KEGG   PATHWAY: mze04020
Entry
mze04020                    Pathway                                
Name
Calcium signaling pathway - Maylandia zebra (zebra mbuna)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mze04020  Calcium signaling pathway
mze04020

Other DBs
GO: 0019722
Organism
Maylandia zebra (zebra mbuna) [GN:mze]
Gene
101467086  sodium/calcium exchanger 2 [KO:K05849]
101487495  sodium/calcium exchanger 1 isoform X1 [KO:K05849]
101471906  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
101467805  sodium/calcium exchanger 1 [KO:K05849]
101482436  slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
101483574  sodium/calcium exchanger 3 [KO:K05849]
101475078  sodium/calcium exchanger 2 isoform X1 [KO:K05849]
101484996  plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
101484596  atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
101479313  atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
101464682  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
101473100  plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
101465548  muscarinic acetylcholine receptor M3 [KO:K04131]
101485814  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
112434385  muscarinic acetylcholine receptor M5-like [KO:K04133]
101475018  adora2a; adenosine receptor A2a isoform X1 [KO:K04266]
101480031  adenosine receptor A2a [KO:K04266]
101468592  adora2b; adenosine receptor A2b [KO:K04267]
101474916  adrb1; beta-1 adrenergic receptor [KO:K04141]
101487412  beta-2 adrenergic receptor [KO:K04142]
101488105  beta-2 adrenergic receptor [KO:K04142]
101464662  beta-1 adrenergic receptor [KO:K04143]
101481307  D(1) dopamine receptor-like [KO:K04144]
101481493  D(1) dopamine receptor [KO:K04144]
101477361  D(1)-like dopamine receptor [KO:K04144]
101468556  D(1)-like dopamine receptor [KO:K05840]
101473590  drd5; D(1B) dopamine receptor [KO:K05840]
112432154  LOW QUALITY PROTEIN: D(1)-like dopamine receptor [KO:K05840]
101474350  LOW QUALITY PROTEIN: D(1)-like dopamine receptor [KO:K05840]
101477198  histamine H2 receptor [KO:K04150]
101476785  histamine H2 receptor-like isoform X1 [KO:K04150]
101474236  5-hydroxytryptamine receptor 4 [KO:K04160]
101474761  5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
101466418  htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
101464971  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101472521  5-hydroxytryptamine receptor 7 [KO:K04163]
101478984  5-hydroxytryptamine receptor 7 [KO:K04163]
101481065  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
101467861  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
101474191  guanine nucleotide-binding protein G(olf) subunit alpha-like [KO:K04633]
101482928  gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
101466326  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101470179  adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101464825  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101474342  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101472004  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101468640  adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101480238  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101468839  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101465620  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101473876  adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
101477119  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101466373  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
101482847  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101482575  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101470440  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101473852  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101485533  pln; cardiac phospholamban [KO:K05852]
101470078  sln; sarcolipin [KO:K22642]
101483402  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
101476618  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101484155  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
112435262  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
101476777  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
101479173  atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101483122  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101468370  sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
101477486  stromal interaction molecule 1 isoform X1 [KO:K16059]
101465674  stromal interaction molecule 1 isoform X2 [KO:K16059]
101805558  stromal interaction molecule 2 precursor [KO:K18196]
101480999  stim2; stromal interaction molecule 2 [KO:K18196]
101472961  calcium release-activated calcium channel protein 1 [KO:K16056]
101487226  calcium release-activated calcium channel protein 1 [KO:K16056]
101470107  protein orai-2 [KO:K16057]
101471946  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101485620  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101474865  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101480057  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
101472797  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04853]
101479917  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101484868  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
101480217  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
101480715  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
101486272  voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101487658  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X2 [KO:K04852]
101485592  voltage-dependent R-type calcium channel subunit alpha-1E isoform X2 [KO:K04852]
101479737  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
101485565  voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04855]
101477663  voltage-dependent T-type calcium channel subunit alpha-1I isoform X2 [KO:K04856]
101464297  voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101470163  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
101470212  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101471490  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101471534  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101467181  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
101476072  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
101469542  glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
101475684  glutamate receptor ionotropic, NMDA 1 isoform X6 [KO:K05208]
101485837  grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101475595  grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101465427  glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
101467299  glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101464421  glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101481152  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
101474831  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101479926  glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101471692  grin3b; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
101484174  glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101469120  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
101477055  p2rx2; P2X purinoceptor 2 [KO:K05216]
101466017  P2X purinoceptor 3 [KO:K05217]
101463859  P2X purinoceptor 3 [KO:K05217]
101483332  p2rx4; P2X purinoceptor 4 [KO:K05218]
101482192  P2X purinoceptor 5 [KO:K05219]
101471200  p2rx5; P2X purinoceptor 5 [KO:K05219]
101482732  p2rx7; P2X purinoceptor 7 [KO:K05220]
101476569  ryanodine receptor 1 isoform X2 [KO:K04961]
101487104  ryanodine receptor 1 isoform X1 [KO:K04961]
101465081  ryanodine receptor 2 [KO:K04962]
101474189  ryr2; ryanodine receptor 2 isoform X2 [KO:K04962]
101486597  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
101476662  ryanodine receptor 3 isoform X1 [KO:K04963]
101487136  triadin [KO:K23449]
101467330  calsequestrin-1 [KO:K23468]
101483608  calsequestrin-1 isoform X1 [KO:K23468]
101486104  calsequestrin-2-like [KO:K23445]
101479636  calsequestrin-2 [KO:K23445]
101480497  calponin homology domain-containing protein DDB_G0272472 isoform X1 [KO:K00476] [EC:1.14.11.16]
112433101  aspartyl/asparaginyl beta-hydroxylase-like isoform X1 [KO:K00476] [EC:1.14.11.16]
112432813  stress response protein NST1-like [KO:K00476] [EC:1.14.11.16]
101470710  fibrous sheath CABYR-binding protein [KO:K00476] [EC:1.14.11.16]
101469127  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
101481047  cysteinyl leukotriene receptor 1 [KO:K04322]
101463912  muscarinic acetylcholine receptor M2 [KO:K04130]
101469188  muscarinic acetylcholine receptor M2 [KO:K04130]
101473942  alpha-1A adrenergic receptor isoform X1 [KO:K04135]
101475209  alpha-1A adrenergic receptor [KO:K04135]
101485219  alpha-1A adrenergic receptor [KO:K04136]
101485649  alpha-1A adrenergic receptor-like [KO:K04136]
101487374  adra1d; alpha-1D adrenergic receptor [KO:K04137]
101480357  agtr1; type-1 angiotensin II receptor [KO:K04166]
101471769  endothelin receptor type B [KO:K04197]
101468288  ednra; endothelin-1 receptor [KO:K04197]
101481778  endothelin receptor type B [KO:K04198]
101475204  ednrb; endothelin receptor type B [KO:K04198]
101478236  endothelin receptor type B-like [KO:K04198]
101482656  proteinase-activated receptor 1 [KO:K03914]
101482965  proteinase-activated receptor 1 [KO:K03914]
101483533  proteinase-activated receptor 1 [KO:K03914]
101485595  proteinase-activated receptor 1-like [KO:K03914]
101478639  f2r; proteinase-activated receptor 1 [KO:K03914]
101467938  metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101483242  grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101480374  metabotropic glutamate receptor 5-like [KO:K04604]
101485032  gastrin-releasing peptide receptor-like [KO:K04169]
101471274  gastrin-releasing peptide receptor [KO:K04169]
101483859  hrh1; histamine H1 receptor [KO:K04149]
101479925  htr2b; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
101473765  htr2a; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2A [KO:K04157]
101470351  5-hydroxytryptamine receptor 2A [KO:K04157]
112436094  5-hydroxytryptamine receptor 2A-like [KO:K04157]
101467798  lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
101474222  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
112433207  neurotensin receptor type 1-like [KO:K04211]
101483844  oxtr; oxytocin receptor [KO:K04229]
101472972  arg8-vasotocin receptor isoform X1 [KO:K04226]
101485029  arg8-vasotocin receptor [KO:K04226]
101467388  leukotriene B4 receptor 1 [KO:K04297]
101467821  platelet-activating factor receptor-like [KO:K04279]
101468134  platelet-activating factor receptor [KO:K04279]
101470550  platelet-activating factor receptor-like [KO:K04279]
112436600  platelet-activating factor receptor-like [KO:K04279]
101473361  prostaglandin E2 receptor EP1 subtype [KO:K04258]
101477875  prostaglandin E2 receptor EP1 subtype [KO:K04258]
101469118  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
101479350  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
101486448  B2 bradykinin receptor [KO:K03916]
101486926  B2 bradykinin receptor [KO:K03916]
101487206  B2 bradykinin receptor [KO:K03916]
101469423  B2 bradykinin receptor-like [KO:K03916]
101483914  substance-P receptor isoform X1 [KO:K04222]
101465590  tacr2; substance-K receptor [KO:K04223]
101480479  neuromedin-K receptor [KO:K04224]
101469465  neuromedin-K receptor [KO:K04224]
101468725  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
101479671  thyrotropin-releasing hormone receptor [KO:K04282]
101483748  thyrotropin-releasing hormone receptor [KO:K04282]
101465378  thyrotropin-releasing hormone receptor [KO:K04282]
101480236  cckar; cholecystokinin receptor type A [KO:K04194]
101484406  cholecystokinin receptor [KO:K04194]
101466528  cholecystokinin receptor-like [KO:K04194]
101476935  C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
101476920  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
101482854  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04634]
101475922  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101473803  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
101483097  guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04635]
101473508  guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
112429710  guanine nucleotide-binding protein subunit alpha-14-like [KO:K04636]
101476410  guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
101482615  guanine nucleotide-binding protein subunit alpha-11 [KO:K04637]
101487082  egf; pro-epidermal growth factor [KO:K04357]
101486967  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
101486854  platelet-derived growth factor subunit A [KO:K04359]
101486813  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
112432818  platelet-derived growth factor subunit A-like [KO:K04359]
101487929  mastermind-like domain-containing protein 1 [KO:K17386]
101473381  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
101466155  pdgfc; platelet-derived growth factor C [KO:K05450]
101468745  putative fibroblast growth factor 1 isoform X1 [KO:K18496]
101481636  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101483487  fgf2; fibroblast growth factor 2 [KO:K18497]
101478433  fibroblast growth factor 20 [KO:K04358]
101472197  fibroblast growth factor 4-like [KO:K04358]
101473890  fgf6; fibroblast growth factor 6 [KO:K04358]
101484789  fgf3; fibroblast growth factor 3 [KO:K04358]
101486215  fgf4; fibroblast growth factor 4 [KO:K04358]
101475147  fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101471616  fgf16; fibroblast growth factor 16 [KO:K04358]
101474337  fibroblast growth factor 8b [KO:K04358]
101475610  fgf7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101466278  fibroblast growth factor 5 [KO:K04358]
101480132  fibroblast growth factor 20 [KO:K04358]
101473889  fibroblast growth factor 18 isoform X1 [KO:K04358]
101464481  fgf10; fibroblast growth factor 10 [KO:K04358]
101478942  fibroblast growth factor 6 [KO:K04358]
101487959  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101481167  fibroblast growth factor 18 isoform X1 [KO:K04358]
101467905  fibroblast growth factor 22 [KO:K04358]
101479827  fgf5; fibroblast growth factor 5 [KO:K04358]
101484510  fgf19; fibroblast growth factor 19 [KO:K22603]
101485258  fgf21; fibroblast growth factor 21 [KO:K22429]
101479227  fgf23; fibroblast growth factor 23 [KO:K22428]
101472090  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
101467969  vegfb; vascular endothelial growth factor B isoform X1 [KO:K05448]
101477124  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
101486579  vascular endothelial growth factor C [KO:K05449]
101479861  vegfd; vascular endothelial growth factor D [KO:K05449]
101468558  nerve growth factor [KO:K02582]
101486340  nerve growth factor [KO:K02582]
101486965  hepatocyte growth factor isoform X1 [KO:K05460]
101470516  hgf; hepatocyte growth factor [KO:K05460]
101485429  mst1; hepatocyte growth factor-like protein [KO:K23441]
101482940  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
101471543  glial cell line-derived neurotrophic factor-like [KO:K05452]
101477281  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
101483528  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101482712  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
101465105  receptor tyrosine-protein kinase erbB-3 isoform X2 [KO:K05084] [EC:2.7.10.1]
101469990  receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
101467929  erbb4; receptor tyrosine-protein kinase erbB-4 isoform X3 [KO:K05085] [EC:2.7.10.1]
101478875  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101471693  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101484671  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101466822  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101480030  tyrosine-protein kinase SRK3 [KO:K04362] [EC:2.7.10.1]
101469987  fibroblast growth factor receptor 1-A isoform X3 [KO:K04362] [EC:2.7.10.1]
101470033  fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
101463957  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101476450  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101477307  fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101479515  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
101478748  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
101463681  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101472847  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101473195  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101477733  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101467169  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101471879  NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
101471509  ntrk3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
101465566  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
101466878  mst1r; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
101469724  macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
101475370  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
112434355  LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret-like [KO:K05126] [EC:2.7.10.1]
101471379  uncharacterized protein LOC101471379 [KO:K10784]
101476884  immunoglobulin lambda-1 light chain [KO:K10785]
101485117  uncharacterized protein LOC101485117 [KO:K10785]
101470821  uncharacterized protein LOC101470821 [KO:K06856]
101465001  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
111500991  Ig heavy chain Mem5-like [KO:K06856]
101469784  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
106674672  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
101468079  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
101473979  plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
101466745  plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
101477371  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
101475994  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101474135  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101464832  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101465812  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101478971  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
101473405  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101470576  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101479429  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101480055  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
101463889  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101470371  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101466928  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101481255  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101479062  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101478770  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101479335  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101473190  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
101486560  tpcn2; two pore calcium channel protein 2 [KO:K14077]
101475291  mucolipin-1 [KO:K04992]
101477595  mucolipin-1 [KO:K04992]
101478611  mcoln2; mucolipin-2 [KO:K04993]
101473080  mucolipin-3-like [KO:K04994]
101483405  mcoln3; mucolipin-3 isoform X1 [KO:K04994]
101473156  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101482860  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
101483399  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101477384  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
101468605  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101464912  voltage-dependent anion-selective channel protein 2 [KO:K15040]
101472641  voltage-dependent anion-selective channel protein 2 [KO:K15040]
101479017  voltage-dependent anion-selective channel protein 2 isoform X2 [KO:K15041]
101473099  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
101464643  ADP/ATP translocase 2 [KO:K05863]
106676295  ADP/ATP translocase 3 [KO:K05863]
101482797  slc25a4; ADP/ATP translocase 1 [KO:K05863]
101486638  peptidyl-prolyl cis-trans isomerase A [KO:K09565] [EC:5.2.1.8]
101486912  peptidyl-prolyl cis-trans isomerase A [KO:K09565] [EC:5.2.1.8]
101479536  peptidyl-prolyl cis-trans isomerase A [KO:K09565] [EC:5.2.1.8]
101470489  troponin C, slow skeletal and cardiac muscles [KO:K05865]
101472796  troponin C, slow skeletal and cardiac muscles [KO:K05865]
101471916  troponin C, skeletal muscle [KO:K12042]
101472191  troponin C, skeletal muscle [KO:K12042]
101468777  calmodulin-like protein 4 isoform X1 [KO:K02183]
101464455  calmodulin [KO:K02183]
101468630  calm3; calmodulin-3 [KO:K02183]
101482160  calmodulin [KO:K02183]
101475860  calm2; calmodulin-2 [KO:K02183]
101468175  LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
101470729  calml4; calmodulin-like protein 4 [KO:K02183]
101469795  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X2 [KO:K00871] [EC:2.7.11.19]
101485765  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
101477269  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X2 [KO:K07190]
101483320  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
101484644  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
101479888  myosin light chain kinase, smooth muscle isoform X3 [KO:K00907] [EC:2.7.11.18]
101471112  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
101471947  myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101477846  myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
101480150  myosin light chain kinase 3 isoform X2 [KO:K00907] [EC:2.7.11.18]
101476093  calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
101475130  calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
101487616  camk1d; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
101480928  calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
101477929  calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
101478990  calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
101466566  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
101480272  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101475499  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5 [KO:K04515] [EC:2.7.11.17]
101479352  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
101474026  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101473593  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101472930  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
112429915  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
101488047  camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101478346  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101470341  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101486266  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101465092  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101468521  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101465581  calcineurin subunit B type 1 [KO:K06268]
101487274  ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
101475416  tfeb; transcription factor EB isoform X1 [KO:K15590]
101479784  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101485322  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101475633  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101481288  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101469216  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
101470988  nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
101467101  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
101485683  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101469790  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
101472500  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
101482591  pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
101466145  protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
101469888  ptk2b; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
101475297  inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101484637  itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
101482768  inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
101487097  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101464257  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101465488  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101478005  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101481445  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
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Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
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Wang MC, Dolphin A, Kitmitto A.
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L-type voltage-gated calcium channels: understanding function through structure.
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FEBS Lett 564:245-50 (2004)
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Reference
PMID:11299192
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Ferrier GR, Howlett SE.
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Reference
PMID:11698232
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Keef KD, Hume JR, Zhong J.
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
PMID:8125957
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Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
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Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
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Yunker AM.
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Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
PMID:9149541
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Yakel JL.
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Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Reference
PMID:10997573
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Fukunaga K, Miyamoto E.
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
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Reference
PMID:9235901
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Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
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Furuichi T, Mikoshiba K.
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Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
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J Neurochem 64:953-60 (1995)
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Reference
PMID:14572802
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Bruce JI, Straub SV, Yule DI.
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Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
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Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
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Lee HC, Munshi C, Graeff R.
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Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
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Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
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Crompton M.
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Mitochondrial intermembrane junctional complexes and their role in cell death.
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J Physiol 529 Pt 1:11-21 (2000)
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Reference
PMID:10508738
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Grewal SS, York RD, Stork PJ.
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Reference
PMID:12972622
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
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Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
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Hutchins JR, Dikovskaya D, Clarke PR.
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
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Tornquist K
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
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Feske S
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
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Reference
PMID:19434403
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Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
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Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mze04010  MAPK signaling pathway
mze04070  Phosphatidylinositol signaling system
mze04210  Apoptosis
KO pathway
ko04020   
LinkDB

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