KEGG   PATHWAY: cbai04540
Entry
cbai04540                   Pathway                                
Name
Gap junction - Camelus bactrianus (Bactrian camel)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
cbai04540  Gap junction
cbai04540

Other DBs
GO: 0005921
Organism
Camelus bactrianus (Bactrian camel) [GN:cbai]
Gene
105077179  GJA1; LOW QUALITY PROTEIN: gap junction alpha-1 protein [KO:K07372]
105076870  GJD2; gap junction delta-2 protein [KO:K07373]
105080960  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
105080234  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105062385  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105063651  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105077813  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105073106  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105069374  PDGFC; platelet-derived growth factor C [KO:K05450]
105067589  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105067960  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105077672  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105074292  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105067674  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105065653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105078489  SOS2; son of sevenless homolog 2 [KO:K03099]
105078987  SOS1; son of sevenless homolog 1 [KO:K03099]
105069943  HRAS; GTPase HRas isoform X1 [KO:K02833]
105062297  KRAS; GTPase KRas [KO:K07827]
105079555  NRAS; GTPase NRas [KO:K07828]
105067475  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105069422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105078209  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105082839  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105069349  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105073493  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105068597  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
105069495  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
105061624  MAPK7; LOW QUALITY PROTEIN: mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
105074725  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105075967  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
105076201  tubulin alpha-1B chain isoform X1 [KO:K07374]
105076202  tubulin alpha-1C chain [KO:K07374]
105083466  tubulin alpha-1C chain-like [KO:K07374]
105064041  TUBA4A; tubulin alpha-4A chain [KO:K07374]
105070558  tubulin alpha-3 chain [KO:K07374]
105070561  tubulin alpha-3 chain [KO:K07374]
105080889  tubulin beta-3 chain-like [KO:K07375]
105078262  TUBB4A; tubulin beta-4A chain [KO:K07375]
105079775  TUBB2A; tubulin beta-2A chain [KO:K07375]
105074100  TUBB; tubulin beta chain [KO:K07375]
105071442  TUBB6; tubulin beta-6 chain [KO:K07375]
105071798  TUBB1; tubulin beta-1 chain [KO:K07375]
105073382  TUBB4B; tubulin beta-4B chain [KO:K07375]
105065534  CSNK1D; casein kinase I isoform delta [KO:K08959] [EC:2.7.11.1]
105071301  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
105075143  TJP1; LOW QUALITY PROTEIN: tight junction protein ZO-1 [KO:K05701]
105080806  ADRB1; beta-1 adrenergic receptor [KO:K04141]
105062066  DRD1; D(1A) dopamine receptor [KO:K04144]
105071802  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
105071803  neuroendocrine secretory protein 55 [KO:K04632]
105081085  DRD2; D(2) dopamine receptor [KO:K04145]
105080525  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105081234  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105063873  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
105068818  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105081635  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105076187  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105074271  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105082946  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
105064797  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105075498  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105068302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105069822  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
105070455  HTR2C; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2C [KO:K04157]
105066136  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
105077300  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
105083519  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
105078179  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
105067298  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105077045  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105082996  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
105082997  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
105070632  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105074761  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105062304  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105064212  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105063941  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105073669  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105074322  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105069394  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
105067608  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
105069370  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
105066302  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
105081869  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
105084003  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
cbai04010  MAPK signaling pathway
cbai04020  Calcium signaling pathway
cbai04060  Cytokine-cytokine receptor interaction
cbai04070  Phosphatidylinositol signaling system
cbai04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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