Entry Name Wnt signaling pathway - Cavia porcellus (domestic guinea pig)
Description Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Cavia porcellus (domestic guinea pig) [GN:
cpoc ]
Gene 100723986 Dkk4; LOW QUALITY PROTEIN: dickkopf-related protein 4 [KO:K02165 ]
100216362 Serpinf1; pigment epithelium-derived factor precursor [KO:K19614 ]
100716325 Sfrp5; LOW QUALITY PROTEIN: secreted frizzled-related protein 5 [KO:K02222 ]
100724174 Lgr4; LOW QUALITY PROTEIN: leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309 ]
100719443 Lgr5; leucine-rich repeat-containing G-protein coupled receptor 5 [KO:K04308 ]
100731039 Lgr6; leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399 ]
100714196 Lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068 ]
100735282 Lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068 ]
100730544 Bambi; BMP and activin membrane-bound inhibitor homolog [KO:K10162 ]
100728748 Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
100717450 Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353 ]
100723761 Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353 ]
101789016 Frat2; LOW QUALITY PROTEIN: GSK-3-binding protein FRAT2 [KO:K03096 ]
100735498 Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085 ]
100720351 Ctnnbip1; beta-catenin-interacting protein 1 isoform X2 [KO:K04493 ]
100713580 Chd8; LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 8 [KO:K04494 ] [EC:5.6.2.-]
100730691 Ccar2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816 ]
100719584 Sox17; LOW QUALITY PROTEIN: transcription factor SOX-17 [KO:K04495 ]
100717853 Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501 ]
100731807 Smad3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605 ]
100729064 Wisp1; WNT1-inducible-signaling pathway protein 1 isoform X1 [KO:K22471 ]
100725136 Ppard; peroxisome proliferator-activated receptor delta [KO:K04504 ]
100734681 Tbl1x; F-box-like/WD repeat-containing protein TBL1X isoform X3 [KO:K04508 ]
100733958 Tbl1xr1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508 ]
100730107 Btrc; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 1A [KO:K03362 ]
100719981 Daam1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512 ]
100719618 Daam2; disheveled-associated activator of morphogenesis 2 isoform X2 [KO:K04512 ]
100727219 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392 ]
100731468 Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
100736181 Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
100729394 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
100714143 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858 ] [EC:3.1.4.11 ]
100727662 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
100730572 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
100727059 Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2 [KO:K04515 ] [EC:2.7.11.17 ]
100719406 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X12 [KO:K04515 ] [EC:2.7.11.17 ]
100727741 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
100725315 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
100728974 Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
100730044 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X4 [KO:K04446 ]
100722868 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
100728433 Nfatc3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
100734178 Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334 ]
Compound Reference Authors Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title Beta-catenin and Tcfs in mammary development and cancer.
Journal Reference Authors Yang Y.
Title Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal Reference Authors Kalderon D.
Title Similarities between the Hedgehog and Wnt signaling pathways.
Journal Reference Authors Nusse R.
Title Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal Reference Authors Jope RS, Johnson GV.
Title The glamour and gloom of glycogen synthase kinase-3.
Journal Reference Authors Veeman MT, Axelrod JD, Moon RT.
Title A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal Reference Authors Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal Reference Authors Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title The way Wnt works: Components and mechanism.
Journal Reference Authors Carethers JM
Title Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal Reference Authors Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal Reference Authors Niehrs C
Title The complex world of WNT receptor signalling.
Journal Reference Authors Abou Ziki MD, Mani A
Title Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal Reference Authors He Y, Ki H, Kim H, Kim K
Title delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal Reference Authors Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal Reference Authors Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal Related KO pathway LinkDB All DBs
