KEGG   PATHWAY: dnm04151
Entry
dnm04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Dasypus novemcinctus (nine-banded armadillo)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
dnm04151  PI3K-Akt signaling pathway
dnm04151

Other DBs
GO: 0043491
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
100913180  VWF; von Willebrand factor precursor [KO:K03900]
101410636  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101410694  [KO:K03456]
101410814  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
101410879  [KO:K04374]
101410923  IFNB1; interferon beta [KO:K05415]
101410933  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101411009  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101411174  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
101411204  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101411312  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
101411471  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
101411552  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101411655  EREG; proepiregulin [KO:K09784]
101411737  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
101411769  YWHAH; 14-3-3 protein eta [KO:K16198]
101411890  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101411907  RXRA; retinoic acid receptor RXR-alpha isoform X2 [KO:K08524]
101412042  NTF3; LOW QUALITY PROTEIN: neurotrophin-3 [KO:K04356]
101412233  KRAS; GTPase KRas isoform X4 [KO:K07827]
101412269  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101412781  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101413067  KITLG; kit ligand isoform X1 [KO:K05461]
101413194  [KO:K04539]
101413281  TSC2; tuberin [KO:K07207]
101413297  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101413382  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101413678  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
101413723  SPP1; osteopontin [KO:K06250]
101413757  IL2; interleukin-2 precursor [KO:K05429]
101413770  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101413834  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
101414002  TNR; tenascin-R isoform X1 [KO:K06252]
101414191  [KO:K16339] [EC:3.1.2.2]
101414193  ITGA1; LOW QUALITY PROTEIN: integrin alpha-1 [KO:K06480]
101414215  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101414225  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101414240  [KO:K07828]
101414245  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
101414407  BAD; bcl2-associated agonist of cell death [KO:K02158]
101414417  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101414637  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101414723  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101414859  ANGPT4; angiopoietin-4 [KO:K05467]
101415110  FGF23; fibroblast growth factor 23 [KO:K22428]
101415186  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
101415497  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101415586  OSM; LOW QUALITY PROTEIN: oncostatin-M [KO:K05418]
101415609  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
101415616  FGF9; fibroblast growth factor 9 [KO:K04358]
101415744  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
101415906  TNN; tenascin-N [KO:K06252]
101416042  EFNA1; ephrin-A1 [KO:K05462]
101416053  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101416069  TP53; cellular tumor antigen p53 [KO:K04451]
101416079  COL2A1; collagen alpha-1(II) chain [KO:K19719]
101416305  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101416334  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101416389  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101416613  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
101416622  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
101416767  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101416890  GHR; growth hormone receptor isoform X1 [KO:K05080]
101416957  ITGA2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
101417003  [KO:K06238]
101417157  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101417330  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101417353  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101417411  [KO:K05438]
101417744  CHAD; chondroadherin [KO:K06248]
101417885  RELA; transcription factor p65 [KO:K04735]
101417906  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101417998  RHEB; GTP-binding protein Rheb [KO:K07208]
101418463  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101418565  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
101418598  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101418722  VEGFA; vascular endothelial growth factor A [KO:K05448]
101418748  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
101418868  [KO:K05414]
101418944  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101419022  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101419124  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101419182  YWHAQ; 14-3-3 protein theta [KO:K16197]
101419231  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101419317  [KO:K05414]
101419480  HRAS; GTPase HRas isoform X1 [KO:K02833]
101419568  FOXO3; forkhead box protein O3 [KO:K09408]
101419695  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
101419758  [KO:K05414]
101419849  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101419977  LAMA2; laminin subunit alpha-2 [KO:K05637]
101420015  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
101420176  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101420251  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
101420313  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
101420406  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
101420422  ITGA7; integrin alpha-7 [KO:K06583]
101420455  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101420546  [KO:K04369] [EC:2.7.12.2]
101420590  LAMB2; LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
101420624  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
101420628  IL4; interleukin-4 [KO:K05430]
101420648  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101420741  [KO:K04536]
101420804  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
101420952  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101421000  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101421083  FGF19; fibroblast growth factor 19 [KO:K22603]
101421086  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101421211  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101421345  TLR2; toll-like receptor 2 [KO:K10159]
101421444  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
101421519  FGF4; fibroblast growth factor 4 [KO:K04358]
101421663  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101421734  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
101421964  FGF3; fibroblast growth factor 3 [KO:K04358]
101422047  FGF21; fibroblast growth factor 21 [KO:K22429]
101422125  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
101422146  ITGA5; integrin alpha-5 [KO:K06484]
101422156  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101422200  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
101422310  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101423038  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
101423093  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
101423341  YWHAG; 14-3-3 protein gamma [KO:K16198]
101423380  ITGA8; integrin alpha-8 [KO:K06584]
101423469  [KO:K06856]
101423570  FGF2; fibroblast growth factor 2 [KO:K18497]
101423605  IL7; interleukin-7 [KO:K05431]
101423744  [KO:K02649]
101423756  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101423941  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101423956  LAMC1; laminin subunit gamma-1 [KO:K05635]
101424098  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
101424204  THBS1; thrombospondin-1 [KO:K16857]
101424389  ITGA11; integrin alpha-11 [KO:K06587]
101424442  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
101424579  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101424631  CREB3L3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101424677  [KO:K04360] [EC:2.7.10.1]
101424862  [KO:K03259]
101424943  IBSP; bone sialoprotein 2 [KO:K06253]
101424995  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101425091  ITGA3; integrin alpha-3 [KO:K06482]
101425111  [KO:K05414]
101425286  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101425404  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
101425452  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
101425577  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101425731  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
101425751  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101425815  ITGA4; integrin alpha-4 [KO:K06483]
101425856  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
101425904  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101425952  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101426197  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
101426371  PGF; placenta growth factor isoform X2 [KO:K16859]
101426399  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101426538  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101426561  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101426791  [KO:K07298] [EC:2.7.11.1]
101426836  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
101426854  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101426900  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
101426945  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101427017  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
101427189  [KO:K13769]
101427206  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101427287  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
101427669  FGFR1; fibroblast growth factor receptor 1 isoform X3 [KO:K04362] [EC:2.7.10.1]
101427698  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101427716  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
101427751  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101427892  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101428113  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101428248  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
101428297  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101428552  BDNF; brain-derived neurotrophic factor [KO:K04355]
101428656  ITGB1; integrin beta-1 [KO:K05719]
101428720  EPOR; erythropoietin receptor [KO:K05079]
101428761  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
101428775  FGF16; fibroblast growth factor 16 [KO:K04358]
101428799  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101428860  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101428978  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101429047  [KO:K04291]
101429084  NTF4; neurotrophin-4 [KO:K12457]
101429125  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
101429151  FGF18; fibroblast growth factor 18 [KO:K04358]
101429162  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X2 [KO:K16340] [EC:3.1.3.16]
101429267  [KO:K07198] [EC:2.7.11.31]
101429362  PRL; prolactin [KO:K05439]
101429481  [KO:K05405]
101429652  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101429772  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101429916  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101430321  ITGA9; integrin alpha-9 [KO:K06585]
101430345  [KO:K11218] [EC:2.7.10.2]
101430411  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
101430570  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101430585  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101430613  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101430817  NRAS; GTPase NRas [KO:K07828]
101431053  COL4A3; collagen alpha-3(IV) chain isoform X2 [KO:K06237]
101431151  F2R; proteinase-activated receptor 1 [KO:K03914]
101431326  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101431880  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
101431970  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
101432315  CSF3; granulocyte colony-stimulating factor [KO:K05423]
101432371  THBS4; thrombospondin-4 [KO:K04659]
101432391  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
101432519  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101432586  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
101432628  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
101432776  JAK1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101432987  [KO:K05414]
101432996  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
101433224  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
101433237  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
101433259  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
101433347  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101433349  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101433497  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
101433544  SOS2; son of sevenless homolog 2 [KO:K03099]
101433564  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101433644  ARTN; artemin isoform X1 [KO:K25415]
101433683  FGF5; fibroblast growth factor 5 [KO:K04358]
101433723  NOS3; LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101433800  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
101433858  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101434020  [KO:K13304] [EC:2.7.11.1]
101434069  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101434210  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101434268  [KO:K11584]
101434507  [KO:K13302] [EC:2.7.11.1]
101434699  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
101434801  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
101434860  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
101434873  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
101435185  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2 [KO:K01596] [EC:4.1.1.32]
101435268  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101435351  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101435604  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101435623  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101435742  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101435889  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
101436215  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
101436389  PKN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
101436464  TLR4; toll-like receptor 4 [KO:K10160]
101436471  ITGB3; integrin beta-3 [KO:K06493]
101436571  PKN3; serine/threonine-protein kinase N3 isoform X2 [KO:K23692]
101436598  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
101436632  PKN2; serine/threonine-protein kinase N2 [KO:K23691]
101436951  FGF7; fibroblast growth factor 7 [KO:K04358]
101437013  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
101437077  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
101437298  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
101437323  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
101437367  IRS1; insulin receptor substrate 1 [KO:K16172]
101437375  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
101437378  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
101437422  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101437556  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101437562  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
101438170  HSP90B1; endoplasmin [KO:K09487]
101438211  SYK; tyrosine-protein kinase SYK isoform X2 [KO:K05855] [EC:2.7.10.2]
101438244  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101438696  [KO:K11583]
101438715  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
101438875  MTCP1; protein p13 MTCP-1 [KO:K16837]
101439024  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101439255  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101439489  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101439742  ITGA10; integrin alpha-10 isoform X2 [KO:K06586]
101439821  LAMB3; laminin subunit beta-3 [KO:K06244]
101440447  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101440502  LAMC2; laminin subunit gamma-2 [KO:K06246]
101440765  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101440768  THBS2; thrombospondin-2 [KO:K04659]
101440782  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
101440851  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101440883  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101440893  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
101441006  LAMB1; laminin subunit beta-1 [KO:K05636]
101441273  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
101441399  [KO:K05085] [EC:2.7.10.1]
101441616  TNC; LOW QUALITY PROTEIN: tenascin [KO:K06252]
101441801  VTN; vitronectin [KO:K06251]
101442177  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101442198  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
101442225  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
101442244  PSPN; persephin [KO:K25416]
101442310  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101442445  EPO; erythropoietin [KO:K05437]
101442624  [KO:K16197]
101442636  NGF; beta-nerve growth factor [KO:K02582]
101442872  [KO:K04079]
101442966  RPS6; 40S ribosomal protein S6 [KO:K02991]
101442978  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101443015  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
101443033  FGF10; fibroblast growth factor 10 [KO:K04358]
101443131  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
101443494  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101443644  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101443761  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101443919  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
101443963  IL6; interleukin-6 [KO:K05405]
101444108  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101444276  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101444386  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
101444399  [KO:K05097] [EC:2.7.10.1]
101444493  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
101444714  FGF6; fibroblast growth factor 6 [KO:K04358]
101445147  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101445333  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
101445389  NRTN; neurturin isoform X2 [KO:K25414]
101445414  PRLR; prolactin receptor [KO:K05081]
101445493  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101445661  AREG; amphiregulin isoform X1 [KO:K09782]
101445813  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101446090  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
101446368  CD19; B-lymphocyte antigen CD19 [KO:K06465]
101446468  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101446801  TSC1; hamartin isoform X1 [KO:K07206]
101446858  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
101446901  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
101447530  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101447727  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
101447838  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101447879  [KO:K05414]
101447903  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
101447924  FGF20; fibroblast growth factor 20 [KO:K04358]
105746538  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105746654  [KO:K04736]
111760787  [KO:K07826]
111763551  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111764136  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111764630  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
dnm00010  Glycolysis / Gluconeogenesis
dnm04010  MAPK signaling pathway
dnm04012  ErbB signaling pathway
dnm04062  Chemokine signaling pathway
dnm04064  NF-kappa B signaling pathway
dnm04068  FoxO signaling pathway
dnm04110  Cell cycle
dnm04115  p53 signaling pathway
dnm04150  mTOR signaling pathway
dnm04210  Apoptosis
dnm04370  VEGF signaling pathway
dnm04510  Focal adhesion
dnm04620  Toll-like receptor signaling pathway
dnm04630  JAK-STAT signaling pathway
dnm04662  B cell receptor signaling pathway
dnm04910  Insulin signaling pathway
KO pathway
ko04151   

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