KEGG   PATHWAY: mmma04152
Entry
mmma04152                   Pathway                                
Name
AMPK signaling pathway - Marmota marmota marmota (Alpine marmot)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
mmma04152  AMPK signaling pathway
mmma04152

Other DBs
GO: 2000479
Organism
Marmota marmota marmota (Alpine marmot) [GN:mmma]
Gene
107153854  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
107157242  Stk11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
107138776  Cab39; calcium-binding protein 39 [KO:K08272]
107141031  Cab39l; calcium-binding protein 39-like [KO:K08272]
107158330  Strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
107138611  Stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
107144519  leptin [KO:K05424]
107141683  Lepr; leptin receptor isoform X2 [KO:K05062]
107156420  Camkk2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
107153902  Adra1a; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
107154358  Adipoq; adiponectin [KO:K07296]
107140684  Adipor1; adiponectin receptor protein 1 isoform X1 [KO:K07297]
107136673  LOW QUALITY PROTEIN: adiponectin receptor protein 1-like [KO:K07297]
107155011  Adipor2; LOW QUALITY PROTEIN: adiponectin receptor protein 2 [KO:K07297]
107149424  adiponectin receptor protein 1-like [KO:K07297]
107146329  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
107141439  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
107158637  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 isoform X2 [KO:K07199]
107158690  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
107138705  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
107148597  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
107148919  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
107151439  LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
107159869  Pfkfb1; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X2 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
107140598  Pfkfb2; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
107150217  Pfkfb3; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X2 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
107143518  Pfkfb4; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
107157625  Fbp1; fructose-1,6-bisphosphatase 1 isoform X1 [KO:K03841] [EC:3.1.3.11]
107157629  Fbp2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
107150196  ATP-dependent 6-phosphofructokinase, platelet type isoform X1 [KO:K00850] [EC:2.7.1.11]
107148581  Pfkm; ATP-dependent 6-phosphofructokinase, muscle type [KO:K00850] [EC:2.7.1.11]
107136169  Pfkl; ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
107137779  Hnf4a; hepatocyte nuclear factor 4-alpha isoform X1 [KO:K07292]
107136902  G6pc2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
107150526  G6pc3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
107150546  G6pc1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
107137458  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
107147855  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
107156765  Crtc2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
107138645  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
107147808  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
107135791  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X3 [KO:K09048]
107149021  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
107156760  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
107146134  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
107139157  Ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X3 [KO:K07202]
107157361  Elavl1; ELAV-like protein 1 [KO:K13088]
107156886  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
107136738  Ccna2; cyclin-A2 isoform X1 [KO:K06627]
107140851  Ccna1; cyclin-A1 [KO:K06627]
107146856  Eef2k; eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
107157280  Eef2; elongation factor 2 [KO:K03234]
107136379  forkhead box protein O1 [KO:K07201]
107140789  Foxo1; forkhead box protein O1 [KO:K07201]
107154329  Foxo3; forkhead box protein O3 [KO:K09408]
107154762  Sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
107157976  Slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
107151265  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
107152717  Gys2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
107151418  Lipe; hormone-sensitive lipase isoform X2 [KO:K07188] [EC:3.1.1.79]
107152270  Hmgcr; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1 [KO:K00021] [EC:1.1.1.34]
107157159  Srebf1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
107157670  Fasn; fatty acid synthase isoform X2 [KO:K00665] [EC:2.3.1.85]
107150363  Acaca; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
107149798  acyl-CoA desaturase 1-like [KO:K00507] [EC:1.14.19.1]
107149799  stearoyl-CoA desaturase isoform X1 [KO:K00507] [EC:1.14.19.1]
107149800  acyl-CoA desaturase 1 [KO:K00507] [EC:1.14.19.1]
107149801  acyl-CoA desaturase 1-like [KO:K00507] [EC:1.14.19.1]
107153622  Scd5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
107149944  stearoyl-CoA desaturase-like [KO:K00507] [EC:1.14.19.1]
107154522  Acacb; acetyl-CoA carboxylase 2 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
107151040  Mlycd; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
107157031  Cpt1a; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
107160253  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
107151236  Cpt1c; LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
107159463  Cidea; cell death activator CIDE-A isoform X2 [KO:K25893]
107148131  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
107155364  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
107137806  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
107145870  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
107159012  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
107153732  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
107138910  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
107152929  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
107153907  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
107147135  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
107143155  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
107135990  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
107143927  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2 [KO:K11584]
107150625  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5 [KO:K11584]
107145931  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
107140569  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
107139175  Tbc1d1; TBC1 domain family member 1 isoform X1 [KO:K18341]
107142434  Rab2a; ras-related protein Rab-2A [KO:K07877]
107145041  Rab8a; ras-related protein Rab-8A [KO:K07901]
107137446  Rab10; ras-related protein Rab-10 [KO:K07903]
107157599  ras-related protein Rab-10-like [KO:K07903]
107157371  Rab11b; ras-related protein Rab-11B [KO:K07905]
107152129  Rab14; ras-related protein Rab-14 [KO:K07881]
107144405  Cftr; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
107144584  Cd36; platelet glycoprotein 4 [KO:K06259]
107139962  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
107148359  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107157066  Ins; insulin [KO:K04526]
107157473  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
107138750  Irs1; insulin receptor substrate 1 [KO:K16172]
107140739  Irs2; insulin receptor substrate 2 [KO:K07187]
107146610  insulin receptor substrate 2-like [KO:K17445]
107143149  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107149519  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107155522  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107139438  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
107141811  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107145061  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107146703  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
107151082  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107140468  Akt3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
107151462  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107146721  Tsc2; tuberin isoform X1 [KO:K07207]
107151973  Tsc1; hamartin [KO:K07206]
107148921  Rheb; GTP-binding protein Rheb isoform X2 [KO:K07208]
107155502  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107157711  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
107151227  Akt1s1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
107150382  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
107157003  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
107155339  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
107151960  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
107150087  Pparg; peroxisome proliferator-activated receptor gamma isoform X2 [KO:K08530]
107159067  Ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
mmma00010  Glycolysis / Gluconeogenesis
mmma00061  Fatty acid biosynthesis
mmma00500  Starch and sucrose metabolism
mmma01040  Biosynthesis of unsaturated fatty acids
mmma04110  Cell cycle
mmma04140  Autophagy - animal
mmma04150  mTOR signaling pathway
mmma04151  PI3K-Akt signaling pathway
mmma04910  Insulin signaling pathway
mmma04920  Adipocytokine signaling pathway
KO pathway
ko04152   
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