KEGG   PATHWAY: ko00904
Entry
ko00904                     Pathway                                
Name
Diterpenoid biosynthesis
  Including
Gibberellin biosynthesis
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
ko00904  Diterpenoid biosynthesis
ko00904

Module
M00927  Gibberellin A12 biosynthesis, GAPP => GA12 [PATH:ko00904]
M00928  Gibberellin A4/A1 biosynthesis, GA12/GA53 => GA4/GA1 [PATH:ko00904]
M00929  Gibberellin A1 biosynthesis, GGPP => GA1 [PATH:ko00904]
Other DBs
GO: 0016102
Orthology
K04120  E5.5.1.13; ent-copalyl diphosphate synthase [EC:5.5.1.13]
K04121  E4.2.3.19; ent-kaurene synthase [EC:4.2.3.19]
K04122  GA3, CYP701; ent-kaurene oxidase [EC:1.14.14.86]
K04123  KAO, CYP88A; ent-kaurenoic acid monooxygenase [EC:1.14.14.107]
K04124  GA3ox; gibberellin 3beta-dioxygenase [EC:1.14.11.15]
K04125  GA2ox; gibberellin 2beta-dioxygenase [EC:1.14.11.13]
K05282  GA20ox; gibberellin-44 dioxygenase [EC:1.14.11.12]
K12917  P450I, CYP68A; cytochrome P450 monooxygenase 1
K12918  P450II, CYP68B; cytochrome P450 monooxygenase 2
K12919  P450III, CYP69A; cytochrome P450 monooxygenase 3
K12920  K12920, DES; GA4 desaturase
K12921  TDC1; taxadiene synthase [EC:4.2.3.17]
K12922  CYP725A2; taxane 13alpha-hydroxylase [EC:1.14.14.106]
K12923  TAT; taxadien-5alpha-ol O-acetyltransferase [EC:2.3.1.162]
K12924  CYP725A1; taxane 10beta-hydroxylase [EC:1.14.14.105]
K12925  TBT; 2alpha-hydroxytaxane 2-O-benzoyltransferase [EC:2.3.1.166]
K12926  DBAT; 10-deacetylbaccatin III 10-O-acetyltransferase [EC:2.3.1.167]
K12927  AG22; abietadiene/neoabietadiene/copalyl diphosphate synthase [EC:4.2.3.18 4.2.3.132 5.5.1.12]
K12928  K12928, ACS; aphidicolan-16beta-ol synthase/syn-copalyl-diphosphate synthase [EC:4.2.3.42 5.5.1.14]
K12929  E4.2.3.8; casbene synthase [EC:4.2.3.8]
K13070  MAS; momilactone-A synthase [EC:1.1.1.295]
K14036  KSL7, DTC1; ent-cassa-12,15-diene synthase [EC:4.2.3.28]
K14037  KSL10; ent-sandaracopimaradiene/labdatriene synthase [EC:4.2.3.29 4.2.3.99]
K14038  KSL5; ent-pimara-8(14),15-diene synthase [EC:4.2.3.30]
K14039  E1.14.14.176; taxadiene 5alpha-hydroxylase [EC:1.14.14.176]
K14040  CYP720B, PTAO; abieta-7,13-dien-18-ol hydroxylase [EC:1.14.14.145]
K14041  TPS-LAS, LPS; levopimaradiene/copalyl diphosphate synthase [EC:4.2.3.32 5.5.1.12]
K14042  TPS-ISO; isopimara-7,15-diene synthase /copalyl diphosphate synthase [EC:4.2.3.44 5.5.1.12]
K14043  CPS4; syn-copalyl-diphosphate synthase [EC:5.5.1.14]
K14044  KSL8, DTC2; stemar-13-ene synthase [EC:4.2.3.33]
K14045  KSL11; stemod-13(17)-ene synthase [EC:4.2.3.34]
K14046  KSL4, DTS2; syn-pimara-7,15-diene synthase [EC:4.2.3.35]
K14047  PADC4; fusicocca-2,10(14)-diene synthase [EC:4.2.3.43]
K16082  KSL6; ent-isokaurene synthase [EC:4.2.3.103]
K16083  CYP71Z6; ent-isokaurene hydroxylase [EC:1.14.14.76]
K16084  CYP76M7_8; ent-cassa-12,15-diene 11-hydroxylase / oryzalexin D synthase [EC:1.14.14.112 1.14.14.123]
K16085  CYP99A2_3; 9beta-pimara-7,15-diene oxidase [EC:1.14.14.111]
K16086  E3.1.7.10; (13E)-labda-7,13-dien-15-ol synthase [EC:3.1.7.10]
K17961  CYP82G1; trimethyltridecatetraene/dimethylnonatriene synthase [EC:1.14.14.58 1.14.14.59]
K17982  TPS04, GES; geranyllinalool synthase [EC:4.2.3.144]
K18113  MDS; miltiradiene synthase / copalyl diphosphate synthase [EC:4.2.3.131 5.5.1.12]
K19571  LPS; levopimaradiene/neoabietadiene/copalyl diphosphate synthase [EC:4.2.3.32 4.2.3.132 5.5.1.12]
K20512  CYP725A3; taxoid 14beta-hydroxylase [EC:1.14.13.146]
K20513  CYP76AH1; ferruginol synthase [EC:1.14.14.175]
K20514  DC1; phyllocladan-16alpha-ol/copalyl diphosphate synthase [EC:4.2.3.45 5.5.1.12]
K20515  PIM1; pimaradiene synthase [EC:4.2.3.147]
K20516  CLS; copal-8-ol diphosphate hydratase [EC:4.2.1.133]
K20517  ABS; cis-abienol synthase [EC:4.2.3.140]
K20518  CAS; copal-8-ol diphosphate hydratase / cis-abienol synthase [EC:4.2.1.133 4.2.3.140]
K20519  SS; sclareol synthase [EC:4.2.3.141]
K20657  CPS-KS; ent-copalyl diphosphate/ent-kaurene synthase [EC:5.5.1.13 4.2.3.19]
K20666  CYP714B; gibberellin 13-oxidase [EC:1.14.-.-]
K21291  CYP71Z7; ent-cassadiene hydroxylase [EC:1.14.14.69]
K21292  CYP503; ent-kaurene oxidase [EC:1.14.14.86]
K21718  CYP76M6; oryzalexin E synthase [EC:1.14.14.122]
K21719  CYP701A8; ent-sandaracopimaradiene 3-hydroxylase / syn-pimaradiene 3-monooxygenase [EC:1.14.14.70 1.14.14.68]
K22634  CYP71BE52; salviol synthase [EC:1.14.14.62]
K22635  CYP76AH3; ferruginol monooxygenase / sugiol synthase [EC:1.14.14.60 1.14.14.65]
K22636  CYP76AH24; ferruginol synthase / ferruginol monooxygenase [EC:1.14.14.175 1.14.14.60]
K22637  CYP76AK1; 11-hydroxysugiol 20-monooxygenase [EC:1.14.14.67]
K22638  CYP76AK6; carnosic acid synthase [EC:1.14.14.61]
K22639  CYP92C5; trimethyltridecatetraene/dimethylnonatriene synthase [EC:1.14.14.58 1.14.14.59]
K22640  CYP92C6; trimethyltridecatetraene synthase [EC:1.14.14.58]
K22945  TPS2; nezukol synthase
K22946  CPS4; ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase
K22947  KSL2; ent-13-epi-manoyl oxide synthase
K22948  E5.5.1.28; (-)-kolavenyl diphosphate synthase
K24460  GA13ox; gibberellin 13-oxidase
K27636  CPS-KS; ent-copalyl diphosphate/ent-kaurene/ent-beyerene synthase
K27849  BAPT; taxoid C-13 O-(3-amino-3-phenylpropanoyl)transferase
K27850  DBTNBT; 3'-N-debenzoyltaxol N-benzoyltransferase
Compound
C00353  Geranylgeranyl diphosphate
C00859  Gibberellin A1
C01414  Casbene
C01699  Gibberellin A3
C02034  Gibberellin A19
C02035  Gibberellin A20
C03579  Gibberellin A8
C06086  Pimaradiene
C06087  Abietate
C06088  Aphidicolin
C06089  ent-Copalyl diphosphate
C06090  ent-Kaurene
C06091  Aconitine
C06092  Veatchine
C06093  Gibberellin A12 aldehyde
C06094  Gibberellin A53
C06095  Gibberellin A44 diacid
C06096  Gibberellin A29
C07394  Paclitaxel
C07601  Ginkgolide A
C09092  Ferruginol
C09094  Geranylgeraniol
C09118  Isopimaric acid
C09163  Pisiferic acid
C09183  Sclareol
C09189  Stevioside
C11700  10-Deacetylbaccatin III
C11853  Gibberellin A14 aldehyde
C11854  Gibberellin A51-catabolite
C11855  Gibberellin A29-catabolite
C11857  Gibberellin A12
C11858  Gibberellin A14
C11859  Gibberellin A37 open lactone
C11860  Gibberellin A15 open lactone
C11861  Gibberellin A24
C11862  Gibberellin A36
C11863  Gibberellin A9
C11864  Gibberellin A4
C11865  Gibberellin A51
C11866  2,3-Dehydro-gibberellin A9
C11867  Gibberellin A7
C11868  Gibberellin A34
C11869  Gibberellin A34-catabolite
C11870  Gibberellin A8-catabolite
C11871  Gibberellin A5
C11872  Kaur-16-en-18-ol
C11873  Kaur-16-en-18-al
C11874  Kaur-16-en-18-oic acid
C11875  ent-7alpha-Hydroxykaur-16-en-19-oic acid
C11876  6beta,7beta-Dihydroxykaurenoic acid
C11877  (+)-Sandaracopimaradiene
C11878  (-)-Abietadiene
C11879  Levopimaradiene
C11880  Neoabietadiene
C11881  Palustradiene
C11882  Abietinol
C11883  Levopimarinol
C11884  Neoabietinol
C11885  Neoabietal
C11886  Levopimarinal
C11887  Abietal
C11888  Levopimaric acid
C11889  Neoabietic acid
C11890  Aphidicolan-16beta-ol
C11893  Cembrene
C11894  Taxa-4(5),11(12)-diene
C11895  Taxa-4(20),11(12)-dien-5alpha-ol
C11896  Taxa-4(20),11(12)-dien-5alpha-yl acetate
C11897  Taxa-4(20),11(12)-dien-5alpha,13alpha-diol
C11898  Taxa-4(20),11(12)-dien-5alpha-acetoxy-10beta-ol
C11899  10-Deacetyl-2-debenzoylbaccatin III
C11900  Baccatin III
C11901  Copalyl diphosphate
C11902  9alpha-Copalyl diphosphate
C11905  Gibberellin A53 aldehyde
C12077  Palustric acid
C13273  Plaunotol
C16523  3'-N-Debenzoyl-2'-deoxytaxol
C16524  3'-N-Debenzoyltaxol
C18015  Momilactone A
C18016  3beta-Hydroxy-9beta-pimara-7,15-diene-19,6beta-olide
C18211  Isopimara-7,15-diene
C18219  Palustradienol
C18220  Palustradienal
C18221  Isopimaradienol
C18222  Isopimaradienal
C18223  Stemar-13-ene
C18224  Stemod-13(17)-ene
C18225  9beta-Pimara-7,15-diene
C18226  ent-Cassa-12,15-diene
C18228  ent-Pimara-8(14),15-diene
C18229  Fusicocca-2,10(14)-diene
C19817  Phyllocladan-16alpha-ol
C20145  ent-Isokaurene
C20146  ent-2alpha-Hydroxyisokaurene
C20149  9beta-Pimara-7,15-dien-19-oate
C20150  ent-11beta-Hydroxycassa-12,15-diene
C20151  10beta,14beta-Dihydroxytaxa-4(20),11-dien-5alpha-yl acetate
C20158  (13E)-Labda-7,13-dien-15-ol
C20185  (12E)-9alpha-Labda-8(17),12,14-triene
C20208  syn-Stemoden-19-oate
C20270  Copal-8-ol diphosphate
C20481  cis-Abienol
C20681  (E,E)-Geranyllinalool
C20700  (E,E)-4,8,12-Trimethyltrideca-1,3,7,11-tetraene
C20711  Miltiradiene
C21425  Abieta-8,11,13-triene
C21560  ent-Sandaracopimaradien-3beta-ol
C21561  Oryzalexin E
C21562  Oryzalexin D
C21656  ent-8alpha-Hydroxylabd-13-en-15-yl diphosphate
C21709  Nezukol
C21714  ent-13-epi-Manoyl oxide
C21735  (-)-Kolavenyl diphosphate
C21796  11-Hydroxyferruginol
C21818  Carnosic acid
C21819  Salviol
C21822  Sugiol
C21823  11-Hydroxysugiol
C21824  11,20-Dihydroxysugiol
C21825  9beta-Pimara-7,15-diene-3beta-ol
C21826  ent-3beta-Hydroxycassa-12,15-dien-2-one
C21830  11,20-Dihydroxyferruginol
C21831  ent-2alpha,3alpha-Dihydroxyisokaurene
Reference
PMID:16137660
  Authors
Long RM, Croteau R.
  Title
Preliminary assessment of the C13-side chain 2'-hydroxylase involved in taxol biosynthesis.
  Journal
Biochem Biophys Res Commun 338:410-7 (2005)
DOI:10.1016/j.bbrc.2005.08.119
Reference
PMID:12089320
  Authors
Walker K, Long R, Croteau R.
  Title
The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus.
  Journal
Proc Natl Acad Sci U S A 99:9166-71 (2002)
DOI:10.1073/pnas.082115799
Related
pathway
ko00900  Terpenoid backbone biosynthesis

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