KEGG   PATHWAY: onl00380
Entry
onl00380                    Pathway                                
Name
Tryptophan metabolism - Oreochromis niloticus (Nile tilapia)
Class
Metabolism; Amino acid metabolism
Pathway map
onl00380  Tryptophan metabolism
onl00380

Module
onl_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:onl00380]
onl_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:onl00380]
onl_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:onl00380]
Other DBs
GO: 0006568 0009851
Organism
Oreochromis niloticus (Nile tilapia) [GN:onl]
Gene
100653403  cyp1b1; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
100689795  [KO:K00658] [EC:2.3.1.61]
100689827  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
100689833  [KO:K00669] [EC:2.3.1.87]
100689951  [KO:K00658] [EC:2.3.1.61]
100690180  [KO:K00669] [EC:2.3.1.87]
100691111  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
100691623  tph1; tryptophan 5-hydroxylase 1 isoform X1 [KO:K00502] [EC:1.14.16.4]
100692897  [KO:K00543] [EC:2.1.1.4]
100693723  [KO:K00128] [EC:1.2.1.3]
100694072  kyat1; kynurenine--oxoglutarate transaminase 1 isoform X2 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
100694382  [KO:K00502] [EC:1.14.16.4]
100694678  kyat3; kynurenine--oxoglutarate transaminase 3 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
100694950  aadat; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X1 [KO:K00825] [EC:2.6.1.7 2.6.1.39]
100695605  [KO:K03334] [EC:1.4.3.2]
100696141  [KO:K00502] [EC:1.14.16.4]
100696662  aoc1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
100697201  [KO:K03334] [EC:1.4.3.2]
100697334  asmt; acetylserotonin O-methyltransferase [KO:K00543] [EC:2.1.1.4]
100697591  tdo2; tryptophan 2,3-dioxygenase [KO:K00453] [EC:1.13.11.11]
100697938  acmsd; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [KO:K03392] [EC:4.1.1.45]
100698670  [KO:K00128] [EC:1.2.1.3]
100699093  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
100701127  [KO:K00252] [EC:1.3.8.6]
100701259  aldh8a1; aldehyde dehydrogenase family 8 member A1 [KO:K23234]
100702686  [KO:K00463] [EC:1.13.11.52]
100702912  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
100703044  [KO:K03334] [EC:1.4.3.2]
100703315  [KO:K03334] [EC:1.4.3.2]
100703423  [KO:K07515] [EC:4.2.1.17 1.1.1.211]
100703463  [KO:K00149] [EC:1.2.1.47 1.2.1.3]
100703971  ddc; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
100704158  [KO:K07515] [EC:4.2.1.17 1.1.1.211]
100704678  [KO:K00252] [EC:1.3.8.6]
100704813  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
100705559  dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
100705674  dhtkd1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [KO:K15791] [EC:1.2.4.-]
100705854  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
100706576  [KO:K00463] [EC:1.13.11.52]
100706625  [KO:K00274] [EC:1.4.3.4]
100706630  kmo; kynurenine 3-monooxygenase [KO:K00486] [EC:1.14.13.9]
100706826  aanat; serotonin N-acetyltransferase isoform X1 [KO:K00669] [EC:2.3.1.87]
100706847  haao; 3-hydroxyanthranilate 3,4-dioxygenase [KO:K00452] [EC:1.13.11.6]
100707184  aldh2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
100707441  [KO:K00149] [EC:1.2.1.47 1.2.1.3]
100707943  [KO:K03334] [EC:1.4.3.2]
100708434  aox6; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
100709249  kynu; kynureninase [KO:K01556] [EC:3.7.1.3]
100709434  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
100709900  afmid; kynurenine formamidase [KO:K01432] [EC:3.5.1.9]
100711847  [KO:K00274] [EC:1.4.3.4]
100712286  [KO:K03781] [EC:1.11.1.6]
102077099  [KO:K00274] [EC:1.4.3.4]
102078289  [KO:K00128] [EC:1.2.1.3]
102082725  [KO:K00149] [EC:1.2.1.47 1.2.1.3]
109194280  [KO:K00149] [EC:1.2.1.47 1.2.1.3]
109196929  [KO:K00149] [EC:1.2.1.47 1.2.1.3]
109197600  [KO:K00274] [EC:1.4.3.4]
109202929  [KO:K03781] [EC:1.11.1.6]
Compound
C00024  Acetyl-CoA
C00078  L-Tryptophan
C00108  Anthranilate
C00322  2-Oxoadipate
C00328  L-Kynurenine
C00331  Indolepyruvate
C00332  Acetoacetyl-CoA
C00398  Tryptamine
C00463  Indole
C00527  Glutaryl-CoA
C00632  3-Hydroxyanthranilate
C00637  Indole-3-acetaldehyde
C00643  5-Hydroxy-L-tryptophan
C00780  Serotonin
C00877  Crotonoyl-CoA
C00954  Indole-3-acetate
C00955  Indole-3-ethanol
C00978  N-Acetylserotonin
C01111  7,8-Dihydroxykynurenate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01249  7,8-Dihydro-7,8-dihydroxykynurenate
C01252  4-(2-Aminophenyl)-2,4-dioxobutanoate
C01598  Melatonin
C01717  4-Hydroxy-2-quinolinecarboxylic acid
C01987  2-Aminophenol
C02161  2-Aminophenoxazin-3-one
C02172  N-Acetylisatin
C02220  2-Aminomuconate
C02298  N-Acetylindoxyl
C02470  Xanthurenic acid
C02693  (Indol-3-yl)acetamide
C02700  L-Formylkynurenine
C02775  2,3-Dihydroxyindole
C02937  Indole-3-acetaldehyde oxime
C02938  3-Indoleacetonitrile
C03227  3-Hydroxy-L-kynurenine
C03230  (Indol-3-yl)glycolaldehyde
C03453  gamma-Oxalocrotonate
C03574  2-Formylaminobenzaldehyde
C03722  Quinolinate
C03824  2-Aminomuconate semialdehyde
C04409  2-Amino-3-carboxymuconate semialdehyde
C05634  5-Hydroxyindoleacetaldehyde
C05635  5-Hydroxyindoleacetate
C05636  3-Hydroxykynurenamine
C05637  4,8-Dihydroxyquinoline
C05638  5-Hydroxykynurenamine
C05639  4,6-Dihydroxyquinoline
C05640  Cinnavalininate
C05641  5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
C05642  Formyl-N-acetyl-5-methoxykynurenamine
C05643  6-Hydroxymelatonin
C05644  3-Methylindolepyruvate
C05645  4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
C05646  5-Hydroxyindolepyruvate
C05647  Formyl-5-hydroxykynurenamine
C05648  5-Hydroxy-N-formylkynurenine
C05651  5-Hydroxykynurenine
C05652  4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
C05653  Formylanthranilate
C05654  5-(2'-Formylethyl)-4,6-dihydroxypicolinate
C05655  5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
C05656  5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
C05658  Indoxyl
C05659  5-Methoxytryptamine
C05660  5-Methoxyindoleacetate
C05663  6-Hydroxykynurenate
C05830  8-Methoxykynurenate
C05831  3-Methoxyanthranilate
C05832  5-Hydroxyindoleacetylglycine
C05834  3-Methyldioxyindole
C05835  2-Formaminobenzoylacetate
C05837  Glucobrassicin
C06212  N-Methylserotonin
C06213  N-Methyltryptamine
C08313  Skatole
C10164  Picolinic acid
C16516  Indolylmethylthiohydroximate
C16517  Indolylmethyl-desulfoglucosinolate
C16518  S-(Indolylmethylthiohydroximoyl)-L-cysteine
C17203  N-Hydroxyl-tryptamine
C22006  (R)-(Indol-3-yl)lactate
C22202  2-Oxoindole-3-acetate
C23064  Didemethylasterriquinone D
Reference
PMID:15749753
  Authors
Woodward AW, Bartel B
  Title
Auxin: regulation, action, and interaction.
  Journal
Ann Bot 95:707-35 (2005)
DOI:10.1093/aob/mci083
Related
pathway
onl00010  Glycolysis / Gluconeogenesis
onl00400  Phenylalanine, tyrosine and tryptophan biosynthesis
onl00760  Nicotinate and nicotinamide metabolism
KO pathway
ko00380   

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