KEGG   PATHWAY: mlk04144
Entry
mlk04144                    Pathway                                
Name
Endocytosis - Mustela lutreola (European mink)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
mlk04144  Endocytosis
mlk04144

Other DBs
GO: 0006897
Organism
Mustela lutreola (European mink) [GN:mlk]
Gene
131836530  ARF6; ADP-ribosylation factor 6 [KO:K07941]
131812389  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
131823296  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
131808865  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
131812734  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
131816943  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
131824867  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
131812916  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
131815273  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
131823530  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
131812901  CLTA; clathrin light chain A isoform X1 [KO:K04644]
131831946  CLTB; clathrin light chain B isoform X1 [KO:K04645]
131811372  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
131815835  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
131818810  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
131817922  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
131815547  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
131824799  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
131818380  AP2S1; AP-2 complex subunit sigma [KO:K11827]
131817786  EHD2; EH domain-containing protein 2 [KO:K12469]
131812377  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
131824456  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
131832405  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
131809893  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
131835794  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
131811852  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
131835965  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
131824666  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
131829150  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
131824031  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
131830605  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
131827098  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
131831964  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
131835676  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
131837043  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
131825173  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
131818004  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
131822150  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
131835526  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
131812440  SH3GL2; endophilin-A1 [KO:K11247]
131823326  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
131808823  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
131813167  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
131826898  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
131829124  AMPH; amphiphysin isoform X1 [KO:K12562]
131815934  EPN3; epsin-3 isoform X1 [KO:K12471]
131816872  EPN2; epsin-2 isoform X1 [KO:K12471]
131818301  EPN1; epsin-1 isoform X1 [KO:K12471]
131823699  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
131810317  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
131813715  SPART; spartin [KO:K19366]
131835843  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
131811099  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
131839136  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
131811444  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
131838605  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
131807816  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
131820095  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
131816965  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
131826635  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
131823540  LDLR; low-density lipoprotein receptor [KO:K12473]
131808821  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
131831686  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
131823851  C-C chemokine receptor type 5 [KO:K04180]
131827466  C-X-C chemokine receptor type 2-like [KO:K04175]
131827467  C-X-C chemokine receptor type 2 [KO:K05050]
131826966  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
131813927  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
131825059  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
131811921  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
131816253  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
131826899  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
131830625  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
131831978  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
131840630  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
131815763  ARRB2; beta-arrestin-2 [KO:K04439]
131829700  WASL; actin nucleation-promoting factor WASL [KO:K23612]
131840212  ACTR2; actin-related protein 2 [KO:K17260]
131826940  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
131829971  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
131826035  actin-related protein 3-like [KO:K18584]
131819189  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
131819191  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
131827465  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
131811253  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
131824203  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
131813113  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
131814674  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
131827073  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
131829561  WIPF3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
131816639  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
131837691  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
131833881  heat shock cognate 71 kDa protein-like [KO:K03283]
131834338  heat shock 70 kDa protein 1-like [KO:K03283]
131834339  heat shock 70 kDa protein 1 [KO:K03283]
131834340  heat shock 70 kDa protein 1-like [KO:K03283]
131832001  heat shock cognate 71 kDa protein-like [KO:K03283]
131809344  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
131839366  WASHC4; WASH complex subunit 4 [KO:K18465]
131826409  WASHC5; WASH complex subunit 5 [KO:K18464]
131828706  WASHC2A; WASH complex subunit 2A isoform X1 [KO:K18462]
131838388  WASHC1; WASH complex subunit 1 isoform X1 [KO:K18461]
131839332  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
131837966  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
131829659  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
131810098  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
131810223  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
131811725  VPS29; vacuolar protein sorting-associated protein 29 [KO:K18467]
131818088  vacuolar protein sorting-associated protein 29-like [KO:K18467]
131838873  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
131827054  vacuolar protein sorting-associated protein 26A-like [KO:K18466]
131828888  VPS26A; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
131817478  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
131820892  SNX12; sorting nexin-12 [KO:K17918]
131830046  sorting nexin-3 isoform X1 [KO:K17918]
131833539  SNX3; sorting nexin-3 [KO:K17918]
131836275  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
131840311  STAMBP; STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
131824289  RAB7A; ras-related protein Rab-7a [KO:K07897]
131816874  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
131838221  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
131827213  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
131811072  tumor susceptibility gene 101 protein-like [KO:K12183]
131810232  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
131812755  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
131823730  MVB12A; multivesicular body subunit 12A isoform X1 [KO:K12186]
131811446  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
131819588  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
131820436  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
131813457  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
131815523  SNF8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
131813460  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
131813623  vacuolar protein-sorting-associated protein 36-like [KO:K12190]
131815801  VPS25; vacuolar protein-sorting-associated protein 25 isoform X1 [KO:K12189]
131816257  CHMP6; charged multivesicular body protein 6 isoform X1 [KO:K12195]
131836394  CHMP4A; charged multivesicular body protein 4a isoform X1 [KO:K12194]
131811049  charged multivesicular body protein 4b-like [KO:K12194]
131807829  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
131826658  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
131840409  CHMP3; charged multivesicular body protein 3 isoform X1 [KO:K12193]
131818193  CHMP2A; charged multivesicular body protein 2a isoform X1 [KO:K12191]
131825238  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
131834062  CHMP7; charged multivesicular body protein 7 [KO:K15053]
131811776  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
131834152  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 4B-like [KO:K12196]
131818405  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
131833735  VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
131810917  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
131818397  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
131813198  CHMP5; charged multivesicular body protein 5 [KO:K12198]
131817730  IST1; IST1 homolog isoform X1 [KO:K19476]
131826405  IST1 homolog [KO:K19476]
131824391  PDCD6IP; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
131835929  SPG21; maspardin [KO:K19367]
131833399  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
131835911  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
131832562  SNX2; sorting nexin-2 [KO:K17917]
131837217  SNX6; sorting nexin-6 [KO:K17920]
131815683  SNX32; sorting nexin-32 isoform X1 [KO:K17920]
131808149  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
131807708  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
131818337  HRAS; GTPase HRas isoform X1 [KO:K02833]
131838068  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
131839436  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
131821377  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
131811641  transforming protein RhoA-like [KO:K04513]
131823928  RHOA; transforming protein RhoA [KO:K04513]
131834381  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
131834384  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
131834396  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
131832674  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
131833285  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
131807890  FOLR2; folate receptor beta [KO:K13649]
131807905  folate receptor alpha-like [KO:K13649]
131829656  CAV1; caveolin-1 isoform X1 [KO:K06278]
131829657  CAV2; caveolin-2 isoform X1 [KO:K12958]
131825800  CAV3; caveolin-3 [KO:K12959]
131840566  EHD3; EH domain-containing protein 3 [KO:K12476]
131836156  EHD4; EH domain-containing protein 4 [KO:K12477]
131839260  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
131824499  RAB5A; ras-related protein Rab-5A [KO:K07887]
131838623  RAB5B; ras-related protein Rab-5B [KO:K07888]
131813200  ras-related protein Rab-5B [KO:K07888]
131816225  RAB5C; ras-related protein Rab-5C [KO:K07889]
131816329  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
131824251  RBSN; rabenosyn-5 isoform X1 [KO:K12481]
131829110  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
131828899  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
131832643  RUFY1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
131815007  EHD1; EH domain-containing protein 1 [KO:K12483]
131810333  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
131824651  SNX4; sorting nexin-4 [KO:K17919]
131810918  RAB31; ras-related protein Rab-31 [KO:K07891]
131808619  RAB22A; ras-related protein Rab-22A [KO:K07891]
131807281  RAB10; ras-related protein Rab-10 [KO:K07903]
131823691  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
131811223  RAB35; ras-related protein Rab-35 isoform X1 [KO:K07876]
131835949  RAB11A; ras-related protein Rab-11A [KO:K07904]
131823412  RAB11B; ras-related protein Rab-11B [KO:K07905]
131840292  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
131820589  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
131830637  RAB11FIP2; rab11 family-interacting protein 2 [KO:K12484]
131828574  ZFYVE27; protrudin isoform X1 [KO:K19368]
131838301  KIF5B; kinesin-1 heavy chain [KO:K10396]
131838554  KIF5A; kinesin heavy chain [KO:K10396]
131826995  KIF5C; kinesin heavy chain [KO:K10396]
131819221  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
131815744  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
131838311  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
131811115  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
131818528  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
131807580  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
131808860  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
131824877  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
131811594  cell division control protein 42 homolog [KO:K04393]
131808912  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
131810066  cell division control protein 42 homolog [KO:K04393]
131833155  cell division control protein 42 homolog [KO:K04393]
131834161  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
131808799  SMAP2; stromal membrane-associated protein 2 [KO:K12486]
131815914  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
131811893  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
131807396  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
131809316  ASAP3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
131826397  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
131815885  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
131809300  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
131824699  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
131807793  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
131825046  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
131832183  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
131827303  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
131829941  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
131838539  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
131807311  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
131839577  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
131812334  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
131840425  PSD4; PH and SEC7 domain-containing protein 4 [KO:K12494]
131820343  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
131828504  PSD; PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494]
131832126  PSD2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
131838326  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 3-like [KO:K12495]
131838384  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
131822018  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
131824274  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
131839440  CYTH4; cytohesin-4 [KO:K18441]
131819875  CYTH3; cytohesin-3 [KO:K18441]
131816552  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
131818065  CYTH2; cytohesin-2 [KO:K18441]
131826748  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
131807490  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
131828508  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
131816372  ADP-ribosylation factor 2 [KO:K07937]
131832726  ARF1; ADP-ribosylation factor 1 [KO:K07937]
131838814  ARF3; ADP-ribosylation factor 3 isoform X1 [KO:K07938]
131824061  ARF4; ADP-ribosylation factor 4 [KO:K07939]
131829718  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
mlk04060  Cytokine-cytokine receptor interaction
mlk04070  Phosphatidylinositol signaling system
mlk04130  SNARE interactions in vesicular transport
mlk04142  Lysosome
mlk04350  TGF-beta signaling pathway
KO pathway
ko04144   
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