KEGG   PATHWAY: hgl03040
Entry
hgl03040                    Pathway                                
Name
Spliceosome - Heterocephalus glaber (naked mole-rat)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
hgl03040  Spliceosome
hgl03040

Other DBs
GO: 0005681
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101711832  Ddx46; DEAD-box helicase 46 [KO:K12811] [EC:5.6.2.7]
101719937  Ddx39b; DExD-box helicase 39B [KO:K12812] [EC:5.6.2.7]
101705515  Dhx16; DEAH-box helicase 16 [KO:K12813] [EC:5.6.2.6]
101706098  Dhx38; DEAH-box helicase 38 [KO:K12815] [EC:5.6.2.6]
101706880  Cdc40; cell division cycle 40 [KO:K12816]
101705105  Prpf18; pre-mRNA processing factor 18 [KO:K12817]
101704043  Dhx8; DEAH-box helicase 8 [KO:K12818] [EC:5.6.2.6]
101724360  Slu7; SLU7 homolog, splicing factor [KO:K12819]
101703351  Dhx15; DEAH-box helicase 15 [KO:K12820] [EC:5.6.2.6]
101708266  Snrpb; small nuclear ribonucleoprotein polypeptides B and B1 [KO:K11086]
101700785  small nuclear ribonucleoprotein-associated protein B-like [KO:K11086]
101717437  Snrpd1; small nuclear ribonucleoprotein D1 polypeptide [KO:K11087]
101706238  Snrpd2; small nuclear ribonucleoprotein D2 polypeptide [KO:K11096]
101719211  Snrpd3; small nuclear ribonucleoprotein D3 polypeptide [KO:K11088]
101725291  small nuclear ribonucleoprotein Sm D3-like [KO:K11088]
101697428  Snrpe; small nuclear ribonucleoprotein polypeptide E [KO:K11097]
101725717  small nuclear ribonucleoprotein F-like [KO:K11098]
101701100  Snrpf; small nuclear ribonucleoprotein polypeptide F [KO:K11098]
101724662  Snrpg; small nuclear ribonucleoprotein polypeptide G [KO:K11099]
101710312  Snrnp70; small nuclear ribonucleoprotein U1 subunit 70 [KO:K11093]
101701871  Snrpa; small nuclear ribonucleoprotein polypeptide A [KO:K11091]
101697231  Snrpc; small nuclear ribonucleoprotein polypeptide C [KO:K11095]
101711870  Prpf40b; pre-mRNA processing factor 40 homolog B [KO:K12821]
101718799  Prpf40a; pre-mRNA processing factor 40 homolog A [KO:K12821]
101716537  Rbm25; RNA binding motif protein 25 [KO:K12822]
101707835  Ddx5; DEAD-box helicase 5 [KO:K12823] [EC:5.6.2.7]
101699595  Tcerg1; transcription elongation regulator 1 [KO:K12824]
101716667  Fus; FUS RNA binding protein [KO:K13098]
101698751  Snrpa1; small nuclear ribonucleoprotein polypeptide A' [KO:K11092]
101708607  Snrpb2; small nuclear ribonucleoprotein polypeptide B2 [KO:K11094]
101716117  Sf3a1; splicing factor 3a subunit 1 [KO:K12825]
101711645  Sf3a2; splicing factor 3a subunit 2 [KO:K12826]
101705541  Sf3a3; splicing factor 3a subunit 3 [KO:K12827]
101707227  Sf3b1; splicing factor 3b subunit 1 [KO:K12828]
101702423  Sf3b2; splicing factor 3b subunit 2 [KO:K12829]
101723195  Sf3b3; splicing factor 3b subunit 3 [KO:K12830]
101712760  Sf3b4; splicing factor 3b subunit 4 [KO:K12831]
101718196  Sf3b5; splicing factor 3b subunit 5 [KO:K12832]
101709432  Sf3b6; splicing factor 3b subunit 6 [KO:K12833]
101706112  Phf5a; PHD finger protein 5A [KO:K12834]
101709728  Ddx42; DEAD-box helicase 42 [KO:K12835] [EC:5.6.2.7]
101702719  U2af1; U2 small nuclear RNA auxiliary factor 1 [KO:K12836]
101725252  U2af2; U2 small nuclear RNA auxiliary factor 2 [KO:K12837]
101711469  Puf60; poly(U) binding splicing factor 60 [KO:K12838]
101726695  Smndc1; survival motor neuron domain containing 1 [KO:K12839]
101721629  Rbm17; RNA binding motif protein 17 [KO:K12840]
101700309  Cherp; calcium homeostasis endoplasmic reticulum protein [KO:K12841]
101705423  U2surp; U2 snRNP associated SURP domain containing [KO:K12842]
101724333  Rp9; retinitis pigmentosa 9 (autosomal dominant) [KO:K19604]
101700991  Lsm2; LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12621]
101708310  Lsm3; LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12622]
101720806  Lsm4; LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12623]
101720314  Lsm5; LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12624]
101699926  Lsm6; LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12625]
101709127  Lsm7; LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12626]
101708401  Lsm8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
106008778  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
101720204  Prpf3; pre-mRNA processing factor 3 [KO:K12843]
101704811  Prpf4; pre-mRNA processing factor 4 [KO:K12662]
101724207  Ppih; peptidylprolyl isomerase H [KO:K09567] [EC:5.2.1.8]
101697344  Prpf31; pre-mRNA processing factor 31 [KO:K12844]
101703114  Snu13; SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) [KO:K12845]
101698234  Snrnp27; small nuclear ribonucleoprotein U4/U6.U5 subunit 27 [KO:K12846]
101700883  Usp39; ubiquitin specific peptidase 39 [KO:K12847]
101706499  Sart1; squamous cell carcinoma antigen recognized by T-cells 1 [KO:K11984]
101715051  Zmat2; zinc finger matrin-type 2 [KO:K12848]
101711167  Prpf38a; pre-mRNA processing factor 38A [KO:K12849]
101720097  Prpf38b; pre-mRNA processing factor 38B [KO:K12850]
101709324  Eftud2; elongation factor Tu GTP binding domain containing 2 [KO:K12852]
101704077  Snrnp200; small nuclear ribonucleoprotein U5 subunit 200 [KO:K12854] [EC:5.6.2.6]
101704761  Prpf6; pre-mRNA processing factor 6 [KO:K12855]
101724713  Prpf8; pre-mRNA processing factor 8 [KO:K12856]
101704694  Snrnp40; small nuclear ribonucleoprotein U5 subunit 40 [KO:K12857]
101701280  U5 small nuclear ribonucleoprotein 40 kDa protein-like [KO:K12857]
101726476  Ddx23; DEAD-box helicase 23 [KO:K12858] [EC:5.6.2.7]
101724854  Txnl4a; thioredoxin like 4A [KO:K12859]
101719630  Prpf19; pre-mRNA processing factor 19 [KO:K10599] [EC:2.3.2.27]
101726375  Cdc5l; cell division cycle 5 like [KO:K12860]
101718582  Bcas2; BCAS2, pre-mRNA processing factor [KO:K12861]
101726396  Plrg1; pleiotropic regulator 1 [KO:K12862]
101714226  Cwc15; CWC15 spliceosome associated protein homolog [KO:K12863]
101701714  Ctnnbl1; catenin beta like 1 [KO:K12864]
101699805  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
101700637  heat shock 70 kDa protein 1B [KO:K03283]
101701238  Hspa6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
101708313  Hspa8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
101709749  Pqbp1; polyglutamine binding protein 1 [KO:K12865]
101719218  Wbp11; WW domain binding protein 11 [KO:K12866]
101720009  Snw1; SNW domain containing 1 [KO:K06063]
101700264  Xab2; XPA binding protein 2 [KO:K12867]
101696385  Syf2; SYF2 pre-mRNA splicing factor [KO:K12868]
101724733  Crnkl1; crooked neck pre-mRNA splicing factor 1 [KO:K12869]
101719994  Isy1; ISY1 splicing factor homolog [KO:K12870]
101709602  Ppil1; peptidylprolyl isomerase like 1 [KO:K12733] [EC:5.2.1.8]
101715585  Ppie; peptidylprolyl isomerase E [KO:K09564] [EC:5.2.1.8]
101713370  Ccdc12; coiled-coil domain containing 12 [KO:K12871]
101697142  Rbm22; RNA binding motif protein 22 [KO:K12872]
101700237  Bud31; BUD31 homolog [KO:K12873]
101724261  Aqr; aquarius intron-binding spliceosomal factor [KO:K12874]
101718648  Acin1; apoptotic chromatin condensation inducer 1 [KO:K12875]
101719673  Eif4a3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:5.6.2.7]
101702668  Rbm8a; RNA binding motif protein 8A [KO:K12876]
101709411  Magoh; mago homolog, exon junction complex core component [KO:K12877]
101710911  Magohb; mago homolog B, exon junction complex core component [KO:K12877]
101719619  Thoc1; THO complex 1 [KO:K12878]
101713273  THO complex subunit 2-like [KO:K12879]
101714686  Thoc2; THO complex 2 [KO:K12879]
101717461  Thoc3; THO complex 3 [KO:K12880]
101714006  Alyref; Aly/REF export factor [KO:K12881]
101698074  Ncbp1; nuclear cap binding protein subunit 1 [KO:K12882]
101713846  Ncbp2; nuclear cap binding protein subunit 2 [KO:K12883]
101711324  Hnrnpa1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
101703162  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
106007802  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101697298  Hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
101726433  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101697590  Hnrnpc; heterogeneous nuclear ribonucleoprotein C (C1/C2) [KO:K12884]
101712830  RNA-binding motif protein, X chromosome-like [KO:K12885]
101699169  Rbmx; RNA binding motif protein, X-linked [KO:K12885]
101697115  heterogeneous nuclear ribonucleoprotein K-like [KO:K12886]
101706445  Hnrnpk; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
101702054  Hnrnpm; heterogeneous nuclear ribonucleoprotein M [KO:K12887]
101726650  Hnrnpu; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
101726771  Pcbp1; poly(rC) binding protein 1 [KO:K12889]
101717304  poly(rC)-binding protein 1 [KO:K12889]
101699866  Srsf1; serine/arginine-rich splicing factor 1 [KO:K12890]
101700593  serine/arginine-rich splicing factor 1 [KO:K12890]
101721554  Srsf2; serine and arginine rich splicing factor 2 [KO:K12891]
101711396  Srsf3; serine and arginine rich splicing factor 3 [KO:K12892]
101703416  Srsf5; serine and arginine rich splicing factor 5 [KO:K12893]
101723832  Srsf4; serine and arginine rich splicing factor 4 [KO:K12893]
101719303  Srsf6; serine and arginine rich splicing factor 6 [KO:K12893]
101704042  Srsf7; serine and arginine rich splicing factor 7 [KO:K12896]
101697219  Srsf9; serine and arginine rich splicing factor 9 [KO:K21123]
101714544  Tra2b; transformer 2 beta homolog (Drosophila) [KO:K12897]
101724725  Tra2a; transformer 2 alpha homolog [KO:K12897]
101718912  Srsf10; serine and arginine rich splicing factor 10 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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