KEGG   PATHWAY: ath04141
Entry
ath04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Arabidopsis thaliana (thale cress)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ath04141  Protein processing in endoplasmic reticulum
ath04141

Other DBs
GO: 0030433 0034976
Organism
Arabidopsis thaliana (thale cress) [GN:ath]
Gene
AT1G78720  SecY protein transport family protein [KO:K10956]
AT1G29310  SecY protein transport family protein [KO:K10956]
AT2G18710  SCY1; SECY homolog 1 [KO:K10956]
AT2G34250  SecY protein transport family protein [KO:K10956]
AT5G60460  Preprotein translocase Sec, Sec61-beta subunit protein [KO:K09481]
AT2G45070  SEC61_BETA; Preprotein translocase Sec, Sec61-beta subunit protein [KO:K09481]
AT3G60540  Preprotein translocase Sec, Sec61-beta subunit protein [KO:K09481]
AT4G24920  secE/sec61-gamma protein transport protein [KO:K07342]
AT3G48570  secE/sec61-gamma protein transport protein [KO:K07342]
AT5G50460  secE/sec61-gamma protein transport protein [KO:K07342]
AT3G20920  translocation protein-like protein [KO:K12275]
AT1G79940  ATERDJ2A; DnaJ / Sec63 Brl domains-containing protein [KO:K09540]
AT4G21180  ATERDJ2B; DnaJ / Sec63 Brl domains-containing protein [KO:K09540]
AT1G76400  Ribophorin I [KO:K12666]
AT2G01720  Ribophorin I [KO:K12666]
AT4G21150  HAP6; ribophorin II (RPN2) family protein [KO:K12667]
AT1G32210  ATDAD1; Defender against death (DAD family) protein [KO:K12668]
AT2G35520  DAD2; Defender against death (DAD family) protein [KO:K12668]
AT5G66680  DGL1; dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit family protein [KO:K12670]
AT1G34130  STT3B; staurosporin and temperature sensitive 3-like b [KO:K07151] [EC:2.4.99.18]
AT5G19690  STT3A; staurosporin and temperature sensitive 3-like A [KO:K07151] [EC:2.4.99.18]
AT1G11560  Oligosaccharyltransferase complex/magnesium transporter family protein [KO:K19478]
AT1G61790  Oligosaccharyltransferase complex/magnesium transporter family protein [KO:K19478]
AT4G29870  Oligosaccharyltransferase complex/magnesium transporter family protein [KO:K26501]
AT4G29735  uncharacterized protein [KO:K26502]
AT1G24320  Six-hairpin glycosidases superfamily protein [KO:K01228] [EC:3.2.1.106]
AT1G67490  GCS1; glucosidase 1 [KO:K01228] [EC:3.2.1.106]
AT4G16660  heat shock protein 70 (Hsp 70) family protein [KO:K09486]
AT5G42020  BIP2; Heat shock protein 70 (Hsp 70) family protein [KO:K09490] [EC:3.6.4.10]
AT5G28540  BIP1; heat shock protein 70 (Hsp 70) family protein [KO:K09490] [EC:3.6.4.10]
AT1G09080  BIP3; Heat shock protein 70 (Hsp 70) family protein [KO:K09490] [EC:3.6.4.10]
AT3G62600  ATERDJ3B; DNAJ heat shock family protein [KO:K09517]
AT5G03160  P58IPK; DnaJ P58IPK-like protein [KO:K09523]
AT3G07770  Hsp89.1; HEAT SHOCK PROTEIN 89.1 [KO:K09487]
AT2G04030  CR88; Chaperone protein htpG family protein [KO:K09487]
AT4G24190  SHD; Chaperone protein htpG family protein [KO:K09487]
AT5G63840  RSW3; Glycosyl hydrolases family 31 protein [KO:K05546] [EC:3.2.1.207]
AT5G56360  PSL4; calmodulin-binding protein [KO:K08288]
AT5G61790  CNX1; calnexin 1 [KO:K08054]
AT5G07340  Calreticulin family protein [KO:K08054]
AT1G09210  CRT1b; calreticulin 1b [KO:K08057]
AT1G56340  CRT1a; calreticulin 1a [KO:K08057]
AT1G08450  CRT3; calreticulin 3 [KO:K08057]
AT3G21160  MNS2; alpha-mannosidase 2 [KO:K01230] [EC:3.2.1.113]
AT1G51590  MNS1; alpha-mannosidase 1 [KO:K01230] [EC:3.2.1.113]
AT1G30000  MNS3; alpha-mannosidase 3 [KO:K23741] [EC:3.2.1.209]
AT2G01470  STL2P; SEC12P-like 2 protein [KO:K14003]
AT5G50650  Transducin/WD40 repeat-like superfamily protein [KO:K14003]
AT5G50550  Transducin/WD40 repeat-like superfamily protein [KO:K14003]
AT3G52190  PHF1; phosphate transporter traffic facilitator1 [KO:K14003]
AT3G62560  Ras-related small GTP-binding family protein [KO:K07953] [EC:3.6.5.-]
AT1G56330  SAR1B; secretion-associated RAS 1B [KO:K07953] [EC:3.6.5.-]
AT1G02620  Ras-related small GTP-binding family protein [KO:K07953] [EC:3.6.5.-]
AT4G02080  SAR2; secretion-associated RAS super family 2 [KO:K07953] [EC:3.6.5.-]
AT1G09180  SARA1A; secretion-associated RAS super family 1 [KO:K07953] [EC:3.6.5.-]
AT2G30050  transducin family protein / WD-40 repeat family protein [KO:K14004]
AT3G01340  Transducin/WD40 repeat-like superfamily protein [KO:K14004]
AT3G63460  transducin family protein / WD-40 repeat family protein [KO:K14005]
AT1G18830  Transducin/WD40 repeat-like superfamily protein [KO:K14005]
AT3G23660  Sec23/Sec24 protein transport family protein [KO:K14006]
AT4G14160  Sec23/Sec24 protein transport family protein [KO:K14006]
AT1G05520  Sec23/Sec24 protein transport family protein [KO:K14006]
AT2G21630  Sec23/Sec24 protein transport family protein [KO:K14006]
AT5G43670  Sec23/Sec24 protein transport family protein [KO:K14006]
AT3G07100  ERMO2; Sec23/Sec24 protein transport family protein [KO:K14007]
AT4G32640  Sec23/Sec24 protein transport family protein [KO:K14007]
AT3G44340  CEF; uncharacterized protein [KO:K14007]
AT1G71220  EBS1; EMS-MUTAGENIZED BRI1 SUPPRESSOR 1 [KO:K11718] [EC:2.4.1.-]
AT1G27520  Glycosyl hydrolase family 47 protein [KO:K10084]
AT5G43710  Glycosyl hydrolase family 47 protein [KO:K10085]
AT5G60640  PDIL1-4; PDI-like 1-4 [KO:K09580] [EC:5.3.4.1]
AT1G77510  PDIL1-2; PDI-like 1-2 [KO:K09580] [EC:5.3.4.1]
AT1G21750  PDIL1-1; PDI-like 1-1 [KO:K09580] [EC:5.3.4.1]
AT3G16110  PDIL1-6; PDI-like 1-6 [KO:K09580] [EC:5.3.4.1]
AT1G52260  PDIL1-5; PDI-like 1-5 [KO:K09580] [EC:5.3.4.1]
AT3G54960  PDIL1-3; PDI-like 1-3 [KO:K09580] [EC:5.3.4.1]
AT1G35620  PDIL5-2; PDI-like 5-2 [KO:K09580] [EC:5.3.4.1]
AT2G47470  UNE5; thioredoxin family protein [KO:K09584] [EC:5.3.4.1]
AT1G04980  PDIL2-2; PDI-like 2-2 [KO:K09584] [EC:5.3.4.1]
AT2G32920  PDIL2-3; PDI-like 2-3 [KO:K09584] [EC:5.3.4.1]
AT2G38960  ERO2; endoplasmic reticulum oxidoreductins 2 [KO:K10950] [EC:1.8.4.-]
AT1G72280  ERO1; endoplasmic reticulum oxidoreductins 1 [KO:K10950] [EC:1.8.4.-]
AT5G35080  OS9; ER lectin-like protein [KO:K10088]
AT2G21160  Translocon-associated protein (TRAP), alpha subunit [KO:K13249]
AT2G16595  Translocon-associated protein (TRAP), alpha subunit [KO:K13249]
AT5G14030  translocon-associated protein beta (TRAPB) family protein [KO:K13250]
AT5G42570  B-cell receptor-associated 31-like protein [KO:K14009]
AT1G11905  B-cell receptor-associated protein 31-like protein [KO:K14009]
AT5G48660  B-cell receptor-associated protein 31-like protein [KO:K14009]
AT3G07190  B-cell receptor-associated protein 31-like protein [KO:K14009]
AT3G20450  B-cell receptor-associated protein 31-like protein [KO:K14009]
AT4G04860  DER2.2; DERLIN-2.2 [KO:K13989]
AT4G29330  DER1; DERLIN-1 [KO:K13989]
AT4G21810  DER2.1; DERLIN-2.1 [KO:K13989]
AT2G43210  Ubiquitin-like superfamily protein [KO:K24348]
AT1G04850  ubiquitin-associated (UBA)/TS-N domain-containing protein [KO:K24348]
AT2G01650  PUX2; plant UBX domain-containing protein 2 [KO:K14011]
AT4G15410  PUX5; serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B prime gamma [KO:K14012]
AT3G21660  UBX domain-containing protein [KO:K14012]
AT4G22150  PUX3; UBA/UBX domain protein [KO:K14012]
AT4G04210  PUX4; plant UBX domain containing protein 4 [KO:K14012]
AT3G53230  AtCDC48B; ATPase, AAA-type, CDC48 protein [KO:K13525]
AT3G09840  CDC48; cell division cycle 48 [KO:K13525]
AT5G03340  AtCDC48C; ATPase, AAA-type, CDC48 protein [KO:K13525]
AT3G63000  NPL41; NPL4-like protein 1 [KO:K14015]
AT2G47970  Nuclear pore localization protein NPL4 [KO:K14015]
AT2G21270  UFD1; ubiquitin fusion degradation 1 [KO:K14016]
AT4G38930  Ubiquitin fusion degradation UFD1 family protein [KO:K14016]
AT2G29070  Ubiquitin fusion degradation UFD1 family protein [KO:K14016]
AT3G12580  HSP70; heat shock protein 70 [KO:K03283]
AT3G09440  Heat shock protein 70 (Hsp 70) family protein [KO:K03283]
AT4G24280  cpHsc70-1; chloroplast heat shock protein 70-1 [KO:K03283]
AT5G49910  cpHsc70-2; chloroplast heat shock protein 70-2 [KO:K03283]
AT5G02490  Hsp70-2; Heat shock protein 70 (Hsp 70) family protein [KO:K03283]
AT5G02500  HSC70-1; heat shock cognate protein 70-1 [KO:K03283]
AT1G56410  ERD2; heat shock protein 70 (Hsp 70) family protein [KO:K03283]
AT1G16030  Hsp70b; heat shock protein 70B [KO:K03283]
AT3G44110  J3; DNAJ homologue 3 [KO:K09503]
AT5G22060  J2; DNAJ homologue 2 [KO:K09503]
AT3G57340  DnaJ heat shock amino-terminal domain protein (DUF1977) [KO:K09518]
AT5G05750  DNAJ heat shock N-terminal domain-containing protein [KO:K09518]
AT5G49060  DnaJ heat shock amino-terminal domain protein (DUF1977) [KO:K09518]
AT5G52640  HSP90.1; heat shock-like protein [KO:K04079]
AT5G56030  HSP81-2; heat shock protein 81-2 [KO:K04079]
AT5G56000  Hsp81.4; HEAT SHOCK PROTEIN 81.4 [KO:K04079]
AT5G56010  HSP81-3; heat shock protein 81-3 [KO:K04079]
AT3G53800  Fes1B; Fes1B [KO:K09562]
AT3G09350  Fes1A; Fes1A [KO:K09562]
AT5G02150  Fes1C; Fes1C [KO:K09562]
AT3G51980  ARM repeat superfamily protein [KO:K09562]
AT1G07400  HSP20-like chaperones superfamily protein [KO:K13993]
AT1G53540  HSP20-like chaperones superfamily protein [KO:K13993]
AT1G59860  HSP20-like chaperones superfamily protein [KO:K13993]
AT2G29500  HSP20-like chaperones superfamily protein [KO:K13993]
AT5G20970  HSP20-like chaperones superfamily protein [KO:K13993]
AT4G10250  ATHSP22.0; HSP20-like chaperones superfamily protein [KO:K13993]
AT1G52560  HSP20-like chaperones superfamily protein [KO:K13993]
AT1G54050  HSP20-like chaperones superfamily protein [KO:K13993]
AT4G21870  HSP20-like chaperones superfamily protein [KO:K13993]
AT4G27670  HSP21; heat shock protein 21 [KO:K13993]
AT4G25200  HSP23.6-MITO; mitochondrion-localized small heat shock protein 23.6 [KO:K13993]
AT5G51440  HSP20-like chaperones superfamily protein [KO:K13993]
AT5G59720  HSP18.2; heat shock protein 18.2 [KO:K13993]
AT3G46230  HSP17.4; heat shock protein 17.4 [KO:K13993]
AT5G12020  HSP17.6II; 17.6 kDa class II heat shock protein [KO:K13993]
AT5G12030  HSP17.6A; heat shock protein 17.6A [KO:K13993]
AT5G37670  HSP20-like chaperones superfamily protein [KO:K13993]
AT1G50670  OTU-like cysteine protease family protein [KO:K13719] [EC:3.1.2.-]
AT3G18860  transducin family protein / WD-40 repeat family protein [KO:K14018]
AT1G16190  RAD23A; Rad23 UV excision repair protein family [KO:K10839]
AT1G79650  RAD23B; Rad23 UV excision repair protein family [KO:K10839]
AT5G38470  RAD23D; Rad23 UV excision repair protein family [KO:K10839]
AT3G02540  RAD23C; Rad23 UV excision repair protein family [KO:K10839]
AT5G16090  RAD23 UV excision repair family protein [KO:K10839]
AT2G17190  ubiquitin family protein [KO:K04523]
AT2G17200  DSK2; ubiquitin family protein [KO:K04523]
AT5G49570  PNG1; peptide-N-glycanase 1 [KO:K01456] [EC:3.5.1.52]
AT3G54130  Josephin family protein [KO:K11863] [EC:3.4.22.-]
AT5G15400  U-box domain-containing protein [KO:K10597] [EC:2.3.2.27]
AT5G05470  EIF2_ALPHA; eukaryotic translation initiation factor 2 alpha subunit [KO:K03237]
AT2G40290  Eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
AT5G19660  S1P; SITE-1 protease [KO:K08653] [EC:3.4.21.112]
AT4G20310  Peptidase M50 family protein [KO:K07765] [EC:3.4.24.85]
AT2G17520  IRE1A; Endoribonuclease/protein kinase IRE1-like protein [KO:K08852] [EC:2.7.11.1 3.1.26.-]
AT4G34100  CER9; RING/U-box superfamily protein [KO:K10661] [EC:2.3.2.27]
AT4G32670  RING/FYVE/PHD zinc finger superfamily protein [KO:K10661] [EC:2.3.2.27]
AT3G17000  UBC32; ubiquitin-conjugating enzyme 32 [KO:K10578] [EC:2.3.2.23]
AT1G17280  UBC34; ubiquitin-conjugating enzyme 34 [KO:K04554] [EC:2.3.2.23]
AT5G50430  UBC33; ubiquitin-conjugating enzyme 33 [KO:K04554] [EC:2.3.2.23]
AT3G46460  UBC13; ubiquitin-conjugating enzyme 13 [KO:K10575] [EC:2.3.2.23]
AT3G55380  UBC14; ubiquitin-conjugating enzyme 14 [KO:K10575] [EC:2.3.2.23]
AT5G59300  UBC7; ubiquitin-conjugating enzyme E2 [KO:K10575] [EC:2.3.2.23]
AT3G16090  Hrd1A; RING/U-box superfamily protein [KO:K10601] [EC:2.3.2.27]
AT1G65040  Hrd1B; RING/U-box superfamily protein [KO:K10601] [EC:2.3.2.27]
AT4G03510  RMA1; RING membrane-anchor 1 [KO:K10666] [EC:2.3.2.27]
AT3G58030  RING/U-box superfamily protein [KO:K10666] [EC:2.3.2.27]
AT4G28270  RMA2; RING membrane-anchor 2 [KO:K10666] [EC:2.3.2.27]
AT4G27470  RMA3; RING membrane-anchor 3 [KO:K10666] [EC:2.3.2.27]
AT1G19310  RING/U-box superfamily protein [KO:K10666] [EC:2.3.2.27]
AT2G23780  RING/U-box superfamily protein [KO:K10666] [EC:2.3.2.27]
AT1G18260  EBS5; HCP-like superfamily protein [KO:K14026]
AT1G73570  HCP-like superfamily protein [KO:K14026]
AT4G25230  RIN2; RPM1 interacting protein 2 [KO:K10636] [EC:2.3.2.36]
AT5G51450  RIN3; RPM1 interacting protein 3 [KO:K10636] [EC:2.3.2.36]
AT3G07370  CHIP; carboxyl terminus of HSC70-interacting protein [KO:K09561] [EC:2.3.2.27]
AT3G08700  UBC12; ubiquitin-conjugating enzyme 12 [KO:K06689] [EC:2.3.2.23]
AT2G16740  UBC29; ubiquitin-conjugating enzyme 29 [KO:K06689] [EC:2.3.2.23]
AT5G56150  UBC30; ubiquitin-conjugating enzyme 30 [KO:K06689] [EC:2.3.2.23]
AT1G64230  UBC28; ubiquitin-conjugating enzyme 28 [KO:K06689] [EC:2.3.2.23]
AT3G08690  UBC11; ubiquitin-conjugating enzyme 11 [KO:K06689] [EC:2.3.2.23]
AT5G41700  UBC8; ubiquitin conjugating enzyme 8 [KO:K06689] [EC:2.3.2.23]
AT1G36340  UBC31; ubiquitin-conjugating enzyme 31 [KO:K06689] [EC:2.3.2.23]
AT5G53300  UBC10; ubiquitin-conjugating enzyme 10 [KO:K06689] [EC:2.3.2.23]
AT3G42830  RING/U-box superfamily protein [KO:K03868] [EC:2.3.2.32]
AT5G20570  RBX1; RING-box 1 [KO:K03868] [EC:2.3.2.32]
AT4G02570  CUL1; cullin 1 [KO:K03347]
AT1G02980  CUL2; cullin 2 [KO:K03347]
AT1G59790  Cullin family protein [KO:K03347]
AT1G59800  Cullin family protein [KO:K03347]
AT1G43140  Cullin family protein [KO:K03347]
AT1G75950  SKP1; S phase kinase-associated protein 1 [KO:K03094]
AT5G42190  E3 ubiquitin ligase SCF complex subunit SKP1/ASK1 family protein [KO:K03094]
AT1G20140  SK4; SKP1-like 4 [KO:K03094]
AT2G25700  SK3; SKP1-like 3 [KO:K03094]
AT2G03170  SK14; SKP1-like 14 [KO:K03094]
AT3G21830  SK8; SKP1-like 8 [KO:K03094]
AT3G21850  SK9; SKP1-like 9 [KO:K03094]
AT3G21860  SK10; SKP1-like 10 [KO:K03094]
AT3G60010  SK13; SKP1-like 13 [KO:K03094]
AT4G34210  SK11; SKP1-like 11 [KO:K03094]
AT4G34470  SK12; SKP1-like 12 [KO:K03094]
AT1G10230  SK18; E3 ubiquitin ligase SCF complex subunit SKP1/ASK1 family protein [KO:K03094]
AT2G03160  SK19; SKP1-like 19 [KO:K03094]
AT2G03190  SK16; SKP1-like 16 [KO:K03094]
AT2G20160  MEO; E3 ubiquitin ligase SCF complex subunit SKP1/ASK1 family protein [KO:K03094]
AT3G25650  SK15; SKP1-like 15 [KO:K03094]
AT3G60020  SK5; SKP1-like 5 [KO:K03094]
AT3G21840  SK7; SKP1-like 7 [KO:K03094]
AT3G53060  SK6; SKP1-like 6 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
ath00510  N-Glycan biosynthesis
ath03050  Proteasome
ath03060  Protein export
KO pathway
ko04141   
LinkDB

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