Entry Name Viral protein interaction with cytokine and cytokine receptor
Description Viruses have evolved diverse mechanisms to evade detection and destruction by the immune system, including copying and repurposing host cytokine and cytokine receptor genes. Viral cytokines and cytokine receptors, together with a group of structurally unique, soluble, cytokine-binding or cytokine receptor-binding proteins, represent the three major molecular strategies for subversion and modulation of the host cytokine networks mainly in large DNA viruses. Viral cytokines and cytokine receptor homologs, including other binding proteins, may activate or inhibit cytokine signaling and possibly affect different aspects of immunity.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map ko04061 Viral protein interaction with cytokine and cytokine receptor
Drug D06555 Amolimogene bepiplasmid (USAN)
D10708 Fostemsavir tromethamine (USAN)
Orthology K03156 TNF, TNFA; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
K03159 TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
K04175 CXCR1, IL8RA, CD181; C-X-C chemokine receptor type 1
K04176 CCR1, CD191; C-C chemokine receptor type 1
K04177 CCR2, CD192; C-C chemokine receptor type 2
K04178 CCR3, CD193; C-C chemokine receptor type 3
K04179 CCR4, CD194; C-C chemokine receptor type 4
K04180 CCR5, CD195; C-C chemokine receptor type 5
K04181 CCR6, CD196; C-C chemokine receptor type 6
K04182 CCR7, CD197; C-C chemokine receptor type 7
K04183 CCR8, CDw198; C-C chemokine receptor type 8
K04184 CCR9, CDw199; C-C chemokine receptor type 9
K04185 CCR10; C-C chemokine receptor type 10
K04186 ACKR4, CCRL1, CCR11; atypical chemokine receptor 4
K04188 CXCR3, GPR9, CD183; C-X-C chemokine receptor type 3
K04189 CXCR4, CD184; C-X-C chemokine receptor type 4
K04190 CXCR5, BLR1, CD185; C-X-C chemokine receptor type 5
K04192 CX3CR1; CX3C chemokine receptor 1
K04193 XCR1; XC chemokine receptor 1
K04304 CXCR7, ACKR3, RDC1; C-X-C chemokine receptor type 7 (atypical chemokine receptor 3)
K04721 TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
K04722 TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
K05050 CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
K05055 IL6R, CD126; interleukin 6 receptor
K05060 IL6ST, GP130, CD130; interleukin 6 signal transducer
K05068 IL2RA, CD25; interleukin 2 receptor alpha
K05069 IL2RB, CD122; interleukin 2 receptor beta
K05070 IL2RG, CD132; interleukin 2 receptor gamma
K05090 CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1 ]
K05134 IL10RA, CD210A; interleukin 10 receptor alpha
K05135 IL10RB, CD210B; interleukin 10 receptor beta
K05136 IL20RA; interleukin 20 receptor alpha
K05137 IL20RB; interleukin 20 receptor beta
K05138 IL22RA1; interleukin 22 receptor alpha 1
K05141 TNFRSF1B, TNFR2, CD120b; tumor necrosis factor receptor superfamily member 1B
K05152 TNFRSF14, HVEM, CD270; tumor necrosis factor receptor superfamily member 14
K05173 IL18R1, IL1RRP, CD218a; interleukin 18 receptor 1
K05174 IL18RAP, ACPL, CD218b; interleukin 18 receptor accessory protein
K05407 PF4, CXCL4; platelet factor 4
K05408 CCL3; C-C motif chemokine 3
K05416 CXCL9; C-X-C motif chemokine 9
K05443 IL10, CSIF; interleukin 10
K05453 CSF1, MCSF; macrophage colony-stimulating factor 1
K05468 LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
K05477 TNFSF14, LIGHT, CD258; tumor necrosis factor ligand superfamily member 14
K05482 IL18, IL1F4; interleukin 18
K05485 IL37, IL1F7; interleukin 37
K05505 CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
K05506 CXCL5_6, SCYB5_6; C-X-C motif chemokine 5/6
K05507 XCL, SCM1; C motif chemokine
K05508 CX3CL1, NTT; C-X3-C motif chemokine 1
K05509 CCL7; C-C motif chemokine 7
K05510 CCL6; C-C motif chemokine 6
K05511 CCL15_23; C-C motif chemokine 15/23
K05512 CCL19, ELC; C-C motif chemokine 19
K05513 CCL28; C-C motif chemokine 28
K05514 CCL1; C-C motif chemokine 1
K10029 PPBP, CXCL7; platelet basic protein
K10030 IL8, CXCL8; interleukin 8
K10031 CXCL12; C-X-C motif chemokine 12
K10032 CXCL13; C-X-C motif chemokine 13
K10033 CXCL14, SCYB14; C-X-C motif chemokine 14
K12499 CCL5; C-C motif chemokine 5
K12671 CXCL10, IP10; C-X-C motif chemokine 10
K12672 CXCL11, I-TAC; C-X-C motif chemokine 11
K12964 CCL4; C-C motif chemokine 4
K13072 CCL25; C-C motif chemokine 25
K14624 CCL2, MCP1; C-C motif chemokine 2
K14625 CCL20; C-C motif chemokine 20
K16062 CCL21, SLC; C-C motif chemokine 21
K16595 CCL13; C-C motif chemokine 13
K16596 CCL8; C-C motif chemokine 8
K16597 CCL11; C-C motif chemokine 11
K16598 CCL27; C-C motif chemokine 27
K19264 gD; Simplexvirus envelope glycoprotein D
K21040 vCCL4b, U83; HHV6 CCR2 chemokine agonist
K21046 UL146; HCMV chemokine vCXCL1
K21049 UL141; Cytomegalovirus protein UL141
K21083 CCL17; C-C motif chemokine 17
K21092 CCL14; C-C motif chemokine 14
K21093 CCL16; C-C motif chemokine 16
K21094 CCL18; C-C motif chemokine 18
K21095 CCL22; C-C motif chemokine 22
K21096 CCL26; C-C motif chemokine 26
K21097 CCL24; C-C motif chemokine 24
K21533 vIL10; Herpesviridae/Poxviridae viral interleukin 10
K21538 vTNFR2; Poxvirus tumor necrosis factor receptor II
K21657 K4; KSHV macrophage inflammatory protein 2
K21658 K4.1; KSHV protein vCCL3
K21667 vGPCR; KSHV G-protein coupled receptor
K21670 vIL6, K2; KSHV interleukin 6
K21807 E6; Alphapapillomavirus protein E6
K22624 vCCL27; MOCV1 CC chemokine receptor antagonist
K22671 CCL9; C-C motif chemokine 9
K22701 TNFRSF10C, TRAILR3, DCR1, CD263; tumor necrosis factor receptor superfamily member 10C
K22702 TNFRSF10D, TRAILR4, DCR2, CD264; tumor necrosis factor receptor superfamily member 10D
K22781 US28; HCMV envelope protein US28
K22784 UL22A; HCMV glycoprotein UL22A
K22973 BARF1; Lymphocryptovirus secreted protein BARF1
K23069 p12I; HTLV-1 accessory protein p12I
K23381 vCCI; Poxvirus chemokine inhibitor
K23382 gG; Simplexvirus envelope glycoprotein G
K23392 vCCL4a, U83; HHV6 CCRs chemokine agonist
K23426 134R; YLDV 134R protein
K23427 7L; Poxvirus chemokine receptor 7L
K23428 2L; TPV TNF binding protein 2L
K23431 HHV6-U12; HHV6 CC-chemokine receptor U12
K23432 HHV7-U12; HHV7 CC-chemokine receptor U12
K23433 HHV6-U51; HHV6 G-protein coupled receptor homolog U51
K23434 HHV7-U51; HHV7 G-protein coupled receptor homolog U51
K24266 gp120; HIV envelope glycoprotein gp120
Reference Authors Alcami A
Title Viral mimicry of cytokines, chemokines and their receptors.
Journal Reference Authors Pontejo SM, Murphy PM
Title Chemokines encoded by herpesviruses.
Journal Reference Authors de Munnik SM, Smit MJ, Leurs R, Vischer HF
Title Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
Journal Reference Authors Vischer HF, Siderius M, Leurs R, Smit MJ
Title Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
Journal Reference Authors Smith CA, Smith TD, Smolak PJ, Friend D, Hagen H, Gerhart M, Park L, Pickup DJ, Torrance D, Mohler K, Schooley K, Goodwin RG
Title Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors.
Journal Reference Authors Isegawa Y, Ping Z, Nakano K, Sugimoto N, Yamanishi K
Title Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor.
Journal Reference Authors Damon I, Murphy PM, Moss B
Title Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.
Journal Reference Authors Dewin DR, Catusse J, Gompels UA
Title Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform.
Journal Reference Authors Fitzsimons CP, Gompels UA, Verzijl D, Vischer HF, Mattick C, Leurs R, Smit MJ
Title Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51.
Journal Reference Authors Wang D, Bresnahan W, Shenk T
Title Human cytomegalovirus encodes a highly specific RANTES decoy receptor.
Journal Reference Authors Viejo-Borbolla A, Martinez-Martin N, Nel HJ, Rueda P, Martin R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcami A
Title Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
Journal Reference Authors Alejo A, Ruiz-Arguello MB, Ho Y, Smith VP, Saraiva M, Alcami A
Title A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.
Journal Reference Authors Tadagaki K, Nakano K, Yamanishi K
Title Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors.
Journal Reference Authors Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG
Title Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.
Journal Reference Authors Najarro P, Lee HJ, Fox J, Pease J, Smith GL
Title Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1.
Journal Reference Authors Najarro P, Gubser C, Hollinshead M, Fox J, Pease J, Smith GL
Title Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue.
Journal Reference Authors Catusse J, Spinks J, Mattick C, Dyer A, Laing K, Fitzsimons C, Smit MJ, Gompels UA
Title Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes.
Journal Reference Authors Liu Y, de Waal Malefyt R, Briere F, Parham C, Bridon JM, Banchereau J, Moore KW, Xu J
Title The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor.
Journal J Immunol 158:604-13 (1997)
Reference Authors Yoon SI, Jones BC, Logsdon NJ, Walter MR
Title Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.
Journal Reference Authors Kotenko SV, Saccani S, Izotova LS, Mirochnitchenko OV, Pestka S
Title Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
Journal Reference Authors Chang WL, Baumgarth N, Yu D, Barry PA
Title Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.
Journal Reference Authors Li H, Wang H, Nicholas J
Title Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.
Journal Reference Authors Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G
Title HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.
Journal Reference Authors Xiang Y, Moss B
Title IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins.
Journal Reference Authors Bartlett NW, Dumoutier L, Renauld JC, Kotenko SV, McVey CE, Lee HJ, Smith GL
Title A new member of the interleukin 10-related cytokine family encoded by a poxvirus.
Journal Reference Authors Strockbine LD, Cohen JI, Farrah T, Lyman SD, Wagener F, DuBose RF, Armitage RJ, Spriggs MK
Title The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.
Journal Reference Authors Snow AL, Martinez OM
Title Epstein-Barr virus: evasive maneuvers in the development of PTLD.
Journal Reference Authors Shim AH, Chang RA, Chen X, Longnecker R, He X
Title Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
Journal Reference Authors Filippova M, Song H, Connolly JL, Dermody TS, Duerksen-Hughes PJ
Title The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.
Journal Reference Authors Brunetti CR, Paulose-Murphy M, Singh R, Qin J, Barrett JW, Tardivel A, Schneider P, Essani K, McFadden G
Title A secreted high-affinity inhibitor of human TNF from Tanapox virus.
Journal Reference Authors Sciortino MT, Medici MA, Marino-Merlo F, Zaccaria D, Giuffre-Cuculletto M, Venuti A, Grelli S, Bramanti P, Mastino A
Title Involvement of gD/HVEM interaction in NF-kB-dependent inhibition of apoptosis by HSV-1 gD.
Journal Reference Authors Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemcovicova I, Wang EC, Stanton RJ, Macauley M, Norris P, Willen L, Ruckova E, Nomoto A, Schneider P, Hahn G, Zajonc DM, Ware CF, Wilkinson GW, Benedict CA
Title Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.
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