KEGG   PATHWAY: mthb04150
Entry
mthb04150                   Pathway                                
Name
mTOR signaling pathway - Macaca thibetana thibetana (Pere David's macaque)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
mthb04150  mTOR signaling pathway
mthb04150

Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126944301  large neutral amino acids transporter small subunit 1 [KO:K13780]
126935461  4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
126957366  sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
126955010  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
126947782  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
126961447  V-type proton ATPase subunit B, brain isoform [KO:K02147]
126934029  V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
126933787  V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
126960887  V-type proton ATPase subunit C 1 [KO:K02148]
126958659  V-type proton ATPase subunit D [KO:K02149]
126933977  V-type proton ATPase subunit E 2 [KO:K02150]
126935228  LOW QUALITY PROTEIN: V-type proton ATPase subunit E 1-like [KO:K02150]
126929711  V-type proton ATPase subunit E 1 [KO:K02150]
126930200  V-type proton ATPase subunit F [KO:K02151]
126951162  V-type proton ATPase subunit F [KO:K02151]
126929766  V-type proton ATPase subunit G 1-like [KO:K02152]
126937541  V-type proton ATPase subunit G 1 [KO:K02152]
126958612  V-type proton ATPase subunit G 1-like [KO:K02152]
126958613  V-type proton ATPase subunit G 1-like [KO:K02152]
126939740  V-type proton ATPase subunit G 3 [KO:K02152]
126952322  V-type proton ATPase subunit G 1-like [KO:K02152]
126953173  V-type proton ATPase subunit G 2 [KO:K02152]
126961417  V-type proton ATPase subunit H isoform X1 [KO:K02144]
126935252  ragulator complex protein LAMTOR1 isoform X1 [KO:K20397]
126934787  ragulator complex protein LAMTOR2 [KO:K20398]
126955217  ragulator complex protein LAMTOR3 [KO:K04370]
126950532  ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
126930218  ragulator complex protein LAMTOR5 isoform X1 [KO:K16344]
126962829  ragulator complex protein LAMTOR5-like [KO:K16344]
126933872  ragulator complex protein LAMTOR5-like [KO:K16344]
126938799  folliculin [KO:K09594]
126955964  folliculin-interacting protein 1 isoform X1 [KO:K20400]
126954895  folliculin-interacting protein 2 isoform X1 [KO:K20401]
126937698  ras-related GTP-binding protein A [KO:K16185]
126946528  ras-related GTP-binding protein B isoform X1 [KO:K16185]
126959940  ras-related GTP-binding protein C [KO:K16186]
126953832  ras-related GTP-binding protein D [KO:K16186]
126957499  sestrin-2 [KO:K20394]
126963943  cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
126950380  cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
126949949  GATOR complex protein MIOS [KO:K20407]
126941217  nucleoporin SEH1 isoform X1 [KO:K14299]
126944829  GATOR complex protein WDR24 [KO:K20408]
126943709  GATOR complex protein WDR59 isoform X1 [KO:K20409]
126949067  protein SEC13 homolog isoform X1 [KO:K14004]
126963915  GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
126948706  GATOR complex protein NPRL2 isoform X1 [KO:K20405]
126944840  GATOR complex protein NPRL3 isoform X1 [KO:K20406]
126957088  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
126941387  E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
126939145  regulatory-associated protein of mTOR [KO:K07204]
126943131  proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
126952739  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
126961623  DEP domain-containing mTOR-interacting protein [KO:K20402]
126944692  target of rapamycin complex subunit LST8 [KO:K08266]
126944601  telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
126964174  TELO2-interacting protein 1 homolog [KO:K20403]
126930591  CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
126951469  growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
126963906  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
126933775  phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
126941161  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
126930540  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
126939023  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
126961225  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
126954783  eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
126956370  eukaryotic translation initiation factor 4E type 1B [KO:K03259]
126932386  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
126947183  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
126939388  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
126935360  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
126931107  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
126941758  eukaryotic translation initiation factor 4B-like [KO:K03258]
126937697  40S ribosomal protein S6 [KO:K02991]
126946738  40S ribosomal protein S6-like [KO:K02991]
126941928  40S ribosomal protein S6-like [KO:K02991]
126939550  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
126932118  STE20-related kinase adapter protein beta [KO:K17532]
126942954  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
126932377  calcium-binding protein 39 [KO:K08272]
126940442  calcium-binding protein 39-like isoform X1 [KO:K08272]
126956450  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
126932625  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
126936889  hamartin isoform X1 [KO:K07206]
126944570  tuberin isoform X1 [KO:K07207]
126953721  TBC1 domain family member 7 isoform X1 [KO:K20396]
126951632  GTP-binding protein Rheb [KO:K07208]
126962526  DNA damage-inducible transcript 4 protein [KO:K08270]
126930178  proto-oncogene Wnt-1 [KO:K03209]
126930501  protein Wnt-2b [KO:K00182]
126951195  protein Wnt-2 [KO:K00182]
126936033  protein Wnt-3a [KO:K00312]
126938314  proto-oncogene Wnt-3 [KO:K00312]
126956796  protein Wnt-4 [KO:K00408]
126930247  protein Wnt-5b [KO:K00444]
126947624  protein Wnt-5a isoform X1 [KO:K00444]
126933008  protein Wnt-6 isoform X1 [KO:K00445]
126949140  protein Wnt-7a [KO:K00572]
126963624  protein Wnt-7b isoform X1 [KO:K00572]
126963076  protein Wnt-8b [KO:K00714]
126957556  protein Wnt-8a [KO:K00714]
126938932  protein Wnt-9b isoform X1 [KO:K01064]
126935947  protein Wnt-9a isoform X1 [KO:K01064]
126930177  protein Wnt-10b [KO:K01357]
126933003  protein Wnt-10a [KO:K01357]
126935098  protein Wnt-11 isoform X1 [KO:K01384]
126950813  protein Wnt-16 [KO:K01558]
126932182  frizzled-7 [KO:K02432]
126949919  frizzled-1 [KO:K02432]
126938678  frizzled-2 [KO:K02235]
126961767  frizzled-3 isoform X1 [KO:K02329]
126934903  frizzled-4 isoform X1 [KO:K02354]
126962319  LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
126933089  frizzled-5 [KO:K02375]
126960879  frizzled-6 isoform X1 [KO:K02376]
126930546  frizzled-10 [KO:K02842]
126950358  frizzled-9 [KO:K02842]
126930738  low-density lipoprotein receptor-related protein 6 [KO:K03068]
126935940  low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
126939681  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
126951679  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
126948407  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
126949239  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
126953141  tumor necrosis factor isoform X1 [KO:K03156]
126930443  tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
126960750  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126935873  insulin isoform X1 [KO:K04526]
126931779  insulin-like growth factor I isoform X1 [KO:K05459]
126942469  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
126959327  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
126939255  growth factor receptor-bound protein 2 [KO:K04364]
126933534  son of sevenless homolog 1 isoform X1 [KO:K03099]
126958499  son of sevenless homolog 2 isoform X1 [KO:K03099]
126935869  GTPase HRas isoform X1 [KO:K02833]
126931572  GTPase KRas [KO:K07827]
126930824  GTPase NRas [KO:K07828]
126949633  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
126949054  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126957976  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126942673  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126944456  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
126929669  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126957229  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
126945242  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
126946218  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
126953765  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
126932885  insulin receptor substrate 1 [KO:K16172]
126961422  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126956531  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126942202  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
126947557  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126952893  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126948170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126963336  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
126944637  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
126944712  LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
126943096  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126959416  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126942032  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126963067  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
126937191  target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
126956440  rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
126936617  proline-rich protein 5-like isoform X1 [KO:K20411]
126963613  proline-rich protein 5 isoform X1 [KO:K20411]
126948741  transforming protein RhoA [KO:K04513]
126938340  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
126944386  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126943319  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126952874  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
mthb00561  Glycerolipid metabolism
mthb04010  MAPK signaling pathway
mthb04140  Autophagy - animal
mthb04151  PI3K-Akt signaling pathway
mthb04152  AMPK signaling pathway
mthb04810  Regulation of actin cytoskeleton
mthb04910  Insulin signaling pathway
KO pathway
ko04150   
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