegfd; vascular endothelial growth factor D [KO:K05449]
117409658  vegfc; vascular endothelial growth factor C [KO:K05449]
117420824  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
117431424  vascular endothelial growth factor C-like [KO:K05449]
117420010  hepatocyte growth factor-like [KO:K05460]
117415028  LOW QUALITY PROTEIN: hepatocyte growth factor-like [KO:K05460]
117408343  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
117420605  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
117413283  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
117963120  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117427860  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117408570  vascular endothelial growth factor receptor 2-like isoform X1 [KO:K05098] [EC:2.7.10.1]
117420387  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2-like [KO:K05098] [EC:2.7.10.1]
117400452  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117407053  vascular endothelial growth factor receptor 1-like isoform X1 [KO:K05096] [EC:2.7.10.1]
117405676  vascular endothelial growth factor receptor 1-like isoform X1 [KO:K05096] [EC:2.7.10.1]
117430671  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117412244  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117412879  vascular endothelial growth factor receptor 3-like isoform X1 [KO:K05097] [EC:2.7.10.1]
117431549  vascular endothelial growth factor receptor 3-like isoform X1 [KO:K05097] [EC:2.7.10.1]
117415916  hepatocyte growth factor receptor-like isoform X1 [KO:K05099] [EC:2.7.10.1]
117420109  hepatocyte growth factor receptor-like isoform X2 [KO:K05099] [EC:2.7.10.1]
117971274  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
117433463  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
117434964  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
117419815  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
117431239  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
117415622  rho GTPase-activating protein 35 [KO:K05732]
117396267  rho GTPase-activating protein 35-like [KO:K05732]
117422398  LOW QUALITY PROTEIN: rho GTPase-activating protein 5-like [KO:K13709]
117422181  LOW QUALITY PROTEIN: rho GTPase-activating protein 5-like [KO:K13709]
117971333  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117404314  rho-related GTP-binding protein RhoA-C [KO:K04513]
117429429  rho-related GTP-binding protein RhoA-D [KO:K04513]
117401697  rho-related GTP-binding protein RhoA-C [KO:K04513]
117412320  transforming protein RhoA [KO:K04513]
117962391  rho-related GTP-binding protein RhoA-D [KO:K04513]
117963525  transforming protein RhoA [KO:K04513]
117413341  LOW QUALITY PROTEIN: protein diaphanous homolog 1-like [KO:K05740]
117431668  protein diaphanous homolog 1-like [KO:K05740]
117400355  rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
117394747  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
117410455  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
117402932  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
117426294  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
117427756  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
117397746  myosin regulatory light chain 2, atrial isoform [KO:K12754]
117966074  myosin regulatory light chain 2, atrial isoform-like [KO:K12754]
117427144  LOW QUALITY PROTEIN: myosin regulatory light polypeptide 9 [KO:K12755]
117431434  myosin regulatory light polypeptide 9 [KO:K12755]
117429842  myosin regulatory light chain 2B, cardiac muscle isoform isoform X1 [KO:K12756]
117962362  myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756]
117399231  myosin regulatory light polypeptide 9 [KO:K12757]
117394724  myosin regulatory light polypeptide 9 [KO:K12757]
117398970  myosin regulatory light chain 2, skeletal muscle isoform type 2-like [KO:K12758]
117398320  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
117411421  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
117973371  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
117962567  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
117398175  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
117399080  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
117962672  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117398682  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117427798  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
117411374  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117402423  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
117415287  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K06270]
117419536  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
117427585  protein phosphatase 1 regulatory subunit 12B-like isoform X1 [KO:K12329]
117432319  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
117434907  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K17457]
117424756  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
117425952  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
117408899  LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
117426995  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
117964469  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
117430381  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
117394608  probable serine/threonine-protein kinase irlB isoform X1 [KO:K00907] [EC:2.7.11.18]
117433415  mylk5; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
117409283  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
117395222  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
117411706  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
117428893  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117401243  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
117965171  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
117424565  actin, cytoplasmic type 5 [KO:K05692]
117418240  actin, cytoplasmic 2 [KO:K05692]
117431529  actb1; actin, cytoplasmic 1 [KO:K05692]
117423427  actin, cytoplasmic type 5 [KO:K05692]
117429881  ras-specific guanine nucleotide-releasing factor 1-like isoform X1 [KO:K04349]
117427608  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
117411201  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117410845  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117410846  calpain-2 catalytic subunit-like isoform X2 [KO:K03853] [EC:3.4.22.53]
117402852  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117403231  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117403377  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117415500  alpha-actinin-4 [KO:K05699]
117422225  alpha-actinin-1 [KO:K05699]
117419763  alpha-actinin-1 [KO:K05699]
117409328  tln1; talin-1 [KO:K06271]
117429449  talin-2 isoform X1 [KO:K06271]
117428050  talin-2-like isoform X1 [KO:K06271]
117401729  filamin-A-like [KO:K04437]
117404347  LOW QUALITY PROTEIN: filamin-A [KO:K04437]
117963976  filamin-B-like [KO:K27392]
117411756  filamin-B isoform X1 [KO:K27392]
117964055  filamin-B-like [KO:K27392]
117973322  actin cytoskeleton-regulatory complex protein pan-1-like isoform X1 [KO:K05760]
117428133  paxillin-like isoform X1 [KO:K05760]
117405915  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
117407398  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
117425185  zyx; zyxin [KO:K06273]
117397401  vasodilator-stimulated phosphoprotein-like isoform X1 [KO:K06274]
117415448  LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein-like [KO:K06274]
117418596  vinculin isoform X1 [KO:K05700]
117415756  vinculin-like isoform X2 [KO:K05700]
117415861  beta-parvin isoform X1 [KO:K06275]
117419825  parvb; beta-parvin isoform X1 [KO:K06275]
117419826  gamma-parvin-like isoform X1 [KO:K06275]
117414900  gamma-parvin-like [KO:K06275]
117434670  parvaa; parvin, alpha a [KO:K06275]
117418593  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
117431063  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
117416317  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117398601  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117423438  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117415905  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117400209  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117411324  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117403056  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117412568  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117414362  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117422488  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117397139  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117405839  LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
117407370  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117435320  catenin beta-1-like isoform X1 [KO:K02105]
117400133  catenin beta-1 [KO:K02105]
117424636  LOW QUALITY PROTEIN: protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
117423489  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117418057  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
117431125  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117409942  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
117966808  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
117962688  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
117400717  focal adhesion kinase 1-like [KO:K05725] [EC:2.7.10.2]
117972064  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
117435256  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
117417151  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
117425425  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
117432219  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
117417457  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117423098  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
117423331  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117407471  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117417119  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117428991  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117401370  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117403662  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117404001  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
117415600  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117418308  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117417288  guanine nucleotide exchange factor VAV3-like isoform X1 [KO:K05730]
117410605  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
117402063  proto-oncogene vav-like [KO:K05730]
117965657  proto-oncogene vav-like [KO:K05730]
117396942  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
117418183  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117431016  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117432597  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117968020  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
117423588  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
117424197  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
117973040  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
117405978  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
117423416  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
117412197  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
117415503  serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
117394359  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
117411121  serine/threonine-protein kinase PAK 5-like isoform X1 [KO:K05736] [EC:2.7.11.1]
117403291  serine/threonine-protein kinase PAK 5-like isoform X1 [KO:K05736] [EC:2.7.11.1]
117400535  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
117973986  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
117421884  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
117424587  cell division control protein 42 homolog [KO:K04393]
117425264  cell division control protein 42 homolog [KO:K04393]
117432225  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117425067  breast cancer anti-estrogen resistance protein 1-like isoform X1 [KO:K05726]
117424712  breast cancer anti-estrogen resistance protein 1-like isoform X1 [KO:K05726]
117427125  crk-like protein [KO:K04438]
117964278  adapter molecule crk-like isoform X1 [KO:K04438]
117428561  crk-like protein [KO:K04438]
117430672  adapter molecule crk-like isoform X1 [KO:K04438]
117418396  LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1-like [KO:K13708]
117415126  LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1 [KO:K13708]
117422459  rap guanine nucleotide exchange factor 1-like isoform X1 [KO:K06277]
117396940  rap guanine nucleotide exchange factor 1-like [KO:K06277]
117417594  ras-related protein Rap-1A [KO:K04353]
117431526  ras-related protein Rap-1A [KO:K04353]
117415871  ras-related protein Rap-1b [KO:K07836]
117419830  ras-related protein Rap-1b [KO:K07836]
117409061  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117415548  LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117962527  mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
117418084  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117431535  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
117413208  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117963780  transcription factor AP-1-like [KO:K04448]
117421449  transcription factor AP-1-like [KO:K04448]
117416589  transcription factor AP-1-like [KO:K04448]
117401403  transcription factor AP-1 [KO:K04448]
117419793  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
117415020  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
117419577  cav1; caveolin-1 isoform X1 [KO:K06278]
117414902  caveolin-1-like isoform X1 [KO:K06278]
117964005  caveolin-1-like [KO:K12958]
117964069  caveolin-2-like [KO:K12958]
117419739  caveolin-2-like [KO:K12958]
117411840  caveolin-2-like [KO:K12958]
117413724  caveolin-2-like [KO:K12958]
117415282  caveolin-2-like [KO:K12958]
117964070  caveolin-3-like [KO:K12959]
117411971  caveolin-3-like [KO:K12959]
117413778  caveolin-3-like [KO:K12959]
117963458  caveolin-3-like [KO:K12959]
117410990  tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
117403304  tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
117395410  shc1; SHC-transforming protein 1 isoform X3 [KO:K06279]
117401420  SHC-transforming protein 2 isoform X1 [KO:K17447]
117962910  SHC-transforming protein 2-like [KO:K17447]
117962916  SHC-transforming protein 3-like [KO:K17448]
117409208  SHC-transforming protein 3 [KO:K17448]
117429071  LOW QUALITY PROTEIN: SHC-transforming protein 4-like [KO:K17449]
117428494  LOW QUALITY PROTEIN: SHC-transforming protein 4-like [KO:K17449]
117422907  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
117424057  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
117973927  son of sevenless homolog 2-like [KO:K03099]
117421958  son of sevenless homolog 2-like [KO:K03099]
117410672  son of sevenless homolog 1-like [KO:K03099]
117402902  son of sevenless homolog 1 isoform X1 [KO:K03099]
117431924  GTPase HRas [KO:K02833]
117434435  GTPase HRas [KO:K02833]
117414023  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
117412241  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
117428255  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117964269  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117973328  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117398123  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117426782  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117401627  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
117404275  ETS domain-containing protein Elk-1-like [KO:K04375]
117435119  G1/S-specific cyclin-D1-like [KO:K04503]
117432035  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117398003  G1/S-specific cyclin-D2-like [KO:K10151]
117419684  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
117433893  G1/S-specific cyclin-D2-like [KO:K10151]
117415323  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
117972988  inhibitor of apoptosis protein-like [KO:K16060]
117405623  inhibitor of apoptosis protein isoform X1 [KO:K16060]
117430831  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
117398525  bcl2-associated agonist of cell death-like [KO:K02158]
117967845  bcl2-associated agonist of cell death-like [KO:K02158]
117399761  apoptosis regulator Bcl-2-like [KO:K02161]
117394930  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
arut04010  MAPK signaling pathway
arut04060  Cytokine-cytokine receptor interaction
arut04070  Phosphatidylinositol signaling system
arut04110  Cell cycle
arut04310  Wnt signaling pathway
arut04512  ECM-receptor interaction
arut04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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