KEGG   PATHWAY: cuca00230
Entry
cuca00230                   Pathway                                
Name
Purine metabolism - Cuculus canorus (common cuckoo)
Class
Metabolism; Nucleotide metabolism
Pathway map
cuca00230  Purine metabolism
cuca00230

Module
cuca_M00005  PRPP biosynthesis, ribose-5P => PRPP [PATH:cuca00230]
cuca_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:cuca00230]
cuca_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:cuca00230]
cuca_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:cuca00230]
cuca_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:cuca00230]
cuca_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:cuca00230]
Other DBs
GO: 0006163 0042278
Organism
Cuculus canorus (common cuckoo) [GN:cuca]
Gene
104054596  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4 [KO:K13755] [EC:3.1.4.17]
104054643  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X2 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
104054890  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
104055011  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
104055208  [KO:K00365] [EC:1.7.3.3]
104055362  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
104055472  GUCY2C; guanylyl cyclase C isoform X1 [KO:K12320] [EC:4.6.1.2]
104055509  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
104055712  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
104055839  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
104055898  ADA2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
104055945  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
104056046  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
104056233  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X2 [KO:K18436] [EC:3.1.4.53]
104056390  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
104056403  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
104056469  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
104056511  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
104056542  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
104056593  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
104056717  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
104056854  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
104056954  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
104056969  NT5C1B; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
104057106  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
104057532  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
104057641  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
104057797  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
104057809  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
104057895  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
104057924  [KO:K01081] [EC:3.1.3.5]
104058067  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
104058111  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3 [KO:K13293] [EC:3.1.4.53]
104058175  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
104058201  ADSS2; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
104058254  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
104058362  ITPA; inosine triphosphate pyrophosphatase isoform X2 [KO:K01519] [EC:3.6.1.66]
104058511  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
104058740  AK6; LOW QUALITY PROTEIN: adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
104058797  [KO:K12319] [EC:4.6.1.2]
104059094  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
104059103  [KO:K01510] [EC:3.6.1.5]
104059134  [KO:K01510] [EC:3.6.1.5]
104059135  [KO:K01510] [EC:3.6.1.5]
104059238  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
104059341  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
104059435  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
104059448  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
104059653  [KO:K12324] [EC:4.6.1.2]
104059770  NT5C2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
104059872  [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
104060047  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
104060075  NT5C1A; cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
104060082  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
104060364  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
104060684  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
104060697  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
104060995  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
104061222  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
104061299  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
104061659  ENTPD5; nucleoside diphosphate phosphatase ENTPD5 isoform X1 [KO:K01511] [EC:3.6.1.6]
104061819  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
104061926  [KO:K00940] [EC:2.7.4.6]
104061927  [KO:K00940] [EC:2.7.4.6]
104062044  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
104062123  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
104062306  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
104062531  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
104062588  ENPP3; LOW QUALITY PROTEIN: ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
104062590  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
104062615  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
104062688  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
104062758  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
104062866  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
104062899  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
104063151  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
104063520  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
104063653  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
104063886  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
104064132  GUCY2F; retinal guanylyl cyclase 2 isoform X1 [KO:K12322] [EC:4.6.1.2]
104064270  PGM2; phosphopentomutase [KO:K15779] [EC:5.4.2.2 5.4.2.7]
104064410  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
104064755  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
104064788  [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
104065131  ADA; adenosine deaminase isoform X2 [KO:K01488] [EC:3.5.4.4]
104065481  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
104065616  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1 [KO:K19021] [EC:3.1.4.17]
104065732  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
104065950  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
104065956  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
104066029  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
104066098  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
104066285  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
104066557  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
104066565  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
104066588  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
104066778  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
104066928  AK8; adenylate kinase 8 isoform X2 [KO:K00939] [EC:2.7.4.3]
104067044  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
104067071  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
104067147  [KO:K13293] [EC:3.1.4.53]
104067155  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
104067229  [KO:K00760] [EC:2.4.2.8]
104067400  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
104067554  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
104067688  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
104067863  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
104067928  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
104068051  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X3 [KO:K18436] [EC:3.1.4.53]
104068131  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
104068138  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
104068195  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
104068382  [KO:K03783] [EC:2.4.2.1]
104068389  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
104068536  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
104068650  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
104068814  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
104068865  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
104068908  [KO:K01081] [EC:3.1.3.5]
104068951  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X2 [KO:K13296] [EC:3.1.4.17]
104069023  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
128850109  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
cuca00030  Pentose phosphate pathway
cuca00220  Arginine biosynthesis
cuca00250  Alanine, aspartate and glutamate metabolism
cuca00260  Glycine, serine and threonine metabolism
cuca00340  Histidine metabolism
cuca00630  Glyoxylate and dicarboxylate metabolism
cuca00730  Thiamine metabolism
cuca00740  Riboflavin metabolism
cuca00790  Folate biosynthesis
KO pathway
ko00230   

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