KEGG   PATHWAY: aju04622
Entry
aju04622                    Pathway                                
Name
RIG-I-like receptor signaling pathway - Acinonyx jubatus (cheetah)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
aju04622  RIG-I-like receptor signaling pathway
aju04622

Organism
Acinonyx jubatus (cheetah) [GN:aju]
Gene
106976066  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
106984839  interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
106986034  NFX1-type zinc finger-containing protein 1 [KO:K27391]
106980168  mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
106972602  ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:5.6.2.6]
106975974  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
106984620  TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
106985572  5-azacytidine-induced protein 2 isoform X2 [KO:K12651]
106980477  TANK-binding kinase 1-binding protein 1 isoform X1 [KO:K12652]
106988817  NF-kappa-B essential modulator isoform X1 [KO:K07210]
106981360  serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
106972924  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
106983140  interferon regulatory factor 3 isoform X3 [KO:K05411]
106988905  interferon regulatory factor 7 [KO:K09447]
128312015  interferon alpha-like [KO:K05414]
128312017  interferon beta-like [KO:K05414]
128312193  interferon alpha-like [KO:K05414]
106971015  interferon alpha-like [KO:K05414]
106971043  interferon alpha-2-like [KO:K05414]
106971134  interferon alpha [KO:K05414]
106989747  interferon alpha [KO:K05414]
106971145  interferon beta [KO:K05415]
128312016  interferon omega-1-like [KO:K05440]
106989748  interferon omega-1-like [KO:K05440]
113593637  interferon omega-1-like [KO:K05440]
113597877  interferon omega-1-like [KO:K05440]
106986384  interferon epsilon [KO:K05442]
106977830  interferon kappa [KO:K05441]
106971422  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
106982870  FAS-associated death domain protein [KO:K02373]
106976163  receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
106987995  caspase-8 [KO:K04398] [EC:3.4.22.61]
106987987  caspase-10 isoform X1 [KO:K04400] [EC:3.4.22.63]
106966935  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
106990012  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
106988322  NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
106965509  NF-kappa-B inhibitor alpha [KO:K04734]
106984704  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
106971136  transcription factor p65 [KO:K04735]
106989490  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
106983077  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
106976941  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
106975243  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
106969894  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
106970668  mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
106989581  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106972806  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
106987636  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
106987637  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
106972759  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106982166  interleukin-8 [KO:K10030]
106983958  tumor necrosis factor [KO:K03156]
106969467  interleukin-12 subunit alpha [KO:K05406]
106967679  interleukin-12 subunit beta isoform X2 [KO:K05425]
106982115  C-X-C motif chemokine 10 [KO:K12671]
106988378  double-stranded RNA-specific adenosine deaminase isoform X2 [KO:K12968] [EC:3.5.4.37]
106989931  E3 ubiquitin/ISG15 ligase TRIM25 isoform X1 [KO:K10652] [EC:2.3.2.27]
106977674  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
106984965  E3 ubiquitin-protein ligase RNF125 [KO:K12170] [EC:2.3.2.27]
106988777  ubiquitin-like protein ISG15 [KO:K12159]
106978885  autophagy protein 5 isoform X1 [KO:K08339]
106978931  ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
106983897  NLR family member X1 [KO:K12653]
106967746  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
106989013  OTU domain-containing protein 5 isoform X7 [KO:K12655] [EC:3.4.19.12]
106969649  suppressor of IKBKE 1 [KO:K12656]
106984213  ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
106989308  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
106977860  triokinase/FMN cyclase isoform X1 [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
Compound
C00046  RNA
Reference
PMID:15208624
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:19120475
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
PMID:19539500
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
PMID:18549796
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
PMID:19615405
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
PMID:19120476
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
PMID:18591413
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
PMID:19076341
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
PMID:18439848
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
PMID:18984593
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
PMID:19224920
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Reference
PMID:32668226
  Authors
Liu G, Gack MU
  Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
  Journal
Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017
Related
pathway
aju04010  MAPK signaling pathway
aju04120  Ubiquitin mediated proteolysis
aju04210  Apoptosis
aju04630  JAK-STAT signaling pathway
KO pathway
ko04622   
LinkDB

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