KEGG   PATHWAY: aju04726
Entry
aju04726                    Pathway                                
Name
Serotonergic synapse - Acinonyx jubatus (cheetah)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
aju04726  Serotonergic synapse
aju04726

Other DBs
GO: 0007210
Organism
Acinonyx jubatus (cheetah) [GN:aju]
Gene
106967384  tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
106977480  tryptophan 5-hydroxylase 1 isoform X2 [KO:K00502] [EC:1.14.16.4]
106968187  aromatic-L-amino-acid decarboxylase isoform X1 [KO:K01593] [EC:4.1.1.28 4.1.1.105]
106974109  synaptic vesicular amine transporter [KO:K08155]
106971854  chromaffin granule amine transporter [KO:K08155]
106965473  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
106986998  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
106988999  voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
106974264  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
106972003  5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
106985374  5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
106989230  5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
106975317  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
106976431  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
106976432  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
106981698  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
106968579  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
106978946  inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
106968786  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
106976077  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
106975306  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
106970449  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106980855  protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
106969232  mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
106990008  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106968512  cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
106968514  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
106968562  cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
106968584  cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
106977949  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
106965834  cytochrome P450 2C21 isoform X1 [KO:K07413] [EC:1.14.14.1]
106965832  cytochrome P450 2C41 isoform X1 [KO:K07413] [EC:1.14.14.1]
106979940  cytochrome P450 2D15 [KO:K07414] [EC:1.14.14.1]
106974984  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
106973491  cytochrome P450 4X1 [KO:K07428] [EC:1.14.14.1]
106989649  polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
106972408  polyunsaturated fatty acid lipoxygenase ALOX12 isoform X2 [KO:K00458] [EC:1.13.11.31]
106972446  arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
106972510  polyunsaturated fatty acid lipoxygenase ALOX15B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
106986637  prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
106967086  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
106983792  5-hydroxytryptamine receptor 3E-like [KO:K04819]
106983794  5-hydroxytryptamine receptor 3C [KO:K04819]
106983795  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3D [KO:K04819]
106980588  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3B [KO:K04819]
106983797  5-hydroxytryptamine receptor 3C-like [KO:K04819]
106980587  5-hydroxytryptamine receptor 3A [KO:K04819]
106981675  5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
106983381  5-hydroxytryptamine receptor 6 [KO:K04162]
106965838  5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
106969942  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
106969924  neuroendocrine secretory protein 55 [KO:K04632]
106984082  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
106973352  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106985791  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
106970052  small conductance calcium-activated potassium channel protein 2 isoform X1 [KO:K04943]
106970661  potassium voltage-gated channel subfamily D member 2 [KO:K04892]
106985742  gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
106974975  gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
106967792  gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
106969310  rap guanine nucleotide exchange factor 3 isoform X2 [KO:K08014]
106974329  amyloid-beta precursor protein isoform X1 [KO:K04520]
113604790  5-hydroxytryptamine receptor 1F [KO:K04153]
106968882  5-hydroxytryptamine receptor 1A [KO:K04153]
106969793  5-hydroxytryptamine receptor 1B [KO:K04153]
106972532  5-hydroxytryptamine receptor 1E [KO:K04153]
106977648  5-hydroxytryptamine receptor 1D [KO:K04153]
106975937  5-hydroxytryptamine receptor 5A [KO:K04161]
113598260  5-hydroxytryptamine receptor 5B [KO:K04161]
106977809  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
106982494  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
106973284  guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [KO:K04534]
106984654  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
106987417  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
106965344  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
106973885  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
106967264  guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
106981966  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
113593204  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3-like [KO:K04540]
106981725  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
106982557  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X3 [KO:K04541]
106970626  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
106973348  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
106989697  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
113593434  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
113592841  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
106969997  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
106985197  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
113596552  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X3 [KO:K04347]
106977369  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
106969996  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
106985188  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1 [KO:K04549]
106979326  caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
106975373  dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
106987957  GTPase HRas isoform X1 [KO:K02833]
106968778  GTPase KRas isoform X1 [KO:K07827]
106969596  GTPase NRas [KO:K07828]
106972677  serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
106970441  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
106977129  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106980282  dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
106986103  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
106986735  voltage-dependent N-type calcium channel subunit alpha-1B isoform X5 [KO:K04849]
106979067  G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
106967007  G protein-activated inward rectifier potassium channel 2 [KO:K05000]
113596242  G protein-activated inward rectifier potassium channel 3 [KO:K05002]
106984374  G protein-activated inward rectifier potassium channel 4 [KO:K04999]
106982268  short transient receptor potential channel 1 isoform X7 [KO:K04964]
106968707  sodium-dependent serotonin transporter isoform X1 [KO:K05037]
106972520  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
106972743  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
aju00380  Tryptophan metabolism
aju00590  Arachidonic acid metabolism
aju04020  Calcium signaling pathway
aju04721  Synaptic vesicle cycle
aju04976  Bile secretion
KO pathway
ko04726   
LinkDB

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