KEGG   PATHWAY: cpoo00230
Entry
cpoo00230                   Pathway                                
Name
Purine metabolism - Crocodylus porosus (Australian saltwater crocodile)
Class
Metabolism; Nucleotide metabolism
Pathway map
cpoo00230  Purine metabolism
cpoo00230

Module
cpoo_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:cpoo00230]
cpoo_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:cpoo00230]
cpoo_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:cpoo00230]
cpoo_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:cpoo00230]
cpoo_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:cpoo00230]
cpoo_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:cpoo00230]
Other DBs
GO: 0006163 0042278
Organism
Crocodylus porosus (Australian saltwater crocodile) [GN:cpoo]
Gene
109305518  [KO:K12319] [EC:4.6.1.2]
109305539  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
109305783  [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
109305785  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
109305851  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
109306067  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
109306170  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
109306485  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
109306845  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
109306869  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
109306984  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
109307106  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
109307134  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
109307346  [KO:K00365] [EC:1.7.3.3]
109307555  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
109307564  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
109307567  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
109307782  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1 [KO:K01518] [EC:3.6.1.17]
109307939  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
109308007  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
109308061  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
109308263  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
109308520  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
109308628  [KO:K12319] [EC:4.6.1.2]
109309070  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
109309349  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
109309404  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
109309490  DCK; deoxycytidine kinase isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
109309696  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
109309697  GUCY1B3; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
109310146  [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
109310329  [KO:K03783] [EC:2.4.2.1]
109310374  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
109310532  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
109310610  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
109310923  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
109310997  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
109311086  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
109311123  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
109311212  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
109311382  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
109311479  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
109311539  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
109311653  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
109311675  ALLC; probable allantoicase isoform X1 [KO:K01477] [EC:3.5.3.4]
109311988  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
109312020  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
109312021  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
109312082  [KO:K01081] [EC:3.1.3.5]
109312126  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
109312140  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
109312247  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
109312359  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
109312530  [KO:K13811] [EC:2.7.7.4 2.7.1.25]
109313281  [KO:K03783] [EC:2.4.2.1]
109313305  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
109313383  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
109313426  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
109313447  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
109313774  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
109313792  [KO:K01510] [EC:3.6.1.5]
109313796  [KO:K01510] [EC:3.6.1.5]
109313797  [KO:K01510] [EC:3.6.1.5]
109313882  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
109313968  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
109314286  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
109314675  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
109314889  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
109314917  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
109315013  [KO:K00940] [EC:2.7.4.6]
109315014  [KO:K00940] [EC:2.7.4.6]
109315055  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
109315364  [KO:K01466] [EC:3.5.2.5]
109315745  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
109315806  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
109315915  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
109316454  CECR1; adenosine deaminase CECR1 isoform X1 [KO:K19572] [EC:3.5.4.4]
109316709  ADSL; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
109316821  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
109316840  GUCY2C; heat-stable enterotoxin receptor isoform X1 [KO:K12320] [EC:4.6.1.2]
109317543  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
109317687  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
109317795  [KO:K11265] [EC:4.6.1.1]
109318335  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
109318356  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
109319147  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
109319344  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
109319446  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
109319793  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109319928  ADSS; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
109319982  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
109320051  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
109320202  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
109320501  PNP; purine nucleoside phosphorylase isoform X1 [KO:K03783] [EC:2.4.2.1]
109320880  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
109321086  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
109321111  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
109321207  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
109321511  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
109321534  [KO:K01081] [EC:3.1.3.5]
109321734  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
109322018  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
109322048  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
109322080  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
109322125  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
109322645  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
109322953  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
109322965  ATIC; bifunctional purine biosynthesis protein PURH isoform X1 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
109323086  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
109323282  [KO:K12324] [EC:4.6.1.2]
109323540  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
109323674  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
109323736  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
109323909  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
109323972  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
109324349  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
109324447  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
109324483  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
109324563  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
109324727  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
109324819  PRUNE1; protein prune homolog isoform X1 [KO:K01514] [EC:3.6.1.11]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
cpoo00030  Pentose phosphate pathway
cpoo00220  Arginine biosynthesis
cpoo00250  Alanine, aspartate and glutamate metabolism
cpoo00260  Glycine, serine and threonine metabolism
cpoo00340  Histidine metabolism
cpoo00630  Glyoxylate and dicarboxylate metabolism
cpoo00730  Thiamine metabolism
cpoo00740  Riboflavin metabolism
cpoo00790  Folate biosynthesis
KO pathway
ko00230   

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