Entry Name Viral protein interaction with cytokine and cytokine receptor
Description Viruses have evolved diverse mechanisms to evade detection and destruction by the immune system, including copying and repurposing host cytokine and cytokine receptor genes. Viral cytokines and cytokine receptors, together with a group of structurally unique, soluble, cytokine-binding or cytokine receptor-binding proteins, represent the three major molecular strategies for subversion and modulation of the host cytokine networks mainly in large DNA viruses. Viral cytokines and cytokine receptor homologs, including other binding proteins, may activate or inhibit cytokine signaling and possibly affect different aspects of immunity.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map ko04061 Viral protein interaction with cytokine and cytokine receptor
Ortholog table Drug D06555 Amolimogene bepiplasmid (USAN)
D10708 Fostemsavir tromethamine (USAN)
Orthology K23381 Poxvirus chemokine inhibitor
K22784 HCMV glycoprotein UL22A
K23382 Simplexvirus envelope glycoprotein G
K21538 Poxvirus tumor necrosis factor receptor II
K22973 Lymphocryptovirus secreted protein BARF1
K05511 C-C motif chemokine 15/23
K21657 KSHV macrophage inflammatory protein 2
K22624 MOCV1 CC chemokine receptor antagonist
K23392 HHV6 CCRs chemokine agonist
K21040 HHV6 CCR2 chemokine agonist
K24266 HIV envelope glycoprotein gp120
K05505 C-X-C motif chemokine 1/2/3
K05506 C-X-C motif chemokine 5/6
K05416 C-X-C motif chemokine 9
K12671 C-X-C motif chemokine 10
K12672 C-X-C motif chemokine 11
K10032 C-X-C motif chemokine 13
K10031 C-X-C motif chemokine 12
K10033 C-X-C motif chemokine 14
K05508 C-X3-C motif chemokine 1
K21533 Herpesviridae/Poxviridae viral interleukin 10
K23069 HTLV-1 accessory protein p12I
K03156 tumor necrosis factor superfamily, member 2
K05468 lymphotoxin alpha (TNF superfamily, member 1)
K05477 tumor necrosis factor ligand superfamily member 14
K21807 Alphapapillomavirus protein E6
K23428 TPV TNF binding protein 2L
K19264 Simplexvirus envelope glycoprotein D
K04721 tumor necrosis factor ligand superfamily member 10
K21049 Cytomegalovirus protein UL141
K05453 macrophage colony-stimulating factor 1
K04176 C-C chemokine receptor type 1
K22781 HCMV envelope protein US28
K23431 HHV6 CC-chemokine receptor U12
K04177 C-C chemokine receptor type 2
K23433 HHV6 G-protein coupled receptor homolog U51
K04178 C-C chemokine receptor type 3
K04179 C-C chemokine receptor type 4
K23432 HHV7 CC-chemokine receptor U12
K23434 HHV7 G-protein coupled receptor homolog U51
K04180 C-C chemokine receptor type 5
K04181 C-C chemokine receptor type 6
K04183 C-C chemokine receptor type 8
K21667 KSHV G-protein coupled receptor
K23427 Poxvirus chemokine receptor 7L
K04184 C-C chemokine receptor type 9
K04186 atypical chemokine receptor 4
K04185 C-C chemokine receptor type 10
K04182 C-C chemokine receptor type 7
K04175 C-X-C chemokine receptor type 1
K05050 C-X-C chemokine receptor type 2
K04188 C-X-C chemokine receptor type 3
K04190 C-X-C chemokine receptor type 5
K04189 C-X-C chemokine receptor type 4
K04304 C-X-C chemokine receptor type 7 (atypical chemokine receptor 3)
K04193 XC chemokine receptor 1
K04192 CX3C chemokine receptor 1
K05134 interleukin 10 receptor alpha
K05135 interleukin 10 receptor beta
K05060 interleukin 6 signal transducer
K05068 interleukin 2 receptor alpha
K05069 interleukin 2 receptor beta
K05070 interleukin 2 receptor gamma
K05173 interleukin 18 receptor 1
K05174 interleukin 18 receptor accessory protein
K05136 interleukin 20 receptor alpha
K05137 interleukin 20 receptor beta
K05138 interleukin 22 receptor alpha 1
K03158 tumor necrosis factor receptor superfamily member 1A
K05141 tumor necrosis factor receptor superfamily member 1B
K03159 lymphotoxin beta receptor TNFR superfamily member 3
K05152 tumor necrosis factor receptor superfamily member 14
K04722 tumor necrosis factor receptor superfamily member 10A/B
K22701 tumor necrosis factor receptor superfamily member 10C
K22702 tumor necrosis factor receptor superfamily member 10D
Reference Authors Alcami A
Title Viral mimicry of cytokines, chemokines and their receptors.
Journal Reference Authors Pontejo SM, Murphy PM
Title Chemokines encoded by herpesviruses.
Journal Reference Authors de Munnik SM, Smit MJ, Leurs R, Vischer HF
Title Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
Journal Reference Authors Vischer HF, Siderius M, Leurs R, Smit MJ
Title Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
Journal Reference Authors Smith CA, Smith TD, Smolak PJ, Friend D, Hagen H, Gerhart M, Park L, Pickup DJ, Torrance D, Mohler K, Schooley K, Goodwin RG
Title Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors.
Journal Reference Authors Isegawa Y, Ping Z, Nakano K, Sugimoto N, Yamanishi K
Title Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor.
Journal Reference Authors Damon I, Murphy PM, Moss B
Title Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.
Journal Reference Authors Dewin DR, Catusse J, Gompels UA
Title Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform.
Journal Reference Authors Fitzsimons CP, Gompels UA, Verzijl D, Vischer HF, Mattick C, Leurs R, Smit MJ
Title Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51.
Journal Reference Authors Wang D, Bresnahan W, Shenk T
Title Human cytomegalovirus encodes a highly specific RANTES decoy receptor.
Journal Reference Authors Viejo-Borbolla A, Martinez-Martin N, Nel HJ, Rueda P, Martin R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcami A
Title Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
Journal Reference Authors Alejo A, Ruiz-Arguello MB, Ho Y, Smith VP, Saraiva M, Alcami A
Title A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.
Journal Reference Authors Tadagaki K, Nakano K, Yamanishi K
Title Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors.
Journal Reference Authors Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG
Title Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.
Journal Reference Authors Najarro P, Lee HJ, Fox J, Pease J, Smith GL
Title Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1.
Journal Reference Authors Najarro P, Gubser C, Hollinshead M, Fox J, Pease J, Smith GL
Title Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue.
Journal Reference Authors Catusse J, Spinks J, Mattick C, Dyer A, Laing K, Fitzsimons C, Smit MJ, Gompels UA
Title Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes.
Journal Reference Authors Liu Y, de Waal Malefyt R, Briere F, Parham C, Bridon JM, Banchereau J, Moore KW, Xu J
Title The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor.
Journal J Immunol 158:604-13 (1997)
Reference Authors Yoon SI, Jones BC, Logsdon NJ, Walter MR
Title Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.
Journal Reference Authors Kotenko SV, Saccani S, Izotova LS, Mirochnitchenko OV, Pestka S
Title Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
Journal Reference Authors Chang WL, Baumgarth N, Yu D, Barry PA
Title Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.
Journal Reference Authors Li H, Wang H, Nicholas J
Title Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.
Journal Reference Authors Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G
Title HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.
Journal Reference Authors Xiang Y, Moss B
Title IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins.
Journal Reference Authors Bartlett NW, Dumoutier L, Renauld JC, Kotenko SV, McVey CE, Lee HJ, Smith GL
Title A new member of the interleukin 10-related cytokine family encoded by a poxvirus.
Journal Reference Authors Strockbine LD, Cohen JI, Farrah T, Lyman SD, Wagener F, DuBose RF, Armitage RJ, Spriggs MK
Title The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.
Journal Reference Authors Snow AL, Martinez OM
Title Epstein-Barr virus: evasive maneuvers in the development of PTLD.
Journal Reference Authors Shim AH, Chang RA, Chen X, Longnecker R, He X
Title Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
Journal Reference Authors Filippova M, Song H, Connolly JL, Dermody TS, Duerksen-Hughes PJ
Title The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.
Journal Reference Authors Brunetti CR, Paulose-Murphy M, Singh R, Qin J, Barrett JW, Tardivel A, Schneider P, Essani K, McFadden G
Title A secreted high-affinity inhibitor of human TNF from Tanapox virus.
Journal Reference Authors Sciortino MT, Medici MA, Marino-Merlo F, Zaccaria D, Giuffre-Cuculletto M, Venuti A, Grelli S, Bramanti P, Mastino A
Title Involvement of gD/HVEM interaction in NF-kB-dependent inhibition of apoptosis by HSV-1 gD.
Journal Reference Authors Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemcovicova I, Wang EC, Stanton RJ, Macauley M, Norris P, Willen L, Ruckova E, Nomoto A, Schneider P, Hahn G, Zajonc DM, Ware CF, Wilkinson GW, Benedict CA
Title Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.
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