| Entry |
|
| Symbol |
GNAS, AHO, AIMAH1, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PITA3, POH, SCG6, SgVI
|
| Name |
(RefSeq) protein GNAS isoform XLas
|
| KO |
| K04632 | guanine nucleotide-binding protein G(s) subunit alpha |
|
| Organism |
|
| Pathway |
| hsa04072 | Phospholipase D signaling pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
| hsa04923 | Regulation of lipolysis in adipocytes |
| hsa04925 | Aldosterone synthesis and secretion |
| hsa04927 | Cortisol synthesis and secretion |
| hsa04928 | Parathyroid hormone synthesis, secretion and action |
| hsa04935 | Growth hormone synthesis, secretion and action |
| hsa04961 | Endocrine and other factor-regulated calcium reabsorption |
| hsa04962 | Vasopressin-regulated water reabsorption |
| hsa05163 | Human cytomegalovirus infection |
| hsa05207 | Chemical carcinogenesis - receptor activation |
|
| Network |
|
| Element |
| N00288 | PTH-PTH1R-PKA signaling pathway |
| N00297 | ACTH-cortisol signaling pathway |
| N00298 | CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway |
| N00321 | Mutation-activated GNAS to ACTH-cortisol signaling pathway |
| N00324 | CRHR-PKA-ACTH signaling pathway |
| N00326 | Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway |
| N00327 | Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway |
| N00410 | DRD1-GNAS-AC-PKA signaling pathway |
| N00411 | HCMV UL33 to GNAS-AC-PKA signaling pathway |
| N00782 | TSH-TG signaling pathway |
| N00885 | LHCGR-GNAS-PKA signaling pathway |
| N00910 | GHRHR-PKA-GH signaling pathway |
| N00915 | AVP-V2R-PKA signaling pathway |
| N00922 | FSHR-GNAS-PKA signaling pathway |
| N01345 | EP/NE-ADRB-cAMP signaling pathway |
| N01346 | Nicotine/NNK to cAMP signaling pathway |
| N01688 | ADRB3-UCP1 signaling pathway |
| N01794 | HCRT-HCRTR signaling pathway |
| N01878 | Glutamate-GRM-GNAQ/S signaling pathway |
| N01897 | Dopamine-DRD-GNAQ/S signaling pathway |
| N01904 | Norepinephrine-ADRB-GNAS signaling pathway |
| N01913 | Melanocortin receptor signaling, MSH |
| N01914 | Melanocortin receptor signaling, AgRP |
|
| Disease |
| H00244 | Pseudohypoparathyroidism |
| H00441 | Progressive osseous heteroplasia |
| H00501 | Fibrous dysplasia, polyostotic |
| H02049 | Bilateral macronodular adrenal hyperplasia |
|
| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
2778 (GNAS)
04020 Calcium signaling pathway
2778 (GNAS)
04072 Phospholipase D signaling pathway
2778 (GNAS)
04024 cAMP signaling pathway
2778 (GNAS)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
2778 (GNAS)
04081 Hormone signaling
2778 (GNAS)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
2778 (GNAS)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
2778 (GNAS)
09152 Endocrine system
04911 Insulin secretion
2778 (GNAS)
04922 Glucagon signaling pathway
2778 (GNAS)
04923 Regulation of lipolysis in adipocytes
2778 (GNAS)
04912 GnRH signaling pathway
2778 (GNAS)
04913 Ovarian steroidogenesis
2778 (GNAS)
04915 Estrogen signaling pathway
2778 (GNAS)
04921 Oxytocin signaling pathway
2778 (GNAS)
04926 Relaxin signaling pathway
2778 (GNAS)
04935 Growth hormone synthesis, secretion and action
2778 (GNAS)
04918 Thyroid hormone synthesis
2778 (GNAS)
04928 Parathyroid hormone synthesis, secretion and action
2778 (GNAS)
04916 Melanogenesis
2778 (GNAS)
04924 Renin secretion
2778 (GNAS)
04925 Aldosterone synthesis and secretion
2778 (GNAS)
04927 Cortisol synthesis and secretion
2778 (GNAS)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
2778 (GNAS)
04270 Vascular smooth muscle contraction
2778 (GNAS)
09154 Digestive system
04970 Salivary secretion
2778 (GNAS)
04971 Gastric acid secretion
2778 (GNAS)
04972 Pancreatic secretion
2778 (GNAS)
04976 Bile secretion
2778 (GNAS)
09155 Excretory system
04962 Vasopressin-regulated water reabsorption
2778 (GNAS)
04961 Endocrine and other factor-regulated calcium reabsorption
2778 (GNAS)
09156 Nervous system
04724 Glutamatergic synapse
2778 (GNAS)
04728 Dopaminergic synapse
2778 (GNAS)
04726 Serotonergic synapse
2778 (GNAS)
04730 Long-term depression
2778 (GNAS)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
2778 (GNAS)
09159 Environmental adaptation
04713 Circadian entrainment
2778 (GNAS)
04714 Thermogenesis
2778 (GNAS)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2778 (GNAS)
05207 Chemical carcinogenesis - receptor activation
2778 (GNAS)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
2778 (GNAS)
05165 Human papillomavirus infection
2778 (GNAS)
09171 Infectious disease: bacterial
05110 Vibrio cholerae infection
2778 (GNAS)
09174 Infectious disease: parasitic
05146 Amoebiasis
2778 (GNAS)
05142 Chagas disease
2778 (GNAS)
09164 Neurodegenerative disease
05012 Parkinson disease
2778 (GNAS)
09165 Substance dependence
05030 Cocaine addiction
2778 (GNAS)
05031 Amphetamine addiction
2778 (GNAS)
05032 Morphine addiction
2778 (GNAS)
05034 Alcoholism
2778 (GNAS)
09166 Cardiovascular disease
05414 Dilated cardiomyopathy
2778 (GNAS)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
2778 (GNAS)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
2778 (GNAS)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
2778 (GNAS)
04031 GTP-binding proteins [BR:hsa04031]
2778 (GNAS)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
2778 (GNAS)
Exosomal proteins of other body fluids (saliva and urine)
2778 (GNAS)
Exosomal proteins of colorectal cancer cells
2778 (GNAS)
Exosomal proteins of bladder cancer cells
2778 (GNAS)
GTP-binding proteins [BR:hsa04031]
Heterotrimeric G-proteins
Alpha Subunits
Alpha type 2 (Gs)
2778 (GNAS)
|
| SSDB |
|
| Motif |
|
| Other DBs |
|
| Structure |
|
| LinkDB |
|
| Position |
20:58839748..58911192
|
| AA seq |
1037 aa
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIP
VENDGEACGPPEVSRPNFQVLNPAFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQ
PGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPP
GLSRVIAQVDGSSQFAAVAASSAVRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSP
WMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADP
DSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAA
ETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRR
RKPQRNLLRNFLVQAFGGCFGRSESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKR
AEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDP
QAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNV
PDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDL
LRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVI
REDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFAR
YTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFN
DCRDIIQRMHLRQYELL |
| NT seq |
3114 nt +upstreamnt +downstreamnt
atgggcgtgcgcaactgcctctacggcaataatatgtcaggacaacgcgatatcccccct
gaaatcggggaacagcccgagcaaccacctttggaggccccaggggcagctgcccccggt
gctgggcctagcccagccgaagagatggagaccgaaccgcctcacaacgagcccatcccc
gtcgagaatgatggcgaggcctgtggacccccagaggtctccagacccaactttcaggtc
ctcaacccggcattcagggaagctggagcccatggaagctacagcccacctcctgaggaa
gcaatgcccttcgaggctgaacagcccagcttgggaggcttctggcctacactggagcag
cctggattccccagtggggtccatgcaggccttgaggccttcggcccagcactcatggag
cccggagccttcagtggtgccagaccaggcctgggaggatacagccctccaccagaagaa
gctatgccctttgagtttgaccagcctgcccagagaggctgcagtcaacttctcttacag
gtcccagaccttgctccaggaggcccaggtgctgcaggggtccccggagctcctcccgag
gagccccaagccctcaggcctgcaaaggctggctccagaggaggctacagccctccccct
gaggagactatgccatttgagcttgatggagaaggatttggggacgacagcccacccccg
gggctttcccgagttatcgcacaagtcgacggcagcagccagttcgcggcagtcgcggcc
tcgagtgcggtccgcctcactcccgccgcgaacgcgcctcccctctgggtcccaggcgcc
atcggcagcccatcccaagaggctgtcagacctccttctaacttcacgggcagcagcccc
tggatggagatctccggacccccgttcgagattggcagcgcccccgctggggtcgacgac
actcccgtcaacatggacagccccccaatcgcgcttgacggcccgcccatcaaggtctcc
ggagccccagataagagagagcgagcagagagacccccagttgaggaggaagcagcagag
atggaaggagccgctgatgccgcggagggaggaaaagtaccctctccggggtacggatcc
cctgccgccggggcagcctcagcggataccgctgccagggcagcccctgcagccccagcc
gatcctgactccggggcaaccccagaagatcccgactccgggacagcaccagccgatcct
gactccggggcattcgcagccgatcccgactccggggcagcccctgccgccccagccgat
cccgactccggggcggcccctgacgccccagccgatcccgactccggggcggcccctgac
gccccagccgatccagatgccggggcggcccctgaggctcccgccgcccctgcggctgct
gagacccgggcagcccatgtcgccccagctgcgccagacgcaggggctcccactgcccca
gccgcttctgccacccgggcagcccaagtccgccgggcggcctctgcagcccctgcctcc
ggggccagacgcaagatccatctcagaccccccagccccgagatccaggctgccgatccg
cctactccgcggcctactcgcgcgtctgcctggcggggcaagtccgagagcagccgcggc
cgccgcgtgtactacgatgaaggggtggccagcagcgacgatgactccagcggagacgag
tccgacgatgggacctccggatgcctccgctggtttcagcatcggcgaaatcgccgccgc
cgaaagccccagcgcaacttactccgcaactttctcgtgcaagccttcgggggctgcttc
ggtcgatctgagagtccccagcccaaagcctcgcgctctctcaaggtcaagaaggtaccc
ctggcggagaagcgcagacagatgcgcaaagaagccctggagaagcgggcccagaagcgc
gcagagaagaaacgcagtaagctcatcgacaaacaactccaggacgaaaagatgggctac
atgtgtacgcaccgcctgctgcttctaggtgctggagaatctggtaaaagcaccattgtg
aagcagatgaggatcctgcatgttaatgggtttaatggagagggcggcgaagaggacccg
caggctgcaaggagcaacagcgatggtgagaaggcaaccaaagtgcaggacatcaaaaac
aacctgaaagaggcgattgaaaccattgtggccgccatgagcaacctggtgccccccgtg
gagctggccaaccccgagaaccagttcagagtggactacatcctgagtgtgatgaacgtg
cctgactttgacttccctcccgaattctatgagcatgccaaggctctgtgggaggatgaa
ggagtgcgtgcctgctacgaacgctccaacgagtaccagctgattgactgtgcccagtac
ttcctggacaagatcgacgtgatcaagcaggctgactatgtgccgagcgatcaggacctg
cttcgctgccgtgtcctgacttctggaatctttgagaccaagttccaggtggacaaagtc
aacttccacatgtttgacgtgggtggccagcgcgatgaacgccgcaagtggatccagtgc
ttcaacgatgtgactgccatcatcttcgtggtggccagcagcagctacaacatggtcatc
cgggaggacaaccagaccaaccgcctgcaggaggctctgaacctcttcaagagcatctgg
aacaacagatggctgcgcaccatctctgtgatcctgttcctcaacaagcaagatctgctc
gctgagaaagtccttgctgggaaatcgaagattgaggactactttccagaatttgctcgc
tacactactcctgaggatgctactcccgagcccggagaggacccacgcgtgacccgggcc
aagtacttcattcgagatgagtttctgaggatcagcactgccagtggagatgggcgtcac
tactgctaccctcatttcacctgcgctgtggacactgagaacatccgccgtgtgttcaac
gactgccgtgacatcattcagcgcatgcaccttcgtcagtacgagctgctctaa |