KEGG   PATHWAY: morg04152
Entry
morg04152                   Pathway                                
Name
AMPK signaling pathway - Microtus oregoni (creeping vole)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
morg04152  AMPK signaling pathway
morg04152

Other DBs
GO: 2000479
Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121458412  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
121459850  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
121447008  Cab39; calcium-binding protein 39 [KO:K08272]
121434853  Cab39l; calcium-binding protein 39-like [KO:K08272]
121436236  Strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
121458910  STE20-related kinase adapter protein beta [KO:K17532]
121444850  STE20-related kinase adapter protein beta-like [KO:K17532]
121463213  leptin [KO:K05424]
121448166  Lepr; leptin receptor isoform X1 [KO:K05062]
121446232  Camkk2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
121456940  Adra1a; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
121465134  Adipoq; adiponectin [KO:K07296]
121465172  Adipor2; adiponectin receptor protein 2 [KO:K07297]
121446329  Adipor1; adiponectin receptor protein 1 [KO:K07297]
121432949  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
121447974  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
121438000  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
121446539  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
121439948  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
121447397  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
121441426  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
121445011  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
121445029  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1-like [KO:K19028] [EC:2.7.1.105 3.1.3.46]
121446048  Pfkfb2; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
121432645  Pfkfb3; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
121464394  Pfkfb4; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
121453372  fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
121453487  fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
121443370  fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
121443387  fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
121432556  ATP-dependent 6-phosphofructokinase, platelet type isoform X1 [KO:K00850] [EC:2.7.1.11]
121441503  Pfkm; ATP-dependent 6-phosphofructokinase, muscle type isoform X1 [KO:K00850] [EC:2.7.1.11]
121435395  Pfkl; ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
121460065  Hnf4a; hepatocyte nuclear factor 4-alpha isoform X1 [KO:K07292]
121442435  G6pc1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
121435992  G6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
121440880  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
121435017  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
121451067  Crtc2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
121433487  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
121463404  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
121458259  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
121459918  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
121450873  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
121437635  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
121439698  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
121442270  Ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
121464765  Elavl1; ELAV-like protein 1 [KO:K13088]
121454505  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
121457865  G1/S-specific cyclin-D1 [KO:K04503]
121452823  Ccna2; cyclin-A2 [KO:K06627]
121452921  Ccna1; cyclin-A1 [KO:K06627]
121458115  Eef2k; eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
121459489  Eef2; elongation factor 2 [KO:K03234]
121449503  LOW QUALITY PROTEIN: elongation factor 2-like [KO:K03234]
121452809  Foxo1; forkhead box protein O1 [KO:K07201]
121450039  Foxo3; forkhead box protein O3 [KO:K09408]
121451034  Sirt1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
121456757  Slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
121437846  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
121449491  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
121450098  Lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
121455744  Hmgcr; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [KO:K00021] [EC:1.1.1.34]
121456564  Srebf1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
121444071  fatty acid synthase-like isoform X1 [KO:K00665] [EC:2.3.1.85]
121444583  fatty acid synthase [KO:K00665] [EC:2.3.1.85]
121456289  Acaca; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
121454221  acyl-CoA desaturase 1 [KO:K00507] [EC:1.14.19.1]
121454234  stearoyl-CoA desaturase 2 [KO:K00507] [EC:1.14.19.1]
121454235  LOW QUALITY PROTEIN: stearoyl-CoA desaturase 4-like [KO:K00507] [EC:1.14.19.1]
121454384  acyl-CoA desaturase 3 [KO:K00507] [EC:1.14.19.1]
121446056  Acacb; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
121447422  Mlycd; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
121454015  Cpt1a; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
121461260  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
121453220  Cpt1c; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
121438832  Cidea; cell death activator CIDE-A isoform X1 [KO:K25893]
121462294  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
121457153  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121438281  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
121449197  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
121457440  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
121457507  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
121458392  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like [KO:K04354]
121453633  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
121436473  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
121442259  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
121455096  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
121464273  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
121452278  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
121454177  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
121452145  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
121450864  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
121434405  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
121435833  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
121460741  Tbc1d1; TBC1 domain family member 1 isoform X1 [KO:K18341]
121460683  ras-related protein Rab-2A-like [KO:K07877]
121451757  Rab2a; ras-related protein Rab-2A [KO:K07877]
121463115  Rab8a; ras-related protein Rab-8A [KO:K07901]
121439640  ras-related protein Rab-10 [KO:K07903]
121439645  ras-related protein Rab-10 [KO:K07903]
121459350  Rab11b; ras-related protein Rab-11B [KO:K07905]
121463164  Rab14; ras-related protein Rab-14 [KO:K07881]
121450991  ras-related protein Rab-14-like [KO:K07881]
121438031  ras-related protein Rab-14 [KO:K07881]
121463441  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
121459014  platelet glycoprotein 4 [KO:K06259]
121434774  platelet glycoprotein 4 [KO:K06259]
121461353  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
121453621  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121457317  Ins; insulin [KO:K04526]
121465153  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
121446925  Irs1; insulin receptor substrate 1 [KO:K16172]
121462188  Irs2; insulin receptor substrate 2 [KO:K07187]
121446140  insulin receptor substrate 1-like [KO:K17445]
121436878  LOW QUALITY PROTEIN: insulin receptor substrate 4-like [KO:K17446]
121437242  LOW QUALITY PROTEIN: insulin receptor substrate 4-like [KO:K17446]
121464321  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121453059  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121448116  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121441780  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
121455952  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121462841  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121448002  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121463628  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
121434429  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121449224  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121435875  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121463682  Tsc2; tuberin isoform X1 [KO:K07207]
121462616  Tsc1; hamartin isoform X1 [KO:K07206]
121439898  Rheb; GTP-binding protein Rheb [KO:K07208]
121448014  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
121441746  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
121436133  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
121444089  regulatory-associated protein of mTOR-like [KO:K07204]
121452091  Akt1s1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
121454174  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121457121  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121462285  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
121437699  Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
121446066  Ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
morg00010  Glycolysis / Gluconeogenesis
morg00061  Fatty acid biosynthesis
morg00500  Starch and sucrose metabolism
morg01040  Biosynthesis of unsaturated fatty acids
morg04110  Cell cycle
morg04140  Autophagy - animal
morg04150  mTOR signaling pathway
morg04151  PI3K-Akt signaling pathway
morg04910  Insulin signaling pathway
morg04920  Adipocytokine signaling pathway
KO pathway
ko04152   
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