KEGG   PATHWAY: arut04115
Entry
arut04115                   Pathway                                
Name
p53 signaling pathway - Acipenser ruthenus (sterlet)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
arut04115  p53 signaling pathway
arut04115

Organism
Acipenser ruthenus (sterlet) [GN:arut]
Gene
117405719  serine-protein kinase ATM-like isoform X1 [KO:K04728] [EC:2.7.11.1]
117407051  serine-protein kinase ATM-like isoform X1 [KO:K04728] [EC:2.7.11.1]
117427120  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
117428486  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
117417029  serine/threonine-protein kinase ATR-like [KO:K06640] [EC:2.7.11.1]
117423407  serine/threonine-protein kinase ATR-like isoform X1 [KO:K06640] [EC:2.7.11.1]
117397432  serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
117966660  serine/threonine-protein kinase Chk1-like isoform X1 [KO:K02216] [EC:2.7.11.1]
117416902  RAB6-interacting golgin-like [KO:K19748]
117403815  gorab; RAB6-interacting golgin [KO:K19748]
117415877  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
117419350  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
117416320  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
117426487  protein Mdm4-like [KO:K10127]
117397003  protein Mdm4-like [KO:K10127]
117970978  cellular tumor antigen p53-like isoform X1 [KO:K04451]
117404615  cellular tumor antigen p53 [KO:K04451]
117397833  relA-associated inhibitor-like isoform X1 [KO:K27356]
117415839  relA-associated inhibitor-like isoform X1 [KO:K27356]
117964374  cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
117419487  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
117435119  G1/S-specific cyclin-D1-like [KO:K04503]
117432035  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117398003  G1/S-specific cyclin-D2-like [KO:K10151]
117419684  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
117433893  G1/S-specific cyclin-D2-like [KO:K10151]
117415323  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
117962597  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
117401103  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
117394697  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
117400643  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
117412504  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
117425694  G1/S-specific cyclin-E1-like [KO:K06626]
117400604  G1/S-specific cyclin-E2-like [KO:K06626]
117394712  G1/S-specific cyclin-E2-like [KO:K06626]
117424350  G1/S-specific cyclin-E1-like [KO:K06626]
117400952  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
117966925  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
117967011  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
117967038  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
117971061  protein reprimo A-like [KO:K10128]
117427205  protein reprimo A-like [KO:K10128]
117401159  protein reprimo A-like [KO:K10128]
117414296  protein reprimo A-like [KO:K10128]
117963921  G2/mitotic-specific cyclin-B1-like [KO:K05868]
117963946  G2/mitotic-specific cyclin-B1-like [KO:K05868]
117966120  G2/mitotic-specific cyclin-B1-like [KO:K05868]
117404009  G2/mitotic-specific cyclin-B1-like [KO:K05868]
117404010  G2/mitotic-specific cyclin-B1-like [KO:K05868]
117404013  G2/mitotic-specific cyclin-B1-like [KO:K05868]
117435703  cyclin N-terminal domain-containing protein 2-like [KO:K21770]
117428092  G2/mitotic-specific cyclin-B2 [KO:K21770]
117429551  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
117414910  cyclin N-terminal domain-containing protein 2-like [KO:K21770]
117418033  cyclin-dependent kinase 1-B-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
117415121  cyclin-dependent kinase 1-B [KO:K02087] [EC:2.7.11.22 2.7.11.23]
117400851  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117971933  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117971936  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117971940  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117416935  LOW QUALITY PROTEIN: growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
117408484  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117400855  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117400856  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117409183  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117409625  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117409629  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117428915  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117401312  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117404259  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
117419434  LOW QUALITY PROTEIN: G2 and S phase-expressed protein 1-like [KO:K10129]
117433967  proline/serine-rich coiled-coil protein 1-like isoform X1 [KO:K10129]
117415291  G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
117962657  zinc finger protein 385A-like [KO:K26543]
117417998  fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
117415262  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
117434910  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
117966494  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
117426878  LOW QUALITY PROTEIN: caspase-8-like [KO:K04398] [EC:3.4.22.61]
117426351  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117408587  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117426603  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117414260  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117419929  BH3-interacting domain death agonist-like [KO:K04726]
117415131  BH3-interacting domain death agonist-like [KO:K04726]
117432031  zgc:153993; apoptosis regulator BAX [KO:K02159]
117434851  apoptosis regulator BAX-like [KO:K02159]
117403657  pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
117969808  apoptosis regulatory protein Siva-like isoform X1 [KO:K22744]
117969838  apoptosis regulatory protein Siva-like isoform X1 [KO:K22744]
117421878  LOW QUALITY PROTEIN: apoptosis regulatory protein Siva-like [KO:K22744]
117394751  LOW QUALITY PROTEIN: apoptosis regulatory protein Siva-like [KO:K22744]
117420711  bcl-2-like protein 1 [KO:K04570]
117434069  bcl-2-like protein 1 [KO:K04570]
117399761  apoptosis regulator Bcl-2-like [KO:K02161]
117394930  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
117402535  quinone oxidoreductase PIG3-like isoform X1 [KO:K10133] [EC:1.-.-.-]
117402536  quinone oxidoreductase PIG3-like [KO:K10133] [EC:1.-.-.-]
117397374  etoposide-induced protein 2.4 homolog [KO:K10134]
117397137  etoposide-induced protein 2.4 homolog [KO:K10134]
117411452  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
117402779  p53 apoptosis effector related to PMP-22-like [KO:K10136]
117416710  zinc finger matrin-type protein 3-like isoform X1 [KO:K10137]
117423765  zinc finger matrin-type protein 3-like [KO:K10137]
117424847  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
117425774  E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
117400603  cytochrome c [KO:K08738]
117426640  cytochrome c-like [KO:K08738]
117412329  cytochrome c [KO:K08738]
117416074  apoptotic protease-activating factor 1-like isoform X1 [KO:K02084]
117419459  apoptotic protease-activating factor 1-like isoform X1 [KO:K02084]
117968643  caspase-9-like isoform X1 [KO:K04399] [EC:3.4.22.62]
117972138  caspase-9-like [KO:K04399] [EC:3.4.22.62]
117425431  caspase-9-like isoform X2 [KO:K04399] [EC:3.4.22.62]
117426078  caspase-9-like isoform X1 [KO:K04399] [EC:3.4.22.62]
117409020  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
117420645  caspase-3-like [KO:K02187] [EC:3.4.22.56]
117420663  caspase-3-like [KO:K02187] [EC:3.4.22.56]
117417733  aifm2; LOW QUALITY PROTEIN: apoptosis-inducing factor 2 [KO:K22745]
117399925  insulin-like growth factor-binding protein 3 [KO:K10138]
117394456  insulin-like growth factor-binding protein 3 [KO:K10138]
117419510  insulin-like growth factor I isoform X1 [KO:K05459]
117414927  insulin-like growth factor I isoform X1 [KO:K05459]
117404447  plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
117962359  plasminogen activator inhibitor 1-like isoform X2 [KO:K03982]
117400494  adgrb1a; adhesion G protein-coupled receptor B1 [KO:K04596]
117394686  adhesion G protein-coupled receptor B1-like isoform X1 [KO:K04596]
117434578  CD82 antigen-like [KO:K06509]
117431922  CD82 antigen-like isoform X2 [KO:K06509]
117421302  thbs1b; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
117432036  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
117972104  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
117964127  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
117410626  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
117403249  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
117394745  ribonucleoside-diphosphate reductase subunit M2 B-like isoform X1 [KO:K10808] [EC:1.17.4.1]
117414183  ribonucleoside-diphosphate reductase subunit M2-like isoform X2 [KO:K10808] [EC:1.17.4.1]
117972757  sestrin-3-like isoform X1 [KO:K10141]
117411304  sestrin-1-like isoform X1 [KO:K10141]
117430347  sestrin-3-like [KO:K10141]
117411942  sestrin-3-like [KO:K10141]
117402954  sestrin-1-like isoform X1 [KO:K10141]
117405779  sestrin-3-like isoform X1 [KO:K10141]
117964108  sestrin-2-like isoform X1 [KO:K20394]
117414093  sestrin-2 isoform X1 [KO:K20394]
117415600  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117418308  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117418002  tuberin-like isoform X1 [KO:K07207]
117431069  LOW QUALITY PROTEIN: tuberin [KO:K07207]
117426674  metalloreductase STEAP3-like isoform X1 [KO:K10142] [EC:1.16.1.-]
117402123  metalloreductase STEAP3-like [KO:K10142] [EC:1.16.1.-]
117416458  E3 ubiquitin-protein ligase COP1-like isoform X1 [KO:K10143] [EC:2.3.2.27]
117412397  E3 ubiquitin-protein ligase COP1-like isoform X1 [KO:K10143] [EC:2.3.2.27]
117408376  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
117421426  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
117964618  cyclin-G1-like [KO:K10145]
117413443  cyclin-G1-like [KO:K10145]
117973133  cyclin-G2-like [KO:K10146]
117408489  cyclin-G2 [KO:K10146]
117429091  protein phosphatase 1D-like [KO:K10147] [EC:3.1.3.16]
117963268  protein phosphatase 1D-like [KO:K10147] [EC:3.1.3.16]
117962438  tumor protein p73-like isoform X1 [KO:K10148]
117425905  tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
arut04110  Cell cycle
arut04210  Apoptosis
arut04218  Cellular senescence
KO pathway
ko04115   
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