PATHWAY: cmao04145 Help
Entry
Name
Phagosome - Colossoma macropomum (tambaqui)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Colossoma macropomum (tambaqui) [GN:
cmao ]
Gene
118813930 sec22bb; vesicle-trafficking protein SEC22b-B isoform X1 [KO:K08517 ]
118800268 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118800271 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118800407 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
118800412 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118800973 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
118801145 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
118812839 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
118802010 H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751 ]
118802186 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
118802187 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118802188 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118802189 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118802191 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
118802193 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118802194 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118802205 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118802206 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
118802767 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
118825909 H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751 ]
118803781 H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751 ]
118803885 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
118803959 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751 ]
118814507 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
118826925 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
118827074 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
118796661 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118827111 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751 ]
118827156 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118827240 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
118827324 H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751 ]
118827398 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118827413 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
118827447 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118805272 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
118805274 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
118805275 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
118827691 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118827709 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118827783 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
118827784 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
118827786 class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751 ]
118827787 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118827788 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
118827790 RLA class I histocompatibility antigen, alpha chain 11/11-like [KO:K06751 ]
118827792 class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751 ]
118800602 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
118800603 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
118800605 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
118800606 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
118800607 SLA class II histocompatibility antigen, DQ haplotype C beta chain-like [KO:K06752 ]
118800608 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
118800609 H-2 class II histocompatibility antigen, E-Q beta chain-like isoform X1 [KO:K06752 ]
118800611 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
118800612 H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752 ]
118800614 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
118800615 H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752 ]
118800617 class II histocompatibility antigen, B-L beta chain-like isoform X1 [KO:K06752 ]
118801628 H-2 class II histocompatibility antigen, A-K beta chain-like [KO:K06752 ]
118801630 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
118801631 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
118801632 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
118801633 H-2 class II histocompatibility antigen, I-E beta chain-like isoform X1 [KO:K06752 ]
118801635 H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752 ]
118801636 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
118801638 H-2 class II histocompatibility antigen, A-B alpha chain-like [KO:K06752 ]
118813015 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
118813018 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
118813073 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
118813082 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
118801800 LOW QUALITY PROTEIN: SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
118801890 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
118802918 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
118802919 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
118802920 RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752 ]
118802922 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
118806102 hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182 ]
118823441 atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
118824832 atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
118798543 si:ch73-173p19.2; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a1 [KO:K02154 ]
118810535 tcirg1a; V-type proton ATPase 116 kDa subunit a3 isoform X1 [KO:K02154 ]
118800432 atp6v0a1b; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
118807316 tcirg1b; T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b isoform X1 [KO:K02154 ]
118824963 atp6v0a2a; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154 ]
118827199 atp6v0a2b; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a [KO:K02154 ]
118821847 atp6v0a1a; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
118814794 atp6v0cb; LOW QUALITY PROTEIN: ATPase H+ transporting V0 subunit cb [KO:K02155 ]
118825743 atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661 ]
118822770 atp6ap1a; ATPase H+ transporting accessory protein 1a [KO:K03662 ]
118799275 si:dkey-13a21.4; LOW QUALITY PROTEIN: ras-related protein rab7 [KO:K07897 ]
118823176 dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413 ]
118798728 LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414 ]
118822993 dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
118808653 dync1i2b; dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415 ]
118805489 dync1i2a; dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415 ]
118805830 dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416 ]
118817647 dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416 ]
118808281 sec61a1; protein transport protein Sec61 subunit alpha-like 1 [KO:K10956 ]
118808361 sec61a1l; protein transport protein Sec61 subunit alpha-like 2 [KO:K10956 ]
118798601 sec61g; protein transport protein Sec61 subunit gamma [KO:K07342 ]
118796891 low affinity immunoglobulin gamma Fc region receptor III-like [KO:K06498 ]
118826276 pulmonary surfactant-associated protein D-like isoform X1 [KO:K10068 ]
118818746 pla2r1; secretory phospholipase A2 receptor isoform X1 [KO:K06560 ]
118825468 LOW QUALITY PROTEIN: macrophage mannose receptor 1-like [KO:K06560 ]
118824326 scarb1; scavenger receptor class B member 1 isoform X1 [KO:K13885 ]
Compound
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
Authors
Stuart LM, Ezekowitz RA
Title
Phagocytosis: elegant complexity.
Journal
Reference
Authors
Tjelle TE, Lovdal T, Berg T
Title
Phagosome dynamics and function.
Journal
Reference
Authors
Dupuy AG, Caron E
Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
Journal
Reference
Authors
Brumell JH, Grinstein S
Title
Salmonella redirects phagosomal maturation.
Journal
Reference
Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
Journal
Reference
Authors
Luzio JP, Pryor PR, Bright NA
Title
Lysosomes: fusion and function.
Journal
Reference
Authors
Sumimoto H
Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
Journal
Related pathway
cmao04620 Toll-like receptor signaling pathway
KO pathway
LinkDB
All DBs