KEGG   PATHWAY: esp04115
Entry
esp04115                    Pathway                                
Name
p53 signaling pathway - Etheostoma spectabile (orangethroat darter)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
esp04115  p53 signaling pathway
esp04115

Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116669567  [KO:K02187] [EC:3.4.22.56]
116670007  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
116670022  [KO:K04402]
116670144  thbs1; thrombospondin-1 [KO:K16857]
116670326  siva1; apoptosis regulatory protein Siva [KO:K22744]
116670369  tp53i3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
116672005  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
116672757  apaf1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
116673033  [KO:K06625]
116673210  [KO:K06643] [EC:2.3.2.27]
116673298  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
116673369  igf1; insulin-like growth factor I [KO:K05459]
116673974  steap3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
116674407  [KO:K10128]
116674443  [KO:K06509]
116675297  [KO:K02159]
116676231  ppp1r13l; relA-associated inhibitor [KO:K27356]
116678421  ppm1d; protein phosphatase 1D isoform X1 [KO:K10147] [EC:3.1.3.16]
116679299  gorab; RAB6-interacting golgin [KO:K19748]
116679825  [KO:K02089] [EC:2.7.11.22]
116679844  [KO:K02206] [EC:2.7.11.22]
116683326  [KO:K02159]
116685783  [KO:K21770]
116685784  [KO:K21770]
116686014  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
116686021  [KO:K02159]
116686339  [KO:K04451]
116686487  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
116687243  [KO:K02089] [EC:2.7.11.22]
116687244  [KO:K02206] [EC:2.7.11.22]
116687435  [KO:K10135]
116687691  [KO:K10152]
116687706  [KO:K06625]
116688325  mdm4; protein Mdm4 isoform X1 [KO:K10127]
116688395  [KO:K26543]
116688562  [KO:K04570]
116688942  [KO:K04722]
116689139  [KO:K10146]
116689559  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
116690064  rchy1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
116690592  [KO:K04596]
116691938  [KO:K05459]
116692011  casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
116692325  [KO:K26543]
116692397  tp73; tumor protein p73 isoform X1 [KO:K10148]
116692614  bcl2l1; bcl-2-like protein 1 [KO:K04570]
116693722  [KO:K10129]
116693795  [KO:K04726]
116694182  [KO:K06509]
116694429  [KO:K04506] [EC:2.3.2.27]
116694490  [KO:K10130]
116694578  [KO:K04503]
116694797  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
116695248  [KO:K10138]
116695543  zmat3; zinc finger matrin-type protein 3 [KO:K10137]
116696019  [KO:K04402]
116697073  [KO:K02187] [EC:3.4.22.56]
116697116  [KO:K10141]
116697164  ccng1; cyclin-G1 [KO:K10145]
116698216  [KO:K08738]
116698338  rprm; protein reprimo [KO:K10128]
116698657  [KO:K02161]
116698760  [KO:K04398] [EC:3.4.22.61]
116698766  [KO:K04398] [EC:3.4.22.61]
116698982  [KO:K04402]
116699335  [KO:K10143] [EC:2.3.2.27]
116699487  [KO:K10138]
116700025  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
116700304  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
116700369  [KO:K10147] [EC:3.1.3.16]
116701033  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
116701361  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
116701484  [KO:K04596]
116701737  [KO:K20394]
116701851  cdk6; LOW QUALITY PROTEIN: cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
116701885  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
116702303  [KO:K10128]
116702780  [KO:K02091] [EC:2.7.11.22]
116703090  [KO:K10151]
116703178  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
116703270  bax; apoptosis regulator BAX [KO:K02159]
116703331  [KO:K02159]
116704170  [KO:K04402]
116704227  [KO:K04722]
116704311  tsc2; tuberin isoform X1 [KO:K07207]
116704379  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
116704476  [KO:K10146]
116705015  [KO:K08738]
116705113  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
116705301  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116705519  [KO:K04390]
116706057  [KO:K16857]
116706273  sesn1; sestrin-1 isoform X1 [KO:K10141]
116706802  [KO:K10808] [EC:1.17.4.1]
116707196  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
esp04110  Cell cycle
esp04210  Apoptosis
esp04218  Cellular senescence
KO pathway
ko04115   

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