KEGG   PATHWAY: mthb04070
Entry
mthb04070                   Pathway                                
Name
Phosphatidylinositol signaling system - Macaca thibetana thibetana (Pere David's macaque)
Class
Environmental Information Processing; Signal transduction
Pathway map
mthb04070  Phosphatidylinositol signaling system
mthb04070

Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126929588  phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
126931472  phosphatidylinositol 4-kinase beta isoform X1 [KO:K19801] [EC:2.7.1.67]
126954803  phosphatidylinositol 4-kinase type 2-beta isoform X1 [KO:K13711] [EC:2.7.1.67]
126962080  phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
126948562  phosphatidylinositol-3-phosphatase SAC1 [KO:K21797] [EC:3.1.3.-]
126962659  phosphatidylinositide phosphatase SAC2 isoform X1 [KO:K21798] [EC:3.1.3.-]
126942537  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
126937646  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
126931668  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
126946778  inositol polyphosphate 5-phosphatase OCRL isoform X1 [KO:K01099] [EC:3.1.3.36]
126959035  LOW QUALITY PROTEIN: type II inositol 1,4,5-trisphosphate 5-phosphatase [KO:K01099] [EC:3.1.3.36]
126936936  phosphatidylinositol polyphosphate 5-phosphatase type IV [KO:K20278] [EC:3.1.3.36]
126951678  synaptojanin-1 isoform X1 [KO:K20279] [EC:3.1.3.36]
126952285  synaptojanin-2 isoform X1 [KO:K20279] [EC:3.1.3.36]
126947557  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126952893  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126948170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126961422  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126956531  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126942202  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
126963336  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
126932568  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
126935021  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1 [KO:K15909] [EC:3.1.3.86]
126955029  inositol polyphosphate 4-phosphatase type II isoform X1 [KO:K01109] [EC:3.1.3.66]
126934279  inositol polyphosphate-4-phosphatase type I A isoform X1 [KO:K01109] [EC:3.1.3.66]
126933084  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
126945389  myotubularin isoform X1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
126945381  myotubularin-related protein 1 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
126935895  myotubularin-related protein 2 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
126963955  myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
126939369  myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
126961436  myotubularin-related protein 7 isoform X1 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
126946504  myotubularin-related protein 8 isoform X1 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
126940723  myotubularin-related protein 6 isoform X1 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
126947695  myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
126930387  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
126962720  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
126938501  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
126961846  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [KO:K13084] [EC:3.1.3.78]
126958302  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1 [KO:K13084] [EC:3.1.3.78]
126941247  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
126936311  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
126931691  phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
126938071  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
126964414  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
126959796  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
126964415  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
126935554  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
126938673  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
126932988  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
126948473  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
126962017  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
126963902  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
126943961  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
126930122  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
126962148  inositol polyphosphate multikinase isoform X1 [KO:K00915] [EC:2.7.1.140 2.7.1.151]
126959842  inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
126935679  inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
126963300  inositol polyphosphate-5-phosphatase A isoform X1 [KO:K01106] [EC:3.1.3.56]
126959672  inositol-tetrakisphosphate 1-kinase isoform X1 [KO:K00913] [EC:2.7.1.159 2.7.1.134]
126937803  inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
126952767  inositol hexakisphosphate kinase 3 isoform X1 [KO:K07756] [EC:2.7.4.21]
126948687  inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
126948689  inositol hexakisphosphate kinase 2 isoform X1 [KO:K07756] [EC:2.7.4.21]
126957482  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1 [KO:K13024] [EC:2.7.4.24]
126959795  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1 [KO:K13024] [EC:2.7.4.24]
126932757  inositol polyphosphate 1-phosphatase isoform X1 [KO:K01107] [EC:3.1.3.57]
126961587  LOW QUALITY PROTEIN: inositol monophosphatase 1-like [KO:K01092] [EC:3.1.3.25]
126941128  inositol monophosphatase 2 isoform X1 [KO:K01092] [EC:3.1.3.25]
126961726  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase [KO:K15759] [EC:3.1.3.7]
126949675  diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
126954823  diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
126931204  diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
126932566  diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
126949989  diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
126939383  diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
126946479  diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
126940364  diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
126948444  diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
126935740  diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
126954551  phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
126929121  phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
126944243  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [KO:K00999] [EC:2.7.8.11]
126947659  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
126930046  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
126952707  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
126938340  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
126944386  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126943319  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126961592  calmodulin-1-like [KO:K02183]
126962311  calmodulin-like protein 5 [KO:K02183]
126962328  calmodulin-like protein 3 [KO:K02183]
126943484  calmodulin-3 isoform X1 [KO:K02183]
126958173  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
126951481  calmodulin-1-like [KO:K02183]
126934255  calmodulin-2 [KO:K02183]
126952282  calmodulin-like protein 6 [KO:K02183]
126959699  calmodulin-1 isoform X1 [KO:K02183]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
mthb04020  Calcium signaling pathway
mthb04144  Endocytosis
mthb04151  PI3K-Akt signaling pathway
mthb04510  Focal adhesion
KO pathway
ko04070   
LinkDB

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