KEGG   PATHWAY: ko04061
Entry
ko04061                     Pathway                                

Name
Viral protein interaction with cytokine and cytokine receptor
Description
Viruses have evolved diverse mechanisms to evade detection and destruction by the immune system, including copying and repurposing host cytokine and cytokine receptor genes. Viral cytokines and cytokine receptors, together with a group of structurally unique, soluble, cytokine-binding or cytokine receptor-binding proteins, represent the three major molecular strategies for subversion and modulation of the host cytokine networks mainly in large DNA viruses. Viral cytokines and cytokine receptor homologs, including other binding proteins, may activate or inhibit cytokine signaling and possibly affect different aspects of immunity.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ko04061  Viral protein interaction with cytokine and cytokine receptor
ko04061

Drug
D06555  Amolimogene bepiplasmid (USAN)
D10707  Fostemsavir (USAN)
D10708  Fostemsavir tromethamine (USAN)
D10734  Temsavir (USAN)
Orthology
K23381  Poxvirus chemokine inhibitor
K22784  HCMV glycoprotein UL22A
K23382  Simplexvirus envelope glycoprotein G
K21538  Poxvirus tumor necrosis factor receptor II
K23391  MOCV1 interleukin 18 binding protein
K22973  EBV secreted protein BARF1
K12499  C-C motif chemokine 5
K05408  C-C motif chemokine 3
K16596  C-C motif chemokine 8
K22671  C-C motif chemokine 9
K21092  C-C motif chemokine 14
K21093  C-C motif chemokine 16
K05511  C-C motif chemokine 15/23
K16595  C-C motif chemokine 13
K05510  C-C motif chemokine 6
K05509  C-C motif chemokine 7
K21657  KSHV macrophage inflammatory protein 2
K22624  MOCV1 CC chemokine receptor antagonist
K23392  HHV6 CCRs chemokine agonist
K21040  HHV6 CCR2 chemokine agonist
K14624  C-C motif chemokine 2
K16598  C-C motif chemokine 27
K16597  C-C motif chemokine 11
K21097  C-C motif chemokine 24
K21096  C-C motif chemokine 26
K05513  C-C motif chemokine 28
K21083  C-C motif chemokine 17
K21095  C-C motif chemokine 22
K21658  KSHV protein vCCL3
K12964  C-C motif chemokine 4
K21659  KSHV protein K6
K24266  HIV envelope glycoprotein gp120
K14625  C-C motif chemokine 20
K05514  C-C motif chemokine 1
K13072  C-C motif chemokine 25
K21094  C-C motif chemokine 18
K05512  C-C motif chemokine 19
K16062  C-C motif chemokine 21
K05505  C-X-C motif chemokine 1/2/3
K05506  C-X-C motif chemokine 5/6
K10030  interleukin 8
K21046  HCMV chemokine vCXCL1
K10029  platelet basic protein
K05407  platelet factor 4
K05416  C-X-C motif chemokine 9
K12671  C-X-C motif chemokine 10
K12672  C-X-C motif chemokine 11
K10032  C-X-C motif chemokine 13
K10031  C-X-C motif chemokine 12
K10033  C-X-C motif chemokine 14
K05507  C motif chemokine 1
K22675  C motif chemokine 2
K05508  C-X3-C motif chemokine 1
K05443  interleukin 10
K21533  EBV viral interleukin 10
K05405  interleukin 6
K21670  KSHV interleukin 6
K05429  interleukin 2
K23069  HTLV-1 accessory protein p12I
K05482  interleukin 18
K05485  interleukin 37
K05444  interleukin 19
K22667  interleukin 20
K22668  interleukin 24
K23426  YLDV 134R protein
K03156  tumor necrosis factor superfamily, member 2
K05468  lymphotoxin alpha (TNF superfamily, member 1)
K05477  tumor necrosis factor ligand superfamily member 14
K21807  HPV protein E6
K23428  TPV TNF binding protein 2L
K19264  Simplexvirus envelope glycoprotein D
K04721  tumor necrosis factor ligand superfamily member 10
K21049  Cytomegalovirus protein UL141
K22633  interleukin 34
K05453  macrophage colony-stimulating factor 1
K04176  C-C chemokine receptor type 1
K22781  HCMV envelope protein US28
K23431  HHV6 CC-chemokine receptor U12
K04177  C-C chemokine receptor type 2
K23433  HHV6 G-protein coupled receptor homolog U51
K04178  C-C chemokine receptor type 3
K04179  C-C chemokine receptor type 4
K23432  HHV7 CC-chemokine receptor U12
K23434  HHV7 G-protein coupled receptor homolog U51
K04180  C-C chemokine receptor type 5
K04181  C-C chemokine receptor type 6
K04183  C-C chemokine receptor type 8
K21667  KSHV G-protein coupled receptor
K23427  Poxvirus chemokine receptor 7L
K04184  C-C chemokine receptor type 9
K04186  atypical chemokine receptor 4
K04185  C-C chemokine receptor type 10
K04182  C-C chemokine receptor type 7
K04175  C-X-C chemokine receptor type 1
K05050  C-X-C chemokine receptor type 2
K04188  C-X-C chemokine receptor type 3
K04190  C-X-C chemokine receptor type 5
K04189  C-X-C chemokine receptor type 4
K04304  C-X-C chemokine receptor type 7 (atypical chemokine receptor 3)
K04193  XC chemokine receptor 1
K04192  CX3C chemokine receptor 1
K05134  interleukin 10 receptor alpha
K05135  interleukin 10 receptor beta
K05055  interleukin 6 receptor
K05060  interleukin 6 signal transducer
K05068  interleukin 2 receptor alpha
K05069  interleukin 2 receptor beta
K05070  interleukin 2 receptor gamma
K05173  interleukin 18 receptor 1
K05174  interleukin 18 receptor accessory protein
K05136  interleukin 20 receptor alpha
K05137  interleukin 20 receptor beta
K05138  interleukin 22 receptor alpha 1
K03158  tumor necrosis factor receptor superfamily member 1A
K05141  tumor necrosis factor receptor superfamily member 1B
K03159  lymphotoxin beta receptor TNFR superfamily member 3
K05152  tumor necrosis factor receptor superfamily member 14
K04722  tumor necrosis factor receptor superfamily member 10A/B
K22701  tumor necrosis factor receptor superfamily member 10C
K22702  tumor necrosis factor receptor superfamily member 10D
K05090  macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
Reference
  Authors
Alcami A
  Title
Viral mimicry of cytokines, chemokines and their receptors.
  Journal
Nat Rev Immunol 3:36-50 (2003)
DOI:10.1038/nri980
Reference
  Authors
Pontejo SM, Murphy PM
  Title
Chemokines encoded by herpesviruses.
  Journal
J Leukoc Biol 102:1199-1217 (2017)
DOI:10.1189/jlb.4RU0417-145RR
Reference
  Authors
de Munnik SM, Smit MJ, Leurs R, Vischer HF
  Title
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
  Journal
Front Pharmacol 6:40 (2015)
DOI:10.3389/fphar.2015.00040
Reference
  Authors
Vischer HF, Siderius M, Leurs R, Smit MJ
  Title
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
  Journal
Nat Rev Drug Discov 13:123-39 (2014)
DOI:10.1038/nrd4189
Reference
PMID:9325239
  Authors
Smith CA, Smith TD, Smolak PJ, Friend D, Hagen H, Gerhart M, Park L, Pickup DJ, Torrance D, Mohler K, Schooley K, Goodwin RG
  Title
Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors.
  Journal
Virology 236:316-27 (1997)
DOI:10.1006/viro.1997.8730
Reference
PMID:9621074
  Authors
Isegawa Y, Ping Z, Nakano K, Sugimoto N, Yamanishi K
  Title
Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor.
  Journal
J Virol 72:6104-12 (1998)
DOI:10.1128/JVI.72.7.6104-6112.1998
Reference
PMID:9600978
  Authors
Damon I, Murphy PM, Moss B
  Title
Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.
  Journal
Proc Natl Acad Sci U S A 95:6403-7 (1998)
DOI:10.1073/pnas.95.11.6403
Reference
  Authors
Dewin DR, Catusse J, Gompels UA
  Title
Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform.
  Journal
J Immunol 176:544-56 (2006)
DOI:10.4049/jimmunol.176.1.544
Reference
  Authors
Fitzsimons CP, Gompels UA, Verzijl D, Vischer HF, Mattick C, Leurs R, Smit MJ
  Title
Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51.
  Journal
Mol Pharmacol 69:888-98 (2006)
DOI:10.1124/mol.105.015222
Reference
  Authors
Wang D, Bresnahan W, Shenk T
  Title
Human cytomegalovirus encodes a highly specific RANTES decoy receptor.
  Journal
Proc Natl Acad Sci U S A 101:16642-7 (2004)
DOI:10.1073/pnas.0407233101
Reference
  Authors
Viejo-Borbolla A, Martinez-Martin N, Nel HJ, Rueda P, Martin R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcami A
  Title
Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
  Journal
PLoS Pathog 8:e1002497 (2012)
DOI:10.1371/journal.ppat.1002497
Reference
  Authors
Alejo A, Ruiz-Arguello MB, Ho Y, Smith VP, Saraiva M, Alcami A
  Title
A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.
  Journal
Proc Natl Acad Sci U S A 103:5995-6000 (2006)
DOI:10.1073/pnas.0510462103
Reference
  Authors
Tadagaki K, Nakano K, Yamanishi K
  Title
Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors.
  Journal
J Virol 79:7068-76 (2005)
DOI:10.1128/JVI.79.11.7068-7076.2005
Reference
  Authors
Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG
  Title
Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.
  Journal
J Leukoc Biol 74:676-82 (2003)
DOI:10.1189/jlb.0503206
Reference
  Authors
Najarro P, Lee HJ, Fox J, Pease J, Smith GL
  Title
Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1.
  Journal
J Gen Virol 84:3325-36 (2003)
DOI:10.1099/vir.0.19591-0
Reference
  Authors
Najarro P, Gubser C, Hollinshead M, Fox J, Pease J, Smith GL
  Title
Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue.
  Journal
J Gen Virol 87:809-16 (2006)
DOI:10.1099/vir.0.81427-0
Reference
  Authors
Catusse J, Spinks J, Mattick C, Dyer A, Laing K, Fitzsimons C, Smit MJ, Gompels UA
  Title
Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes.
  Journal
Eur J Immunol 38:763-77 (2008)
DOI:10.1002/eji.200737618
Reference
PMID:8992974
  Authors
Liu Y, de Waal Malefyt R, Briere F, Parham C, Bridon JM, Banchereau J, Moore KW, Xu J
  Title
The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor.
  Journal
J Immunol 158:604-13 (1997)
Reference
  Authors
Yoon SI, Jones BC, Logsdon NJ, Walter MR
  Title
Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.
  Journal
Structure 13:551-64 (2005)
DOI:10.1016/j.str.2005.01.016
Reference
  Authors
Kotenko SV, Saccani S, Izotova LS, Mirochnitchenko OV, Pestka S
  Title
Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
  Journal
Proc Natl Acad Sci U S A 97:1695-700 (2000)
DOI:10.1073/pnas.97.4.1695
Reference
  Authors
Chang WL, Baumgarth N, Yu D, Barry PA
  Title
Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.
  Journal
J Virol 78:8720-31 (2004)
DOI:10.1128/JVI.78.16.8720-8731.2004
Reference
  Authors
Li H, Wang H, Nicholas J
  Title
Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.
  Journal
J Virol 75:3325-34 (2001)
DOI:10.1128/JVI.75.7.3325-3334.2001
Reference
  Authors
Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G
  Title
HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.
  Journal
Blood 98:823-9 (2001)
DOI:10.1182/blood.v98.3.823
Reference
  Authors
Xiang Y, Moss B
  Title
IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins.
  Journal
Proc Natl Acad Sci U S A 96:11537-42 (1999)
DOI:10.1073/pnas.96.20.11537
Reference
  Authors
Bartlett NW, Dumoutier L, Renauld JC, Kotenko SV, McVey CE, Lee HJ, Smith GL
  Title
A new member of the interleukin 10-related cytokine family encoded by a poxvirus.
  Journal
J Gen Virol 85:1401-12 (2004)
DOI:10.1099/vir.0.79980-0
Reference
PMID:9557689
  Authors
Strockbine LD, Cohen JI, Farrah T, Lyman SD, Wagener F, DuBose RF, Armitage RJ, Spriggs MK
  Title
The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.
  Journal
J Virol 72:4015-21 (1998)
DOI:10.1128/JVI.72.5.4015-4021.1998
Reference
  Authors
Snow AL, Martinez OM
  Title
Epstein-Barr virus: evasive maneuvers in the development of PTLD.
  Journal
Am J Transplant 7:271-7 (2007)
DOI:10.1111/j.1600-6143.2006.01650.x
Reference
  Authors
Shim AH, Chang RA, Chen X, Longnecker R, He X
  Title
Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
  Journal
Proc Natl Acad Sci U S A 109:12962-7 (2012)
DOI:10.1073/pnas.1205309109
Reference
  Authors
Filippova M, Song H, Connolly JL, Dermody TS, Duerksen-Hughes PJ
  Title
The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.
  Journal
J Biol Chem 277:21730-9 (2002)
DOI:10.1074/jbc.M200113200
Reference
  Authors
Brunetti CR, Paulose-Murphy M, Singh R, Qin J, Barrett JW, Tardivel A, Schneider P, Essani K, McFadden G
  Title
A secreted high-affinity inhibitor of human TNF from Tanapox virus.
  Journal
Proc Natl Acad Sci U S A 100:4831-6 (2003)
DOI:10.1073/pnas.0737244100
Reference
  Authors
Sciortino MT, Medici MA, Marino-Merlo F, Zaccaria D, Giuffre-Cuculletto M, Venuti A, Grelli S, Bramanti P, Mastino A
  Title
Involvement of gD/HVEM interaction in NF-kB-dependent inhibition of apoptosis by HSV-1 gD.
  Journal
Biochem Pharmacol 76:1522-32 (2008)
DOI:10.1016/j.bcp.2008.07.030
Reference
  Authors
Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemcovicova I, Wang EC, Stanton RJ, Macauley M, Norris P, Willen L, Ruckova E, Nomoto A, Schneider P, Hahn G, Zajonc DM, Ware CF, Wilkinson GW, Benedict CA
  Title
Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.
  Journal
Cell Host Microbe 13:324-35 (2013)
DOI:10.1016/j.chom.2013.02.003
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