KEGG   PATHWAY: msam04350
Entry
msam04350                   Pathway                                
Name
TGF-beta signaling pathway - Micropterus salmoides (largemouth bass)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
msam04350  TGF-beta signaling pathway
msam04350

Other DBs
GO: 0007179
Organism
Micropterus salmoides (largemouth bass) [GN:msam]
Gene
119882263  chrd; chordin isoform X1 [KO:K04657]
119916335  nog2; noggin-2 [KO:K04658]
119916502  nog3; noggin-3 [KO:K04658]
119898485  noggin-3-like [KO:K04658]
119894737  LOW QUALITY PROTEIN: noggin-like [KO:K04658]
119886227  nbl1; neuroblastoma suppressor of tumorigenicity 1 isoform X1 [KO:K19558]
119917429  grem2a; gremlin-2 [KO:K23318]
119909287  grem1a; gremlin-1a [KO:K23318]
119910153  grem1b; gremlin-1 [KO:K23318]
119909012  thbs1b; thrombospondin-1 [KO:K16857]
119910151  thrombospondin-1-like [KO:K16857]
119882172  decorin-like [KO:K04660]
119918080  dcn; decorin [KO:K04660]
119906160  fmodb; fibromodulin [KO:K08121]
119886542  fmoda; fibromodulin a [KO:K08121]
119886890  zgc:113307; lumican isoform X1 [KO:K08121]
119908480  lft1; lefty1 [KO:K04668]
119892396  fsta; follistatin-A isoform X1 [KO:K04661]
119916133  bone morphogenetic protein 2-like [KO:K21283]
119883176  bmp16; bone morphogenetic protein 16 [KO:K21283]
119908523  bmp2b; bone morphogenetic protein 2b [KO:K21283]
119903030  anti-dorsalizing morphogenic protein [KO:K21283]
119910406  bmp4; bone morphogenetic protein 4 [KO:K04662]
119907990  bmp6; bone morphogenetic protein 6 [KO:K16620]
119903469  inhbb; inhibin beta B chain [KO:K22687]
119885930  inhibin beta B chain [KO:K22687]
119909065  inhibin beta B chain-like [KO:K22687]
119902102  tfa; transferrin-a [KO:K14736]
119917025  bmp5; bone morphogenetic protein 5 [KO:K04663]
119905306  bmp7b; bone morphogenetic protein 7b isoform X1 [KO:K16621]
119885515  bone morphogenetic protein 7-like [KO:K16621]
119906838  bmp8a; bone morphogenetic protein 8A [KO:K16622]
119886677  gdf5; growth/differentiation factor 5 [KO:K04664]
119898009  gdf6a; growth/differentiation factor 6-A [KO:K20012]
119906712  gdf6b; growth/differentiation factor 6-B [KO:K20012]
119900870  amh; muellerian-inhibiting factor [KO:K04665]
119897144  tumor necrosis factor-like [KO:K03156]
119906688  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
119890788  thrombospondin type-1 domain-containing protein 4-like [KO:K23377]
119899092  thrombospondin type-1 domain-containing protein 4-like [KO:K23377]
119906549  thrombospondin type-1 domain-containing protein 4-like [KO:K23377]
119890205  fbn1; LOW QUALITY PROTEIN: fibrillin-1 [KO:K06825]
119917373  ltbp1; LOW QUALITY PROTEIN: latent-transforming growth factor beta-binding protein 1 [KO:K19559]
119882881  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
119896887  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
119889077  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
119910740  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
119909133  transforming growth factor beta-3 proprotein-like [KO:K13377]
119897052  inhbaa; inhibin subunit beta Aa [KO:K04667]
119902753  inhbab; inhibin subunit beta Ab [KO:K04667]
119891900  spaw; southpaw [KO:K04666]
119887503  nodal homolog [KO:K04666]
119914826  nodal homolog 2-A-like [KO:K04666]
119911452  bone morphogenetic protein receptor type-1A-like isoform X1 [KO:K04673] [EC:2.7.11.30]
119891347  bmpr1ba; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
119914293  bmpr1bb; bone morphogenetic protein receptor, type IBb isoform X1 [KO:K13578] [EC:2.7.11.30]
119910627  acvr1l; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
119904033  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
119903610  bone morphogenetic protein receptor type-2-like [KO:K04671] [EC:2.7.11.30]
119901066  bmpr2b; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
119903741  acvr2aa; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
119905275  acvr2ab; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
119881913  hemojuvelin-like [KO:K23100]
119898229  LOW QUALITY PROTEIN: hemojuvelin-like [KO:K23100]
119889827  neo1a; neogenin 1a isoform X1 [KO:K06766]
119912409  tfr2; transferrin receptor protein 2 isoform X1 [KO:K23910]
119912484  tfr1b; LOW QUALITY PROTEIN: transferrin receptor 1b [KO:K06503]
119887120  transferrin receptor protein 1-like [KO:K06503]
119902413  tfr1a; transferrin receptor 1a [KO:K06503]
119893348  rgma; repulsive guidance molecule A [KO:K23096]
119900898  rgmd; RGM domain family, member D [KO:K23096]
119892235  rgmb; RGM domain family member B [KO:K06847]
119905834  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
119903766  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
119898112  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
119907257  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
119885655  si:dkey-264d12.4; epithelial membrane protein 3 [KO:K26257]
119905639  epithelial membrane protein 3-like [KO:K26257]
119895465  lrrc32; transforming growth factor beta activator LRRC32 [KO:K26316]
119888380  transforming growth factor beta activator LRRC32-like [KO:K26316]
119907112  nrros; transforming growth factor beta activator LRRC33 [KO:K26317]
119905633  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
119885701  activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
119897268  activin receptor type-2B-like isoform X1 [KO:K13596] [EC:2.7.11.30]
119901828  activin receptor type-2B-like [KO:K13596] [EC:2.7.11.30]
119904031  activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
119906559  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162]
119898861  smad1; mothers against decapentaplegic homolog 1 [KO:K04676]
119888841  smad5; mothers against decapentaplegic homolog 5 [KO:K16790]
119895177  smad9; mothers against decapentaplegic homolog 9 [KO:K16791]
119891755  mothers against decapentaplegic homolog 2 [KO:K04500]
119890083  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
119893375  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
119891427  mothers against decapentaplegic homolog 4-like [KO:K04501]
119898232  mothers against decapentaplegic homolog 4-like [KO:K04501]
119907298  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
119887885  mothers against decapentaplegic homolog 4-like [KO:K04501]
119914352  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
119890561  mothers against decapentaplegic homolog 6-like [KO:K04677]
119893246  smad6b; mothers against decapentaplegic homolog 6b [KO:K04677]
119914319  smad7; mothers against decapentaplegic homolog 7 [KO:K19631]
119883833  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
119885091  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
119899331  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
119900820  zfyve9b; zinc finger FYVE domain-containing protein 9 [KO:K04679]
119914039  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
119902840  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
119884920  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
119896622  cullin-1 [KO:K03347]
119895680  skp1; S-phase kinase-associated protein 1 [KO:K03094]
119891295  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119886325  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119904984  rho-related GTP-binding protein RhoA-C [KO:K04513]
119905430  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
119905729  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
119886229  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
119901969  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
119882311  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
119891592  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
119888909  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
119895758  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
119882554  rps6kb1b; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
119899805  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
119895400  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
119897237  hepcidin-1 [KO:K23106]
119897995  hepcidin-like [KO:K23106]
119897996  hepcidin-like [KO:K23106]
119897997  hepcidin-like [KO:K23106]
119897998  hepcidin-like isoform X1 [KO:K23106]
119886563  id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
119910505  id2a; DNA-binding protein inhibitor ID-2a [KO:K17693]
119910175  id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
119898089  id4; DNA-binding protein inhibitor ID-4 [KO:K17695]
119886258  rbl1; retinoblastoma-like protein 1 [KO:K04681]
119890105  transcription factor E2F4-like [KO:K04682]
119893941  e2f4; transcription factor E2F4 isoform X1 [KO:K04682]
119901889  e2f5; transcription factor E2F5 [KO:K04682]
119882035  transcription factor Dp-1-like [KO:K04683]
119904272  tfdp1a; transcription factor Dp-1a [KO:K04683]
119916588  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
119884942  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
119899431  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
119889798  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
119885812  sp1; transcription factor Sp1 [KO:K04684]
119901877  skila; ski-like protein isoform X1 [KO:K18499]
119905991  skia; v-ski avian sarcoma viral oncogene homolog a [KO:K26503]
119886367  skib; v-ski avian sarcoma viral oncogene homolog b isoform X1 [KO:K26503]
119889934  paired amphipathic helix protein Sin3a-like isoform X1 [KO:K11644]
119893958  sin3aa; SIN3 transcription regulator family member Aa isoform X1 [KO:K11644]
119907183  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
119909029  histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
119910104  probable histone deacetylase 1-B isoform X1 [KO:K06067] [EC:3.5.1.98]
119895296  ncor1; LOW QUALITY PROTEIN: nuclear receptor corepressor 1 [KO:K04650]
119910678  tgif1; homeobox protein TGIF1 [KO:K19383]
119886945  flocculation protein FLO11 [KO:K19553]
119882023  mych; myelocytomatosis oncogene homolog [KO:K04377]
119911475  myca; transcriptional regulator Myc-A [KO:K04377]
119902666  transcriptional regulator Myc-1-like [KO:K04377]
119898939  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
119889343  pitx2; pituitary homeobox 2 isoform X1 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
msam04010  MAPK signaling pathway
msam04110  Cell cycle
msam04120  Ubiquitin mediated proteolysis
msam04210  Apoptosis
KO pathway
ko04350   
LinkDB

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