KEGG   PATHWAY: ngi03040
Entry
ngi03040                    Pathway                                
Name
Spliceosome - Nannospalax galili (Upper Galilee mountains blind mole rat)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
ngi03040  Spliceosome
ngi03040

Other DBs
GO: 0005681
Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103745031  Ddx46; DEAD-box helicase 46 [KO:K12811] [EC:5.6.2.7]
103724455  Ddx39b; DExD-box helicase 39B [KO:K12812] [EC:5.6.2.7]
103740570  Dhx16; DEAH-box helicase 16 [KO:K12813] [EC:5.6.2.6]
103735612  Dhx38; DEAH-box helicase 38 [KO:K12815] [EC:5.6.2.6]
103749550  Cdc40; cell division cycle 40 [KO:K12816]
103725353  Prpf18; pre-mRNA processing factor 18 [KO:K12817]
103738267  Dhx8; DEAH-box helicase 8 [KO:K12818] [EC:5.6.2.6]
103724555  Slu7; SLU7 homolog, splicing factor [KO:K12819]
103737503  Dhx15; DEAH-box helicase 15 [KO:K12820] [EC:5.6.2.6]
103751141  Snrpb; small nuclear ribonucleoprotein polypeptides B and B1 [KO:K11086]
103728983  Snrpd1; small nuclear ribonucleoprotein D1 polypeptide [KO:K11087]
103749201  Snrpd2; small nuclear ribonucleoprotein D2 polypeptide [KO:K11096]
103738070  Snrpd3; small nuclear ribonucleoprotein D3 polypeptide [KO:K11088]
103745662  small nuclear ribonucleoprotein E-like [KO:K11097]
103730581  small nuclear ribonucleoprotein E-like [KO:K11097]
103731869  Snrpe; small nuclear ribonucleoprotein polypeptide E [KO:K11097]
103733264  Snrpf; small nuclear ribonucleoprotein polypeptide F [KO:K11098]
103728999  small nuclear ribonucleoprotein F-like [KO:K11098]
103725905  Snrpg; small nuclear ribonucleoprotein polypeptide G [KO:K11099]
103743647  Snrnp70; small nuclear ribonucleoprotein U1 subunit 70 [KO:K11093]
103750774  Snrpa; small nuclear ribonucleoprotein polypeptide A [KO:K11091]
103739680  Snrpc; small nuclear ribonucleoprotein polypeptide C [KO:K11095]
103733961  Prpf40a; pre-mRNA processing factor 40 homolog A [KO:K12821]
103746529  Prpf40b; pre-mRNA processing factor 40 homolog B [KO:K12821]
103747391  Rbm25; RNA binding motif protein 25 [KO:K12822]
103740926  Ddx5; DEAD-box helicase 5 [KO:K12823] [EC:5.6.2.7]
103724527  Tcerg1; transcription elongation regulator 1 [KO:K12824]
103726321  Fus; FUS RNA binding protein [KO:K13098]
103747196  Snrpa1; small nuclear ribonucleoprotein polypeptide A' [KO:K11092]
103734357  U2 small nuclear ribonucleoprotein B'' [KO:K11094]
103740450  Sf3a1; splicing factor 3a subunit 1 [KO:K12825]
103737297  Sf3a2; splicing factor 3a subunit 2 [KO:K12826]
103747700  Sf3a3; splicing factor 3a subunit 3 [KO:K12827]
103746171  Sf3b1; splicing factor 3b subunit 1 [KO:K12828]
103725018  Sf3b2; splicing factor 3b subunit 2 [KO:K12829]
103735634  Sf3b3; splicing factor 3b subunit 3 [KO:K12830]
103742657  Sf3b4; splicing factor 3b subunit 4 [KO:K12831]
103731469  Sf3b5; splicing factor 3b subunit 5 [KO:K12832]
103746556  Sf3b6; splicing factor 3b subunit 6 [KO:K12833]
103743478  Phf5a; PHD finger protein 5A [KO:K12834]
103744751  Ddx42; DEAD-box helicase 42 [KO:K12835] [EC:5.6.2.7]
103729339  U2af1; U2 small nuclear RNA auxiliary factor 1 [KO:K12836]
103729932  U2af1l4; U2 small nuclear RNA auxiliary factor 1 like 4 [KO:K12836]
103744795  U2af2; U2 small nuclear RNA auxiliary factor 2 [KO:K12837]
103735276  Puf60; poly(U) binding splicing factor 60 [KO:K12838]
103741079  Smndc1; survival motor neuron domain containing 1 [KO:K12839]
103727300  Rbm17; RNA binding motif protein 17 [KO:K12840]
103726920  Cherp; calcium homeostasis endoplasmic reticulum protein [KO:K12841]
103748359  U2surp; U2 snRNP associated SURP domain containing [KO:K12842]
103726229  Rp9; retinitis pigmentosa 9 (autosomal dominant) [KO:K19604]
103724427  Lsm2; LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12621]
103751469  Lsm3; LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12622]
103726873  Lsm4; LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12623]
103729460  Lsm5; LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12624]
103729401  Lsm6; LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12625]
103737293  Lsm7; LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12626]
103737332  Lsm8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
103742671  Prpf3; pre-mRNA processing factor 3 [KO:K12843]
103734561  Prpf4; pre-mRNA processing factor 4 [KO:K12662]
103741900  Ppih; peptidylprolyl isomerase H [KO:K09567] [EC:5.2.1.8]
103729675  Prpf31; pre-mRNA processing factor 31 [KO:K12844]
103743470  Snu13; SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) [KO:K12845]
103725914  Snrnp27; small nuclear ribonucleoprotein U4/U6.U5 subunit 27 [KO:K12846]
103739801  Usp39; ubiquitin specific peptidase 39 [KO:K12847]
103725045  Sart1; squamous cell carcinoma antigen recognized by T-cells 1 [KO:K11984]
103736056  Zmat2; zinc finger matrin-type 2 [KO:K12848]
103730248  Prpf38a; pre-mRNA processing factor 38A [KO:K12849]
103747857  Prpf38b; pre-mRNA processing factor 38B [KO:K12850]
103738304  Eftud2; elongation factor Tu GTP binding domain containing 2 [KO:K12852]
103738236  Snrnp200; small nuclear ribonucleoprotein U5 subunit 200 [KO:K12854] [EC:5.6.2.6]
103742278  Prpf6; pre-mRNA processing factor 6 [KO:K12855]
103730512  Prpf8; pre-mRNA processing factor 8 [KO:K12856]
103746146  Snrnp40; small nuclear ribonucleoprotein U5 subunit 40 [KO:K12857]
103750560  Ddx23; DEAD-box helicase 23 [KO:K12858] [EC:5.6.2.7]
103746972  Txnl4a; thioredoxin like 4A [KO:K12859]
103740168  Prpf19; pre-mRNA processing factor 19 [KO:K10599] [EC:2.3.2.27]
103730761  Cdc5l; cell division cycle 5 like [KO:K12860]
103734934  Bcas2; BCAS2, pre-mRNA processing factor [KO:K12861]
103750992  Plrg1; pleiotropic regulator 1 [KO:K12862]
103725805  Cwc15; CWC15 spliceosome associated protein homolog [KO:K12863]
103752025  Ctnnbl1; catenin beta like 1 [KO:K12864]
103745996  heat shock 70 kDa protein 1B-like [KO:K03283]
103746770  Hspa6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
103727922  Hspa8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
103724426  Hspa1l; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
103741654  Pqbp1; polyglutamine binding protein 1 [KO:K12865]
103752317  Wbp11; WW domain binding protein 11 [KO:K12866]
103739468  SNW domain-containing protein 1 [KO:K06063]
103743302  Xab2; XPA binding protein 2 [KO:K12867]
103725059  Syf2; SYF2 pre-mRNA splicing factor [KO:K12868]
103740663  Crnkl1; crooked neck pre-mRNA splicing factor 1 [KO:K12869]
103730330  Isy1; ISY1 splicing factor homolog [KO:K12870]
103739649  Ppil1; peptidylprolyl isomerase like 1 [KO:K12733] [EC:5.2.1.8]
103728443  peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
103732356  Ccdc12; coiled-coil domain containing 12 [KO:K12871]
103747089  Rbm22; RNA binding motif protein 22 [KO:K12872]
103726471  Bud31; BUD31 homolog [KO:K12873]
103740517  Aqr; aquarius intron-binding spliceosomal factor [KO:K12874]
103739470  Acin1; apoptotic chromatin condensation inducer 1 [KO:K12875]
103730586  Eif4a3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:5.6.2.7]
103729513  Rbm8a; RNA binding motif protein 8A [KO:K12876]
103737464  Magoh; mago homolog, exon junction complex core component [KO:K12877]
103738748  Magohb; protein mago nashi homolog 2 [KO:K12877]
103728975  Thoc1; THO complex 1 [KO:K12878]
103734851  Thoc2; THO complex 2 [KO:K12879]
103745406  Thoc3; THO complex 3 [KO:K12880]
103730234  Alyref; Aly/REF export factor [KO:K12881]
103745703  Ncbp1; nuclear cap binding protein subunit 1 [KO:K12882]
103738499  Ncbp2; nuclear cap binding protein subunit 2 [KO:K12883]
103738899  Hnrnpa1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
103748244  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
103751780  Hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
103737084  heterogeneous nuclear ribonucleoprotein C-like [KO:K12884]
103735136  heterogeneous nuclear ribonucleoprotein C-like [KO:K12884]
103740149  Rbmx; RNA binding motif protein, X-linked [KO:K12885]
103747091  Hnrnpk; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
103743321  Hnrnpm; heterogeneous nuclear ribonucleoprotein M [KO:K12887]
103746874  Hnrnpu; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
103743469  poly(rC)-binding protein 1 [KO:K12889]
103725910  Pcbp1; poly(rC) binding protein 1 [KO:K12889]
103741791  Srsf1; serine and arginine rich splicing factor 1 [KO:K12890]
103730644  Srsf2; serine and arginine rich splicing factor 2 [KO:K12891]
103739653  Srsf3; serine and arginine rich splicing factor 3 [KO:K12892]
103744206  Srsf5; serine and arginine rich splicing factor 5 [KO:K12893]
103748370  Srsf6; serine and arginine rich splicing factor 6 [KO:K12893]
103745906  Srsf4; serine and arginine rich splicing factor 4 [KO:K12893]
103732806  Srsf7; serine and arginine rich splicing factor 7 [KO:K12896]
103740031  Srsf9; serine and arginine rich splicing factor 9 [KO:K21123]
103740787  Tra2a; transformer 2 alpha homolog [KO:K12897]
103726176  Tra2b; transformer 2 beta homolog (Drosophila) [KO:K12897]
103746424  Srsf10; serine and arginine rich splicing factor 10 [KO:K12900]
103751351  uncharacterized LOC103751351 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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