KEGG   PATHWAY: morg04666
Entry
morg04666                   Pathway                                
Name
Fc gamma R-mediated phagocytosis - Microtus oregoni (creeping vole)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
Pathway map
morg04666  Fc gamma R-mediated phagocytosis
morg04666

Other DBs
GO: 0006909
Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121438466  immunoglobulin epsilon heavy chain-like [KO:K06856]
121450949  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
121438010  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
121455102  low affinity immunoglobulin gamma Fc region receptor III-like [KO:K06472]
121442024  low affinity immunoglobulin gamma Fc region receptor III-like [KO:K06472]
121455101  low affinity immunoglobulin gamma Fc region receptor IV-like isoform X1 [KO:K06463]
121442023  low affinity immunoglobulin gamma Fc region receptor IV-like [KO:K06463]
121446215  Ptprc; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
121460158  Hck; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
121451525  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
121453505  tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
121444492  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
121464321  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121453059  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121448116  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121441780  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
121455952  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121462841  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121448002  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121434429  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121449224  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121435875  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121454174  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121457121  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121460138  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
121447066  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
121455195  Prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
121432846  Prkce; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
121443425  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121466018  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121458143  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121464725  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121455158  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
121465529  cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
121465746  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
121465816  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
121465889  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
121449910  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
121461167  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
121449512  Marcks; myristoylated alanine-rich C-kinase substrate [KO:K12561]
121448270  Marcksl1; MARCKS-related protein [KO:K13536]
121456999  Pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
121452721  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
121455811  Plpp1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
121459445  Plpp2; LOW QUALITY PROTEIN: phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
121448357  Plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
121457079  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
121436240  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
121436286  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
121458065  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
121449728  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
121446343  Ncf1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
121462978  Gsn; gelsolin isoform X1 [KO:K05768]
121452305  Scin; adseverin isoform X1 [KO:K05768]
121462677  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
121459399  Vav1; proto-oncogene vav [KO:K05730]
121450228  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
121448012  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
121442572  wiskott-Aldrich syndrome protein homolog [KO:K05747]
121442675  LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein homolog [KO:K05747]
121450139  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
121459418  Actr2; actin-related protein 2 isoform X1 [KO:K17260]
121446270  Actr3; actin-related protein 3 [KO:K18584]
121439980  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
121464770  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
121465138  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
121447106  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
121446239  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
121433088  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
121455432  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
121463173  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
121464919  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
121461239  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
121449617  Wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
121448124  Wasf2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
121464989  Wasf3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
121458901  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121447291  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121446420  Limk1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
121459809  LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
121436566  LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
121454073  Cfl1; cofilin-1 [KO:K05765]
121452566  Cfl2; cofilin-2 [KO:K05765]
121459837  cofilin-1-like [KO:K05765]
121450990  cofilin-1-like [KO:K05765]
121438025  cofilin-1-like [KO:K05765]
121446264  cofilin-1-like [KO:K05765]
121440819  cofilin-1 [KO:K05765]
121459372  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
121453833  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
121450461  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
121437835  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
121452281  Arf6; ADP-ribosylation factor 6 [KO:K07941]
121456193  Crk; adapter molecule crk isoform X1 [KO:K04438]
121464797  Crkl; crk-like protein [KO:K04438]
121457447  Dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
121461057  Asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
121438893  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
121432362  Asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
121448158  Asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
121455099  low affinity immunoglobulin gamma Fc region receptor II-like [KO:K12560]
121442022  low affinity immunoglobulin gamma Fc region receptor II-like [KO:K12560]
121447511  Inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
121463745  Inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1 [KO:K15909] [EC:3.1.3.86]
121458898  GRB2-associated-binding protein 2 [KO:K08091]
121447346  GRB2-associated-binding protein 2 [KO:K08091]
121457992  Lat; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
121451922  Dnm2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
121453245  Bin1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
121443931  Amph; amphiphysin isoform X1 [KO:K12562]
121433578  Myo10; unconventional myosin-X isoform X1 [KO:K12559]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:12488490
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
DOI:10.1189/jlb.72.6.1092
Reference
PMID:11708889
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
DOI:10.1006/smim.2001.0330
Reference
PMID:15466916
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
DOI:10.1189/jlb.0804439
Reference
PMID:11244038
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
DOI:10.1146/annurev.immunol.19.1.275
Reference
PMID:18322649
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
DOI:10.1007/s00018-008-7578-4
Reference
PMID:10376013
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
DOI:10.1002/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#
Reference
PMID:10577498
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
DOI:10.1002/jlb.66.5.712
Reference
PMID:10224668
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
DOI:10.1016/S1357-2725(98)00108-3
Reference
PMID:11228151
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
PMID:17050193
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
DOI:10.1532/IJH97.06140
Reference
PMID:17308335
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200
Reference
PMID:11304556
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
DOI:10.1084/jem.193.8.955
Reference
PMID:15485887
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
DOI:10.1074/jbc.M408188200
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
DOI:10.1074/jbc.273.16.9393
Reference
PMID:12821647
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
DOI:10.1083/jcb.200212158
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
DOI:10.1074/jbc.273.1.441
Reference
PMID:10601359
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
DOI:10.1084/jem.190.12.1849
Reference
PMID:10755615
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
DOI:10.1016/S1074-7613(00)80181-8
Reference
PMID:10586078
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
DOI:10.1002/jlb.63.5.521
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)
Related
pathway
morg04020  Calcium signaling pathway
morg04142  Lysosome
morg04144  Endocytosis
morg04810  Regulation of actin cytoskeleton
KO pathway
ko04666   
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