KEGG   PATHWAY: eai04726
Entry
eai04726                    Pathway                                
Name
Serotonergic synapse - Equus asinus (ass)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
eai04726  Serotonergic synapse
eai04726

Other DBs
GO: 0007210
Organism
Equus asinus (ass) [GN:eai]
Gene
106835485  TPH1; tryptophan 5-hydroxylase 1 isoform X1 [KO:K00502] [EC:1.14.16.4]
106826108  TPH2; tryptophan 5-hydroxylase 2 isoform X1 [KO:K00502] [EC:1.14.16.4]
106822940  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
106836377  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
106831222  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
106839455  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
106822066  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X8 [KO:K04851]
106826963  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
106823553  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X3 [KO:K04857]
106827891  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
106840829  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
106829676  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
106825688  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
106823182  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
106823191  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
106835172  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
106833627  PLCB3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
106848450  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
106834887  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
106834634  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
106835567  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
106823831  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106840859  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
106845632  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
106848262  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106841342  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
106841343  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
106841344  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
106841348  PLA2G4B; cytosolic phospholipase A2 beta isoform X2 [KO:K16342] [EC:3.1.1.4]
106846782  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
106842116  LOW QUALITY PROTEIN: cytochrome P450 2C21-like [KO:K07413] [EC:1.14.14.1]
106846703  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
106846096  cytochrome P450 2C19-like isoform X1 [KO:K07413] [EC:1.14.14.1]
106842115  LOW QUALITY PROTEIN: cytochrome P450 2C21-like [KO:K07413] [EC:1.14.14.1]
106828038  cytochrome P450 2C18-like [KO:K07413] [EC:1.14.14.1]
106842117  cytochrome P450 2C19-like isoform X1 [KO:K07413] [EC:1.14.14.1]
106842118  cytochrome P450 2C42-like [KO:K07413] [EC:1.14.14.1]
106846082  cytochrome P450 2C42-like isoform X1 [KO:K07413] [EC:1.14.14.1]
106848498  cytochrome P450 2D14-like [KO:K07414] [EC:1.14.14.1]
106848497  cytochrome P450 2D14-like [KO:K07414] [EC:1.14.14.1]
106848499  cytochrome P450 2D14-like isoform X1 [KO:K07414] [EC:1.14.14.1]
106845102  cytochrome P450 2D14-like [KO:K07414] [EC:1.14.14.1]
106848501  vitamin D(3) 25-hydroxylase-like [KO:K07414] [EC:1.14.14.1]
106845104  cytochrome P450 2D14-like isoform X1 [KO:K07414] [EC:1.14.14.1]
106833456  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
106833866  cytochrome P450 4X1-like [KO:K07428] [EC:1.14.14.1]
106846725  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
106844160  ALOX12; polyunsaturated fatty acid lipoxygenase ALOX12 [KO:K00458] [EC:1.13.11.31]
106844233  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
106844159  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
106844231  ALOX15B; polyunsaturated fatty acid lipoxygenase ALOX15B isoform X2 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
106842002  PTGS1; prostaglandin G/H synthase 1 isoform X1 [KO:K00509] [EC:1.14.99.1]
106846783  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
106840327  HTR3B; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3B [KO:K04819]
106840340  HTR3A; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3A [KO:K04819]
106834553  5-hydroxytryptamine receptor 3E-like isoform X1 [KO:K04819]
106834554  5-hydroxytryptamine receptor 3C-like [KO:K04819]
106838509  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
106839816  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
106830029  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
106825087  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
106825115  neuroendocrine secretory protein 55 [KO:K04632]
106823728  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
106844316  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
106824036  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106832185  KCNN2; small conductance calcium-activated potassium channel protein 2 isoform X1 [KO:K04943]
106829876  KCND2; potassium voltage-gated channel subfamily D member 2 [KO:K04892]
106837688  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
106832152  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
106841259  GABRB1; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
106836844  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X3 [KO:K08014]
106842471  amyloid-beta precursor protein isoform X1 [KO:K04520]
106823262  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
106844440  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
106835865  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
106839990  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
106835916  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
106823372  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
123285301  5-hydroxytryptamine receptor 5B isoform X1 [KO:K04161]
106830727  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X2 [KO:K04630]
106827362  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
106833450  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
106822188  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
106845218  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
106839312  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
106847320  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
106829312  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
106837154  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
106839490  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
106826827  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
106834701  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
106824013  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
106834157  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123281285  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
106826868  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
106838935  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
106826929  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
106825068  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
106836191  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X2 [KO:K04547]
106838940  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
106826447  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X2 [KO:K04549]
106830081  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
106837352  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
106824973  HRAS; GTPase HRas isoform X1 [KO:K02833]
106825548  KRAS; GTPase KRas isoform X2 [KO:K07827]
106829397  GTPase KRas-like [KO:K07827]
106835678  NRAS; GTPase NRas [KO:K07828]
106847984  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
106842618  BRAF; serine/threonine-protein kinase B-raf isoform X8 [KO:K04365] [EC:2.7.11.1]
106829345  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106830991  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106840602  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
106844288  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
106822757  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
106824778  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
106844532  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
106835808  KCNJ9; G protein-activated inward rectifier potassium channel 3 isoform X3 [KO:K05002]
106845695  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
106838128  TRPC1; short transient receptor potential channel 1 isoform X2 [KO:K04964]
106822048  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
106838325  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
106838326  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
eai00380  Tryptophan metabolism
eai00590  Arachidonic acid metabolism
eai04020  Calcium signaling pathway
eai04721  Synaptic vesicle cycle
eai04976  Bile secretion
KO pathway
ko04726   
LinkDB

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