KEGG   PATHWAY: lcat04142
Entry
lcat04142                   Pathway                                
Name
Lysosome biogenesis - Lemur catta (Ring-tailed lemur)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
lcat04142  Lysosome biogenesis
lcat04142

Other DBs
GO: 0005764
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620206  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
123620343  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
123620407  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
123620504  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
123620645  CTNS; cystinosin isoform X1 [KO:K12386]
123620790  OSBPL7; oxysterol-binding protein-related protein 7 [KO:K20463]
123620962  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
123621035  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
123621189  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
123621651  NPC1; NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
123621659  OSBPL1A; oxysterol-binding protein-related protein 1 isoform X1 [KO:K20174]
123621898  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
123621957  SPG11; spatacsin isoform X1 [KO:K19026]
123622048  LAMP5; lysosome-associated membrane glycoprotein 5 isoform X1 [KO:K28774]
123622135  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
123622155  TMEM175; endosomal/lysosomal potassium channel TMEM175 isoform X1 [KO:K24915]
123622158  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
123622174  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
123622222  BLOC1S6; biogenesis of lysosome-related organelles complex 1 subunit 6 [KO:K20188]
123622322  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
123622350  TTI1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
123622469  BLOC1S4; biogenesis of lysosome-related organelles complex 1 subunit 4 [KO:K08366]
123622512  OSBPL2; oxysterol-binding protein-related protein 2 [KO:K20174]
123622527  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
123622555  AP5S1; AP-5 complex subunit sigma-1 [KO:K19024]
123622659  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
123622682  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
123623010  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
123623025  SUMF1; formylglycine-generating enzyme isoform X1 [KO:K13444] [EC:1.8.3.7]
123623201  TLR9; toll-like receptor 9 [KO:K10161]
123623243  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
123623244  HYAL1; hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
123623245  HYAL3; hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
123623455  VPS13C; vacuolar protein sorting-associated protein 13C isoform X1 [KO:K19525]
123623488  CLTB; clathrin light chain B isoform X1 [KO:K04645]
123623512  [KO:K01365] [EC:3.4.22.15]
123623549  [KO:K02151]
123623565  ARL8B; LOW QUALITY PROTEIN: ADP-ribosylation factor-like protein 8B [KO:K07955]
123623783  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
123623799  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
123623804  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
123623911  AP2S1; AP-2 complex subunit sigma [KO:K11827]
123623963  BLOC1S3; biogenesis of lysosome-related organelles complex 1 subunit 3 [KO:K20186]
123623970  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
123624743  SCARB2; lysosome membrane protein 2 [KO:K12384]
123625137  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
123625175  PLA2G15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
123625207  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
123625319  MEAK7; MTOR-associated protein MEAK7 isoform X1 [KO:K27947]
123625385  GALNS; LOW QUALITY PROTEIN: N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
123625470  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
123625652  RAB7A; LOW QUALITY PROTEIN: ras-related protein Rab-7a [KO:K07897]
123625813  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
123625988  SLC15A4; solute carrier family 15 member 4 [KO:K14638]
123626018  TPCN1; two pore channel protein 1 isoform X1 [KO:K16896]
123626061  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
123626077  VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
123626108  ABCB9; ABC-type oligopeptide transporter ABCB9 [KO:K05656]
123626127  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
123626241  SNAP29; synaptosomal-associated protein 29 [KO:K08509]
123626268  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
123626391  [KO:K02150]
123626444  CLN8; protein CLN8 [KO:K12360]
123626488  ASAH1; acid ceramidase isoform X1 [KO:K12348] [EC:3.5.1.23]
123626492  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
123626496  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
123626546  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
123626593  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
123626611  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
123626753  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
123626778  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
123626948  ARL8A; ADP-ribosylation factor-like protein 8A [KO:K07955]
123627122  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
123627207  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
123627360  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
123627722  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
123627981  VAMP7; vesicle-associated membrane protein 7 isoform X1 [KO:K08515]
123627996  TLR8; toll-like receptor 8 [KO:K10170]
123627997  TLR7; toll-like receptor 7 isoform X1 [KO:K05404]
123628492  ATP6AP1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
123628552  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
123628577  TFE3; transcription factor E3 [KO:K09105]
123628798  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
123630149  VPS39; vam6/Vps39-like protein [KO:K20183]
123630307  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
123630322  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
123630530  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
123631444  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
123631449  CLCN7; H(+)/Cl(-) exchange transporter 7 isoform X1 [KO:K05016]
123631452  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
123631490  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
123631502  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
123631517  AP5Z1; AP-5 complex subunit zeta-1 isoform X1 [KO:K19025]
123631609  AP4M1; AP-4 complex subunit mu-1 isoform X1 [KO:K12402]
123631618  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
123631655  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
123631721  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
123631757  NEU1; sialidase-1 isoform X1 [KO:K01186] [EC:3.2.1.18]
123631767  CLN6; ceroid-lipofuscinosis neuronal protein 6 [KO:K12359]
123631776  PPT2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
123631822  [KO:K02153]
123631859  TFEB; transcription factor EB [KO:K15590]
123631933  SLC29A1; equilibrative nucleoside transporter 1 isoform X1 [KO:K15014]
123632342  ROGDI; protein rogdi homolog isoform X1 [KO:K24628]
123632350  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
123632388  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
123632482  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
123632661  GUSB; LOW QUALITY PROTEIN: beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
123632781  CLN3; battenin [KO:K12389]
123632993  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
123633002  SLC17A5; sialin isoform X1 [KO:K12301]
123633066  RRAGD; ras-related GTP-binding protein D [KO:K16186]
123633131  OSTM1; osteopetrosis-associated transmembrane protein 1 [KO:K23863]
123633148  CD164; sialomucin core protein 24 [KO:K06546]
123633156  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
123633233  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
123633333  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
123633432  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
123633923  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
123633926  CTSK; cathepsin K isoform X1 [KO:K01371] [EC:3.4.22.38]
123634063  GBA; lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
123634088  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
123634235  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
123634301  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
123634417  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
123634479  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
123634842  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
123634993  SORT1; sortilin isoform X1 [KO:K12388]
123635019  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
123635068  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
123635291  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
123635463  MCOLN3; mucolipin-3 [KO:K04994]
123635464  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
123635473  DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
123635704  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
123635727  RRAGC; ras-related GTP-binding protein C [KO:K16186]
123635865  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
123636596  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
123636627  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
123636881  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
123637027  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
123637103  MAN2B1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
123637125  VAMP8; vesicle-associated membrane protein 8 [KO:K08512]
123637263  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
123637952  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
123637959  [KO:K04370]
123637996  AP1M1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
123638052  SLC36A1; proton-coupled amino acid transporter 1 [KO:K14209]
123638054  [KO:K14209]
123638055  GM2A; ganglioside GM2 activator [KO:K12383]
123638241  BLOC1S5; biogenesis of lysosome-related organelles complex 1 subunit 5 isoform X1 [KO:K20187]
123638296  DTNBP1; dysbindin isoform X1 [KO:K20189]
123638357  BORCS8; BLOC-1-related complex subunit 8 isoform X1 [KO:K20822]
123638513  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
123638582  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
123638623  TLR3; toll-like receptor 3 [KO:K05401]
123638653  KXD1; kxDL motif-containing protein 1 [KO:K20818]
123638670  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
123638750  [KO:K14209]
123638891  SLC36A3; proton-coupled amino acid transporter 3 [KO:K14209]
123639283  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
123639381  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
123639430  [KO:K16344]
123639556  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
123639683  CD63; CD63 antigen [KO:K06497]
123639728  BLOC1S1; biogenesis of lysosome-related organelles complex 1 subunit 1 [KO:K20185]
123639996  BORCS5; BLOC-1-related complex subunit 5 isoform X1 [KO:K20819]
123639997  [KO:K02150]
123640038  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
123640178  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
123640287  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
123640372  [KO:K21398]
123640373  [KO:K21398]
123640741  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
123641084  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
123641135  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
123641307  CTSW; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
123641350  AP5B1; AP-5 complex subunit beta-1 isoform X1 [KO:K19022]
123641494  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
123641901  SLC29A2; equilibrative nucleoside transporter 2 isoform X1 [KO:K15014]
123642224  SLC36A4; proton-coupled amino acid transporter 4 [KO:K14209]
123642241  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
123642352  SMPD1; sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
123642366  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
123642673  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
123642746  [KO:K20456]
123642773  SLC15A3; solute carrier family 15 member 3 [KO:K14638]
123642805  TPCN2; two pore channel protein 2 isoform X1 [KO:K14077]
123642821  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
123642884  CTSF; LOW QUALITY PROTEIN: cathepsin F [KO:K01373] [EC:3.4.22.41]
123642904  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
123642930  OSBPL5; oxysterol-binding protein-related protein 5 isoform X1 [KO:K20464]
123642962  AP2A2; AP-2 complex subunit alpha-2 [KO:K11824]
123643415  GPR155; integral membrane protein GPR155 [KO:K28455]
123643596  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
123643687  OSBPL6; oxysterol-binding protein-related protein 6 isoform X1 [KO:K20463]
123644013  SLC11A1; LOW QUALITY PROTEIN: natural resistance-associated macrophage protein 1 [KO:K12347]
123644037  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
123644572  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
123644632  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
123644739  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
123644767  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
123644814  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
123645082  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
123645132  AP3S2; AP-3 complex subunit sigma-2 [KO:K12399]
123645151  TMEM251; transmembrane protein 251 isoform X1 [KO:K26747]
123645195  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
123645230  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
123645593  ABCA2; ATP-binding cassette sub-family A member 2 [KO:K05642]
123645783  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
123645869  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
123646015  VPS13A; vacuolar protein sorting-associated protein 13A isoform X1 [KO:K19525]
123646132  CLTA; clathrin light chain A isoform X1 [KO:K04644]
123646236  [KO:K01365] [EC:3.4.22.15]
123646312  STX17; syntaxin-17 isoform X1 [KO:K08491]
123646487  RRAGA; ras-related GTP-binding protein A [KO:K16185]
123646492  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
123646682  SLC2A6; solute carrier family 2, facilitated glucose transporter member 6 [KO:K08144]
123646721  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
123646932  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
123646963  [KO:K01197] [EC:3.2.1.35]
123646964  [KO:K01197] [EC:3.2.1.35]
123646965  [KO:K01197] [EC:3.2.1.35]
123647007  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
123647238  [KO:K01197] [EC:3.2.1.35]
123647395  [KO:K01197] [EC:3.2.1.35]
123647543  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
123647618  ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1 [KO:K19027]
123647669  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
123647683  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
123647708  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
123647778  OSBPL3; oxysterol-binding protein-related protein 3 isoform X1 [KO:K20463]
123647986  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
123648425  ARSB; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
123648517  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
123648546  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
123648580  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
123648607  AP3S1; AP-3 complex subunit sigma-1 [KO:K12399]
123648666  AP5M1; AP-5 complex subunit mu-1 isoform X1 [KO:K19023]
123648819  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
123648967  CLN5; ceroid-lipofuscinosis neuronal protein 5 isoform X1 [KO:K12390]
123649703  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
123650071  BORCS7; BLOC-1-related complex subunit 7 [KO:K20821]
123650132  BLOC1S2; biogenesis of lysosome-related organelles complex 1 subunit 2 isoform X1 [KO:K16750]
123650283  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
123650384  [KO:K12382]
123650389  SLC29A3; equilibrative nucleoside transporter 3 isoform X1 [KO:K15014]
123650409  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
123650429  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
123650610  ARSG; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
123650612  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
123650622  ABCA5; cholesterol transporter ABCA5 isoform X1 [KO:K05648]
123650672  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
123650743  GAA; LOW QUALITY PROTEIN: lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
123650784  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
123650889  CD68; macrosialin [KO:K06501]
123650925  BORCS6; BLOC-1-related complex subunit 6 [KO:K20820]
Compound
C00002  ATP
C00008  ADP
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Reference
PMID:19672277
  Authors
Saftig P, Klumperman J
  Title
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.
  Journal
Nat Rev Mol Cell Biol 10:623-35 (2009)
DOI:10.1038/nrm2745
Reference
PMID:31611045
  Authors
Savini M, Zhao Q, Wang MC
  Title
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
  Journal
Trends Cell Biol 29:876-887 (2019)
DOI:10.1016/j.tcb.2019.08.008
Reference
PMID:33433692
  Authors
Meyer-Schwesinger C
  Title
Lysosome function in glomerular health and disease.
  Journal
Cell Tissue Res 385:371-392 (2021)
DOI:10.1007/s00441-020-03375-7
Reference
PMID:34345172
  Authors
Allemailem KS, Almatroudi A, Alrumaihi F, Almatroodi SA, Alkurbi MO, Basfar GT, Rahmani AH, Khan AA
  Title
Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics.
  Journal
Int J Nanomedicine 16:5065-5098 (2021)
DOI:10.2147/IJN.S321343
Reference
PMID:36096887
  Authors
Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
  Title
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
  Journal
Nat Commun 13:5351 (2022)
DOI:10.1038/s41467-022-33025-1
Reference
PMID:38357444
  Authors
Liu Q, Wang W, Xu L, Zhang Q, Wang H
  Title
The host mannose-6-phosphate pathway and viral infection.
  Journal
Front Cell Infect Microbiol 14:1349221 (2024)
DOI:10.3389/fcimb.2024.1349221
Reference
PMID:38711187
  Authors
He Y, Fan Y, Ahmadpoor X, Wang Y, Li ZA, Zhu W, Lin H
  Title
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases.
  Journal
Med Res Rev 44:2472-2509 (2024)
DOI:10.1002/med.22047
Reference
PMID:40759742
  Authors
Radulovic M, Yang C, Stenmark H
  Title
Lysosomal membrane homeostasis and its importance in physiology and disease.
  Journal
Nat Rev Mol Cell Biol 27:71-87 (2026)
DOI:10.1038/s41580-025-00873-w
Reference
PMID:41214333
  Authors
Watson ET, Wegeng WR, Aravani S, Ernst AM, von Blume J
  Title
Mechanistic insights into cargo sorting and export from the Golgi apparatus.
  Journal
Nat Rev Mol Cell Biol 26:940-956 (2025)
DOI:10.1038/s41580-025-00907-3
Related
pathway
lcat00511  Other glycan degradation
lcat00531  Glycosaminoglycan degradation
lcat04130  SNARE interactions in vesicular transport
lcat04140  Autophagy - animal
lcat04144  Endocytosis
lcat04145  Phagosome
lcat04150  mTOR signaling pathway
lcat04620  Toll-like receptor signaling pathway
KO pathway
ko04142   

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