KEGG   PATHWAY: lco04625
Entry
lco04625                    Pathway                                
Name
C-type lectin receptor signaling pathway - Larimichthys crocea (large yellow croaker)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
lco04625  C-type lectin receptor signaling pathway
lco04625

Organism
Larimichthys crocea (large yellow croaker) [GN:lco]
Gene
104920460  hras; GTPase HRas [KO:K02833]
104924376  kras; GTPase KRas isoform X1 [KO:K07827]
104930345  GTPase HRas [KO:K07827]
104929243  mras; ras-related protein M-Ras [KO:K07831]
104937938  ras-related protein R-Ras isoform X1 [KO:K07830]
104919110  rras2; ras-related protein R-Ras2 [KO:K07830]
104940217  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109141199  putative transcription factor p65 homolog isoform X1 [KO:K04735]
104935826  relb; transcription factor RelB isoform X1 [KO:K09253]
104936631  interleukin-12 subunit alpha [KO:K05406]
104922998  interleukin-12 subunit beta [KO:K05425]
104938187  interleukin-12 subunit beta [KO:K05425]
104924236  il12b; interleukin-12 subunit beta isoform X1 [KO:K05425]
104923462  interleukin-1 beta [KO:K04519]
104935660  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
104919515  tyrosine-protein phosphatase non-receptor type 11 isoform X4 [KO:K07293] [EC:3.1.3.48]
104934925  ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
104923921  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104938682  uncharacterized protein LOC104938682 isoform X2 [KO:K04466] [EC:2.7.11.25]
104930409  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104928982  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104936701  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
104932460  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
104921973  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
104931270  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
104924371  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
104933529  itpr3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104935198  calmodulin [KO:K02183]
109138087  calm2; calmodulin-2 [KO:K02183]
104920473  calml4; calmodulin-like protein 4 [KO:K02183]
104936930  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
104931207  calm1; calmodulin-1 [KO:K02183]
104929377  calm3; calmodulin-3 [KO:K02183]
104919475  calglandulin [KO:K02183]
104920567  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104937635  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104924602  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
104937942  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104934810  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104930901  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
104918540  calcineurin subunit B type 1 [KO:K06268]
104931050  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104926509  nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
104923880  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
104935381  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
104918786  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
104927020  nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104937656  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
104925242  il10; interleukin-10 [KO:K05443]
104924319  egr2; E3 SUMO-protein ligase EGR2 [KO:K12496]
104928251  early growth response protein 2b [KO:K12496]
104931151  egr3; early growth response protein 3 [KO:K12497]
104921828  ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
104933455  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
104929510  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104932685  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104924727  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
109142120  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
104924732  caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
104939982  card9; caspase recruitment domain-containing protein 9 isoform X2 [KO:K12794]
104917716  bcl10; B-cell lymphoma/leukemia 10 [KO:K07368]
104917832  mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369] [EC:3.4.22.-]
104923641  mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369] [EC:3.4.22.-]
104918990  mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
104938225  caspase-8 [KO:K04398] [EC:3.4.22.61]
104938227  caspase-8 [KO:K04398] [EC:3.4.22.61]
104924422  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
104933745  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
104921662  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104931204  NF-kappa-B inhibitor alpha [KO:K04734]
104928653  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
104931067  tumor necrosis factor [KO:K03156]
104931068  tumor necrosis factor-like [KO:K03156]
104933337  tumor necrosis factor-like [KO:K03156]
104919509  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104923726  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104925765  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
104939458  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
104926599  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
104924523  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104924524  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104926477  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104922720  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
104924269  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
104928586  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104927418  jun; transcription factor AP-1 [KO:K04448]
104926010  transcription factor AP-1 [KO:K04448]
104937023  transcription factor AP-1 [KO:K04448]
104935532  cblb; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
104924055  fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
104936428  high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
104932986  CD209 antigen-like protein C isoform X1 [KO:K06563]
109138247  CD209 antigen-like protein C [KO:K06563]
104918032  arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
104933039  rho-related GTP-binding protein RhoA-C [KO:K04513]
104933314  transforming protein RhoA [KO:K04513]
104931794  rho-related GTP-binding protein RhoA-C [KO:K04513]
104932082  transforming protein RhoA [KO:K04513]
104918352  rho-related GTP-binding protein RhoA-B [KO:K04513]
104934413  ksr1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
104931385  kinase suppressor of Ras 1 isoform X1 [KO:K14958]
104936706  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
104923863  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
104928382  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
104925246  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
104926239  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
104920795  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
104939165  LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
104931961  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11221]
104934846  il17d; interleukin-17D [KO:K05492]
104934191  ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
104933539  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
104917650  cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
104939366  ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
104927342  bcl3; B-cell lymphoma 3 protein [KO:K09258]
104927913  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104925241  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
104922235  dc-sign; CD209 antigen-like protein E precursor [KO:K10059]
104922236  CD209 antigen-like protein E [KO:K10059]
104927097  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104919391  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104934900  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104921281  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104933269  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104935068  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104928409  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
104935222  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104930938  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
104921004  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
104934458  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3 [KO:K02649]
104918516  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104940519  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104931217  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104924791  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104935530  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104927096  E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
104921042  irf1; interferon regulatory factor 1 [KO:K09444]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
KO pathway
ko04625   
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