KEGG   PATHWAY: ccae04115
Entry
ccae04115                   Pathway                                
Name
p53 signaling pathway - Cyanistes caeruleus (blue tit)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
ccae04115  p53 signaling pathway
ccae04115

Organism
Cyanistes caeruleus (blue tit) [GN:ccae]
Gene
111922126  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
111923021  GTSE1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
111923695  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
111923855  SERPINB5; serpin B5 [KO:K10139]
111923860  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
111924074  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
111924218  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
111924323  [KO:K08738]
111924489  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
111924512  SESN3; sestrin-3 isoform X1 [KO:K10141]
111924530  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
111926052  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
111926792  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
111926793  [KO:K10136]
111927137  SESN1; sestrin-1 isoform X1 [KO:K10141]
111927439  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
111928077  BID; BH3-interacting domain death agonist [KO:K04726]
111928985  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
111929370  [KO:K10141]
111929449  CCNG2; cyclin-G2 [KO:K10146]
111930045  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
111930145  CD82; CD82 antigen [KO:K06509]
111930172  DDB2; LOW QUALITY PROTEIN: DNA damage-binding protein 2 [KO:K10140]
111930312  THBS1; thrombospondin-1 [KO:K16857]
111930656  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111930732  PIDD1; p53-induced death domain-containing protein 1 [KO:K10130]
111930789  [KO:K04722]
111930915  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111931484  AIFM2; apoptosis-inducing factor 2 isoform X1 [KO:K22745]
111931551  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
111931632  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111931990  [KO:K04398] [EC:3.4.22.61]
111932284  STEAP3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
111932581  COP1; E3 ubiquitin-protein ligase RFWD2 isoform X1 [KO:K10143] [EC:2.3.2.27]
111932718  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
111933350  ZMAT3; zinc finger matrin-type protein 3 [KO:K10137]
111933508  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
111933973  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
111934176  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
111934633  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
111934658  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
111935332  SHISA5; protein shisa-5 [KO:K10135]
111935751  CCNG1; cyclin-G1 [KO:K10145]
111936136  IGF1; insulin-like growth factor I [KO:K05459]
111936184  TSC2; tuberin isoform X1 [KO:K07207]
111936476  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
111938137  BCL2L1; bcl-2-like protein 1 [KO:K04570]
111938513  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
111938600  TP73; tumor protein p73 [KO:K10148]
111938818  [KO:K04722]
111939082  SFN; 14-3-3 protein sigma [KO:K06644]
111939252  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
111939368  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
111939687  MDM4; protein Mdm4 [KO:K10127]
111939904  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
111941727  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
111942919  SESN2; sestrin-2 isoform X1 [KO:K20394]
111943854  BAX; apoptosis regulator BAX [KO:K02159]
111944570  [KO:K19748]
111944648  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
111945572  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
ccae04110  Cell cycle
ccae04210  Apoptosis
ccae04218  Cellular senescence
KO pathway
ko04115   

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