KEGG   PATHWAY: cpoc04510
Entry
cpoc04510                   Pathway                                
Name
Focal adhesion - Cavia porcellus (domestic guinea pig)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
cpoc04510  Focal adhesion
cpoc04510

Other DBs
GO: 0005925
Organism
Cavia porcellus (domestic guinea pig) [GN:cpoc]
Gene
100733209  Col1a1; collagen alpha-1(I) chain [KO:K06236]
100719158  Col1a2; collagen alpha-2(I) chain isoform X2 [KO:K06236]
100733907  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
100718624  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
100718202  Col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100732595  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
100730120  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
100717641  Col4a5; collagen alpha-5(IV) chain [KO:K06237]
100732315  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
100732068  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100716662  Col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
100717588  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
100717027  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
100732346  Col6a1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
100734770  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
100725525  Col9a2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
100723407  Col9a1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100716721  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
100714826  Lama1; laminin subunit alpha-1 [KO:K05637]
100719656  Lama5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
100717292  Lama3; laminin subunit alpha-3 [KO:K06240]
100716529  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100721521  Lamb1; laminin subunit beta-1 [KO:K05636]
100732418  Lamb2; laminin subunit beta-2 [KO:K06243]
100735299  Lamb3; laminin subunit beta-3 [KO:K06244]
101787649  LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
100734278  Lamc1; laminin subunit gamma-1 [KO:K05635]
100733999  Lamc2; laminin subunit gamma-2 [KO:K06246]
100729645  Lamc3; laminin subunit gamma-3 [KO:K06247]
100731923  Chad; chondroadherin [KO:K06248]
100723362  Reln; reelin [KO:K06249] [EC:3.4.21.-]
100727882  Thbs1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
100720036  Thbs4; thrombospondin-4 [KO:K04659]
100720040  Comp; LOW QUALITY PROTEIN: cartilage oligomeric matrix protein [KO:K04659]
100735538  Thbs2; thrombospondin-2 [KO:K04659]
100714970  Thbs3; thrombospondin-3 isoform X1 [KO:K04659]
100732865  Fn1; fibronectin isoform X1 [KO:K05717]
100715233  Spp1; LOW QUALITY PROTEIN: osteopontin [KO:K06250]
100727771  Vtn; vitronectin [KO:K06251]
100727512  Tnxb; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
100729387  Tnn; tenascin-N isoform X2 [KO:K06252]
100713399  Tnr; tenascin-R isoform X1 [KO:K06252]
100725345  Tnc; tenascin isoform X1 [KO:K06252]
100732530  Vwf; von Willebrand factor precursor [KO:K03900]
100730180  Ibsp; bone sialoprotein 2 [KO:K06253]
100729544  Itga1; integrin alpha-1 [KO:K06480]
100729266  Itga2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
100727374  Itga2b; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
100734983  Itga3; integrin alpha-3 isoform X2 [KO:K06482]
100718628  Itga4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
100725679  Itga5; integrin alpha-5 [KO:K06484]
100731242  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
100716758  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
100721946  Itga8; integrin alpha-8 [KO:K06584]
100716659  Itga9; integrin alpha-9 [KO:K06585]
100719833  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
100730700  Itga11; integrin alpha-11 isoform X1 [KO:K06587]
100728575  Itgav; integrin alpha-V [KO:K06487]
100719502  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
100731365  Itgb3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
100718717  Itgb4; integrin beta-4 isoform X2 [KO:K06525]
100713066  Itgb5; integrin beta-5 [KO:K06588]
100718631  Itgb6; integrin beta-6 isoform X2 [KO:K06589]
100727605  Itgb7; integrin beta-7 [KO:K06590]
100727946  Itgb8; integrin beta-8 [KO:K06591]
100727813  Emp2; epithelial membrane protein 2 [KO:K26256]
100731469  Pdgfb; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
100722571  Pdgfc; platelet-derived growth factor C [KO:K05450]
100713757  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
100714471  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
100135551  Igf1; insulin-like growth factor I precursor [KO:K05459]
100713483  Vegfa; vascular endothelial growth factor A isoform X2 [KO:K05448]
100724743  Vegfb; vascular endothelial growth factor B isoform X2 [KO:K16858]
100734450  Pgf; placenta growth factor isoform X3 [KO:K16859]
100724469  Vegfc; vascular endothelial growth factor C [KO:K05449]
100733371  Vegfd; LOW QUALITY PROTEIN: vascular endothelial growth factor D [KO:K05449]
100730730  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
100726209  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100726506  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100734840  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100726761  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100725363  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100732326  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100715831  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100718790  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100727657  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100731563  Emp1; epithelial membrane protein 1 isoform X1 [KO:K26255]
100728509  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100718086  Arhgap35; LOW QUALITY PROTEIN: rho GTPase-activating protein 35 [KO:K05732]
100715491  Arhgap5; rho GTPase-activating protein 5 [KO:K13709]
100733542  Rhoa; transforming protein RhoA [KO:K04513]
100724692  Diaph1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
100718968  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100713798  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100719658  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100725728  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
100731839  Myl10; myosin regulatory light chain 10 [KO:K12756]
100720941  myosin regulatory light chain 12B [KO:K12757]
100721213  myosin regulatory light chain 12B-like isoform X2 [KO:K12757]
100728751  Mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100728198  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100730372  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100721697  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100727982  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100729743  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X3 [KO:K12329]
100714649  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
100728232  Mylk3; myosin light chain kinase 3 isoform X3 [KO:K00907] [EC:2.7.11.18]
100724875  Mylk2; LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100721558  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
100715277  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2 [KO:K00889] [EC:2.7.1.68]
100728992  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
100717867  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
100731713  Actg1; actin, cytoplasmic 2 [KO:K05692]
100135470  Actb; actin, cytoplasmic 1 [KO:K05692]
100731687  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
100725761  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100721342  Actn1; alpha-actinin-1 isoform X2 [KO:K05699]
100733111  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
100730922  Tln1; talin-1 isoform X4 [KO:K06271]
100716884  Tln2; talin-2 isoform X1 [KO:K06271]
100725162  Flna; filamin-A isoform X2 [KO:K04437]
100722132  Flnb; filamin-B isoform X1 [KO:K27392]
100732427  Pxn; paxillin isoform X1 [KO:K05760]
100135559  Ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
100727523  Zyx; zyxin [KO:K06273]
100722137  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100722183  Vcl; vinculin isoform X4 [KO:K05700]
100727221  Parvg; gamma-parvin [KO:K06275]
100723823  Parvb; beta-parvin [KO:K06275]
100729337  Parva; alpha-parvin [KO:K06275]
100735138  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100719925  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100714724  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100724315  Akt3; LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100714392  Gsk3b; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100732604  Ctnnb1; catenin beta-1 [KO:K02105]
100713627  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100717697  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100733947  Prkcg; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100720622  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100727986  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100735084  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100734206  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100730242  Pik3r1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100734044  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100723659  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100713221  Vav1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
100714719  Vav3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
100728155  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100727219  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100731468  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
100736181  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100714662  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100713135  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100721049  Pak3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
100736193  Pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100731594  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100713585  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
100717195  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
100713475  Bcar1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
100718486  Crk; adapter molecule crk [KO:K04438]
100723968  Crkl; crk-like protein [KO:K04438]
100734315  Dock1; dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
100727953  Rapgef1; rap guanine nucleotide exchange factor 1 isoform X2 [KO:K06277]
100713608  Rap1a; ras-related protein Rap-1A [KO:K04353]
100713271  ras-related protein Rap-1b-like [KO:K07836]
100734094  Rap1b; ras-related protein Rap-1b [KO:K07836]
100722333  Mapk8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
100718766  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100714249  Mapk9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100728775  Jun; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
100717765  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
100718512  Cav1; caveolin-1 isoform X1 [KO:K06278]
106028787  Cav2; caveolin-2 [KO:K12958]
100721682  Cav3; caveolin-3 [KO:K12959]
100728124  Fyn; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
100734561  Shc1; SHC-transforming protein 1 isoform X2 [KO:K06279]
100723025  SHC-transforming protein 2 [KO:K17447]
100732336  Shc3; SHC-transforming protein 3 [KO:K17448]
100717842  Shc4; SHC-transforming protein 4 [KO:K17449]
100715453  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
100721165  Sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
100726398  Sos2; son of sevenless homolog 2 [KO:K03099]
100735038  Hras; GTPase HRas isoform X1 [KO:K02833]
100720110  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100712888  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100715180  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100725692  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100727907  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
100729808  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
100730596  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
100718785  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100713574  Birc3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
100715527  Birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
100715778  Xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100734151  Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100733337  Bcl2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
cpoc04010  MAPK signaling pathway
cpoc04060  Cytokine-cytokine receptor interaction
cpoc04070  Phosphatidylinositol signaling system
cpoc04110  Cell cycle
cpoc04151  PI3K-Akt signaling pathway
cpoc04310  Wnt signaling pathway
cpoc04512  ECM-receptor interaction
cpoc04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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