Entry Name Serotonergic synapse - Dasypus novemcinctus (nine-banded armadillo)
Description Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class Organismal Systems; Nervous systemBRITE hierarchy
Pathway map Other DBs Organism Dasypus novemcinctus (nine-banded armadillo) [GN:
dnm ]
Gene 101410636 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
101413297 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
101413654 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
101413770 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
101414215 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
101415315 HTR1A; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 1A [KO:K04153 ]
101419849 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
101419878 PLCB4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
101420315 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
101421427 CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853 ]
101423121 GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534 ]
101424598 KCND2; potassium voltage-gated channel subfamily D member 2 isoform X1 [KO:K04892 ]
101424635 KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000 ]
101424669 KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997 ]
101426538 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
101426647 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
101427179 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
101427206 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
101428251 KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999 ]
101428860 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
101430353 ALOX12B; LOW QUALITY PROTEIN: arachidonate 12-lipoxygenase, 12R-type [KO:K08021 ] [EC:1.13.11.-]
101431251 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857 ]
101431301 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X9 [KO:K04850 ]
101431308 KCNN2; small conductance calcium-activated potassium channel protein 2 [KO:K04943 ]
101431326 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
101440883 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
101441349 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
101442978 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
101444811 GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181 ]
101445685 GABRB2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181 ]
101446603 GABRB3; gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181 ]
101447591 KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002 ]
101447951 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X2 [KO:K04630 ]
111763551 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
111764136 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
111764630 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05964 11-Dehydro-thromboxane B2
Reference Authors Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
Title Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
Journal Reference Authors Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
Title Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
Journal Reference Authors Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
Title Multiplicity of mechanisms of serotonin receptor signal transduction.
Journal Reference Authors Noda M, Higashida H, Aoki S, Wada K
Title Multiple signal transduction pathways mediated by 5-HT receptors.
Journal Reference Authors Daubert EA, Condron BG
Title Serotonin: a regulator of neuronal morphology and circuitry.
Journal Reference Authors Chameau P, van Hooft JA
Title Serotonin 5-HT(3) receptors in the central nervous system.
Journal Reference Authors Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
Title Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
Journal Reference Authors Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
Title Epoxyeicosanoid signaling in CNS function and disease.
Journal Reference Authors Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
Title The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
Journal Reference Authors Albert PR, Tiberi M
Title Receptor signaling and structure: insights from serotonin-1 receptors.
Journal Reference Authors Durham PL, Russo AF
Title Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
Journal Reference Authors Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
Title Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
Journal Reference Authors Lezoualc'h F, Robert SJ
Title The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
Journal Reference Authors Durham PL, Russo AF
Title Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
Journal Reference Authors Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
Title Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
Journal Reference Authors Nestler EJ, Hyman SE, Malenka RC.
Title Molecular neuropharmacology: A foundation for clinical neuroscience
Journal The McGraw-Hill Companies, Inc. (2001)
Related KO pathway
