Entry Name B cell receptor signaling pathway - Papio anubis (olive baboon)
Description B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map Other DBs Organism Papio anubis (olive baboon) [GN:
panu ]
Gene 100510873 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649 ]
100997330 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
100997894 CD79B; B-cell antigen receptor complex-associated protein beta chain isoform X1 [KO:K06507 ]
101000384 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333 ]
101002278 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101002848 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332 ]
101002971 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
101003935 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
101004091 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
101004976 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
101007421 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369 ] [EC:3.4.22.-]
101008175 PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X3 [KO:K12230 ]
101008699 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
101009981 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
101011136 FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X3 [KO:K12560 ]
101011641 CD79A; B-cell antigen receptor complex-associated protein alpha chain isoform X1 [KO:K06506 ]
101011983 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861 ]
101015074 VAV2; guanine nucleotide exchange factor VAV2 isoform X7 [KO:K05730 ]
101016465 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
101016993 CARD11; caspase recruitment domain-containing protein 11 isoform X1 [KO:K07367 ]
101022083 DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X2 [KO:K12229 ]
101022961 VAV3; guanine nucleotide exchange factor VAV3 isoform X6 [KO:K05730 ]
101024785 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
101025310 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348 ] [EC:3.1.3.16 ]
101025841 BANK1; B-cell scaffold protein with ankyrin repeats isoform X7 [KO:K26239 ]
101026693 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348 ] [EC:3.1.3.16 ]
101026781 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X6 [KO:K02580 ]
103880198 LILRA5; LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Niiro H, Clark EA.
Title Regulation of B-cell fate by antigen-receptor signals.
Journal Reference Authors Kurosaki T.
Title Genetic analysis of B cell antigen receptor signaling.
Journal Reference Authors Nitschke L.
Title The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal Reference Authors Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title Complement: central to innate immunity and bridging to adaptive responses.
Journal Reference Authors Kurosaki T.
Title Regulation of B-cell signal transduction by adaptor proteins.
Journal Reference Authors Nitschke L, Tsubata T.
Title Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal Reference Authors Jumaa H, Hendriks RW, Reth M.
Title B cell signaling and tumorigenesis.
Journal Reference Authors Rickert RC.
Title Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal Reference Authors Zouali M, Sarmay G
Title B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal Reference Authors Chiles TC.
Title Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal Reference Authors Allam A, Marshall AJ
Title Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal Reference Authors Gold MR
Title To make antibodies or not: signaling by the B-cell antigen receptor.
Journal Reference Authors Fu C, Turck CW, Kurosaki T, Chan AC
Title BLNK: a central linker protein in B cell activation.
Journal Reference Authors Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal Reference Authors Shinohara H, Maeda S, Watarai H, Kurosaki T
Title IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal Related panu04610 Complement and coagulation cascades
KO pathway
