KEGG   PATHWAY: lcat04144
Entry
lcat04144                   Pathway                                
Name
Endocytosis - Lemur catta (Ring-tailed lemur)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
lcat04144  Endocytosis
lcat04144

Other DBs
GO: 0006897
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123649488  ARF6; ADP-ribosylation factor 6 [KO:K07941]
123645883  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
123633587  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
123633964  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
123646423  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
123621237  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
123630263  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
123646411  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
123635307  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
123634378  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
123646132  CLTA; clathrin light chain A isoform X1 [KO:K04644]
123623488  CLTB; clathrin light chain B isoform X1 [KO:K04645]
123626268  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
123620407  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
123623804  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
123642962  AP2A2; AP-2 complex subunit alpha-2 [KO:K11824]
123620343  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
123630322  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
123623911  AP2S1; AP-2 complex subunit sigma [KO:K11827]
123623889  EHD2; EH domain-containing protein 2 [KO:K12469]
123645745  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
123627989  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
123648366  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
123635652  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
123624147  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
123621890  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
123631693  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
123630443  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
123647442  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123624835  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
123650464  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
123622909  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123623468  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
123645036  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123641479  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
123630580  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
123623983  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
123645732  SH3 domain-containing kinase-binding protein 1-like [KO:K12470]
123645068  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
123645749  SH3GL2; endophilin-A1 [KO:K11247]
123633981  SH3GL1; endophilin-A2 [KO:K11247]
123635441  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
123646380  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
123643971  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
123647136  AMPH; amphiphysin isoform X1 [KO:K12562]
123621110  EPN2; epsin-2 isoform X1 [KO:K12471]
123624791  EPN1; epsin-1 isoform X1 [KO:K12471]
123620465  EPN3; epsin-3 isoform X1 [KO:K12471]
123638020  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
123635660  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
123649214  SPART; spartin isoform X1 [KO:K19366]
123623075  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
123621591  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
123639534  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
123627975  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
123642600  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
123639656  RNF41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
123622421  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
123631568  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
123620537  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
123645044  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
123634498  LDLR; low-density lipoprotein receptor [KO:K12473]
123634390  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
123648500  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
123623100  CCR5; C-C chemokine receptor type 5 [KO:K04180]
123643506  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
123643346  C-X-C chemokine receptor type 2-like [KO:K05050]
123643644  CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
123643287  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
123630112  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
123648827  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
123625781  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
123642864  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
123621160  LOW QUALITY PROTEIN: G protein-coupled receptor kinase 4-like [KO:K08291] [EC:2.7.11.16]
123622219  GRK4; LOW QUALITY PROTEIN: G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
123623451  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
123650408  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
123621227  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
123641024  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
123647694  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
123636985  ACTR2; actin-related protein 2 [KO:K17260]
123647054  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
123643747  ACTR3; actin-related protein 3 [KO:K18584]
123631571  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
123631573  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
123643505  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
123636875  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
123626065  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
123623074  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
123646053  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
123627032  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
123646986  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
123643412  WIPF1; LOW QUALITY PROTEIN: WAS/WASL-interacting protein family member 1 [KO:K19475]
123620864  WIPF2; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
123631751  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
123631752  heat shock 70 kDa protein 1-like [KO:K03283]
123631753  heat shock 70 kDa protein 1 [KO:K03283]
123647169  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
123641226  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
123648561  heat shock cognate 71 kDa protein [KO:K03283]
123635556  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
123639350  WASHC4; WASH complex subunit 4 isoform X1 [KO:K18465]
123645005  WASHC5; WASH complex subunit 5 isoform X1 [KO:K18464]
123650021  WASH complex subunit 2-like isoform X1 [KO:K18462]
123620506  WASH complex subunit 1 [KO:K18461]
123620507  WASH complex subunit 1-like [KO:K18461]
123621136  WASH complex subunit 1-like [KO:K18461]
123639379  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
123647417  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
123640690  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
123635044  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
123635905  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
123626061  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
123641135  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
123650429  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
123625137  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
123628747  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
123633133  SNX3; sorting nexin-3 [KO:K17918]
123622593  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
123637060  STAM-binding protein [KO:K11866] [EC:3.4.19.12]
123625652  RAB7A; LOW QUALITY PROTEIN: ras-related protein Rab-7a [KO:K07897]
123650696  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
123625692  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
123643613  LOW QUALITY PROTEIN: signal transducing adapter molecule 2-like [KO:K04705]
123643663  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
123642509  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
123645841  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
123639371  MVB12A; multivesicular body subunit 12A isoform X1 [KO:K12186]
123644855  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
123632619  VPS37D; vacuolar protein sorting-associated protein 37D isoform X1 [KO:K12185]
123626106  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
123626500  VPS37A; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
123642777  VPS37C; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
123620753  SNF8; vacuolar-sorting protein SNF8 [KO:K12188]
123649285  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
123620975  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
123650675  CHMP6; charged multivesicular body protein 6 [KO:K12195]
123622427  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
123650838  CHMP4A; charged multivesicular body protein 4a isoform X1 [KO:K12194]
123645176  CHMP4C; charged multivesicular body protein 4c isoform X1 [KO:K24782]
123624760  CHMP2A; charged multivesicular body protein 2a isoform X1 [KO:K12191]
123630631  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
123626493  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
123621873  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
123625158  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
123633324  VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
123621830  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
123625400  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
123646217  CHMP5; charged multivesicular body protein 5 [KO:K12198]
123624995  IST1; IST1 homolog isoform X1 [KO:K19476]
123627571  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
123631326  SPG21; maspardin [KO:K19367]
123633432  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
123630961  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
123648506  SNX2; sorting nexin-2 isoform X1 [KO:K17917]
123622610  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
123641297  SNX32; sorting nexin-32 isoform X1 [KO:K17920]
123650237  SNX6; sorting nexin-6 isoform X1 [KO:K17920]
123622361  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123642937  HRAS; GTPase HRas isoform X1 [KO:K02833]
123623027  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
123639296  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
123628744  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
123623278  RHOA; transforming protein RhoA [KO:K04513]
123643616  transforming protein RhoA-like [KO:K04513]
123631673  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
123631675  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
123631677  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123631716  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
123641077  FOLR2; folate receptor beta [KO:K13649]
123641079  folate receptor alpha-like [KO:K13649]
123647402  CAV1; caveolin-1 isoform X1 [KO:K06278]
123647403  CAV2; caveolin-2 [KO:K12958]
123623506  CAV3; caveolin-3 [KO:K12959]
123636769  EHD3; EH domain-containing protein 3 [KO:K12476]
123629897  EHD4; EH domain-containing protein 4 [KO:K12477]
123639450  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
123628394  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
123639672  RAB5B; ras-related protein Rab-5B [KO:K07888]
123620954  RAB5C; ras-related protein Rab-5C [KO:K07889]
123650826  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
123625992  RBSN; rabenosyn-5 [KO:K12481]
123627426  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
123621812  RUFY1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
123650248  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
123641404  EHD1; EH domain-containing protein 1 [KO:K12483]
123633919  VPS45; vacuolar protein sorting-associated protein 45 [KO:K12479]
123630456  SNX4; sorting nexin-4 isoform X1 [KO:K17919]
123621502  RAB31; ras-related protein Rab-31 [KO:K07891]
123622064  RAB22A; ras-related protein Rab-22A isoform X1 [KO:K07891]
123636686  RAB10; ras-related protein Rab-10 [KO:K07903]
123639881  RAB8A; ras-related protein Rab-8A [KO:K07901]
123625944  RAB35; ras-related protein Rab-35 isoform X1 [KO:K07876]
123631555  RAB11A; ras-related protein Rab-11A [KO:K07904]
123635622  RAB11B; ras-related protein Rab-11B [KO:K07905]
123637043  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
123649778  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
123626689  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
123650163  ZFYVE27; protrudin isoform X1 [KO:K19368]
123639600  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
123639891  KIF5B; kinesin-1 heavy chain [KO:K10396]
123643313  KIF5C; kinesin heavy chain [KO:K10396]
123631379  RAB11FIP3; rab11 family-interacting protein 3 [KO:K12485]
123620305  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
123626590  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
123621670  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
123622725  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
123625220  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
123635996  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
123630254  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
123635868  CDC42; cell division control protein 42 homolog [KO:K04393]
123632988  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
123635696  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
123620245  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
123625884  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
123645037  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
123634428  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
123636579  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
123630414  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [KO:K12489]
123650866  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
123636025  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
123641071  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
123637355  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
123637906  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
123644160  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
123647510  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
123639591  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
123622770  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 [KO:K12492]
123640270  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
123642662  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
123637162  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
123637848  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
123626344  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
123650087  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
123638124  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
123640212  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
123628038  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
123631542  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
123639292  CYTH4; cytohesin-4 [KO:K18441]
123623870  CYTH2; cytohesin-2 [KO:K18441]
123620606  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
123644466  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
123622697  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
123650088  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
123649125  ARF1; ADP-ribosylation factor 1 [KO:K07937]
123620563  ARL17A; LOW QUALITY PROTEIN: ADP-ribosylation factor-like 17-like [KO:K07937]
123640436  ARF3; ADP-ribosylation factor 3 [KO:K07938]
123623365  ARF4; ADP-ribosylation factor 4 [KO:K07939]
123647408  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
lcat04060  Cytokine-cytokine receptor interaction
lcat04070  Phosphatidylinositol signaling system
lcat04130  SNARE interactions in vesicular transport
lcat04142  Lysosome
lcat04350  TGF-beta signaling pathway
KO pathway
ko04144   
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