KEGG   PATHWAY: gaf00380
Entry
gaf00380                    Pathway                                
Name
Tryptophan metabolism - Gambusia affinis (western mosquitofish)
Class
Metabolism; Amino acid metabolism
Pathway map
gaf00380  Tryptophan metabolism
gaf00380

Module
gaf_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:gaf00380]
gaf_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:gaf00380]
gaf_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:gaf00380]
Other DBs
GO: 0006568 0009851
Organism
Gambusia affinis (western mosquitofish) [GN:gaf]
Gene
122836906  tdo2a; tryptophan 2,3-dioxygenase A [KO:K00453] [EC:1.13.11.11]
122827979  ido1; indoleamine 2,3-dioxygenase 1 [KO:K00463] [EC:1.13.11.52]
122842685  indoleamine 2,3-dioxygenase 2-like [KO:K00463] [EC:1.13.11.52]
122829588  afmid; kynurenine formamidase [KO:K01432] [EC:3.5.1.9]
122842243  kynurenine 3-monooxygenase isoform X1 [KO:K00486] [EC:1.14.13.9]
122827457  kynu; kynureninase isoform X1 [KO:K01556] [EC:3.7.1.3]
122842190  haao; 3-hydroxyanthranilate 3,4-dioxygenase [KO:K00452] [EC:1.13.11.6]
122839524  acmsd; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase isoform X1 [KO:K03392] [EC:4.1.1.45]
122825258  aldh8a1; 2-aminomuconic semialdehyde dehydrogenase [KO:K23234] [EC:1.2.1.32]
122835739  dhtkd1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [KO:K15791] [EC:1.2.4.-]
122846715  dlst; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
122836063  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
122822059  glutaryl-CoA dehydrogenase, mitochondrial-like [KO:K00252] [EC:1.3.8.6]
122829232  glutaryl-CoA dehydrogenase, mitochondrial-like isoform X1 [KO:K00252] [EC:1.3.8.6]
122845967  hadhab; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b [KO:K07515] [EC:4.2.1.17 1.1.1.211]
122839879  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
122842314  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
122829089  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial isoform X1 [KO:K00022] [EC:1.1.1.35]
122844604  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
122825812  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
122846775  kyat1; kynurenine--oxoglutarate transaminase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
122838168  kynurenine--oxoglutarate transaminase 3-like [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
122820150  aadat; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [KO:K00825] [EC:2.6.1.7 2.6.1.39]
122846231  tryptophan 5-hydroxylase 1-like [KO:K00502] [EC:1.14.16.4]
122835380  tph1a; tryptophan 5-hydroxylase 1a [KO:K00502] [EC:1.14.16.4]
122836199  tph2; tryptophan 5-hydroxylase 2 isoform X1 [KO:K00502] [EC:1.14.16.4]
122831291  ddc; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
122847269  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A isoform X1 [KO:K00274] [EC:1.4.3.4]
122840321  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
122844550  aldh3a2b; aldehyde dehydrogenase family 3 member A2b [KO:K00128] [EC:1.2.1.3]
122830675  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
122833113  aldehyde dehydrogenase family 3 member A2-like isoform X1 [KO:K00128] [EC:1.2.1.3]
122821381  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
122838667  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
122841585  aldh9a1b; LOW QUALITY PROTEIN: 4-trimethylaminobutyraldehyde dehydrogenase B [KO:K00149] [EC:1.2.1.47 1.2.1.3]
122838345  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
122827269  aox6; aldehyde oxidase 6 isoform X1 [KO:K00157] [EC:1.2.3.1]
122846142  asmt2; acetylserotonin O-methyltransferase 2 [KO:K00543] [EC:2.1.1.4]
122839351  asmt; acetylserotonin O-methyltransferase [KO:K00543] [EC:2.1.1.4]
122830249  aanat1; serotonin N-acetyltransferase [KO:K00669] [EC:2.3.1.87]
122821519  aanat2; arylalkylamine N-acetyltransferase 2 [KO:K00669] [EC:2.3.1.87]
122822124  serotonin N-acetyltransferase-like [KO:K00669] [EC:2.3.1.87]
122842251  cytochrome P450 1B1 isoform X1 [KO:K07410] [EC:1.14.14.1]
122833314  il4i1; L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
122820715  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
122820716  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
122820989  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
122820990  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
122824085  aoc1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
122835926  cat; catalase [KO:K03781] [EC:1.11.1.6]
Compound
C00024  Acetyl-CoA
C00078  L-Tryptophan
C00108  Anthranilate
C00322  2-Oxoadipate
C00328  L-Kynurenine
C00331  Indolepyruvate
C00332  Acetoacetyl-CoA
C00398  Tryptamine
C00463  Indole
C00527  Glutaryl-CoA
C00632  3-Hydroxyanthranilate
C00637  Indole-3-acetaldehyde
C00643  5-Hydroxy-L-tryptophan
C00780  Serotonin
C00877  Crotonoyl-CoA
C00954  Indole-3-acetate
C00955  Indole-3-ethanol
C00978  N-Acetylserotonin
C01111  7,8-Dihydroxykynurenate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01249  7,8-Dihydro-7,8-dihydroxykynurenate
C01252  4-(2-Aminophenyl)-2,4-dioxobutanoate
C01598  Melatonin
C01717  4-Hydroxy-2-quinolinecarboxylic acid
C01987  2-Aminophenol
C02161  2-Aminophenoxazin-3-one
C02172  N-Acetylisatin
C02220  2-Aminomuconate
C02298  N-Acetylindoxyl
C02470  Xanthurenic acid
C02693  (Indol-3-yl)acetamide
C02700  L-Formylkynurenine
C02775  2,3-Dihydroxyindole
C02937  Indole-3-acetaldehyde oxime
C02938  3-Indoleacetonitrile
C03227  3-Hydroxy-L-kynurenine
C03230  (Indol-3-yl)glycolaldehyde
C03453  gamma-Oxalocrotonate
C03574  2-Formylaminobenzaldehyde
C03722  Quinolinate
C03824  2-Aminomuconate semialdehyde
C04409  2-Amino-3-carboxymuconate semialdehyde
C05634  5-Hydroxyindoleacetaldehyde
C05635  5-Hydroxyindoleacetate
C05636  3-Hydroxykynurenamine
C05637  4,8-Dihydroxyquinoline
C05638  5-Hydroxykynurenamine
C05639  4,6-Dihydroxyquinoline
C05640  Cinnavalininate
C05641  5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
C05642  Formyl-N-acetyl-5-methoxykynurenamine
C05643  6-Hydroxymelatonin
C05644  3-Methylindolepyruvate
C05645  4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
C05646  5-Hydroxyindolepyruvate
C05647  Formyl-5-hydroxykynurenamine
C05648  5-Hydroxy-N-formylkynurenine
C05651  5-Hydroxykynurenine
C05652  4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
C05653  Formylanthranilate
C05654  5-(2'-Formylethyl)-4,6-dihydroxypicolinate
C05655  5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
C05656  5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
C05658  Indoxyl
C05659  5-Methoxytryptamine
C05660  5-Methoxyindoleacetate
C05663  6-Hydroxykynurenate
C05830  8-Methoxykynurenate
C05831  3-Methoxyanthranilate
C05832  5-Hydroxyindoleacetylglycine
C05834  3-Methyldioxyindole
C05835  2-Formaminobenzoylacetate
C05837  Glucobrassicin
C06212  N-Methylserotonin
C06213  N-Methyltryptamine
C08313  Skatole
C10164  Picolinic acid
C16516  Indolylmethylthiohydroximate
C16517  Indolylmethyl-desulfoglucosinolate
C16518  S-(Indolylmethylthiohydroximoyl)-L-cysteine
C17203  N-Hydroxyl-tryptamine
C22006  (R)-(Indol-3-yl)lactate
C22202  2-Oxoindole-3-acetate
Reference
PMID:15749753
  Authors
Woodward AW, Bartel B
  Title
Auxin: regulation, action, and interaction.
  Journal
Ann Bot 95:707-35 (2005)
DOI:10.1093/aob/mci083
Related
pathway
gaf00010  Glycolysis / Gluconeogenesis
gaf00400  Phenylalanine, tyrosine and tryptophan biosynthesis
gaf00760  Nicotinate and nicotinamide metabolism
KO pathway
ko00380   
LinkDB

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