KEGG   PATHWAY: msam04141
Entry
msam04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Micropterus salmoides (largemouth bass)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
msam04141  Protein processing in endoplasmic reticulum
msam04141

Other DBs
GO: 0030433 0034976
Organism
Micropterus salmoides (largemouth bass) [GN:msam]
Gene
119882419  selenos; selenoprotein S [KO:K14025]
119882814  rad23aa; RAD23 homolog A, nucleotide excision repair protein a [KO:K10839]
119883053  hspa8b; LOW QUALITY PROTEIN: heat shock protein family A (Hsp70) member 8b [KO:K03283]
119883319  ssr3; translocon-associated protein subunit gamma [KO:K13251]
119883771  [KO:K23741]
119884813  [KO:K08056] [EC:5.3.4.1]
119884920  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
119885408  atf4b; activating transcription factor 4b [KO:K04374]
119885482  fbxo2; F-box only protein 2 [KO:K10099]
119885650  yod1; ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
119885913  rpn1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
119886045  [KO:K13249]
119886127  [KO:K10956]
119886147  os9; protein OS-9 [KO:K10088]
119886247  edem1; ER degradation-enhancing alpha-mannosidase-like protein 1 isoform X1 [KO:K10084]
119886256  sec61a1; protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
119886274  sec13; LOW QUALITY PROTEIN: protein SEC13 homolog [KO:K14004]
119886517  rpn2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
119886607  hspbp1; hsp70-binding protein 1 [KO:K09562]
119886612  ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
119886641  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
119887453  [KO:K12667]
119887497  [KO:K10839]
119888117  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
119888152  sil1; nucleotide exchange factor SIL1 [KO:K14001]
119888233  [KO:K19478]
119888258  sec24b; protein transport protein Sec24B isoform X1 [KO:K14007]
119888515  canx; calnexin [KO:K08054]
119888580  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
119888636  lman2; vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082]
119888662  ubxn1; UBX domain-containing protein 1 [KO:K24348]
119888693  wfs1b; wolframin isoform X1 [KO:K14020]
119888840  syvn1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
119888975  [KO:K06689] [EC:2.3.2.23]
119889172  ern1; LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
119889875  [KO:K10636] [EC:2.3.2.36]
119890012  [KO:K10636] [EC:2.3.2.36]
119890180  dnaja2a; dnaJ homolog subfamily A member 2a [KO:K09503]
119890589  zgc:153993; apoptosis regulator BAX [KO:K02159]
119890619  ero1a; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
119891200  ufd1l; ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
119891305  prkcsh; glucosidase 2 subunit beta [KO:K08288]
119891702  si:dkey-13n15.2; protein transport protein Sec24C [KO:K14007]
119891735  xbp1; X-box-binding protein 1 [KO:K09027]
119891826  [KO:K10575] [EC:2.3.2.23]
119892082  baxa; BCL2 associated X, apoptosis regulator a [KO:K02159]
119892113  [KO:K13525]
119892126  [KO:K03173] [EC:2.3.2.27]
119892142  [KO:K13989]
119892229  [KO:K14007]
119892352  [KO:K23741]
119892358  [KO:K04523]
119892454  ube2d4; ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
119892863  [KO:K14005]
119893117  hsp90b1; endoplasmin [KO:K09487]
119893369  mbtps1; membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
119893415  herpud1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
119893500  dnaja2b; dnaJ homolog subfamily A member 2b [KO:K09503]
119893714  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
119893914  [KO:K14014]
119894003  tmem258; transmembrane protein 258 [KO:K26502]
119895033  sec24a; protein transport protein Sec24A isoform X1 [KO:K14007]
119895062  stt3a; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
119895135  [KO:K09542]
119895190  hyou1; hypoxia up-regulated protein 1 isoform X1 [KO:K09486]
119895232  sar1b; GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
119895269  [KO:K03283]
119895311  [KO:K03283]
119895319  [KO:K03283]
119895386  ube2g1a; ubiquitin-conjugating enzyme E2 G1a [KO:K10575] [EC:2.3.2.23]
119895680  skp1; S-phase kinase-associated protein 1 [KO:K03094]
119895682  [KO:K03283]
119895688  [KO:K03283]
119895757  [KO:K01367] [EC:3.4.22.52]
119896515  dnajb1a; dnaJ homolog subfamily B member 1a [KO:K09507]
119896543  [KO:K03283]
119896558  [KO:K09561] [EC:2.3.2.27]
119896572  [KO:K09561] [EC:2.3.2.27]
119896622  [KO:K03347]
119896813  [KO:K01230] [EC:3.2.1.113]
119896814  [KO:K08057]
119896884  [KO:K14003]
119896886  [KO:K14003]
119897130  [KO:K04523]
119897252  [KO:K01230] [EC:3.2.1.113]
119897276  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
119897584  krtcap2; keratinocyte-associated protein 2 [KO:K28202]
119897619  [KO:K02161]
119897632  [KO:K02161]
119897674  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
119897977  derl1; derlin-1 isoform X1 [KO:K11519]
119898105  [KO:K07151] [EC:2.4.99.18]
119898261  [KO:K01230] [EC:3.2.1.113]
119898309  hsc70; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
119898408  [KO:K09027]
119898630  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
119898754  [KO:K08852] [EC:2.7.11.1 3.1.26.-]
119898950  mogs; mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
119898994  dnaja1; dnaJ homolog subfamily A member 1 [KO:K09502]
119899110  wfs1a; wolframin isoform X1 [KO:K14020]
119899297  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119899360  tusc3; tumor suppressor candidate 3 isoform X1 [KO:K19478]
119899463  dnajb1b; dnaJ homolog subfamily B member 1b [KO:K09507]
119899467  [KO:K13525]
119899606  sec23b; protein transport protein Sec23B [KO:K14006]
119899745  p4hb; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
119899861  rrbp1b; ribosome-binding protein 1b isoform X1 [KO:K14000]
119899878  [KO:K01367] [EC:3.4.22.52]
119899880  capn2l; calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
119899881  capn8; calpain-8 [KO:K03853] [EC:3.4.22.53]
119899882  [KO:K03853] [EC:3.4.22.53]
119900724  calr; calreticulin [KO:K08057]
119900762  cryaa; alpha-crystallin A chain [KO:K09541]
119900801  atf6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
119900853  edem3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
119900957  ubxn6; UBX domain-containing protein 6 isoform X1 [KO:K14011]
119901281  [KO:K10839]
119901627  [KO:K09525]
119901859  [KO:K08057]
119901881  sec62; translocation protein SEC62 [KO:K12275]
119901910  bag1; BAG family molecular chaperone regulator 1 [KO:K09555]
119902077  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
119902518  dad1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
119902535  [KO:K10661] [EC:2.3.2.27]
119902754  dnajc1; LOW QUALITY PROTEIN: dnaJ homolog subfamily C member 1 [KO:K09521]
119903529  ubxn4; UBX domain-containing protein 4 isoform X1 [KO:K24348]
119903753  ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
119903979  dnajb2; dnaJ homolog subfamily B member 2 isoform X1 [KO:K09508]
119904119  nfe2l2a; nuclear factor erythroid 2-related factor 2a [KO:K05638]
119904140  uggt2; UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [KO:K11718] [EC:2.4.1.-]
119904141  dnajc3a; dnaJ homolog subfamily C member 3a [KO:K09523]
119904498  man1a2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB isoform X1 [KO:K01230] [EC:3.2.1.113]
119904572  dnajb11; dnaJ homolog subfamily B member 11 [KO:K09517]
119904610  dnajc10; dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
119904802  [KO:K13249]
119905235  [KO:K10100]
119905236  [KO:K10100]
119905237  [KO:K10100]
119905287  zgc:113278; translocating chain-associated membrane protein 1-like 1 [KO:K14010]
119905299  dnajc5ab; dnaJ homolog subfamily C member 5 [KO:K09525]
119905458  nfe2; transcription factor NF-E2 45 kDa subunit [KO:K05638]
119905557  bcap31; B-cell receptor-associated protein 31 [KO:K14009]
119905623  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
119905803  nsfl1c; NSFL1 cofactor p47 [KO:K14012]
119905855  hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
119905981  ssr4; translocon-associated protein subunit delta [KO:K04571]
119905988  edem2; ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
119905989  ddost; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
119905997  [KO:K09525]
119906546  [KO:K05546] [EC:3.2.1.207]
119906728  ngly1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
119906754  [KO:K04523]
119907121  [KO:K07151] [EC:2.4.99.18]
119907199  atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
119907280  rnf5; E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
119907281  ssr2; translocon-associated protein subunit beta [KO:K13250]
119907718  [KO:K08056] [EC:5.3.4.1]
119908004  txndc5; thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
119908482  sec63; translocation protein SEC63 homolog [KO:K09540]
119908561  sec61g; protein transport protein Sec61 subunit gamma [KO:K07342]
119908666  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
119908722  pdia4; protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
119908761  dnajc5ga; dnaJ (Hsp40) homolog, subfamily C, member 5 gamma a isoform X1 [KO:K09525]
119908763  sel1l; protein sel-1 homolog 1 [KO:K14026]
119908862  pdia6; protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
119908886  hsp90aa1.1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha 1 [KO:K04079]
119908887  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
119908938  [KO:K10661] [EC:2.3.2.27]
119909090  ubxn2a; UBX domain-containing protein 2A isoform X1 [KO:K24349]
119909350  tram1; translocating chain-associated membrane protein 1 [KO:K14010]
119909529  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
119909531  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
119909551  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
119909577  man1a1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
119909865  [KO:K01367] [EC:3.4.22.52]
119909942  atxn3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
119910044  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
119910047  [KO:K14006]
119910090  uggt1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
119910177  sec23a; LOW QUALITY PROTEIN: protein transport protein Sec23A [KO:K14006]
119910188  [KO:K06689] [EC:2.3.2.23]
119910299  [KO:K01367] [EC:3.4.22.52]
119910300  [KO:K01367] [EC:3.4.22.52]
119910301  [KO:K01367] [EC:3.4.22.52]
119910381  [KO:K09525]
119910877  hspa4l; heat shock 70 kDa protein 4L [KO:K09485]
119910966  [KO:K09525]
119911359  prkn; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
119911773  sec24d; LOW QUALITY PROTEIN: protein transport protein Sec24D [KO:K14007]
119912106  dnajc3b; dnaJ homolog subfamily C member 3b [KO:K09523]
119912348  [KO:K08288]
119912465  plaa; phospholipase A-2-activating protein [KO:K14018]
119912604  mbtps2; membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
119913079  ostc; oligosaccharyltransferase complex subunit ostc [KO:K26501]
119913283  [KO:K13249]
119913377  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
119914179  hspa5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
119914203  [KO:K10575] [EC:2.3.2.23]
119914215  [KO:K23741]
119914238  sec31a; LOW QUALITY PROTEIN: protein transport protein Sec31A [KO:K14005]
119914339  si:ch211-282j22.3; ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
119914342  rad23b; UV excision repair protein RAD23 homolog B isoform X1 [KO:K10839]
119914559  derl2; derlin-2 [KO:K13989]
119914587  rnf185; E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
119914602  lman1; protein ERGIC-53 [KO:K10080]
119914612  ero1b; ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
119914658  [KO:K03173] [EC:2.3.2.27]
119914703  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
119915031  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
119915573  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119915702  sec31b; protein transport protein Sec31A [KO:K14005]
119915706  nploc4; nuclear protein localization protein 4 homolog [KO:K14015]
119915823  dnajb12b; dnaJ homolog subfamily B member 12b isoform X1 [KO:K09518]
119915850  sec24c; protein transport protein Sec24C isoform X1 [KO:K14007]
119915962  [KO:K09561] [EC:2.3.2.27]
119916002  ube2d1b; ubiquitin-conjugating enzyme E2 D1b isoform X1 [KO:K06689] [EC:2.3.2.23]
119916202  sar1aa; GTP-binding protein SAR1b isoform X1 [KO:K07953] [EC:3.6.5.-]
119916908  rrbp1a; ribosome-binding protein 1a isoform X1 [KO:K14000]
119916995  [KO:K06689] [EC:2.3.2.23]
119917030  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119917047  dnajb12a; dnaJ homolog subfamily B member 12a [KO:K09518]
119917186  bag2; BAG family molecular chaperone regulator 2 [KO:K09556]
119917329  erlec1; endoplasmic reticulum lectin 1 [KO:K14008]
119917497  sar1ab; secretion associated, Ras related GTPase 1Ab [KO:K07953] [EC:3.6.5.-]
119917655  [KO:K01367] [EC:3.4.22.52]
119917657  [KO:K03853] [EC:3.4.22.53]
119917792  [KO:K23741]
119918483  ckap4; cytoskeleton-associated protein 4 [KO:K13999]
Compound
C00076  Calcium cation
G00009  
G00010  
G00011  
G00012  
G10694  
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
msam00510  N-Glycan biosynthesis
msam03050  Proteasome
msam03060  Protein export
msam04210  Apoptosis
KO pathway
ko04141   

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