KEGG   PATHWAY: mze04371
Entry
mze04371                    Pathway                                
Name
Apelin signaling pathway - Maylandia zebra (zebra mbuna)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
mze04371  Apelin signaling pathway
mze04371

Other DBs
GO: 0060183
Organism
Maylandia zebra (zebra mbuna) [GN:mze]
Gene
101466326  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101470179  adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101464825  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101474342  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101472004  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101468640  adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101480556  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101473262  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101483853  adcy6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101480238  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101468839  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101465620  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101473876  adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
101477119  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101466373  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
101482847  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101482575  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101470440  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101473852  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101473301  hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
101485272  lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
101479970  apln; apelin [KO:K05225]
101478342  apelin receptor A-like [KO:K04174]
101480814  apelin receptor B [KO:K04174]
101486660  apelin receptor A [KO:K04174]
101487808  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101470797  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101486294  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101481843  guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101468881  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101480944  gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101487059  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101463772  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101464387  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101485059  gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101484117  gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101465914  gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101479181  guanine nucleotide-binding protein subunit beta-5b [KO:K04539]
101476846  gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101468814  gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101477020  gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101476464  gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101478744  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101486173  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101478343  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101477410  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
101469176  gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101471056  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101473727  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
101470124  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112429968  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
101486189  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101476389  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101486963  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101476454  gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101482854  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04634]
101475922  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101473803  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
101475994  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101474135  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101464832  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101465812  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101478971  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
101463889  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101470371  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101466928  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101481255  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101476569  ryanodine receptor 1 isoform X2 [KO:K04961]
101487104  ryanodine receptor 1 isoform X1 [KO:K04961]
101465081  ryanodine receptor 2 [KO:K04962]
101474189  ryr2; ryanodine receptor 2 isoform X2 [KO:K04962]
101486597  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
101476662  ryanodine receptor 3 isoform X1 [KO:K04963]
101468777  calmodulin-like protein 4 isoform X1 [KO:K02183]
101464455  calmodulin [KO:K02183]
101468630  calm3; calmodulin-3 [KO:K02183]
101482160  calmodulin [KO:K02183]
101475860  calm2; calmodulin-2 [KO:K02183]
101468175  LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
101470729  calml4; calmodulin-like protein 4 [KO:K02183]
101485683  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101486794  protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
101468101  protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
101464569  LOW QUALITY PROTEIN: Na(+)/H(+) exchanger beta [KO:K05742]
101464596  slc9a1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
101467086  sodium/calcium exchanger 2 [KO:K05849]
101487495  sodium/calcium exchanger 1 isoform X1 [KO:K05849]
101471906  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
101467805  sodium/calcium exchanger 1 [KO:K05849]
101482436  slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
101483574  sodium/calcium exchanger 3 [KO:K05849]
101475078  sodium/calcium exchanger 2 isoform X1 [KO:K05849]
101479888  myosin light chain kinase, smooth muscle isoform X3 [KO:K00907] [EC:2.7.11.18]
101471112  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
101471947  myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101477846  myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
101480150  myosin light chain kinase 3 isoform X2 [KO:K00907] [EC:2.7.11.18]
101478915  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101482094  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101476377  myosin light chain 3 [KO:K12749]
101483891  myl4; myosin light chain 4 [KO:K12750]
101474892  hras; GTPase HRas [KO:K02833]
101465888  kras; GTPase KRas isoform X1 [KO:K07827]
101485266  GTPase HRas [KO:K07827]
101467469  ras-related protein R-Ras isoform X2 [KO:K07830]
101468923  rras2; ras-related protein R-Ras2 [KO:K07830]
101469336  mras; ras-related protein M-Ras [KO:K07831]
101470685  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101465184  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101484555  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101478402  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101486997  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101474234  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101485102  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
101465875  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101478146  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101464876  rps6; 40S ribosomal protein S6 [KO:K02991]
101471620  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101474181  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101482173  pik3r6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
101463967  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
101482467  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
101466926  phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
101467814  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101480630  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101469973  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101476427  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101466452  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101471360  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101483521  egr1; early growth response protein 1 [KO:K09203]
101482048  early growth response protein 1 [KO:K09203]
101485200  jag1; protein jagged-1 [KO:K06052]
101481214  protein jagged-1b [KO:K06052]
101484507  neurogenic locus notch homolog protein 2 isoform X1 [KO:K20995]
101485361  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
101467298  G1/S-specific cyclin-D1 [KO:K04503]
101469697  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
101485817  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
101487246  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
101470672  becn1; beclin-1 [KO:K08334]
101486259  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
101482496  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
101473350  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
101467126  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
101487955  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
101471464  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
101470867  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
101465686  prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
101471783  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
101476687  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
101467149  5'-AMP-activated protein kinase subunit gamma-1 isoform X3 [KO:K07200]
101480396  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
101485259  5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
101482213  5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
101480402  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X7 [KO:K07202]
101475731  nrf1; nuclear respiratory factor 1 isoform X1 [KO:K11831]
101484483  tfam; transcription factor A, mitochondrial [KO:K11830]
101475954  Krueppel-like factor 2 [KO:K17845]
101473001  Krueppel-like factor 2 [KO:K17845]
101473156  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101482860  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
101483399  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101472915  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
101466738  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
101488047  camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101478760  hdac5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
101464986  histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
101483031  hdac4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
101477103  mef2a; myocyte-specific enhancer factor 2A isoform X1 [KO:K09260]
101485187  mef2b; myocyte-specific enhancer factor 2B [KO:K09261]
101471731  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
101479529  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
101477395  mef2d; myocyte-specific enhancer factor 2D isoform X1 [KO:K09262]
101482893  myocyte-specific enhancer factor 2D homolog isoform X1 [KO:K09262]
101479229  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101470473  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
101480714  mothers against decapentaplegic homolog 2 isoform X3 [KO:K23605]
101486706  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
101485832  mothers against decapentaplegic homolog 3 [KO:K23605]
101481185  mothers against decapentaplegic homolog 4 [KO:K04501]
101485614  mothers against decapentaplegic homolog 4 [KO:K04501]
101485383  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
101467180  mothers against decapentaplegic homolog 4 [KO:K04501]
101471135  acta2; actin, aortic smooth muscle [KO:K12313]
101464797  B-cadherin-like [KO:K05689]
111500340  EP-cadherin [KO:K05689]
101479144  B-cadherin [KO:K05689]
101470923  B-cadherin-like [KO:K05689]
101466391  ctgf; connective tissue growth factor [KO:K06827]
101480357  agtr1; type-1 angiotensin II receptor [KO:K04166]
101481046  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
101472111  plat; tissue-type plasminogen activator isoform X1 [KO:K01343] [EC:3.4.21.68]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
DOI:10.1016/j.tips.2015.06.002
Reference
PMID:22140623
  Authors
Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
  Journal
Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
Reference
PMID:25275559
  Authors
Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
  Journal
Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
Reference
PMID:18272138
  Authors
Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
  Journal
Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
Reference
PMID:25652330
  Authors
Folino A, Montarolo PG, Samaja M, Rastaldo R
  Title
Effects of apelin on the cardiovascular system.
  Journal
Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
Reference
PMID:23943882
  Authors
O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
  Journal
J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
  Authors
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
  Journal
Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
Reference
PMID:26254105
  Authors
Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
  Title
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
  Journal
Vascul Pharmacol 76:1-10 (2016)
DOI:10.1016/j.vph.2015.08.005
Reference
PMID:21725702
  Authors
Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
  Title
Apelin, diabetes, and obesity.
  Journal
Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
Reference
PMID:23924696
  Authors
Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
Reference
PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
  Journal
Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
Reference
PMID:20539939
  Authors
Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
  Title
PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
  Journal
Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
Reference
PMID:26607438
  Authors
Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
  Title
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
  Journal
Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
Reference
PMID:27979574
  Authors
Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
  Journal
Int J Cardiol 230:164-170 (2017)
DOI:10.1016/j.ijcard.2016.11.215
Reference
PMID:16182514
  Authors
Carmen GY, Victor SM
  Title
Signalling mechanisms regulating lipolysis.
  Journal
Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
Reference
PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
  Journal
Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
  Journal
Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
  Authors
Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
  Journal
Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
  Journal
Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
  Journal
J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
Reference
PMID:25139773
  Authors
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
  Title
Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
  Journal
Diabetes Metab Res Rev 31:433-52 (2015)
DOI:10.1002/dmrr.2600
Reference
PMID:21464822
  Authors
Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
  Title
Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
  Journal
Lab Invest 91:1018-28 (2011)
DOI:10.1038/labinvest.2011.55
Reference
PMID:22995518
  Authors
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
  Title
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
  Journal
Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
DOI:10.1161/ATVBAHA.112.300317
Reference
PMID:22028387
  Authors
Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, Parini A, Kunduzova O
  Title
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
  Journal
Eur Heart J 33:2360-9 (2012)
DOI:10.1093/eurheartj/ehr389
Reference
PMID:26944568
  Authors
Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
  Journal
Clin Chim Acta 456:81-8 (2016)
DOI:10.1016/j.cca.2016.02.025
Reference
PMID:19093215
  Authors
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
  Title
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
  Journal
Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
Reference
PMID:23603510
  Authors
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
  Title
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
  Journal
Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
  Authors
Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
  Title
The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
  Journal
Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
Reference
PMID:26756969
  Authors
Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
  Title
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
  Journal
J Cell Mol Med 20:495-505 (2016)
DOI:10.1111/jcmm.12754
Reference
PMID:27825851
  Authors
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
  Journal
Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
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